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INTERVIEW

2020 Biologicals Special 1


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Getting your biorationals on
the fast track to international
market success
All-round regulatory and scientific support for:

MEET US

• Biopesticides

at ABIM 2020
in Basel

• Basic and low-risk substances
• Biostimulants and fertilisers – soil aids,
soil conditioners or plant aids
• Organic/precision farming and IPM
Our knowledge is the key to your success.

2 2020 Biologicals Special

SCC Scientific Consulting Company
Chemisch-Wissenschaftliche Beratung GmbH

Am Grenzgraben 11 55545 Bad Kreuznach Germany
www.scc-gmbh.de

2020 Biologicals Special 1


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2 2020 Biologicals Special

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2020 Biologicals Special 3


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CONTENTS
INTERVIEW

Advertiser Index
Advanced Biological Marketing (ABM)

P14

Agri Star

P40

AgriThority

P64

Azotic Technologies

P32

Beijing Kingbo Biotech Co.,Ltd

P48

Beijing Multigrass Formulation

P4

BESTAR

P3

Biolchim

P8

Certis USA

P44

Compliance Services International (CSI)

P66

CropTrials GmbH

P68

DOGAL

P56

Eurofins Agroscience Services Group

P15

Grupo Vigna Brasil

P31

Hangzhou Pulan Biotechnology

P63

Ingevity

P28

INTERMAG Sp. z o.o.

P36

IPL Biologicals Limited

P2

Leili Marine BioIndustry INC.

P52

Kwizda Agro GmbH

P34

LOMON CORPORATION

P50

M2i Biocontrol

P67

Plant Health Care

P11

Scientific Consulting Company (SCC)

P1

Seipasa

P16

Shan Dong Peng Bo Bio Technology

P20

Staphyt

Inside Front Cover

STK

P24

Tradecorp

P54

Verdesian Life Sciences U.S. LLC.

P67

Opportunities or Challenges?
- Changes in EU Registration Regulation in 2019

06

Biolchim: Adjust Strategy Under 2019-nCoV, Break Through the
Encirclement and Lead Again

08

Plant Health Care: Focus on Plant Response Elicitors Technology, Boost
Company's Rapid Development

11

Seipasa: Focus on the American Market, Develop Biotechnology Products

16

PRODUCT FOCUS
New Registrations of Microbial Pesticides in US from 2015 to 2018

19

Botanical Pesticides Approved/Launched in Europe, US in Spring 2020

22

Regev™ – A Broad-spectrum Hybrid Fungicide for Plant Disease Control

24

Biorational Developments in Open Field Crops

27

Ingevity: Enhance the Efficiency of Micronutrients with Pine-based Kraft
Lignin

28

Azotic’s Natural Nitrogen Fixing Technology Is A Must for Agriculture

32

Kwizda Agro: Driving Innovation in Biologicals

34

Complementary Approach to Biostimulation

36

How to Achieve Constant Quality in Horticulture

38

Agri Star is Positioned as the Leader in the Bio-Inputs Market in Argentina

40

VIEWPOINT

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AGROPAGES
TEL：+86-571-87240039
EMAIL：

4 2020 Biologicals Special

Biopesticide in Latin America: The Market Is Changing, Where Are the
Future Opportunities?

42

Viral Insecticides: Technological Innovation, A New Blue Ocean of Future
Pesticides

46

Timing, One the Keys to Maximise Results When Using Biostimulants

54

RNAi Opens A New Vista for Pest Control

58

France: Reducing Chemical Pesticide Use And Developing Biological
Control

60

Biopesticides – A Fast-growing Multibillion Market

62

COMPANY DIRECTORY

64

Disclaimer: If some advertisements and product profiles in this issue contain references to active ingredients still under patent protection in certain countries, such content are
deemed inapplicable to those countries.


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Opportunities or Challenges?

- Changes in EU Registration Regulation in 2019

S

CC – Scientific Consulting Company – was founded in 1989 by Dr. Friedbert Pistel.
Since then, it has become one of Europe’s largest privately owned and independent

regulatory consulting companies, supporting its global customers with all their registration
needs for agrochemicals and biorationals, including biostimulants and fertilisers and other
industries.
What kind of company is SCC? What has happened to the EU's registration policy
for biopesticides and biostimulants in 2019? What are the points to note when registering
biopesticides or biostimulants in the EU? Taking this opportunity, AgroPages interviewed Dr
Lars Huber, Head of Biorationals, Fertilisers and IPM of SCC.

mean that we are not actively working in

products. Sale revenues for such products

technical progress in regards to agrochemical

registration projects also outside EU such

often do not justify the investments necessary

practices such as Integrated Pest Management

as in US, Australia or Southern American

for a registration. There are some support

(IPM), Sustainability or Precision Farming

or Asian countries. Although, normally we

schemes in place in certain countries but

as well as testing methods to be used for

cover all this work via our global network of

they are still too few and they have to be

study conduct. Overall, requirements for

cooperation partners, all of them having in-

expanded. But it’s not always the financial

the registration of plant protection products

depth knowledge of the national requirements

investment itself that detain companies from

become more and more complex but also

and authorities. Thus, we are already acting on

the registration. Often, the reasons are the

more individualised, specifically considering

a global scale with international registration

uncertainties and the lack of harmonisation

the characteristics of the individual active

projects but of course we will expand further

in regards to data requirements, requests

substance and/or product. This allows for

if our clients require respective services.

for post-submissions during the registration

General topics and trends are given by the

very specific, substance-orientated approaches

procedure or the timelines. Thus, a regulatory

in regards to requirements, studies and

harmonisation and a fast track procedure,

scientific justifications for study waivers for
biorationals. Thus, dossiers in general get
more complex and scientifically demanding
but, on the other hand, increased acceptance
of scientific argumentation and use of public
literature offers possibilities to reduce study
requirements and thus registration costs at
least for biorationals.

In the field of Agrochemicals and
Biorationals, after more than
30 years of development, SCC
has become a leading consulting
company in this field. What
do you think is the distinctive
service of SCC compared with
other companies? Why do many
companies choose to cooperate

with SCC?

types of natural substances under plant

Asian customers as best as possible. On the

protection as well as fertiliser/biostimulant

other hand this enables us to offer our other

regulatory frameworks. This includes not

clients services in Asian countries and at least

only the work in regards to registration

partially use synergies, knowledge and data

projects but also in R&D as well as academia

produced for registrations in Europe or US

research projects. These different activities

for example for registrations in Asia.

provide for in-depth knowledge, scientifically

oriented testing and registration strategies
for all types of biorationals and regulatory

Lars: According to the feedback from our

frameworks.

clients as well as cooperation partners, CROs

have no own labs for example we are able
always to choose the lab or CRO most suited
to conduct a specific study in regards to its
scientific experience as well as in regards

What does a typical SCC global
customer look like? Who are your
target customers? What are your
plans for future development and
expansion into new markets /
regions?

At present, SCC has operations in
overseas countries such as Japan
and China. Please summarize
the global development of SCC,
especially in the core market?

to economic suitability or timing of studies.

and involves many different areas of the
registration process. On the one hand,
there are the data requirements itself which

clearly are not or only partially suitable for
biopesticides, i.e. natural substances and

Lars: Due to SCCs mode of operation,

at least in regards to the admissibility of an
application, would be required. Participation
of EFSA in pre-submission meeting is a
necessary first step to be welcomed but
additional improvements in the regulatory
registration process are also be necessary.

Regarding biostimulant
registration, is there any change
in EU biostimulant registration
policy in 2019? In the biostimulant
registration section, what services
can SCC provide to help customers
obtain registration quickly?

especially microorganisms. These have to
be revised and adapted. Respective scientific

Lars: In 2019 the new EU regulation on

work dates already back more than two

fertilisers entered into force. This regulation

especially the already mentioned independent

decades but has not been included in the

also includes biostimulants and plant aids for

character, there is no typical global customer.

regulatory process. This implementation

example. This of course changed registration

SCC cooperates, and is able to cooperate,

is currently ongoing on authority level and,

possibilities significantly as the regulation

with the full scale of customers interested

after a delay of many years, hopefully will

introduces EU-harmonised rules. Regrettably,

in or in need of regulatory and scientific

lead to significant improvements in the near

applicability of the regulation will be in 2022

services for plant protection products,

future. On the other hand, the specifics of

only as the respective guidelines and guidance

according to the countries in which

biostimulants, fertilisers and other related

biopesticides have to be considered more

have to be developed in the meantime. Until

registrations are envisaged e.g. EU and US.

products. Of course, in cooperation with

detailed in the regulatory process. For one,

then, respective products still have to be

Differences in regards to rules, regulatory

our other departments, biocides or REACH

the Modes of Action of many biopesticides

registered on a national level if applicable.

frameworks and procedures as well as data

projects for example can also be handled.

require not a curative but a preventive use.

National registrations can be a good basis for

requirements between countries are one of

Some of our clients conduct much of the

Others do not act directly on target organisms

a subsequent registration as an EU-fertilising

but have an indirect Mode of Action acting via

product. Thus, SCC can assist clients to

Could you describe the status and
some trends of the agrochemical
consulting industry? What do you
think is the biggest challenge in
the consulting industry?

and authorities, one of the most distinctive
features of SCC is our independence. As we

Lars: This is a very complex issue

and regulatory, and synergies allow for
the development of innovative and future-

Regarding the registration
of biopesticides, is there any
change in the EU's biopesticide
registration policy in 2019? How
do you think the EU's biopesticide
registration policy should be
changed to drive the rapid
development of biopesticides?

Lars: Status and challenges differ

This feature also emphasises the quality and

Lars: In the case of plant protection

the biggest challenges. Simultaneously, this

relevant work themselves. Other clients work

neutrality of data monitored or provided by

products and especially biorationals requests

results in a quite different, country-specific

with cooperation or distribution partners or

the defence systems of plants. This requires

achieve national registrations in important

SCC in dossiers in the eyes of evaluators and

from clients from Asian countries for

status quo in regards to active substance

even split forces between active substances

not only their IPM use in the agricultural

target markets and evaluate the possible

authorities. Furthermore, this independence

registrations in Europe increased in recent

and product registrations. One of the most

and products. Still, other clients require the

practise but also the incorporation and

registrability of individual products or

acceptance of IPM in the regulatory process.

product portfolios according to the upcoming

ensures high flexibility and enables us to offer

years. This is partly due to the changes

recent examples is the establishment of a

full SCC service from R&D issues, study

all different types of projects according to the

brought on by the new plant protection

new legal and regulatory framework for

monitoring, dossier writing, applications,

In spite of the fact that IPM is mandatory

EU rules. Thus, SCC can support clients in

needs of the client.

and sustainability goals, regulations and

biostimulants in EU, clearly differentiating

defence and follow-up. Thus, there is no

in EU since 2014 for all professional users,

attaining national registrations and allow

guidelines in EU. SCC responded to these

between biostimulants and biopesticides. In

typical SCC customer or even a target

the regulatory process and the requirements

for an early entry into core markets and for

customer.

do not reflect this. This applies especially

core products and prepare for the subsequent

to active substances and products with a

EU-wide registration of the products after

very narrow range of applications and niche

applicability of the EU harmonised rules.

Another important fact, especially in case
of the quite new and constantly changing field

increasing demands from Asian customers by

other countries, such a strict differentiation

of the registration of biorationals is the long-

intensifying or establishing a SCC presence

or definitions are missing or only under

term experience of SCC with all different

in certain Asian countries to be able to attend

development.

