Bài giảng chuyển hóa các chất - Chuyển Hóa Lipid part 8 pdf

CÊu tróc cña phospholipidCÊu tróc cña phospholipid
H2C-O-C-R1
R2-C-O-CH
H2C-O-P-O-X
Phospholipase B
Phospholipase C
Phospholipase
D
Phospholipid
Phospholipase A
O
O
O
O
Sù thuû ph©n glycerophospholipid
Sù thuû ph©n lecithin
 Tæng hîp lecithinTæng hîp lecithin (CS(CS TK)TK)
Cholin
PhosphoCholin
XDP-Cholin
PhosphatidylCholin
(Lecithin)
ATP
ADP
XTP
PPi
XMP
Diglycerid
(CH
3
)

3
N
+
-CH
2
-CH
2
OH ( hoÆc Ethanolamin)
(CH
3
)
3
N
+
-CH
2
-CH
2
O- ( hoÆc P-ethanolamin)
P
(CH
3
)
3
N
+
-CH
2
-CH
2

O-XDP ( hoÆcXDP-thanolamin)
 Tõ Base nit¬ (Cholin, Ethanolamin…)
“P”
H.Ho¸
Acid Phosphatidic
XDP-diglycerid
Phosphatidyl cholin
(Lecithin)
Phosphatidyl serin
Phosphatidyl ethanolamin
XTP
PPi
XMP
Serin
CO
2
S-Adenosyl methionin
S-Adenosyl homocystein
HOCH
2
-CHNH
2
-COOH (Serin)
CH
2
O-COR
1
CHO-COR
2
CH

2
O- - OCH
2
– CHNH
2
- COOH
P
+ CH
3
 Tõ acid Phosphatidic (Chñ yÕu, quan träng & ?)
1- GPL
2- GPL
3- GPL
Néi dung bµI gi¶ngNéi dung bµI gi¶ng
§§¹i c¬ng¹i c¬ng
I.I. Tiªu ho¸, hÊp thu vµ vËn chuyÓn lipidTiªu ho¸, hÊp thu vµ vËn chuyÓn lipid
II.II. ChuyÓn ho¸ ChuyÓn ho¸ acid bÐoacid bÐo
2.1. 2.1.  oxyho¸ oxyho¸ acid bÐo acid bÐo nno, C ch½n (o, C ch½n ( O/TKSGK)O/TKSGK)
2.2. Tæng hîp acid bÐo (bµo t2.2. Tæng hîp acid bÐo (bµo tươươngng, ty thÓ), ty thÓ)
III.III. ChuyÓn ho¸ ChuyÓn ho¸ triglyceridtriglycerid
3.1. Tho¸i ho¸ TG3.1. Tho¸i ho¸ TG
3.2. Tæng hîp TG3.2. Tæng hîp TG
IV.IV. ChuyÓn ho¸ ChuyÓn ho¸ glycerophospholipidglycerophospholipid/ lecithin/ lecithin
V.V. ChuyÓn ho¸ cña c¸c thÓ cetonChuyÓn ho¸ cña c¸c thÓ ceton
VI.VI. ChuyÓn ho¸ cña ChuyÓn ho¸ cña cholesterolcholesterol