Pediatric emergency medicine trisk 2186 2186

Product/drug

Indication(s)

Dose

Pearls

Packed red blood Anemia
cells (pRBCs)

Volume of packed
• Desired Hb level
RBCs = ([desired
dictated by
hemoglobin
clinical situation
current hemoglobin] ã 10 mL/kg of
ì patient’s blood
pRBCs should
volume)/hemoglobin
raise the Hb
of packed RBCs
about 2 g/dL
Estimated blood
(often used
volume (mL) =
empirically in
weight (kg) ì 70
acute blood loss)
mL/kg

ã Rate of transfusion
Estimated hemoglobin
is dictated by
of unit of packed
clinical
RBCs = 19–25 g/dL
presentation and
differs for acute
versus chronic
etiologies of
anemia

Platelets

One unit per 5–10 kg
(∼50–60 mL/unit),
≥5.5 × 1010
platelets/unit
OR
One apheresis unit
(∼200 mL), ≥3 ×
1011 platelets/unit

Thrombocytopenia
with bleeding
Platelet function
defects

• Use with
caution/clear

clinical need for
patients with ITP,
DIC, TTP, HIT
• Random donor
units are a pooled
donor source. An
apheresis unit is
from a single
donor
• One unit of
random donor
platelets should
increase count by
5,000–10,000/μL
in average adult
• One apheresis unit
should increase
count by 30,000–