Ch. 44 Warm-Up
1. Draw and label the parts of a
nephron.
2. What are the 4 main functions of a
nephron?
3. Where does each function in #2
above occur in a nephron?
4. In the glomerulus, which
substances are filtered? Which
substances remain in the blood?
Controlling the Internal
Environment
Chapter 44
What you must know:
Three categories of nitrogenous waste,
which animal groups produce each, and
why.
The components of a nephron, and what
occurs in each region.
How hormones affect water balance by
acting on the nephron.
Osmoregulation: control solute
concentrations and balance water gain/loss
Excretion: removal of nitrogenous wastes
from body
Types of Nitrogenous Wastes:
Wastes
1. Ammonia – water soluble, very toxic;
aquatic animals
2. Urea – produced by liver; less toxic,
conserves water; most vertebrates
3. Uric acid – excreted as paste or crystals;
birds & reptiles
Types of Nitrogenous Wastes
Various forms of excretory
systems
Protonephridia - Platyhelminthes (Planaria)
Metanephridia - Annelida
Malpighian tubules – Insects, arthropods
Kidneys - Vertebrates
How to make
Water and solutes enter filtrate; blood
urine:
cells and proteins remain in body
fluid.
Reclaim glucose, vitamins,
hormones
Add toxins and excess ions
Filtrate leaves body as urine
Mammalian Excretory
System
Nephrons: functional units of the
kidney
• Glomerulus: filtrate forced into
Bowman’s capsule.
• Blood cells and proteins DO
NOT enter filtrate
Processing of blood filtrate:
1. Proximal tubule: secretion & reabsorption
2.
3.
4.
5.
change volume and composition of filtrate
Bicarbonate, NaCl, water is absorbed
Descending loop of Henle: reabsorb water
Ascending loop of Henle: reabsorb salt
Distal tubule: K+ and NaCl levels regulated
Collecting duct: filtrate becomes more
concentrated; minimize water loss
From blood filtrate to urine
SECRETION
FILTRATION
REABSORPTION
EXCRETION
Hormones
Antidiuretic Hormone
(ADH): urine
concentration, reduce H2O
loss
Also called vasopressin
Renin/angiotensin II:
raise blood pressure
Aldosterone: Na+
reabsorption, H2O
retention, blood volume,
pressure
Blood
Pressure
Regulation
Urine exits kidney
through Ureters
Bladder:
Bladder stores
urine
Urethra:
Urethra urine
exits body
Believe it or not…
Your kidneys are only 4 in long and weigh about
5 oz (weight of ½ unfinished can of pop)
Usually we urinate 1.5-2.5 liters/day
44 gallons of blood is filtered by kidneys
everyday-2 bathtubs full
Fresh urine is cleaner than spit, cleaner than
your hands after they have been washed and
cleaner than the sandwich you will eat for lunch
Gandhi drank urine every day (Tantric Yoga
practice)
Gladiators brushed their teeth with it
Colonial housewives cleaned their home with it
1st football=pig bladder