6 2020 Biologicals Special

The fact that SCC has not established
offices in additional countries does not

2020 Biologicals Special 7


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Biolchim:

Adjust Strategy Under 2019-nCoV,
Break Through the Encirclement and Lead Again

B

our bio-stimulants can play a crucial role,

agronomic problems and needs. So, growers

support to our subsidiaries and continue to

becoming year after year “standard practice”

choose our products because they know

develop products through the WIN platform

for the farmers. A history of success is

that when we launch a product, we have

with the help of local partners, distributors,

our product (BLUPRINS) for improving

tested it in situations, even in geographical

universities, international research centres.

sprouting and uniformity in cherries in Chile,

environments where their problem occurs. We

This is to position our products in the best

which is today a consolidated solution which

solve the problem close to the farmers, not in

possible way and be close to the needs of

many farmers apply to produce quality

the laboratory.

farmers all over the world.

cherries even in areas with high temperatures.
Another example is the application of two of
our star products like Folicist and Fylloton,

iolchim is a leader in the production and commercialization of special fertilizers in Italy and in the
world. Biolchim today is a synonym for biostimulants: innovative products in all aspects, in the raw

materials they contain as well as in the agronomic performances that characterize them. Biolchim operates in
more than 75 countries worldwide, and is a company where Research and Development represent the main

which in Peru are widely used by blueberry
producers to enhance the productivity of this
crop of which the cultivated area is increasing

year by year.

gear that drives the whole business activity.
Affected by the 2019-nCoV in 2020, most companies in the world will be affected to varying degrees
in their construction and sales. As a leader in the specialty fertilizer industry, how does the epidemic affect
Biolchim? In this difficult environment, how does Biolchim break through itself and adjust the follow-up
plan? Taking this opportunity, AGROPAGES interviewed Marco Civitareale, Product Manager of Biolchim.

What is the impact of the
outbreak of 2019-nCoV in 2020
on Biolchim's overall business? In
this particular situation, how did
Biolchim carry out related work?

technical support. We expect this model to

where there is the presence of nematodes that

still be rewarded by the market even after the

create an important stress on the plant.

crisis. We all remain united and work in the
same direction to get out of this situation and
become stronger than we were before, when
all this started.

Marco: The impact was very strong, in

Kriss Bio is an organic product for

increasing fruit size.
Therefore, in the second half of 2020 we

At present, there are many types
of special fertilizers on the market.
What do you think is the biggest
competitive advantage of special
fertilizers from Biolchim? From
the perspective of dealers or
growers, how do you think they
should choose an excellent special
fertilizer product? 

Could you share with us the
performance of Biolchim in new
product development, product
launch and sales performance in
2019? In terms of international
market development, what
level of Biolchim's international
business is currently at? What
plans does Biolchim have in the
future for international market
development?

At present, special fertilizers are
developing towards functional
fertilizers. Do you agree with this
theory? In your opinion, if special
fertilizers want to break through

the bottleneck in the future, what
aspects of attention and research
should be paid attention to?
Marco: In our opinion, special fertilizers,
in particular biostimulants are much more
than functional fertilizers, in the sense that

Marco: In 2019 the important

the part that is functional is only a feature of

growth curve continued in national and

the biostimulant. Biostimulants have a root,

international markets, and special products

an application, that is much deeper and wider.

and biostimulants saw a relevant increase.

The peculiarity of marketing these products

Biolchim's plan for the future is certainly

is that they have to relate to the application

linked to the very important activities of

in the individual areas of use. Biostimulants

through the WIN platform which ensures

the subsidiaries present at an international

have to be developed, studied and applied

the development close to where there are

level, therefore we would strengthen the

where they arrive on the market.

Marco: Our products are developed

will continue to develop what was launched
and planned in January.

the sense that we had to reorganize ourselves
from the point of view of managing suppliers,
supplies and sales activities very quickly.
The company has been and is strong, and
therefore we managed to handle the impact
fairly well, in terms of production, in the

The first half of 2020 has passed.
For the second half of the year,
what is Biolchim's plan to increase
product sales? What are the new
product launch plans?

acquisition of raw materials, which obviously
suffered enormous delays, and also from the

Marco: In the second half of the year,

Nowadays growers in Latin
America are increasingly accepting
biostimulants and specialty
fertilizers. Could you share with
us some of Biolchim’s experience
in developing the Latin American
market?

point of view of the sales. We managed to

not being sure of being able to work as before

keep the connection alive with our customers,

the crisis and travel we will continue with

with our network, with our end users and

online technical / marketing support activities

also to maintain the connections within the

and with online customer management. We

practices in several Latin-American Countries

group in the various areas, in the various

will be present in a different way but we’ll

are today more focused to export markets.

departments. This is due to the great sense

be always effectively close to our customers.

Chile and Peru, for instance, as well as

of responsibility, a great motivation, a great

The product launch plan for us is always

Brazil and Colombia nowadays are among

desire to overcome this terrible crisis that we

at the beginning of the year, so there will

the biggest exporters of fruits to the US,

and our collaborators have. In this moment

a consolidation of what was launched in

Europe and Asian markets. Farmers to keep

of crisis, we continue to guarantee the three

January, therefore the products Vhera, Vhera

competitiveness need often to improve fruit

fundamental characteristics that we have

Life and Kriss Bio.

qualities, or to maintain a certain yield even

always had as a group. The focus on concrete

Vhera and Vhera Life are part of the

Marco: Yes, this is true. Farming

under stress conditions and/or to concentrate

results, the great capacity for innovation

strategy of supporting crop productivity even

harvest to catch the proper time window

and finally the ability to provide continuous

in difficult environments, such as in soils

for exporting. In those particular conditions

8 2020 Biologicals Special

2020 Biologicals Special 9


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Plant Health Care: Focus on Plant Response Elicitors
Technology, Boost Company's Rapid Development
country. Current distribution elsewhere is
patchy, with sales building in countries such
as Spain, UK, Turkey and S. Africa, but with
many other countries where we have limited
or no presence.  

P

We know that Plant Health Care’s
R&D effort is now focusing on its
next-generation plant response
elicitor technology (PREtec).
Could you tell us what is PREtec?
Why should companies focus on
this area?

lant Health Care is a leading provider of
proprietary biological products to global

What are the products which
Plant Health Care sells today?

agricultural markets. The company attaches

technology – are peptides (short chains
of amino acids) derived originally from

great importance to product R&D and is famous

Plant Health Care’s Commercial

naturally occurring harpin proteins. PREtec

for its core Plant Response Elicitors technology

business is driven by sales of Harpin αß,

peptides act by initiating a complex defense

(PREtec).

a recombinant protein which acts as a

mechanism in plants, analogous in some ways

Why should the company focus on Plant

powerful biostimulant, promoting the yield

to a broad spectrum immune response in

Response Elicitors research? What products

and quality of crops. Plant Health Care also

animals. This protective response makes the

does the company currently have and how

sells the proprietary soil treatment Myconate

plant resistant to a wide range of fungal and

does the specific market perform? What are the

in selected countries. Plant Health Care sells

bacterial diseases during the growing season.

plans for the future? With these questions, we

Harpin αß and Myconate through specialist

In addition to protecting against various

interviewed Christopher Richards, the CEO of

distributors around the world. In Mexico,

diseases, PREtec peptides enhance tolerance

Plant Health Care.

Plant Health Care also distributes third-

to abiotic stress such as drought, leading

party biological products in addition to our

to enhanced plant growth and yield. The

Harpin αß business.

company has three distinct PREtec platforms,

Could you share with us what kind
of company Plant Health Care is?
Plant Health

Care®

is a leading provider

of proprietary agricultural biological products

focused either on disease control, nematode

Where is Plant Health Care active
around the world with current
sales?

and technology solutions focused on improving
crop performance. We offer products to

Plant Health Care has outstanding

control, or biostimulants.

What do you think are the
significant advantages of plant
immune proteins products?
Where are the future market
opportunities for plant immune
proteins?

improve the health, vigour and yield of major

market access, through strong relationships

field crops such as corn, soybeans, cotton and

with well-established distributors in a

rice, as well as speciality crops such as fruits

range of countries; we are also seeking

and vegetables. We operate globally through

additional distributors in some areas. In

subsidiaries, distributors and supply agreements

the USA, we sell through two of the five

with major industry partners.

largest ag input distributors, which gives

pesticides, PREtec peptides are

us outstanding market coverage. In Brazil,

environmentally friendly and do not interact

products help growers to protect their crops

we are currently selling into sugar cane

directly with disease pests. Consequently,

from stress and diseases, and to produce higher

and seeking distributors for sales into other

these pests are not expected to develop

quality fruit and vegetables, with a favourable

crops. In Mexico, we sell a broad range

resistance. Because of their unique mode of

environmental profile.

of products to retailers across the entire

action, PREtec peptides complement and are

Our innovative, patent-protected biological

10 2020 Biologicals Special

PREtec – Plant Response Elicitors

Unlike the action of most chemical

2020 Biologicals Special 11


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compatible with existing chemical fungicides

response and those that do are known to have

and can be deployed as part of an IPM

formulation limitations, to cause a drag on

strategy. As concerns about the environmental

crop yield, or to act via poorly understood

footprint of large-scale agriculture continue

mechanisms. PREtec peptides have none of

to grow, farmers and consumers will

these shortcomings. Rather, PREtec is based

increasingly demand ‘greener’ products such

on cutting-edge science built up over years

Infuse Your Yield with
®
the Power of EMPLOY

as PREtec.

of research and development to develop a

EMPLOY is the biochemical plant health

promoter that offers reduction of cracking of
cherries, improvement of coloring and fruit
sizing of tree fruit, and increased overall yield
of certain crops. This is because it contains
the 2nd generation of the Harpin protein, a
naturally occurring compound produced by
pathogenic bacteria that signals plants’ growth
and pathogen pathways.

are under development and we are very

• Improve fruit size for tree fruit
• Improve fruit color
• Improve yields for certain crops
• Even fruit ripening
• Rainfast in 30 minutes
• Improves plant photosynthesis

The opportunities for PREtec are very

new class of products that are stable, can be

broad: Plant Health Care is partnering with

formulated as liquids or dry granules, and

a number of companies globally exploring a

deliver dependable results.

variety of PREtec product concepts in both
specialty and row crops, through both foliar
and seed treatment application, and as solo
products and mix partners. Solutions to some
of the most pressing problems facing farmers
optimistic about the ability of PREtec to bring

Which market areas is Plant Health
Care focusing on now? What are
the future market development
plans?
Currently, Plant Health Care has
commercial operations in the US, Mexico,

are excited about the potential of our lead

Brazil, Chile, Peru, Spain, UK, Italy, Greece,

PREtec peptide, PHC279, as a seed treatment

Morocco, Turkey, Portugal and South Africa.

for the management of Asian soybean rust

Our plans are to expand into Argentina and

in Brazil, as well as in the US to enhance

Taiwan when we receive regulatory approvals.

the activity of foliar fungicides in corn, soy

Plant Health Care products are focused

and vegetable crops. In the medium-term,

into the specialty and row crops markets

our PREtec peptide for nematode control is

delivering yield and quality improvements to

delivering impressive results from multi-state

those crops which give the grower a greater

field testing in soy and specialty crops and

return for their crop.

is expected to be embraced by growers after

Compared with other companies
that do plant immune proteins
on the market, what do you think
is the biggest advantage of Plant
Health Care?

In terms of product line, does
Plant Health Care plan to expand

the existing product line? If
so, could you share with us the
company's existing product line
and R & D pipeline?
Absolutely. Today we market and sell

This is a great question. There are very

CEO of Plant Health Care

 

added value to growers. In the near-term, we

receiving regulatory approval.

Christopher Richards

Harpin ab and Myconate into the row crop

few products currently on the market that

and specialty crop markets. We are excited

claim to work via stimulating plants’ immune

about the launch of our next generation

technology we call PREtec. Plant Health
Care has filed for the first PREtec product

registrations in the US and Brazil and
we expect registrations in 2021 with first
potential sales in 2022. Plant Health Care is
finalizing the scale up of the manufacturing
and will be looking to produce on a full-scale
basis to meet the product launch dates. In
parallel, we are looking for complementary
products to sell through our strong network of
distribution relationships.
 

