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>B\Vh?;]SBCE;<mT8+nBU+oAB…;€;<\]^;<
8+XU-
vB1JŽV1JŽVB:V,C-
>B\Vh?;]SBCE;<;+Ž\H;Au;1JuAB>B\Vh?-
•+xU89>?Bg`1,ƒ:mTB>B,t;U+oA,ƒ:-
=<4J<
5<4J<
6<4J<
213<4J<
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ƒ:mTB>B,t;U+oA,ƒ:1,ƒ:B+C:-
]SBiU89>?Bg`1y>;+JŽV1Av81B+VBV\:81y>;+
Al;<F8-
x8<?t?J+>81JŽVB:V,C-

]SB<?t?J+>BJ+‚;<B•;-
?:+ˆ?1y?:;gC1y?:+TA\]^;<:B?Q8+XU1N•+xU
89>?Bg`
5<4J<
3<4J<
[<4J<
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21G<4J<
b?771?M34IU
b?771?M34?=?
$,a"
ŽVB:V,C1y?:-
v81JŽV-
uA1Av818+hB+-
]SB<?t?J+>81,ƒ:B+C:1JuA
32A<4J<
622A<4J<
522A<4J<
=22A<4J<
&'0>BB+X8;<F8;+g;8hVN]^Bk*B+XU;+L;89]SB;€A5222
27  71c
=3P8
7N:8F`?6/ :C?M=?6 b?771?M34 b8M?FH:N
de49<=:H
IJ3KGL49
6D?
522\I; 522\I; =22\I; [22\I;
32  =M[
7?FHM37
+‚;<B… GJB:\ +‚;<B… +‚;<B…

$ 63A<4J< 32A<4J< 63A<4J<
+V‡B6<4;<T`
3A<46J<
E6KGB7
f$  7g49
41T4
6ccf 6cf6 6c_2 6ccf

27  Ih49
4GJ7R127
:\WX49
•B1  :A  ‘1
B+gC  #C1  +?1
’1“B
•B1  :A  ‘1
B+gC  #C1  +?1
’1“B
•B1  :A
‘1B+gC#C1
+?1’1“B
•B1  :A  ‘1
B+gC#C1+?1’1
“B
D41  A4
K[41
Œ;  NO;+  B:V1
B…  8+•  ;XC
;]S;<
X8  8W;+  ;<F8
J+?;+?@8NxB:V

W;+  w;  NO;+
B:V1  B…  8+•
;XC;]S;<
W;+w;NO;+B:V1
B…8+•;XC;]S;<
&'5
 !
2.1-ASPARTAME(E951)-C
14
H
18
N
2
O
5
2.1.1-Giới thiệu chung

O;<F8;T`N]^BU+>8+?@;mTV;€A6c[3yj?”:AuB+\:8u9-9V;<J+?‚;<N:;<8+W
;<+?@A8+CEBB+E;<\j\Vi8mZ88+]ˆ;<1‚;<N|\TANwAx8W8:,U:98:Au\H;8:`-;<N|
8l;+BzU+>8+?@;9:mO;<F8Bs::,U:98:AuJ+?8l;+Bz;ZA;…89H;;<…;8:`-TV;+ƒ;<
;€A6cf2k*N|B‚;<;+L;,PQR;<:,U:98:Au;+]Ax8B+X88hV;<F8-…N]^B,P
QR;<9x;<9|?89H;8+Z<?S?mS?,nB…A‡889V;<J+Vt;<[222\Vh?8+nBU+oA;+]y>;+
JŽV1`V<VC98-…N]^BB+VU+iU,PQR;<89V;<;]SBB…<:,mTV;€A6cf=189V;<B>B
,t;U+oAW8;+?@8;€;<;+]uU,?Q?u8u1BVJuQ?u8uDmTBt89V;<Q]^BU+oA-
?@;;:`U:98:AN]^B8+]ˆ;<Ah?+…:Q]S?B>B8H;:;Qu
Cấu tạo
i41Bs::U:98:A
2.1.2-Thành phần hóa học
:?8+T;+U+I;B+W;+Bs::,U:98:Au\TU+u;`\:\:;?;umT:,U:98?B:B?QaN]^By?Z8NZ;
mS?8H;:,U:98:8u\TAx8AV;VJWB+8+WB+1Ax889V;<52:A?;V:B?QBXC8hV;H;U9V8u?;

