Chapter 105. Malignancies of Lymphoid Cells (Part 12) ppsx

Chapter 105. Malignancies of
Lymphoid Cells
(Part 12)
Table 105-
10 Clinical Characteristics of Patients with Common Types
of Non-Hodgkin's Lymphomas (NHL)

Dis
ease
M
edian
Age,
years
Fre
quency in
Children

Male

S
tage
I/II vs
III/IV,
%
B

Sympt
oms,
%
B
one

Marro
w
Involve
ment,
%
Gastro
intestinal
Tract
Involvement,
%

Survi
ving
5
years

B 6 Rar
9
3
7 3
cell
chronic
lymphocyt
ic
leukemia/
small
lymphocyt
ic
lymphoma

5 e 3 vs 91 3 2 1
Ma
ntle cell
lymphoma

6
3
Rar
e 4
2
0 vs 80

2
8
6
4
9
7
Ext
ranodal
marginal
zone B
cell
lymphoma
of MALT
6
0
Rar
e 8
6

7 vs 33

1
9
1
4
50
4
type
Fol
licular
lymphoma

5
9
Rar
e 2
3
3 vs 67

2
8
4
2
4
2
Dif
fuse large
B cell
lymphoma

6
4
~25
% of
childhood
NHL
5
5
4 vs 46

3
3
1
6
18
6
Bur
kitt's
lymphoma

3
1
~30
% of
childhood
NHL
9
6
2 vs 38

2
2
3
3
11
5
Pre
cursor T
cell
lymphobla
stic
2
8
~40
% of
childhood
NHL
4
1
1 vs 89

2
1
5
0
4
6
lymphoma

An
aplastic
large
T/null cell
lymphoma

3
4
Co
mmon 9
5
1 vs 49

5
3
1
3
9
7
Per
ipheral T
cell non-
Hodgkin's
lymphoma

6
1
~5
% of
childhood

NHL
5
2
0 vs 80

5
0
3
6
15
5

Note: MALT, mucosa-associated lymphoid tissue.
The diagnosis of typical B cell CLL is made when an increased number of
circulating lymphocytes (i.e., >4 x 10
9
/L and usually >10 x 10
9
/L) is found (Fig.
105-6) that are monoclonal B cells expressing the CD5 antigen. Finding bone
marrow infiltration by the same cells confirms the diagnosis. The peripheral blood
smear in such patients typically shows many "smudge" or "basket" cells, nuclear
remnants of cells damaged by the physical shear stress of making the blood smear.
If cytogenetic studies are performed, trisomy 12 is found in 25–30% of patients.
Abnormalities in chromosome 13 are also seen.