What are Plant Health Care's
requirements for partners in
choosing a distribution partner?
Does the company have plans to
explore new markets such as Brazil
and China?
It is a great question. Plant Health Care is
a small biological company so when choosing
our distribution partner first we are looking
for leading distributors who have a strong
presence in the row crop and specialty crop
markets. Next we are looking for partners
who have strong technical and marketing
skills with a presence in the market to reach
the grower. Lastly, we look for partners who
want to add new technology to their portfolio
and extract value from the market that is
meaningful for both parties. This alignment
with large distributors is what sets us apart

from other biological companies and gives
us confidence in our growth plans for the
business. We are currently open to inquiries
from distributors interested in exploring
opportunities for Harpin αβ in crops where we
have demonstrated compelling performance,
such as soy, corn, cane, and citrus in Brazil,

Contact your local Wilbur-Ellis retailer for the solution that is right for you.

actives.wilburellis.com

12 2020 Biologicals Special

For information only. Not a label. Prior to use, always read and follow the product label directions. WILBUR-ELLIS logo is a registered trademark of Wilbur-Ellis Company LLC. Employ is a registered trademark of Plant Health Care, Inc. K-93553

South Asia, China and East Asia.

2020 Biologicals Special 13


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A Complete Line of Biological
Seed Treatments for All Crops.

Contact Brad Custis
to learn more at
011.419.232.2461 Ext 137
14 2020

Biologicals Special
or


ABM1st.com | P.O. Box 222 | Van Wert, OH 45891

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2020 Biologicals Special 15


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The latter is responsible for the launch of two
new Seipasa products, Biocinnafol (natural
plant-derived acaricides / fungicides for the
prevention of mites and powdery mildew)
and Biocrifol (insecticides containing natural
pyrethrins, for the prevention of thorns) on
the Mexican market Sucking pests). 
In July 2017, Seipasa reached a longterm cooperative relationship with Israeli
biopesticide company STK, which will jointly
develop and exclusively distribute Seipasa's

Seipasa: Focus on the American Market,
Develop Biotechnology Products

patented bacterial agent Bacillus subtilis in
the United States. This patented strain can

quickly form a probiotic community around
the plant roots and leaves, prevent pathogens

Pedro Peleato, CEO of Seipasa

from entering the plant through the roots and
plant surface, and block the development of
pathogens by plant induced SAR (system
acquired resistance).
 In order to better understand the

T

company's strategic intention to focus on
he Americas region, especially Latin

Seipasa is a pioneer in the development of

In January 2020, Seipasa signs a

the American market, we also took the

natural plant protection products, biostimulants

strategic cooperation agreement with French

opportunity to interview the CEO of Seipasa

most attractive regions for crop protection

and nutrition products in Spain. Over the past

multinational company Suez, Suez will sell

Pedro Peleato.

companies. With more and more fruits and

two decades, high-value solutions produced

four products of Seipasa in Chile, including

vegetables produced in the Americas imported

and registered by the company have been

Bryosei, Kynetic4, Seiland and Sweetsei.

into high-end markets such as Europe in

used in most agricultural systems worldwide.

recent years, local requirements for pesticides

Currently, Seipasa has carried out business in

agreement with Ecuador distributor QSI-

and fertilizers have also risen to a new level.

more than 20 countries.

Ecuador S.A, a company with 41 years

America, has become one of the

The demand for green, environmentally

After sorting out the trajectory of Seipasa's

In September 2019, Seipasa signed an

of experience, providing various types of

We have noticed that Seipasa
has selected partners in the
Americas, Mexico, Peru, Chile
and other Americas. Why does
Seipasa set strategic markets in the
Americas?

friendly, residue-free biopesticides and

development in the Americas in the past three

solutions for different industrial sectors and

biostimulant products in the Americas has

years, it can be found that Seipasa's market

agriculture.

increased significantly. Focusing on the

development in the Americas has selected

American market has become an important

strong local distributors for cooperation. These

distribution agreement with Peru’s Agritop

The agri-food industry is a global market

strategic layout for many European

distributors may become potential partners of

(a company specializing in plant nutrition).

with numerous points of connection between

companies. The Seipasa company we

domestic companies interested in exploring the

Agritop is responsible for providing

all countries and continents. Seipasa is a fully

analyzed for you today is one such company.

American market.

biological solutions that meet the current

In July 2019, Seipasa signed a

market requirements in Peru according to
customer needs, that is, no residues and high
efficiency for pests and diseases controlled
products.
In May 2019, Seipasa signed an
agreement with Summit Agro USA, which
distributes Seican biological pesticides in
the United States. Seican has a dual action
mode of insecticide and acaricide. Seican is
developed from a formula based on plantderived substances, with low dosage and
high efficacy.
In September 2018, Seipasa signed
a strategic cooperation agreement with
Innovak Global, Mexico's leading biological
solution development and sales company.

16 2020 Biologicals Special

 

integrated actor in the agri-food production

innovation and research applied to active

chain and, as such, interacts with the main

principles of botanical and microbiological

players in the market from the point of view

origin. It is clear that the Latin American

of regulation, production, distribution or

market emulates all that is happening in

consumption. The market is calling out for

Europe and that, furthermore, Europe is a

Seipasa’s natural technology solutions and

major importer of agri-food products grown

the American continent is no different. The

in Latin America. This strategic connection

same widespread trend we see throughout

and continuous exchange between both

Europe for the consumption of healthy,

markets is the reason why we are reinforcing

residue-free fruit and vegetables has also

our position in the American market.

grown strongly in Latin America.  To respond

 

to this demand, producers need solutions that
can fight off pests and diseases and improve
crop health from a sustainable, efficient and
cost-effective point of view. This is Seipasa’s
goal in developing its natural technology
model, backed by its strong commitment to

Can you disclose which
markets Seipasa will focus on in the
next phase?
Seipasa is commercially present in
4 continents and in over 25 countries
worldwide. We currently have a catalogue of
45 products with phytosanitary registrations
and our aim is to reinforce and broaden our
presence in the USA and Latin America.
This process will come about via new

phytosanitary registrations, once all the
applications that are currently under way are
approved. Our international growth project
also includes Africa where we already have
a business unit in operation. We are focusing
on developing this market and are laying
down the foundations for extremely strong
growth in this area. We are also currently
carrying out an in-depth, strategic analysis of
the Asian market to define the advantages and
opportunities this region can offer us.

2020 Biologicals Special 17


INTERVIEW

PRODUCT FOCUS

We know Seipasa and Suez
signed an alliance for the distribution
of biostimulants in Chile. Why choose
Suez? Do you have any requirements in
choosing a distribution partner?

New Registrations of Microbial
Pesticides in US from 2015 to 2018

The key aspect is the alignment of strategic
values within the context of a clear commitment to

transforming the agricultural system into a much
more sustainable and efficient model.  Suez is a

By Paul Zheng, Editor of AgroPages

multinational with more than 160 years’ experience
in the sustainable management of natural resources.
Its innovation and research policy is geared towards
managing water, an essential and increasingly
scarce resource in agriculture.
Seipasa and Suez share a series of strategic
values that align us totally. Our natural technology

What is the current Seipasa product line?

model, the development of innovative and highly
technical solutions for residue-free fruit and

Seipasa is a company that specialises in the development of biopesticide and biostimulant

vegetable growing mean that we align perfectly

solutions based on substances of botanical and microbiological origin. Our competitive edge

with Suez’s commitment to sustainable management

is that we are capable of identifying and selecting the most efficient materials and applying

of the resources needed for agriculture. On this

technology to obtain the best from these active principles. We use the raw materials provided

solid base we have built our alliance which, at this

by nature while but employing the most advanced technology that science provides. At

initial stage, is focused on the Chilean market of

Seipasa we develop solutions that adapt to the needs of each country and type of agriculture

which Suez has ample knowledge and expertise.

and continue to advance in the development of new biocontrol solutions.

B

iopesticide has been highly recognized due to its small side effect,
high safety and environment-friendly property, having become

a new trend of pesticide development worldwide. Biopesticides in

A Summary of New Registrations of Active
Ingredients of Microbial Pesticides in the United
States from 2015 to 2018

Europe have development rapidly in the last few years, but unfortunately
Europe is not developed into the world’s largest biopesticide market

As mentioned above, the sales of microbial pesticides accounted for 2

because of the restraint from the regulatory procedures in the EU. Today

/ 3 of the total sales of biopesticides in the United States, which indicates

I would like to talk about the world's most mature and also the largest

that microbial pesticide is currently the main trend of development of

biopesticide market – the U.S. market.

biopesticides. In this paper, we are presenting the active ingredients of
microbial biopesticides newly registered in the United States from 2015

Simplified biopesticide registration process,
having greatly promoted the development of
biopesticides

Natural technology

According to the report of MarketsandMarkets, the global sales of

to 2018. Many of them have been the first-time registration in the world,
which we hope can provide a reference to our biopesticide counterparts
in China.

Pseudomonas chlororaphis AFS009

biopesticides exceeded $3.3 billion in 2017, which is expected to reach

for global agriculture

$9.5 billion by 2025, at a compound annual growth rate of as high as

In August 2017, the American biopesticide company AgBiome

13.9%. As the world's largest biopesticide sales country, in 2017 the

obtained EPA’s approval of registration of the biopesticide Howler™.

sales of biopesticides in the United States accounted for 1 / 3 of the

It is the first product developed by AgBiome and launched to market

total global sales of biopesticides, of which the microbial biopesticides

by AgBiome Innovations, which is used for prevention and control of

accounted for 67% of the total sales of biopesticides in the United States.

a series of fungi and oomycetes diseases. AgBiome declares that the
activity of the fungicide is 20 times higher than the existing biological

The rapid development of biopesticides in the United States is

solutions. It also says that the product can completely supplant chemical

attributed mainly to the demand from organic product market and the

pesticides in respect of control effect. This is a rare statement, as

strong support of the US Environmental Protection Agency (EPA).

biological product manufacturers generally acknowledge that their

According to statistics, by the end of 2019 the U.S. Environmental

products can reduce the use of conventional chemical pesticides rather

Protection Agency approved about 1,401 biopesticide registrations,

than complete replacement of chemical pesticides.

involving nearly 400 active ingredients, in which biochemical pesticides
accounted for 57.5%, microbial pesticides accounted for 36% and

Muscodor albus SA-13

other miscellaneous accounted for 6.5%. The simplified biopesticide
registration process of EPA has greatly improved the efficiency of

Biopesticides · Biostimulants · Fertilizers
products available

Anuncio_SEIPASA GLOBAL_Agropages_may2020.indd 1

www.seipasa.com

In November 2016, the biological fumigant MBI-601 EP of Marrone

registration, having much reduced the time and cost associated with

Bio Innovations was granted registration in the United States. According

registration. We can say that EPA has pioneered simplification of the

to information, MBI-601 EP can be used for treatment of agricultural

process of biopesticide registration, which is a good reference and worth

and horticultural soils, which can control and inhibit plant parasitic

learning by other countries.

nematodes, soil pests and soil borne diseases. Its active ingredient,


Tel. +34 962 541 163 •
30/4/20 10:24

2020 Biologicals Special 19


PRODUCT FOCUS

PRODUCT FOCUS

Muscodor albus, can produce a variety of chemical

Bacillus mycoides isolate J

substances, which not only can kill or inhibit the
growth of some destructive nematodes and pests,

The first choice for synergism in the post-plant conditioning era

Zhineng Cong(ZNC)

In 2016, the LifeGard WG of the US Certis, Mitsui Chemical, was granted registration

but also can control specific plant diseases such

in the United States, with the active ingredient being Bacillus mycoides, which is the first

as root rot, damping off, blight and greensickness.

biopesticide in the world to act via induced resistance against fungal and viral diseases. In

In addition to soil treatment, the novel microbial

that year, the product won the world's best biological innovation award. LifeGard WG is

pesticide is expected to have more applications

registered mainly for control of potato early blight, late blight and powdery mildew. So far,

to lawn, forestry seedling, post-harvest and seed

the product has been sold in most of the regions of the United States and Canada, with a

treatment.

good market response.