mT\TAx8B:ByV•`\?B8]ˆ;<8n;+]:,U:9:<?;uN]^B8lA8+X`U9V8u?;Bs:;+?YC\Vh?8+nB
mL81;+];<J+‚;<N…;<m:?89ŠB+sNhV89V;<Nx;<mL81B…8+•+Vh8Nx;<;+]Ax88>B
;+g;JWB+8+WB+–C>89l;+89C`Y;8W;+?@C8+I;J?;+89V;<;|V-
TAx8,t;U+oA89:VNw?B+X889V;<B+C89l;+C9u:18+:A<?:–C>89l;+8hV<\CBV,ud\T+:?
B+X8NE?–C:;<-
#
2.1.3-Tính chất của aspartame
•,U:98:Au\TAx8B+X8;<F8;+g;8hV-‡BQ‹;…B…B+K,EB:\V9?uB‹;<mS?N]z;<
,:BB:9V,u;+];<;…;<F8+ˆ;J+Vt;<522\I;-
•+‚;<N•\h?Q]mOJ+…B+OC
• ?E;<;+]B>BQ?UuU8?QJ+>B1:,U:98:AB…B+v:;€;<\]^;<J+Vt;<GB:\4<a6_
—4<d-
•+KBI;Ax8\]^;<9X8;+˜:,U:98:AN|8hV9:Nx;<F8BI;8+?Z8-*VN…;€;<\]^;<
B+†;<8:N]:mTVBˆ8+•,™J+‚;<N>;<J•-
•O;<F8Bs:;…B+†;<8:BtA;+L;N]^BB+LA+ˆ;mTJiVQT?\gC+ˆ;,VmS?N]z;<-
•+‚;<w;NO;+j;+?@8NxmTUB:V-
•+g;+s`QI;89V;<;]SB;H;;]SB;<F8B…:,U:98:AJ+‚;<<?ƒN]^B\gC-+V89x;
:,U:98:AmS?,:BB+:9?;+V‡B:Bu,C\•:A8+l+{;+^U;<F8+ˆ;mTw;NO;++ˆ;J+?+:?
B+X8Nv;<9?H;<Ax8Al;+
•x8:;Bs::,U:98:AuU+R8+CxBmTVUmT;+?@8Nxš8+XU;+X8jUN›;<N?@;aU
œ315d
•9V;<QC;<QOB+AE?\?H;JZ8Bs:u,8uB…J+t;€;<8+s`U+g;\TA<?tANx;<F81•
89h;<8+>?J+‚1NxoAQ]S?fžm:;+?@8NxU+Š;<:,U:98:AuyY;89V;<mT?;€A-
2.1.4-Điều chế
,U:98:AN]^BN?YCB+ZyŸ;<B>B+\H;Au;mT8w;<+^U-
•Lên men
*‹;<,E\]^;<\S;B>Bm?J+Co;N‡B89];<<•A-•\:mCAmT-<\C8:A?BCAN•,t;•CX8
9:B>B:B?Q:A?;e:,U9:8?BmTeU+u;`\:\:;?;-
‚?89]z;<\ 8]j;<B+V,nU+>889?•;Bs:m?J+Co;<•A;]SBXA18+vB€;1;<C•;
B:ByV;mT;<C•;;?8ˆ-

¡+vB€;\TB>B\Vh?B:ByV;+`Q9:8;+]AL8AW:1N]z;<<\CBV,u+V‡B,:BB+:9V,u-
¡<C•;B:ByV;;+]:B?Q:Bu8?B19]^C+V‡BB>B+?Q9VB:ByV;-
¡<C•;;?8ˆ;+]=\˜;<+V‡BC9H-
…\T;+ƒ;<N?YCJ?@;B+s`ZCN•m?J+Co;8w;<+^U9:B>B:B?Q:A?;AV;<ACE;-
<VT?9:BŠ;Ax8,EB>B`ZC8EJ+>B;+]B>Bm?8:A?;1:B?Q:A?;D
■Tổng hợp
,U:98:AuB…8+•N]^B8w;<+^UyŸ;<;+?YCU+]ˆ;<U+>U+…:+FBJ+>B;+:C-x8
89V;<U+]ˆ;<U+>U8+]z;<Q‹;<;+],:C
Quá trình xử líe+u;`\:\:;?;8+CN]^B8¢–C>89l;+\H;Au;N]^BB+VU+t;v;<mS?
Au8:;V\8hV8+T;++^UB+X8<F?\T£U+u;`\:\:;?;Au8`\u,8u9-Š;:B?Q:,U:98?BU+t?
–C:Ax8–C>89l;+U+t;v;<N•B+uB>BmO89W89V;<U+g;8PB…8+•t;++]j;<NZ;U+t;
v;<8hV:,U:98:A1NtAytVU+t;v;<B+K•t`9:jB>BmO89WBI;8+?Z8-
Sau khi đã được xử lý phù hợp: B+†;<N]^ByˆAmTVyl;+U+t;v;<mT89x;\„;
89V;<5G<?zj;+?@8NxU+Š;<-+?N…;+?@8NxN]^B8€;<\H;[32a6Gc2kdmTQC`89l
89V;<5G<?z-:CN…1U+t;v;<N]^B\TA;<Cx?NZ;;+?@8NxU+Š;<-…N]^BU+:
\V|;<mS?QC;<A‚?8+WB++^UmTN]^B\TAJZ88?;+je6f2a22kd-?;+8+•8+CN]^B
,™N]^B\FBN•8>B+9?H;<9:9•?\TAJ+‚-+ƒ;<8?;+8+•;T`B+K\T,t;U+oA89C;<<?:;
mTQ‹;<B+VU+t;v;<JZ-
%
>B8?;+8+•;T` N]^BB+C`•;+…:8+T;+:,U:98:AyŸ;<U+t;v;<mS?:B?Q:Bu8?B-
+t;v;<N]^B8+nB+?@;89V;<Ax8B>?y•;\S;B+v:QC;<QOB+:B?Q1B+X8•†B8>BQ
mT5-+†;<N]^B89x;\„;mTB+VU+t;v;<89V;<65<?z-
+X8•†B8>BQN]^B\Vh?y˜yŸ;<B>B+\FBmTB+];<BX8N•8+CQC;<A‚?-+I;B+X8
9•;BŠ;\h?N]^B8?;+B+ZyŸ;<B>B++Š:8:;89V;<QC;<QOB+u8:;V\mTN]^BJZ88?;+\h?-
+ƒ;<8?;+8+•;T`,™N]^B\FBmT\TAJ+‚B+V9:,t;U+oABCE?B‹;<N…\Tyx8
?:C?M=?6
ACID ASPARTIC +PHENYLALANIN ASPARTAM
"03j8FGB49:\WX49
>B8wB+vBB…C`8W;+?@;;:`;+]wB+vB;‚;<\]ˆ;<–CEB8Zakd1wB+vB`8Z
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