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Endocarditis
Endocarditis is an infection of cardiac valves most commonly caused by S. aureus, viridans streptococci, the socalled HACEK organisms (Haemophilus noninfluenzae species, Actinobacillus actinomycetemcomitans,
Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae ), and Coxiella (Q-fever). Endocarditis is
more common in children with existing structural heart disease. The most common symptoms are fever, chills,
fatigue, myalgias, and examination findings may include evidence of embolic phenomenon (pulmonary infarcts,
intracranial or subconjunctival hemorrhages), Janeway lesions (nontender hemorrhagic macules on palms/soles),
immunologic phenomenon (glomerulonephritis, Osler nodes [red, tender raised lesions on palms/soles], or Roth
spots [white-centered retinal hemorrhages]). The diagnosis is based on the modified Duke criteria, which combine
major criteria (blood culture positivity with an organism known to cause endocarditis; echocardiogram findings)
with minor criteria, which include predisposing structural heart disease, fever, and embolic or immunologic
phenomenon. ED-based diagnosis involves obtaining several large-volume blood cultures before antibiotics are
initiated to optimize culture yield. The laboratory should be instructed to hold the blood cultures for several weeks,
as some of the organisms causing endocarditis are fastidious. Empiric management in the critically ill child with
suspected endocarditis should cover MRSA and gram-negative organisms (e.g., with bactericidal antibiotics such
as vancomycin and cefotaxime). Standard precautions should be used.
Myocarditis
Myocarditis is a variably painful inflammation of the myocardium primarily caused by viral infections, most
commonly enteroviruses, but parvovirus, influenza, parainfluenza, and adenovirus, and other viruses can also
cause myocarditis. In children with a consistent travel history, Chagas disease (Trypanosoma cruzi ) and parasitic
infections can also cause myocarditis. Myocarditis has been found in 15% to 20% of sudden infant death syndrome
victims and the same proportion of adolescents who suffer from sudden cardiac death. Early symptoms mimic the
nonspecific findings of viral infections; the most common symptoms are shortness of breath, vomiting, poor
feeding, rhinorrhea, and fever. Chest pain is more commonly verbalized by older children. The most common
examination findings are tachypnea, hepatomegaly, fever, and crackles. Findings may become more obvious after a
child receives fluid boluses, emphasizing the importance of serial examinations between fluid boluses. EKGs are
abnormal in over 90% of patients; the most common EKG findings are sinus tachycardia, low-voltage QRS
complexes, and T-wave inversion. Chest radiographs are abnormal in 60% to 90% of children, most commonly
showing cardiomegaly and pulmonary edema. Laboratory evaluation should include troponin, creatine kinase MB,
B-type natriuretic peptide (BNP), and early cardiology intervention should be sought. Standard precautions should
be used.
Pericarditis is caused by a more heterogeneous group of pathogens (enterovirus being the primary viral etiology,