EU Standard Biostimulant

Table 1: 2015 – 2018 New Registrations of Microbial Pesticides in US

Bio-fungicides

ZNC is saving
Ultra- high
activity
1-10ppb effective,
10-20 times that of
brassinolide

Super
function

Growth promotion,
disease resistance,
stress resistance and
improvement of the
effects of fertilizers

First-Time
Registration

Owner

Trade Name

Bacillus subtilis FMCH002

2018

FMC

-

Bacillus licheniformis FMCH001

2018

FMC

AVODA

Bacillus subtilis BU1814

2017

BASF

VELONDIS

SEIPASA

Bacillus subtilis IAB/BS03

Ultra
low cost
0.03 yuan(RMB)/15
liters of water
Flush: 1.6
yuan(RMB)/666.7
square meters

Active Ingredients

The main functions :

Bacillus mycoides AFS009

2015

Fungisei

IBERFOL

Milagrum Plus

INVESTIGACIONES Y APLICACIONES
BIOTECNOLOGICAS

Mildore

QUIMICAS MERISTEM

BACIX

AgBiome Innovations

Howler

Valent USA

VBC-90052

LIDOCHEM

VARNIMO IF

2017

Bio-nematocides
Bacillus amyloliquefaciens
PTA-4838

2016

Muscodor albus strain SA-13

2016

Marrone Bio Innovations

ENNOBLE

Bacillus mycoides isolate J

2016

CERTIS USA

LIFEGARD

Bio insecticides

Address: No.1, North Tianmen street,
Tai'an City, Shandong Province
E-mail:

20 2020 Biologicals
Special

Tel: 15610341616

Bacillus thuringiensis Kurstaki
EVB-113-19

2016

AEF Global

BIOPROTEC

Bacillus thuringiensis subsp SA-10

2016

CERTIS USA

Btt SDTC

Bacillus thuringiensis subsp. Israelensis SUM-6218

2016

SUMMIT CHEMICAL CO. DBA SUMMIT
RESPONSIBLE SOLUTIONS

DUNKS

Cotton armyworm nucleopolyhedro virus BV-0003

2015

CERTIS USA

SPOD-X LC

Spodoptera frugiperda nucleopolyhedro virus 3AP2

2016

AGBITECH

FAWLIGEN

Papaya ringspot viral protein

2016

UNIVERSITY OF FLORIDA

X17-2 Papaya

Beet armyworm nucleopolyhedro virus BV-0004

2015

Andermatt Biocontrol

SPEXIT

2020 Biologicals Special 21


PRODUCT FOCUS

PRODUCT FOCUS

Botanical Pesticides Approved/Launched
in Europe, US in Spring 2020
Product from ORO AGRI

By Joyce Wang
Editor of AgroPages

B

otanical pesticides, as a substitution for
chemical pesticide, mitigate the problem
of harmful residues and pesticide resistance,
as many botanical pesticides have shown an
ideal efficacy to control agricultural pests.
These products have multiple modes
of action and are harmless to non-target
organisms. In the past years, research has
shown constant improvement in the control
effect of botanical pesticides. Pyrethrum,
azadirachtin and plant essential oil are
commonly active ingredients in these products.
Such products make a great contribution
to organic farming in developed countries
and play an important role in agricultural
production and post-harvest preservation in
developing countries.
Today, there are mainly four types
of botanical pesticides for pest control:
pyrethrum, rotenone, azadirachtin and plant
essential oil. Some vegetable extracts, such
as garlic-derived ingredient, are relatively
less used worldwide. The desired safety and
efficacy of botanical pesticides enable them to
be alternatives to chemical products.
This article present four botanical
pesticides approved or launched in Europe and

the United States in spring 2020.

22 2020 Biologicals Special

Oro Agri is a global market-oriented
business company, developing and providing
biological products for crop protection and
yield increase. Its products are sold to more
than 85 countries across five continents, with
180 employers in more than 23 countries.
The company has production plants in Brazil,
South Africa and North America, as well as
a contract manufacturer in Spain. The orange
oil products from Oro Agri are biological
pesticides which provide multi-functions of
insecticide, acaricide and fungicide, of which
PREV-AM® has been applied successfully in
South Europe for more than three years, and
has also been launched in the Chinese market.
In February 2020, Oro Agri launched a
new version of PREV-AM – Oroganic, in
the Netherlands. It is a novel insecticide/
acaricide/fungicide based on the active
substance of the natural orange oil, with builtin adjuvant. The product has been approved
by the Dutch Board for the Authorization
of Plant Protection Products (CTGB), for
application on tomatoes, bell peppers,
chilies, Cucurbitaceae (like cucumbers) and
ornamentals (such as cut-flowers). Oroganic
can be used to control spider mite, whitefly,

thrips, aphid, scaly insect and mealybug, as
well as diseases such as botrytis , powdery
mildew and downy mildew.
According to the company, Oroganic is
quick and effective in controlling targeted
insect pests without leaving harmful residues,
and there is no requirement for pre-harvest
and post-harvest intervals. Oroganic's mode
of action reduces the risk of pest becoming
resistant to the active ingredients. The product
has a low impact on beneficial insect and
mite, being an ideal choice for Integrated Pest
Management (IPM).
Oroganic can be used with a combination
of other biological control solutions, or tank-

mixed with many other crop protection
products. Regular use in the irrigation
system will not cause chemical residue
deposition or nozzle-plugging. Oroganic is
not easily affected by the pH of the tank-mix
formulations. Moreover, the product is both
hydrophilic and lipophilic, which is good for
tank-mix formulations to penetrate into insect
pest and the plant’s superficial wax coat.
Oro Agri is working on research,
registration and label extension for the
product’s other uses. Now the company
has registrations pending in more than 20
countries.

Products from Sym Agro
In order to effectively control the
common insect pests and diseases such as
powdery mildew, botrytis , mite and worm
for hemp growers, Sym Agro has assembled
a suite of broad-spectrum biopesticides to
improve the control efficacy. This assemblage
includes four biological control products,
three of which are vegetal pesticides, granted
the organic certification. In addition to hemp,
these products can be applied to various
crops.

Cinnerate is a fast-acting acaricide/
fungicide/insecticide, based on cinnamon
aldehyde, emulsified with potassium oleate.
The innovative formulation enables the
product to be effective with low application
rates. It has an eradicative effect against
various diseases such as powdery mildew,
botrytis and rust. Cinnerate can control most
mite and other insect species.
Cinnerate provides multiple modes of
action and is an ideal product for resistance
management. Cinnerate affects the oxidation
of fungal mitochondria, which interferes with
the enzyme activity of the cell membrane,
causing quick dehydration and making

symptoms disappear. Moreover, the product
can inhibit the growth of fungal mycelium,
hinder the germination of the fruiting body,
disrupt the disease life cycle and prevent its
further spread.
In terms of harmful mites and insects,
Cinnerate asphyxiates them by sealing their
spiracles. Cinnerate can also disturb the
nervous system, and inhibit glucose uptake
and use. This leads to effective control of all
mite life stages, including the eggs.
Cinnerate has little to no impact on the
beneficial insect population. The product
is compatible with most of the biological
control products and can be used with
chemical fungicides and acaricide to create
a synergistic effect. In addition to hemp,
Cinnerate is approved for the application to
most of the crop varieties.

azadirachtin, the product has dual modes of
action. It primarily regulates the growth of
insects, with a repellent effect. The product
controls more than 300 different insect
species, including aphid, thrips, leafminer,
leafhopper, beetle, mealybug, weevil,
Lepidoptera and pear psylla, etc.
AzaPro kills the insect larvae and nymphs
by interfering with ecdysone, thereby making
it impossible for them to become reproducing

adults. The product is lethal to sucking and
chewing pests with minimal effect on nontarget beneficial insects. Although it is
difficult to control with sprays to kill insects
that feed on the undersides of the leaves,
AzaPro is able to penetrate the leaves to
control these pests. Repeated application of
the product forms a protective barrier within
the plants to prevent the growth of pest
populations.
Furthermore, AzaPro contains 75% fewer
oil carriers than competing products. The
product can thus reduce the oil accumulation
on crops, and leave no visible oil residue on
the produce.

AzaPro is an insect growth regulator,
which controls various insect species, and is a
nematicide as well. With the highly bioactive

Alluma contains 15% refined garlic oil
(Allyl polysulfides+Allicin), which is a stable
and long-lasting formulation. It acts as an
insecticide, insect repellent and miticide, as
well as a feeding and oviposition deterrent.
After insect uptakes Alluma, the product
inhibits its chitin. Alluma also acts on the
pest’s sensing faculties, disguising the odor
signal emitted by crops and thus preventing
females from laying eggs. The product
controls various Lepidoptera, thrip, weevil,

soft-bodied insect species and mites.
Alluma can be used either alone or
tank-mixed with other pesticides enhancing
overall pest control. The experimental
result has revealed a high synergistic effect
when Alluma is applied with Cinnerate
or azadirachtin. The product is of great
help in the control of tough insect pests.
Besides hemp, Alluma can be used on fruits,
vegetables, herbs and field crops.
More biopesticides approved/launched
worldwide in spring 2020 are as below:

Biopesticides approved/launched worldwide in spring 2020

Company

Product

Ingredient

Oro Agri

Oroganic

Orange oil

Spider mites, whiteflies, thrips, aphids,
scaly insects and mealybugs

Greenhouse tomato, pimento, chili,
cucurbitaceae, ornamental plant

Netherlands

Bayer

Zhuorun

EndophyteQST713

Soil-borne diseases

Tomato, potato

China

Bioworks

PERpose Plus

Hydrogen peroxide

Fungi, algae

Fruit, vegetable, tobacco

US

Kenogard

Romeo

Saccharomyces cerevisiae cell
wall

Various fungal diseases

Grape, tomato, eggplant,
cucurbitaceae, strawberry, lettuce

Spain

Alluma

Garlic oil

Mites, thrips, lepidopteran pests

Cinnerate

Cinnamon oil

Various fungi and majority of mites

AVIV

Novel bacillus subtilis
IAB/BS03

Soil-borne diseases.

AzaPro

Azadirachtin

Over 300 kinds of insect pests, mites,
nematodes

Sym-Agro

Target Pest

Bacillus thuringiensis subspecies
Box tree moths, cabbage loopers, corn
aizawai (ABTS-1857),
earworm, leafrollers, tomato leafminers
insecticidal proteins

Valent
BioSciences

XenTari

Xeda Italia

Xedavir

Trichoderma asperellum TV1

Verdera

Mycostop

Summit Agro

Timorex Act

Target Crop

Hemp

Country

US

Fruiting vegetables, tree nuts, herbs
and spices, grape, etc.

