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Suspect neonatal sepsis in any newborn presenting with hypothermia,
respiratory distress, hypoperfusion, or feeding difficulty.
Any neonate presenting with a concern for infection should be
hospitalized until cultures are proven negative.
Apnea is a common presentation of viral upper respiratory tract
infections (including respiratory syncytial virus infection) in a neonate.
Enteroviral infections are more severe in the neonate than children,
resulting in meningitis, acute fulminant hepatitis, and heart failure from
myocarditis.
RELATED CHAPTERS
Signs and Symptoms
Apnea: Chapter 14
Cyanosis: Chapter 21
Fever: Chapter 31
Septic-Appearing Infant: Chapter 73
Tachycardia: Chapter 77
Medical, Surgical, and Trauma Emergencies
Dermatologic Urgencies and Emergencies: Chapter 88
Infectious Disease Emergencies: Chapter 94
The Children’s Hospital of Philadelphia Clinical Pathway
ED Clinical Pathway for Evaluation/Treatment of Febrile Young
Infants (0–56 Days Old)
URL: />Authors: R. Scarfone, MD; P. Gala, MD; A. Murray, MD; M.K. Funari,
RN; J. Lavelle, MD; L. Bell, MD; C. Jacobstein, MD
Posted: August 2010, last revised August 2019
Neonatal Sepsis
CLINICAL PEARLS AND PITFALLS