Pediatric emergency medicine trisk 2187 2187

50,000/μL in
average adult
Fresh-frozen
plasma (FFP)

Bleeding associated
with abnormal
coagulation panel
Factor deficiency
replacement
Reversal of vitamin
K antagonist
Massive transfusion
requirement

10–20 mL/kg/dose
(∼200–250
mL/unit)

Cryoprecipitate
(Cryo)

Bleeding associated 1–2 units for every 10
with deficiency of
kg of body weight
fibrinogen, FVIII,
FXIII, or VWF

• Contains all
plasma-clotting
factors, but with

variable
concentrations

• Contains
fibrinogen, FVIII,
FXIII, and VWF

Recombinant
Factor VIII products:
factor products
treatment or
prophylaxis of
FVIII deficiency
Factor IX products:
treatment or
prophylaxis of
FIX deficiency
Factor VII (rFVIIa):
treatment or
prophylaxis of
FVII deficiency or
treatment or
prophylaxis for
FVIII or FIX
patients with
inhibitors

Factor VIII: (number • Plasma-derived
of units = desired
factor

level [%] × weight
replacement
of patient [kg] × 0.5)
products also
available
Factor IX: (number of
units = desired level
[%] × weight of
patient [kg])
Factor VII:
Replacement: 15–30
mcg/kg q4–q6hr
FVIII or FIX
inhibitors: 90
mcg/kg q2hr, space
as clinically
tolerated

Antihemophilic
factor/VWF
complex

von Willebrand
disease (VWD)

Dosing based on
VWF:RCo units/kg

Prothrombin
complex

concentrates

Bleeding with
Consult hematologist,
deficiency of FII,
dose for factor
FVII, FIX, FX, or
replacement based
familial vitamin K
on specific factor
deficiency or

• Contraindicated in
DIC, HIT, or
known
hypersensitivity