Canada

Soil-borne diseases such as Pythium,
Phytophthora capsici, Rhizoctonia,
Verticillium

Various crops

Italy

Streptomyces

griseochromogenes K61

Damping off, root and crown rot, wilt

Greenhouse ornamentals, vegetables,
herbs

Canada

Extract of Melaluca
alternifolia

Various fungal diseases such as powdery
mildew, early blight, botrytis

Fruit and vegetable crops

US

2020 Biologicals Special 23


PRODUCT FOCUS

Regev™ – A Broad-spectrum Hybrid
Fungicide for Plant Disease Control

Modes of action
As a Hybrid, Regev combines the modes of action of the botanical extract with
a synthetic chemical molecule. The fungicidal and antimicrobial activities of TTO

against fungal pathogens, as documented, are derived from its ability to inhibit
respiration and disrupt the permeability barrier presented by the membrane structures
of living organisms. Our recents studies showed that TTO is effective against spore
germination and significantly inhibited lesion development and the sporulation of
fungal pathogens. TTO was found to disrupt the fungal cell membrane and cell wall
in plant tissues infected with pathogenic fungi [see Figure 1], which explains why
it exhibited a strong curative activity against fungal pathogens, making it a unique

By Prof. Moshe Reuveni
Chief Scientist, STK bio-ag technologies, Israel

product and enabling growers to use it even when the disease was already visible on
the tissue. In addition, TTO was found to be an activator of defense mechanisms and
systemically induce resistance in plants.
The sterol biosynthesis inhibitors, including difenoconazole, affect the
fungal cell membrane by inhibiting the C-14 demethylation of lanosterol or
24-methylenedihydrolanosterol, a biosynthesis step that occurs during the conversion
of lanosterol to ergosterol, the final product of fungal cell membrane sterol synthesis.
The different modes of action of TTO and difenoconazole, i.e. a combination of
a natural product with broad-spectrum activity (TTO) and a traditional site-specific
chemical, make Regev an effective and unique tool for resistance management,

Introduction
The global search for plant-protection solutions that
are both environmentally safe and efficacious is driven by
the need to supply food to the ever-growing population.
The call for chemical load reduction is an important aspect
of sustainable agriculture. Recently, documented issues of
widespread environmental contamination, toxicity to nontarget organisms and negative effects on human health by
synthetic agrochemicals have led to a resurgence of interest

in "natural" means of pest and pathogen controls, including
an intensified search for new sources of biopesticides and

which is suitable for Integrated Pest Management programs. This combination results
are required to increase options for controlling plant diseases. The newly developed
Regev EC by the Israeli bio-tech company, STK Bio-Ag Technologies, is a hybrid
formulation: it contains 200 g/L of the systemic triazole fungicide difenoconazole
plus 400 g/L of TTO. This unique prepacked formulation provides various
mechanisms of action against a broad spectrum of plant pathogens with improved
efficacy.
Hybrid solutions can be the "bridge" between conventional agrochemical
farming and sustainable farming. That’s because it is a "pre-mix", so it is easy-touse, in the exact same way as the grower’s current chemical pesticide. To the best
of our knowledge, this is the first bio and chemical-based hybrid product.

botanical pesticides. The latest solutions are generally used in

in a reduced synthetic chemical load on the environment compared to other mixtures
based on two traditional chemicals.

Field trials

untreated (upper).

cereals, fruits and vegetables. Diseases effectively controlled by Regev include
powdery mildews, apple scab (Venturia inaequalis ), Black Sigatoka (Mycosphaerella

of Regev's activity against apple scab caused by Venturia

fijiensis ) in bananas, species of Alternaria , Cercospora, Botrytis, Rhizoctonia,

inaequalis .

Pyricularia, Helminthosporium, Sclerotium and more. Numerous trials have been
conducted with various crops and in different countries. Here, we present an example

A field trial was undertaken in Northern Israel in a
major apple growing region and the efficacy of Regev
was examined, compared to the systemic fungicide,
difenoconazole. Untreated trees served as controls. Six

be (but are not always) involved in plant defense. Among the

foliar sprays of each fungicide were applied, starting

latest solutions, essential oils are considered to be attractive

from the green tip at 6-10-day intervals. Treatments were

for plant protection.

arranged in a randomized complete block design. The

Tea tree oil (TTO) is a valuable essential oil extracted

results given in Figs. 2 and 3 show that difenoconazole

by the steam distillation of Melaleuca alternifolia leaves

inhibited scab development on apple trees compared

(belonging to family Myrtaceae). It contains many

to untreated control trees. However, Regev (TTO +

components of terpenes, sesquiterpenes, and their respective

difenoconazole) was significantly more effective in

alcohol. The oil has proven to be an effective antiseptic,

controlling apple scab.

fungicide and bactericide. In the recent decade, it was found
to be effective against a broad range of plant-pathogenic

Resistance management

fungi in numerous crops, including vegetables, herbs, coffee,
rice, grapevines, bananas, and fruit trees.

Figure 1. A section of fungal hyphae in the intracellular space of the mesophyll

Figure 2. Efficacy of Regev (TT+Difenoconazole) and difenoconazole in controlling

and multiple modes of action with a lower risk for fungicide

tissue of TTO-treated leaves: (a) at low magnification (x20,000=a) and (b) at high

apple scab. Different letters on bars indicate a significant difference (P < 0.05).

resistance, and which place a smaller chemical load on the

magnification (x50,000). Note the destruction and breakdown of the cell wall,

environment, concomitantly with consistent disease control,

causing leakage of cell content.

24 2020 Biologicals Special

in controlling apple scab on fruits and leaves compared to

Regev is currently used for controlling a broad range of diseases on arable crops,

crop protection and contain secondary metabolites, which can

New effective alternatives that can provide different

Figure 3. Efficacy of Regev (TTO+Difenoconazole, lower)

Regev has a unique multiple functional activity and
presents a very low probability for the development of
resistance or cross-resistance in plant pathogens, so it
could be an important tool in preventing the development

2020 Biologicals Special 25


PRODUCT FOCUS

of cross-resistance during the season. Its application

PRODUCT FOCUS

Summary

Biorational Developments in Open Field Crops

The different modes of action of TTO and difenoconazole, created by the combination

By Jan Mostert

can be rotated with products that exhibit differing
modes of action and to which populations of fungal
pathogens have shown a loss of sensitivity, so that the

of a natural product (TTO) with broad-spectrum activity and a traditional site-specific

population of individuals less sensitive to chemical

chemical, make Regev an effective and unique tool for resistance management. It presents

products can be reduced. Studies showed that Regev

multiple modes of action (FRAC Groups F7 and G1) to help prevent the development

(TTO plus difenoconazole) improved the sensitivity

of resistance. This combination results in a reduced chemical load on the environment

of difenoconazole against fungal isolates, which

compared to other mixtures based on two traditional chemicals, leading to reduced residual

exhibited a lower sensitivity to difenoconazole, and

potential.

subsequently, delayed the emergence of resistance to
this fungicide.

The preventive and curative activity of Regev, related to its efficiency of contact,
mesosystemic plus systemic activity by a single application, together with the indirect
activity via the host plant by systemic resistance, leaving little residue and providing

Registration

significant added value to growers, make Regev an important component in the control
of plant diseases. Regev has an expanded spectrum over either component alone and has

Regev has already been registered in the USA,
Israel, the Philippines, Serbia and various Latin

demonstrated activity over a wide range of plant diseases. It can therefore be an efficacious
and easy-to-use "bridge" solution for controlling various diseases.

American countries for various crops and diseases. It
is currently in the process of being registered in Brazil
and the EU.

Please contact with any questions about this article or Regev
hybrid fungicide.

Head of Biorationals Innovation Team, Certis Europe

T

he current focus on the ‘greening’
of agriculture and horticulture crop

protection in Europe is not new, nor is it likely

learnt. It is vital to adjust both the products

to go away. Considerable progress has been

used and the application techniques to

made in some sectors already, but there is

achieve more reliable and more effective

still a lot of work to be done to meet the ever-

control in an open field cropping situation.

increasing demands of governments, the value

For example, in open field crops, elements

chain and consumers for more sustainable and

such as rainfastness can become critical and a

environmentally friendly production.

spraying technique that targets pests correctly,
for example if they are found on the underside

justifiable, this could offer improved

providing growers with Biorational crop

of leaves, is vital. Since most Biorational

opportunities for early detection of pests and

protection solutions for sustainable production

products are not systemic, control is only

diseases even in open field crops. Such new

and is at the forefront of new innovative

effective if they can be applied on the spots

technologies could bring a definite advantage

product developments, continuing to extend

where the pest or disease has been detected at

for more optimal use and so performance

its footprint in the market. Biorationals

an early infestation level, so preferably even

of Biorational products in outdoor cropping

are defined as “registered plant protection

before damage to the crop occurs. Aphids

situations too.

products generally derived from the natural

who hide on the underside of the leaves for

environment, offering improved benefits

example, can only adequately be controlled

development pipeline, while others such as

for plants, people and the planet, which are

with a Biorational product, if the product

Eradicoat Max and Neudosan®** are already

increasingly important factors for Integrated

is applied to the underside of the leaves.

registered or in the registration process of

Crop Production to satisfy requirements of

Many open field crops are sprayed by tractor

different countries and coming to the market

the value chain and consumers .”

mounted booms, whose nozzles spray mainly

soon. Certis aims to have over 30% of sales

The biorationals portfolio of Certis

downwards. This application technology

coming from Biorationals by 2025. The major

includes many products for use in protected

does not really support the efficacy of a

challenge is to create innovative production

cropping, as well as several that are already

Biorational aphicide. Work is moving forward

and application technology to facilitate the

registered and used effectively in open field

and researchers are encouraged by the

effective use of Biorationals in open field

crops*. Whilst the production of protected

improvements seen, as progress is made.

crops. Without such innovation the use of

Certis Europe has a long history of

crops such as tomatoes, cucumbers, peppers

+

However, work on open field crops is
well underway and much has already been

In protected cropping situations new

New products are in the Certis

Biorationals in field crops will not advance

and strawberries using biorational control

technology, such as drones and robots

products in effective Integrated Pest

for monitoring the crop to detect and

Management programmes is now quite

identify pests and diseases early on, are

normal, the successful transfer of such

being tested or even in use already. If such

ferric-phosphate, a salt (potassium bicarbonate)

techniques to open field crops is clearly not

developments continue to be successful and

to control powdery mildew, as well as Bacillus

just a matter of ‘copy and paste’.

their use becomes accepted and economically

thuringiensis and pheromone products for pest

very quickly.
* Examples include slug pellets based on

control solutions in fruit and vegetables and
Trichodermas as a microbial solution against soil
diseases.
** Neudosan® is a registered trademark
of Neudorff and is based on fatty acid-based
potassium salt with insecticidal and acaricidal
activity. It is already EU approved and currently
sold in Germany on both greenhouse and open
field crops. It has approval for use on organic
crops in Germany. Registrations in other EU
countries are anticipated via Mutual Recognition
procedures according to Regulation 1107/2009.

26 2020 Biologicals Special

2020 Biologicals Special 27


PRODUCT FOCUS

PRODUCT FOCUS

Crop friendliness without sacrificing performance

Ingevity: Enhance the Efficiency of
Micronutrients with Pine-based Kraft Lignin

Demonstrated plant health and crop height in the field

Kraft lignin’s inherent functionalities (phenolic hydroxyl,

Ingevity collaborated with The University of Florida on a tomato

carboxylate) form much weaker complexation with metal ions when

greenhouse study of kraft lignin-based micronutrient products (Table 1)

compared to those from EDTA. Figure 1 compares the complexation

to determine the efficiency plant health and crop yield. A blend of various

stability constants (Log K, where K is the equilibrium constant)

uncomplexed inorganics, including sodium borate (Na2B4O7); copper

of several model phenolic compounds and aromatic carboxylic

sulfate (CuSO4); iron sulfate (FeSO4); magnesium sulfate (MnSO4);

acids with different divalent cations, using EDTA as a reference.

sodium molybdate (NaMoO4); and ZnSO4, was used as the control group to

The weaker complexation stability is advantageous for ions to be

compare to a blank study group excluding inorganics. In the experimental

released from the complex and absorbed by the plant rooting or foliar

groups, one inorganic salt was replaced by the kraft lignin complexed

system. In turn, the regenerated lignosulfonates can complex with the

product and applied to soil types with pH levels of 6.0 and 7.5. Crop

remaining micronutrients.

height was measured after 16 days of the application, and plant yield was
represented by fresh weight and dry weight provided in Table 2. All lignin-

A

Guigui Wan

Liang Yuan

Technical Team Lead,

Senior Chemist,

Agrochemicals, Ingevity

Agrochemicals, Ingevity

ccording to recent United Nations estimates, the
world’s population is projected to grow to nearly

Ligands

The multifunctional value of kraft lignin for micronutrient
applications

Complexation Stability Constant(Log K)
Zn2+

Cu2+

Ni2+

Co2+

Resorcinol

5.15

7.30

6.10

5.8

Benzoic acid

0.74

1.51

0.55

0.55

DPDCA

7.99

8.60

7.84

7.26

EDTA

16.50

18.80

18.62

16.31

10 billion by 2050, which will require boosting agricultural

demand by an estimated 50% to meet this global food

Ingevity's bio-derived kraft lignin aids as a micronutrient complexing

challenge1. To support this need, farmers worldwide must

agent for water-soluble metal ions due to its unique 3-D structure, suitable

increase crop production by enhancing productivity on

molecular weight and multifunctional moiety-metal interaction capabilities.

existing agricultural land through innovative methods like

Compared to the commonly used chelating agent EDTA, kraft lignin’s multi-

precision farming and plant nutrition management. Proper

level complexation structure adapts to a wider pH range, allowing application

plant health maintenance, such as soil and foliar applications

compatibility with various soil properties. Its weaker complexation strength offers

of micronutrients and fertilizers, is crucial to optimize nutrient

easier release of metals into soils and plant leaves. Also, the hydrophilic sulfonate

uptake and support growing crop yield.

groups make kraft lignin a natural humectant, ensuring prolonged absorption

Micronutrients are essential for plant growth and play

time of the agricultural chemical. Lastly, when formulated with insoluble metal

Figure 1. Complexation stability constants (Log K) of model phenolic
and aromatic carboxylic acid compounds with divalent cations
compared to EDTA.

