A blood test may help reduce antibiotic use

A blood test may help
reduce antibiotic use
It Can Detect Within 2 Hours If Bacteria Or Virus Is Source Of Infection,
Reduce Drug Consumption


Contd..
A new blood test can help cut down on unnecessary use of antibiotics by
detecting within two hours if bacteria or virus is the source of an infection,
scientists say .It could stop patients being given antibiotics when they are not
needed, scientists say .It is still at a laboratory stage but the team is working on a
portable device too.
A team of scientists from several medical centres in Israel, in collaboration with
the company MeMed, developed the new test. A large clinical study has validated
the ability of the diagnostic blood test to determine whether a patient has an
acute bacterial or viral infection. Unlike most infectious disease diagnostics that
rely on direct pathogen detection, the assay decodes the body's immune
response to accurately characterize the cause of the infection.


Contd..
Bacterial and viral infections are often clinically indistinguishable, leading to antibiotic overuse
and contributing to the spread of antibiotic resistance. The inability to rapidly differentiate
infections also results in the underuse of antibiotics, estimated to occur in 20-40% of all By
conducting extensive screening of immune system proteins in patients with acute infections,
researchers identified three soluble pro teins that are uniquely activated by bacteria or viruses.
They then developed pro prietary algorithms that integrate these proteins to produce an
immune signature that ac curately identifies the cause of infection. “The ImmunoXpert
immune signature was devel oped and independently valis dated on a cohort of 1,002 patients
with acute infections and yielded highly accurate re sults, with sensitivity and spec bacterial
infections, putting patients at risk of complications and increasing healthcare costs. “Antibiotic

misuse is a pressing public health concern, with devastating healthcare and economic
consequences,“ Eran Eden, CEO of MeMed, noted.


Contd..
“Rapid, accurate and actionable diagnostic tools are an important part of the solution
because they can aid physicians in making better informed treatment decisions,“
Eden said. The technology leverages the fact that bacteria and viruses trigger
different pathways in the immune system. ificity greater than 90%,“ researchers said.
The assay was validated in a diverse group of paediatric and adult patients at
different time points after the onset of symptoms (from the first day up to 12 days)
and across 56 different pathogen species. ImmunoXpert remained robust over all
sub-groups studied.
The predictive power of the assay's immune signature outperformed routine
biomarker and laboratory tests, as well as combinations of these tests, researchers
said.The research was published in the journal PLOS ONE.


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