Pediatric emergency medicine trisk 0886 0886

important causes of hemolysis. Other extrinsic causes of RBC destruction include
the autoimmune, microangiopathic, and drug-induced hemolytic anemias.
Birth trauma, when associated with cephalohematoma, extensive bruising, or
swallowed maternal blood, can result in hyperbilirubinemia. Intracranial,
pulmonary, or other concealed hemorrhage can also lead to extravascular
hemolysis. Similarly, polycythemia, caused by delayed clamping of the cord or
maternal–fetal or fetal–fetal transfusion (in multiple gestations), increases the
RBC mass and causes jaundice in neonates thereby increasing the risk for
supraphysiologic serum bilirubin. Various hypersplenic states, including splenic
sequestration crisis in sickle cell disease, may result in anemia with
accompanying hemolysis and hyperbilirubinemia.