As a natural humectant, kraft lignin provides improved wetting

oxides, Ingevity’s kraft lignin can serve as an excellent dispersant by providing

composed of minerals like iron, zinc, manganese, boron

impressive surface coverage and steric stabilization. Table 1 includes Ingevity’s

lignin (ZnSO4-KLS) complexes can absorb 8% moisture, while zinc

and copper, micronutrient solutions can be applied in soil

most frequently used products in micronutrition applications.

sulfate (ZnSO4) only absorbs 1%. Formulations with kraft lignin dry

or by foliar application as soluble metal salts, insoluble

more slowly than sulfate solutions and EDTA complexes, allowing

metal carbonate or metal oxides. Organic carriers such as

longer uptake time for foliar applications. A naturally derived product,

Table 1. Ingevity kraft lignin products designed for micronutrient applications.

acid and kraft lignosulfonates (kraft lignin) play a prominent

Property

role in the dissolution of micronutrients and their transport to
plant roots.
Specialty chemical producer Ingevity is the world’s largest
producer of kraft lignin, and as such offers an array of high-

Degree of sulfonation
Molecular weight

Reax® 260

Reax 88A

Reax 100M

>5.0

2.9

3.4

20,000

3,100

2,000

quality, sustainable lignosulfonates. These bio-based

pH

5.5

4.3

8.8

lignosulfonates protect micronutrients from oxidization or

OMRI list

Yes

No

No

-

5%

12.5%

precipitation, remediate leaf burn, and extend the absorption
time on the crop. With a low molecular weight, kraft lignin
contributes to low viscosity formulations without threatening

Ammonium sulfate tolerance*

yield. For example, more than a 20% crop height and yield increase was
observed when using complexed zinc or magnesium.

Table 2. University of Florida tomato greenhouse study of Ingevity’s kraft
lignin micronutrient formulations.

Increase in Height

LS-Metal after 16 Days, mm
Test Experiment
Complex
Soil
Soil

pH 6.0

pH 7.5

Fresh
Dry wt., g
wt., g

1

Blank

-

87

12

122

15.3

2

All
Inorganics*

-

92

25

164

23.3

3

Except Fe

Fe

93

30

199

28.7

4

Except Zn

Zn

118

32

210

29

5

Except Mn

Mn

109

35

205

28.8

6

Except Cn

Cn

98

33

190

26.3

kraft lignin does not cause phytotoxicity, remediating leaf burn if
nutrient overdose occurs.

* Based on a 2.5% lignosulfonate and 3.79% zinc sulfate formula.

Table 3. Third-party field trials of Ingevity’s kraft lignin micronutrient
formulations.

Crop

Location
and soil
type

Reax
product and
application
rate

Method of
application

Comments

Rice

Texas, wet, pH
7.5

Reax Zinc 14.8lbs/acre

Soil

Chlorosis correction,
61% yield increase

Sorghum Kansas, pH 6.6

Reax Zinc - 11lbs/
acre

Knifed in soil

Chlorosis correction,
37% yield increase

NC Muck nearly drained Soybean deficient
in all metals, pH
4.5

Reax Copper 0.75 lbs/acre;
Reax Manganese 1.50lbs/acre; Reax
lron - 1.00lbs/acre

Broadcast in 188-22 suspension,
banded at
planting in 1034-0, banded at
planting in1034-0

Control 4lbs/acre
copper and 4lbs/
acre manganese as
sulfates. 12%yield
increase

Carrots

Reax Manganese
2lbs/100 gals
200gpa

Foliar spray

Complete greening
of leaves within one
week of application.
30% increase in
yield over control

the environment.

1. Nikos Alexandratos and Jelle Bruinsma, “World Agriculture Towards 2030/2050: the 2012 Revision,” Food and Agriculture Organization of the United Nations,

Plant Yield

and prolonged foliar absorption. As shown in Figure 2, zinc-kraft

an important role in balanced crop nutrition. Commonly

ethylenediaminetetraacetic acid (ETDA), amino acid, humic

based experiment groups demonstrated increased crop height and plant

Figure 2. Moisture uptake study of ZnSO4 and ZnSO4-KLS complex.

Florida - Muck

June 2012, />
28 2020 Biologicals Special

2020 Biologicals Special 29


PRODUCT FOCUS

PRODUCT FOCUS

loading, low viscosity and long-term solution

the metal solutions are demonstrated in Figure

consistency and control in the manufacturing of

party field trials for rice, sorghum, soybean

stability, Ingevity’s kraft lignin products

3. A sulfite lignin product with 30% solid is

dispersants and surfactant systems. The incorporation

and carrots among different soil conditions

provide farmers with formulation flexibility,

also used for the comparison study. Solutions

of Ingevity’s kraft lignin products into micronutrient

(Table 3). The application of zinc complexes

reduced shipping cost and improved user

prepared with Reax 100M exhibit impressive

formulations and processes not only protects

with Ingevity’s kraft lignin corrected

friendliness.

stability with no precipitations. Solutions

micronutrients from oxidization or precipitation,

Ingevity also conducted additional third-

Ingevity’s

Reax®

containing sulfite lignin were initially cloudy

but also remediates leaf burn and extends the

for rice and 37% for sorghum. For soybeans

designed for micronutrients complexation,

after blending and separation was observed

absorption time on the crop without threatening the

tested on a nearly drained and metal-deficient

offering a high degree of functionality for

after three days.

environment. Ingevity kraft lignin products allow

soil, 12% crop yield was observed with a

optimal metal complexation and aqueous

60% lower application rate of the KLS-metal

solubility, and a low molecular weight

as copper oxide (Cu2O) and manganese

concentration micronutrient products, rendering cost

complexes. Following the foliar application

decreasing solution viscosity. For example,

carbonate (MnCO3), are insoluble, meaning

savings and improving field performance.

of complexed magnesium, carrots showed

a solution with 40% Reax 100M can be

the settling of these particles over time

complete greening of leaves within one week

easily prepared by simple mixing to achieve

will negatively impact the formulation’s

of application and a 30% yield increase.

a readily flowable solution viscosity of

application efficiency. Ingevity’s kraft lignin

approximately 30 centipoises. A nearly

products have proven valuable in dispersing

saturated ZnSO4 solution with 15% of

insoluble metals and challenging pesticides

zinc and a MnSO4 solution with 12% of

due to their steric stabilization abilities. A

magnesium were prepared in deionized water.

formula was created with the ratio given in

Stable KLS-metal complexation solutions

Table 4, and the average particle size in the

products are typically delivered in liquid

can be prepared from any given ratio

suspension was 3-4 micrometers (μm). Figure

form, the formulation viscosity and stability

between the 40% Reax 100M solution and

4 below shows no precipitation from the

are key considerations in the process of

the metal solutions, indicating formulation

suspension after testing the formulation at 45

production, storage and field application.

flexibility with the use of a wide range of

℃ for one week. Even after nine weeks of

Common undesirable formulation

concentrations.

storage at 45 ℃ , the formulation has minimal

chlorosis and increased the yield by 61%

Easier formulation and reduced
costs
Since lignosulfonate-based micronutrient

For illustration, solutions with a weight

performances include high product viscosity
and formation of precipitates. With high-solid

100M is specifically

Metal oxides or carbonates, such

farmers to formulate low-viscosity and high-solid

Ingevity also introduced a bio-based line of
sticker adjuvants under the name AltaHance®

Figure 4. Stability for aqueous suspension of metal oxides and carbonates in the presence
of Ingevity’s kraft lignin products.

that are beneficial for micronutrient applications.
AltaHance products provide tunable rainfastness,
accelerated spreading, increased penetration, and
high performance under challenging conditions.
Learn more about these products in the recent

Achieve the highest crop yield with pine-based technology

ArgoPages feature “Bio-based adjuvants: The future

As the world's largest producer of kraft lignosulfonates, Ingevity is committed to quality,

of sustainable agriculture.”

particle growth and good suspensibility.

ratio of 1:2 between Reax 100M solution and

• Biopesticides, PGRs and Agrochemicals
• (Bio)Fertilizers and Innoculants

Table 4. Aqueous suspension of metal oxides

• Seeds and Biotech (GMO)

and metal carbonates with Ingevity’s kraft
lignin products.

Figure 3. Photo of lignosulfonate metal complexation solutions as observed after three days.
Solution A: 7 grams (g) of Reax 100M solution (40% solid) and 14 g of ZnSO4 solution (15%
element Zn); Solution B: 7 g of Reax 100M solution and 14 g of MnSO4 solution (12% element
Mn); Solution C: 7 g of sulfite lignin solution (30% solid) and 14 g of ZnSO4 solution; Solution D:
7 g of sulfite lignin solution and 14 g of MnSO4 solution.

30 2020 Biologicals Special

Ingredient

Wt%

Cu2O

6.7

NaMnO4

3.2

MnCO3

9.4

ZnO

15.1

Surfactant

1

Ingevity KLS

2.5

Defoamer

0.1

Thickener

0.1

Water

Up to 100

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2020 Biologicals Special 31


PRODUCT FOCUS

PRODUCT FOCUS

Azotic’s Natural Nitrogen Fixing Technology
Is A Must for Agriculture

Also, when N-Fix® was applied with the
full recommended level of N there was a
significant increase in yield of 7% equivalent
to 300 kg/ha.
This technology generates high yield

production in agriculture combined with

A

nitrogen sustainability. It is ubiquitous to
zotic Technologies, a UK-based

will grow to 10 billion in 2050. Increasing

enables plants to fix nitrogen from the air and

global ag-tech company, was

food production sufficiently to meet future

replace up to 50 per cent of their nitrogen

established in January 2012 to develop and

demand whilst reducing pollution will be

needs as an alternative to fertiliser. This is a

commercialise a natural nitrogen-fixing

a major challenge for agriculture. Also,

patented innovative technology which will

technology (N-Fix®). N-Fix® is a disruptive

soil degradation and the reduction of

have a huge impact on agriculture – Azotic’s

technology which has the potential to totally

arable land compounds this issue. Azotic’s

strain of Gd is unique in its ability to colonise

transform agriculture and is unique to

natural nitrogen fixing technology, which is

plant cells intracellularly. Azotic is the only

Azotic. A marketable product is now being

environmentally friendly, will boost plant

company offering an “intracellular” strain of

commercialised with positive benefits to

efficiency and increase crop yields.

Gd in non-legumes. The bacterium Gd does

growers.

