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Back to Browse Journals » OncoTargets and Therapy » Volume 4
Original Research
Highly Accessed
Downregulation of CD44 reduces
doxorubicin resistance of CD44+CD24- breast
cancer cells
Abstract
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Authors Phuc PV, Nhan PLC, Nhung TH, Tam NT, Hoang NM, Tue VG, Thuy DT, Ngoc PK
Published 21 June 2011 Volume 2011:4 Pages 71—78
DOI />Review by Single-blind
Peer reviewer comments 3
Pham Van Phuc, Phan Lu Chinh Nhan, Truong Hai Nhung, Nguyen Thanh Tam, Nguyen Minh
Hoang, Vuong Gia Tue, Duong Thanh Thuy, Phan Kim Ngoc
Laboratory of Stem Cell Research and Application, University of Science, Vietnam National
University, Ho Chi Minh, Vietnam
Background: Cells within breast cancer stem cell populations have been confirmed to have a
CD44+CD24- phenotype. Strong expression of CD44 plays a critical role in numerous types of
human cancers. CD44 is involved in cell differentiation, adhesion, and metastasis of cancer cells.
Methods: In this study, we reduced CD44 expression in CD44+CD24- breast cancer stem cells
and investigated their sensitivity to an antitumor drug. The CD44+CD24- breast cancer stem cells
were isolated from breast tumors; CD44 expression was downregulated with siRNAs followed
by treatment with different concentrations of the antitumor drug.
Results: The proliferation of CD44 downregulated CD44+CD24- breast cancer stem cells was
decreased after drug treatment. We noticed treated cells were more sensitive to doxorubicin,
even at low doses, compared with the control groups.
Conclusions: It would appear that expression of CD44 is integral among the CD44+CD24- cell
population. Reducing the expression level of CD44, combined with doxorubicin treatment, yields
promising results for eradicating breast cancer stem cells in vitro. This study opens a new
direction in treating breast cancer through gene therapy in conjunction with chemotherapy.
Keywords: antitumor drugs, breast cancer stem cells, CD44, CD44+CD24- cells, doxorubicin
This work is published and licensed by Dove Medical Press Limited. The full terms of this
license are available at and incorporate
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For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
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