Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Edited by Ghazala Hayat pot

PERIPHERAL
NEUROPATHY – ADVANCES
IN DIAGNOSTIC AND
THERAPEUTIC APPROACHES

Edited by Ghazala Hayat










Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches
Edited by Ghazala Hayat


Published by InTech
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Copyright © 2012 InTech
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First published February, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from


Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches,
Edited by Ghazala Hayat
p. cm.
ISBN 978-953-51-0066-9

Contents

Preface IX
Part 1 Insights into Etiology of Peripheral Neuropathies 1
Chapter 1 Etiological Role of Dynamin
in Charcot-Marie-Tooth Disease 3
Kohji Takei and Kenji Tanabe
Chapter 2 Predictors of Chemotherapy-Induced
Peripheral Neuropathy 21
Yuko Kanbayashi and Toyoshi Hosokawa
Chapter 3 Targeting Molecular Chaperones
in Diabetic Peripheral Neuropathy 39
Chengyuan Li and Rick T. Dobrowsky
Part 2 Methods of Investigation of Peripheral Neuropathies 63
Chapter 4 Role of Skeletal Muscle MRI
in Peripheral Nerve Disorders 65
Nozomu Matsuda, Shunsuke Kobayashi and Yoshikazu Ugawa
Chapter 5 Blink Reflex Alterations in Various Polyneuropathies 85
Figen Guney
Part 3 Clinical Manifestations of Peripheral Neuropathies 95
Chapter 6 Polyneuropathy and Balance 97
Kathrine Jáuregui-Renaud
Chapter 7 Clinical Cases in Pediatric Peripheral Neuropathy 117
Leigh Maria Ramos-Platt

Chapter 8 Neuropathies Associated with Cosmetic Surgeries 139
Alexander Cárdenas-Mejía, Xitlali Baron, Colin Coulter,
Javier Lopez-Mendoza and Claudia Gutiérrez
VI Contents

Part 4 Advances in Therapy of Peripheral Neuropathies 153
Chapter 9 Multimodal Analgesia for Neuropathic Pain 155
Jorge Guajardo Rosas, Faride Chejne Gomez
and Ricardo Plancarte Sanchez
Chapter 10 Cell Therapy for Diabetic Neuropathy 163
Julie J. Kim and Young-Sup Yoon
Chapter 11 Cell Therapy for Ischemic Peripheral Neuropathy 179
Yousuke Katsuda, Ken Arima, Hisashi Kai and Tsutomu Imaizumi
Chapter 12 Gene and Cell Therapy for Peripheral Neuropathy 189
Deirdre M. O’Connor, Thais Federici and Nicholas M. Boulis










Preface

Over the last two decades we have seen extensive progress within the practice of
neurology. We have refined our understanding of the etiology and pathogenesis for
both peripheral and central nervous system diseases, and developed new therapeutic

approaches towards these diseases.
Peripheral neuropathy is a common disorder seen by many specialists and can pose a
diagnostic dilemma. Many etiologies, including drugs that are used to treat other
diseases, can cause peripheral neuropathy. However, the most common cause is
Diabetes Mellitus, a disease all physicians encounter. Disability due to peripheral
neuropathy can be severe, as the patients suffer from symptoms daily.
This book addresses the advances in the diagnosis and therapies of peripheral
neuropathy over the last decade. The basics of different peripheral neuropathies is
briefly discussed, however, the book focuses on topics that address new approaches to
peripheral neuropathies.

The book is divided into four sections: I) Etiology, II) Methods of Investigation, III)
Clinical Manifestations and IV) Advances in Therapies of Peripheral Neuropathy.
The topics located in the first section address the role of Dynamin in Charcot Marie
Tooth, molecular chaperones in diabetic neuropathy and predictors for
chemotherapy induced peripheral neuropathy. Section II covers different
approaches to investigate peripheral neuropathies. Electrophysiological studies, an
integral diagnostic tool, are discussed throughout the book, but a complete chapter
was not dedicated to the classical methods of investigation in order to address
relatively new methods. MRI scans are increasingly used to diagnose peripheral
nerve pathology. A chapter in this section covers the important aspects of this
technology and possible indications. Section III consists of clinical manifestations of
peripheral neuropathies in children. A chapter is dedicated to the disabling length
dependent neuropathies due to compromised balance. Section IV comprises of
advances in therapeutic approaches. Gene and cell therapy is the future of many
disorders, especially in peripheral nervous system disorders. Cell therapy in diabetic
neuropathy and ischemic neuropathies has been discussed in detail. Current
therapies for neuropathic pain are also included.
X Preface

This book will be valuable for specialists in the area and serve as a resource to general
neurologists and primary care physicians.
I dedicate this book to our patients who are our inspiration to find the cause and cure
for diverse peripheral neuropathies.
I would like to take this opportunity to thank all of the authors for their dedication and
effort throughout the editing process. I hope this book will add to our ever expanding
knowledge of this common but complex disorder.

Prof. Ghazala Hayat
Department of Neurology & Psychiatry,
Clinical Neurophysiology,
Neuromuscular Diseases,
Saint Louis University,
USA



Part 1
Insights into Etiology
of Peripheral Neuropathies