Humanity depends on fixed nitrogen to

all crops and provides a cost benefit to the
grower through reduced fertiliser costs and
increased yields. Another benefit is cleaner
and superior quality food for the consumer.
Peter Blezard, CEO of Azotic, said:
“Agriculture requires more efficient and
sustainable farming practices in order
to increase food supply and maintain
biodiversity. Positive results highlight the
efficacy of our revolutionary technology in

not persist as a free-living soil bacterium, it

making crops nitrogen-fixing and with the

fertilise crops and boost food production.

has been found only when associated with

total nitrous oxide (N2O) emissions, mainly

Although nitrates are added in vast quantities

plant material, most notably sugar-cane.

from the application of fertilisers, and 20

to increase crop productivity, this is a very

per cent of greenhouse gas discharges which

inefficient process with up to 30% of nitrates

way to deliver nitrogen to plants; it is

encouraged to adopt more sustainable

impacts on climate change¹. Agriculture must

applied on the land ending up in coastal

applied to plants via the seed in order to

farming practices. The movement towards

has achieved positive results in the USA

change in order to reduce nitrogen pollution

waters and leached into the atmosphere. This

create a symbiotic relationship within the

climate smart agriculture has encouraged

through a Grower Partner Programme. It is

which is damaging to human health. It will

has adversely affected the earth’s nitrogen

plant enabling it to substitute the nitrogen

the use of biologicals, bio-fertilisers and

now registered and officially available in all

be essential to improve biodiversity in order

balance therefore agriculture needs to change.

it normally takes up from the soil with

seed treatments. Agriculture must progress

50 US states. Commercial sales on corn and

N-Fix® is a novel technology which is

atmospheric nitrogen – thus reducing

and adopt new innovative technologies and

soybean in the US has reduced the need for

Agriculture accounts for 80 percent of

to future proof agriculture for subsequent

resulting increased yields. This technology
is a must for commercial agriculture where

Azotic’s N-Fix® technology is a new
This ground-breaking nitrogen technology

generations. Azotic’s natural nitrogen fixing

derived from a naturally occurring beneficial

dependency on nitrogen fertilisers. It works

practices. Transparency will be important

applied nitrogen fertiliser on average by 27%

technology provides a sustainable solution to

food grade bacterium Gluconacetobacter

from within plant cells to fix nitrogen from

in all aspects of the food chain especially

without impacting yield. On corn, applied in-

fertiliser overuse and nitrogen pollution.

diazotrophicus (Gd). This is neither genetic

root to leaf all season long. It contains no

farming. N-Fix® is an ideal fit; it is a world

furrow, it delivers on average between 5-13%

modification (GM) nor bio-engineering. This

toxins, is environmentally friendly and helps

first organic technology providing sustainable

yield increase and in some cases up to 20%.

reduce nitrogen pollution. It has proven

nitrogen which will boost agriculture.

In addition, observations have indicated:

efficacy in strategic crops which include corn,

Biological nitrogen fixation will improve

▪ Early tillering.

soybean, rice, wheat and others.

modern agriculture at a time when more food

▪ Improved rooting with more fine roots

It is estimated that the world population

Market demand for food is changing
with the emphasis on greater food security.
Consumers require good quality food

and a more robust root system as the plant

without damaging the ecosystem.

matures.

Azotic's N-Fix® technology won the

▪ Better plant vigour with advanced

and supermarkets realise the need for

AgroPages Awards for Novel Fertilisers

more sustainable produce. Agriculture

in 2018 and judged to having great market

has to change; it must reduce emissions

potential in China. Azotic Technologies

of greenhouse gases, nitrates and other

was awarded Frost and Sullivan’s 2015

contaminants into the environment as well

Technology Innovation Award for the

positive results. In three Vietnamese rice trials

as increasing food supply. Sustainability

European Alternative Fertiliser Industry.

the overall response was a mean average

is critical, unless the footprint of the food

Analysts independently evaluated the

20% (825 kg/ha) yield increase across all

system on the environment is reduced, the

technology’s attributes and future business

the field trials (2017). Further rice trials in

capacity of the earth to produce food for

value to recognise the Company as having

Thailand and the Philippines showed that

humankind will be compromised with grave

strong overall performance, highlighting the

there was a positive effect on yield at all of

implications for future food security.

importance of a ground-breaking agricultural

the trials; the N-Fix® treated plots yielded

The continued production and use of

32 2020 Biologicals Special

is needed to feed an increasing population

growth stages throughout the life cycle.
▪ Plant tissue tests revealed more nitrogen
in the plant up through mid-vegetative stages.
Rice trials in Asia have shown very

solution that allows plants to extract nitrogen

17% (645 kg/ha) more than the untreated,

synthetic nitrogen-based fertilisers is no

from the air rather than from polluting

with a 1 t/ha (29%) increase being seen at

longer sustainable and growers are being

fertilisers.

50% of the recommended fertiliser N (2018).

yield, cost and pollution needs can be
optimised”
Azotic’s progression is quite remarkable.
The company has developed its own strain of

Gluconacetobacter diazotrophicus (Gd) and
transformed that into a marketable product.
The scale up and production of an inoculant
via the development of a specific fermentation
process has resulted in the first commercial
product of its kind. Azotic is delivering this
technology to market and continues to add
value with new IP. Through its development
work on N-Fix, Azotic has identified a
new platform nitrogen technology; It will

commercialise technologies based on this
platform through appropriate partnerships in
R&D and routes to market. There is a pipeline
of products under development and these
include a dry formulation and a foliar spray.
Azotic’s nitrogen fixing technology is a
must for agriculture and will certainly change
current farming practices. New technologies
including N-Fix will play a pivotal role in
propelling sustainable agriculture forward.

¹Agriculture and climate change, McKinsey
& Company 2020.

2020 Biologicals Special 33


PRODUCT FOCUS

PRODUCT FOCUS
Kwizda Agro – a unique player in the Biologicals
scene
“New Technologies” is one of Kwizda Agro’s four main
areas alongside the distribution of crop protection products,
Tolling, and Biocides. The foundation stems from Kwizda Agro's
decision a few years ago to focus its research and development
almost entirely on sustainable solutions based on natural extracts,
minerals or microorganisms. Today, almost 100% percent of the
investments in research and development are targeted at green
solutions and over a third of the company’s employees work with

biological crop protection.
“Kwizda Agro is uniquely positioned to develop innovative
and highly potent products for sustainable agriculture and
forestry. As an Austrian company we are able to take recourse
to know-how of conventional, but first and foremost organic

Credits - Robert Staudinger

agriculture. With over 100 advisors on the field in Austria,
Hungary and Romania, we feed the knowledge and experience of
practical users with latest research findings into our innovation
process. Manufacturing ourselves, and having a strong focus
on formulation, we can develop products which are affordable

Kwizda Agro:

solutions to the grower and combine sustainability with modern
product features,” Business Unit Manager Catalina Bardewyk
says. “This shows Kwizda Agro’s dedication to sustainable

Driving Innovation in Biologicals

agriculture”.

Strong partnerships as a basis for innovation

W

hile over the past years availability of

“New Technologies”, which focuses on the development and international

active substances in crop protection

distribution of proprietary biological products, Kwizda Agro emphasizes

has steadily been decreasing in Europe due

its dedication to sustainable agriculture. In the past few years, the company

to ever more ridged regulation, farmers have

has been able to develop, produce and successfully market numerous

been struggling to keep their crops healthy. To

innovations in the field of organic crop protection.

support growers, the Austrian crop protection
company Kwizda Agro has put a strong focus
on developing organic active ingredients in
accordance with European Union's Green Deal
and thereby offering reliable and sustainable
solutions to protect their crops and maintain
high quality yields.
Kwizda Agro, a subsidiary of the family
owned Kwizda Holding, has had a strong focus
on sustainable agriculture since its founding in
1926. Known as one of the leading distributors
in Central and Eastern Europe, the company

has proven to be able to successfully position
and integrate biologicals in spraying programs.
And with the foundation of its business unit

34 2020 Biologicals Special

In research, development and the production of biological
crop protection products, Kwizda Agro works closely with a
network of leading academic institutes, biocontrol startups,
family businesses and agricultural advisors. “Collaboration in
research and development, registration as well as distribution is
the key to accelerate innovation, to develop, produce and market
new active ingredients and formulations and make them broadly
available to the public,” Bardewyk says.
To advance innovation, Kwizda Agro looks out for new
partnerships, to open up new core markets and share investments.
This applies in particular to the registration of new active
substances.

Discovering future markets and expanding further
Over the next few years Kwizda Agro will develop and roll
out further innovations in the fields of arable crops, horticulture
as well as forestry:
In 2021 Kwizda Agro will introduce its new soil fungicide
Xilon®

based on a selected Trichoderma strain in arable crops

such as oilseeds and corn. Its unique combination of a broad
pathogen control, and improvement of plant and soil health will

benefit conventional and organic farmers all over Central and
Eastern Europe. “From now on Kwizda Agro is introducing

Union’s Green Deal, providing tools for a modern, sustainable and integrated
agriculture,” Bardewyk notes.
In 2021, KWIZDA will also launch its biological deer repellent TRICO®
in the U.S. and Canada. In Europe, the product is currently the gold standard
for the protection of young trees against deer damage in professional forestry.
Besides being an indispensable part of sustainable afforestation, Trico® will
also close a gap in effective and convenient deer damage control in residential
premises.
To this end, research is increasingly carried out in the field of biological
foliar fungicides for horticulture, with a strong emphasis on grapes and the
control of Peronospora . Numerous active ingredients and formulations are being
tested in field trials, while some have already started the registration process.
Kwizda Agro intends to expand further and to be perceived as a strong and
relevant partner for the development and distribution of primarily biological
products in selected focus countries. Their innovative products support
European Union’s Green Deal and give conventional and organic farmers
tools for a modern, sustainable and integrated agriculture maintaining an intact
environment.

biologicals also into broad acre crops and contributes to European

2020 Biologicals Special 35


PRODUCT FOCUS

PRODUCT FOCUS

hundreds of experiments done by scientist and
proved on the field by farmers on beneficial
effects on different crops and in a different
climate conditions. The unique feature of this
biostimulants is its positive effect on flower

Complementary Approach to Biostimulation

pollen vitality, pollination and fertilization.
Those effects are primarily associated with
an increase in the vigor of pollen grains and
their better adhesion to the surface of the

By Wiesław Ciecierski, Global Key Account Manager of INTERMAG

stigma, and with the intensification of pollen
tube development. It’s a worldwide problem
of declining population of pollinating insects,
therefore longer ability of flower to be

T

pollinated is contributing to higher and better
he one of the main challenges of

and pesticide active ingredients to surface

or microorganisms whose function when

yield. Stimulating physiological processes

present agriculture is to provide

and ground water is the main issue to be

applied to plants or to soil is to stimulate

and the uptake of nutrients supplied to plants

enough food for growing human population

solved. Human population health depends on

natural processes to enhance or benefit

from the soil solution, as well as those applied

and at the same time to reduce negative

availability of sufficient clean water and food

nutrient uptake, nutrient efficiency, tolerance

on leaves are extremely important during

impact of pesticide and fertilizer use on

without pesticide residues.

to abiotic stress and crop quality”. It is not

stress conditions. Better use of Nitrates in a

mentioned about biotic stress to not confuse

stress condition benefits twice. Firstly plants

environment. Agriculture beside industry

The use of products dedicated for

has the highest direct impact on environment

professional farming which can contribute to

with plant protection products mode of action.

are better fed and secondly there is no, or

and while in industrial sector many solution

environment protection is a need of present

However in case of biostimulants their mode

much lower leakage of Nitrates to the surface

limiting emissions of dangerous substances

days Ensuring the appropriate amount of

of action to biotic stress mitigation is indirect

and ground water.

have been used (e.g. filters on chimneys or

fertilizer and limiting exposure to pesticides

and does not really interact with pathogen

water cleaning facilities) in agriculture except

may be achieved through use of advanced

or pest but makes plant stronger with better

which is based on bioavailable silicon. This

for banning several most poisoning active

tools called biostimulants. Finally in 2019 EU

established self-defense mechanisms.

product is dedicated mainly to crops which

ingredients not much so far has been done.

