Bài giảng chuyển hóa các chất - Chuyển Hóa Lipid part 4 ppt

2.1. 2.1.  oxy ho¸ Acid bÐooxy ho¸ Acid bÐo


Oxy ho¸ AB no, C ch½nOxy ho¸ AB no, C ch½n
X¶y ra trong ty thÓ cña tÕ bµo X¶y ra trong ty thÓ cña tÕ bµo
+ Ho¹t ho¸ AB: + Ho¹t ho¸ AB: ABAB + CoA + ATP + CoA + ATP Acyl CoA + AMP + PPi+ AMP + PPi
Ii. chuyÓn ho¸ acid bÐoIi. chuyÓn ho¸ acid bÐo
Acyl CoA SyntethaseAcyl CoA Syntethase
AMP + PPi
R-CH
2
-CH
2
-CH
2
-COOH
Acid bÐo (n ch½n, no)
Acyl-CoASyntetase
HS-CoA
ATP
 
Acyl-CoA
R-CH
2
-CH
2
-CH
2
-CO~S-CoA
+ VËn chuyÓn a.bÐo tõ bµo t¬ng + VËn chuyÓn a.bÐo tõ bµo t¬ng  ty thÓty thÓ
Acyl CoAAcyl CoA + Carnitin + Carnitin  AAcylcyl CarnitinCarnitin

AcylAcyl Carnitin chuyÓn tõ bµo t¬ng Carnitin chuyÓn tõ bµo t¬ng  ty thÓ ty thÓ
Gi¶i phãng Carnitin Gi¶i phãng Carnitin  AcylCoAAcylCoA
VËn chuyÓn acid bÐo vµo trong ty thÓ theo hÖ thèng vËn chuyÓn
acyl-carnitin/carnitin
+ +  oxy ho¸ AcylCoA (nC) trong ty thÓ qua 4 ph¶n øngoxy ho¸ AcylCoA (nC) trong ty thÓ qua 4 ph¶n øng
11. . Khö hydro lÇn 1 t¹oKhö hydro lÇn 1 t¹o



Dehydro Dehydro Acyl CoAAcyl CoA
2. Hîp H2. Hîp H
22
O t¹o O t¹o

Hydroxy Hydroxy Acyl CoAAcyl CoA
3. Khö 3. Khö hydro lÇnhydro lÇn 2 t¹o 2 t¹o

Ceto Ceto Acyl CoA Acyl CoA
4. Ph©n c¾t 4. Ph©n c¾t

Ceto Ceto Acyl CoA Acyl CoA  Acyl CoA (nAcyl CoA (n 2)C + 2)C + Acetyl CoAAcetyl CoA (2C) (2C)
ThiolaseThiolase
Acyl CoA (nAcyl CoA (n 2)C 2)C > 1, 2, 3, 4 > 1, 2, 3, 4 >>………………. . > Acyl CoA (4C) > Acyl CoA (4C)
Acyl CoA (4C)Acyl CoA (4C) => 2 Acetyl CoA=> 2 Acetyl CoA
S¶n phÈm thu ®îc: Acetyl CoA
+ Vßng -Oxy ho¸
R-CH
2
-CH
2

-CH
2
-CO~S-CoA
R-CH
2
-CH=CH-CO~CoA
R-CH
2
-CH-CH
2
-CO~S.CoA
OH
R-CH
2
-C-CH
2
-CO~S.CoA
O
R-CH
2
-CO~S-CoA + CH
3
CO~S-CoA
Acyl-CoA DH
Acyl-CoA (n-2)C
Acetyl-CoA
CoA.HS
-HydroxyacylCoA DH
Enoyl Hydrase
FAD

+
FADH + H
+
HOH
NAD
+
NADH + H
+
-CetoAcyl-CoA
-HydroxyAcyl-CoA
,-DehydroAcyl-CoA
( Enoyl-CoA)
Thiolase
Acyl-CoA

(1)
(2)
(3)
(4)
Vßng xo¾n LynenVßng xo¾n Lynen
Feodor Lynen (§øc)
1911-1979
Gi¶i thëng Nobel 1964Gi¶i thëng Nobel 1964