Council approved definition of biostimulants

Biostimulants offer a novel approach to

can be exposed to different abiotic and biotic

Leakage of fertilizers especially Nitrates

“Plant biostimulants contain substances and/

the improvement of crucial physiological

stresses. Rapid climate changes associated

processes in plants. We can find on the market

with higher pressure of unfavorable weather

many products considered as biostimulants

condition often lead to significant losses of

manufactured mainly from organic sources

yield quantity and quality. At the same time

like seaweed, humic acids and amino acids.

climate change can stimulate higher pest and

Those products are marketed as a remedy

diseases pressure. Therefore stronger plants

for very broad range of problems caused

immune mechanism is crucial for limiting use

by different unfavorable growth conditions,

of pesticides with the same, effective diseases

either biotic or abiotic. INTERMAG approach

and pests control. From the very beginning

to farming is focused on complementarity,

OPTYSIL has been tested by scientist and

which is based on precise recommendation

researches from independent institutes and

of each of our specific biostimulants which

universities for better knowledge about its

contain unique compounds of beneficial

activity and mode of action. In Institute

elements: titanium, silicon and vanadium.

of Plant Physiology of Polish Academy of

Three biostimulants dedicated for different

Science several experiments have shown

purposes during growing season.

significant increase of plant tolerance to

TYTANIT is our first biostimulants

36 2020 Biologicals Special

Second of our biostimulants is OPTYSIL

drought condition. This activity has been

invented in the 90s but its beneficial

proved on many hectares of farm land

properties are even more important in

especially on corn fields, but not only. Optysil

present days then years ago. TYTANIT

has a unique ability to increase plant tissue

active ingredient is patent protected aTium

firmness which is very beneficial in fruit

compound with eco-friendly profile, safe to

production by making them more resistant to

natural environment and operators. There are

injury during harvest, transport and storage.

On the other hand hard tissue is less attractive

as a remedy for “all the pain of this world”

for different types of pests and more difficult

in agriculture meaning of course. Learning

to penetrate by pathogen’s appressorium.

from mistakes is a good idea but avoiding

Excellent tank mix compatibility due to

mistakes is even better. It has been proved

close to neutral pH distinguish this product

many times in agriculture practice that

from many others on the market. Including

overdosing or sticking to one or two active

OPTYSIL to crop management program will

ingredient leads in time to lower activity and

benefit with higher and better yield. Due to

in case of pesticides, selection of resistant

lower pressure from pests and pathogens

forms. Alternate application of different

lower rates or fewer number of pesticide

compound is always recommended by

sprays can be done.

experienced agronomists. Professional plant

VANADOO containing patent protected

protection and fertilization quite often are not

active ingredient AVADIUM is our latest

enough to achieve satisfactory yield quality

achievement focused on stimulating growth

and quantity. The usage of biostimulants

of bulbs, storage roots and tubers. It’s mainly

is a need for better crop management, but

dedicated to arable crops and vegetables.

biostimulants in this case must be as much

After cereals and legumes root, bulb and

professional as plant protection products

tuber crops play an important role in food

and fertilizers. What we have to look for is

and feed production, therefore increasing

complementarity which can be achieved by

yield quantity and quality without increasing

using biostimulators from different groups

application of fertilizers and crop protection

and mode of action. It happens quite often

products is very important as in the most

that on the same field specific actions have

of annual crops. Quality is better mainly by

to be done on crop to reach certain goal,

increasing content of sugar and proteins.

therefore different biostimulants tools

Conducted trials shown yield increase of at

have to be used. INTERMAG has been

least 15% on sugar beet and up to 50% on

developing its own technology for most of

root celery. The unique, efficacy has been

the worldwide important crops by using

shown in numerous trials and experiments

TYTANIT, OPTYSIL and VANADOO and

conducted by scientists as well as farmers.

new biostimulants which will be even more

Liquid formulation of the product with close

suitable for dramatic changes in growing

to neutral pH makes it compatible with most

conditions. We are keeping in mind that we

of commonly used plant protection products

have to produce healthy food, have access to

and others foliar applied agrochemicals.

clean water and save environment for future

There is no single biostimulant solution

generations.

2020 Biologicals Special 37


PRODUCT FOCUS

PRODUCT FOCUS
GROWTH IMBALANCE: WHAT DOES IT IMPLY
When the crop goes into production, it is essential that development is balanced.
The root must be efficient, the leaf surface well expanded and the plant metabolism
must work perfectly. In conditions of nutritional imbalance (e.g. excess of vigour) or
of stress (thermal, water, salt), the formation and growth of the floral stage cannot take
place in an optimal way: this entails flower abortions and fruit uneven development,
with important losses on revenues. In fact, in fresh tomato, the lack of uniformity of
size and colouring of the fruits of the same stage leads to the need to sell the product
"not in bunches", at a lower price.

FORTIFY, REGULATE, PROMOTE
Today there are new ways to ensure a constant harvest that stands out on the
market for its high organoleptic characteristics. In the world of nutrition, the highest
innovation is NOV@® It is a biostimulant of plant growth and fruit enlargement,
which exploits the synergistic properties of the plant extracts that formulate it to
promote the development and efficiency of the root system and improve the structure
of the soil. But that's not all: the coordinated supply of polysaccharides, vitamins
and micronutrients stimulates the primary metabolism and promotes the correct
hormonal balance in the tissues. With the application of NOV@® in the fertigation of
horticultural plants it is possible to promote a more balanced crop development (short
internodes, greater leaf surface, thicker tissues) and stimulate the growth of the fruits,
which thus reach larger and more uniform sizes. With NOV@® farmers specialized in

horticulture today can:

How to Achieve Constant Quality in Horticulture

- favour rooting and overcome transplant stress;
- promote radical development and optimize the absorption of nutrients;
- balance the vegetative and productive activity of the plants;
- increase crop size and quality.

T

ransplant stress, poor rooting and sub-optimal nutritional absorption are some of the
main factors that jeopardize good horticultural production. To ensure abundant and

quality harvests it is essential to adequately support the plants, promoting the right balance
between vegetation and production. Innovative nutrition avoids unnecessary waste.

HOW TO USE NOV@
NOV@® is used in fertigation in the post-transplant phase, post-fruit setting 1st
bunch and fruit growth stages. Thanks to its properties NOV@® is ideal for use in
combination with the GREEN-GO® line formulations (NPK + Ca microcrystalline
fertigation products with high solubility and purity) and micronutrients.

WHAT TO AIM FOR AND WHAT TO WATCH OUT FOR
In horticulture, only those who are able to best intercept the market

TRANSPLANT: WHAT YOU NEED TO KNOW
Planting in a new environment represents a strong stress for

demand can be successful. To "be present" when prices are rewarding,

seedlings. In the first days following the transplant, the crop inevitably

plants must be balanced, harvests regular and organoleptic characteristics

undergoes a growth arrest, which in some cases can affect engraftment

always at the top. In the cultivation cycles of tomato, courgette and any

or adversely affect the entire crop cycle. The stressful conditions to

other vegetable, many events that can undermine the growth balance.

which plantlets are subjected, leads them to slow down their radical

Planting is a first stress, to which the inefficiency of the root system

development and its capillarization, losing part of the ability to absorb

can be added, as well as the inadequate availability of nutrients, the

water and nutrients. The effect on the aerial development of the plant

unfavourable environmental conditions. All or some of these negative

is immediate: the seedlings tend to spin and the fruit setting of the first

factors can significantly reduce yields and quality.

flowers (which are often those of greater value) is compromised.

38 2020 Biologicals Special

CULTURE

TIME OF APPLICATION

DOSAGE

Horticultural and open field
industrial plants

- 10-20 days after transplanting;
- post-fruit set 1st bunch;
- fruit enlargement.

15-20 L/ha

Greenhouse vegetables

- 10-20 days after transplanting;
- post-fruit set 1st bunch;
- fruit enlargement.

1,5-2 L/1000 m2

Contact the Biolchim technical service to define the most suitable
strategy for your plantation.

2020 Biologicals Special 39

PRODUCT FOCUS

PRODUCT FOCUS

Agri Star is Positioned as the Leader
in the Bio-Inputs Market in Argentina

Agri Star is an Argentinian company founded
in 2005. From its inception, it has demonstrated
significant achievement in the development and
distribution of environmentally friendly products,
becoming one of the leaders in the field with
significant short-term growth.
During the latest 10 years, Agri Star has been
working on the incorporation of specialties to
position itself within the bio-inputs market. In
2014, the firm began to trade its first own organic
insecticide “StarEco”, earning critical distribution
and development agreements with foreign
companies. This was the beginning of exciting
developments in the Agri Star portfolio.
“Signing distribution and development
agreements open us to this market and to the interest
of many leading bio-input companies looking for
the right partner to introduce their products into the
region. Agri Star is a pioneer when it comes to biocrop protection and bio-fertilization, and we are
sure that this is the future of the industry.”
40 2020 Biologicals Special

Foreign Company Agreements
Along with the development of these bioinputs, Agri Star has completed agreements with
companies from the United States (Certis LLC,
Plato Industries Ltd) and Portugal (CEV S.A.)
for the exclusive distribution of their products
in Argentina. Regarding Plato Industries, the
agreement relates to the pheromone system for the
control of cotton boll weevil. The agreement with
Certis coordinates the distribution of CYD-X LC
Carpovirus and Bacillus Thuringesis Ecotech in
Argentina. Most recently, the agreement signed
with the CEV company in 2019 is for the exclusive
distribution of a fungicide based on BLAD Problad
Verde.
In recent weeks, Agri Star entered into a
technology transfer agreement with a foreign
University. The objective of the agreement is
not only the manufacture and distribution of a
highly effective biological insecticide, but also
the patent of the product and the knowledge of the
manufacturing process.

“Currently, we have a complete portfolio of
our own and third party products to satisfy the
organic and low-residue market demand”, said Eng.
Ezequiel Nardini, Agri Star Manager, when asked
about the importance of obtaining commercial
agreements with foreign partners.

Next Steps
All the work done in the recent years is due to the generation of
multiple critical international commercial agreements. Currently,
there are advanced negotiations with a leading European company
to create a joint venture where Agri Star will handle the bio-input
products, as well as the national and regional agreements with
local companies operating in Argentina and the region.
These milestones solidify Agri Star's position as the leader in
bio-inputs in Argentina.

Eng. Ezequiel Nardini
Agri Star Manager

2020 Biologicals Special 41


VIEWPOINT

VIEWPOINT

Biopesticide in Latin America:
The Market is Changing,
Where Are the Future Opportunities?

Matias Santipolo

Gustavo Herrmann

Gregorio M. Katz

Eduardo Perez

Marketing Director of Rizobacter

Commercial Director of

Director of TENSAC

Commercial Director of Biotrop

Koppert Brazil

biopesticide products tends to continue to
grow, following the world trends where the
biopesticide market grows at rates of 14% per
year and the chemical market grows 4.5%.
Gustavo Herrmann: The demand is
becoming more consistent, as the growers

companies pay attention to
and enter the South American
biopesticide market. Where do
you think the future market
opportunities for South American
biopesticides are?

market was valued at USD 305.1 million in

What has changed in the South
American biopesticide market in

the past few years?

2017 and is expected to register a CAGR
of 16.4% during the forecast period (2018-

Matias Santipolo: The South American

crops.
Eduardo Perez: The main opportunity
market is in the food production for export.

and economic sustainability. The market

a great opportunity for biopesticides because

And in the next few years, it is expected to

(specially the industry) is becoming more

there are no launches of chemical active

be an increase in extensive crops.

professional, as the requirements for quality

ingredients in the coming years that will solve

and high performance are increasing from

all the problems that farmers currently have.

users.

The solutions will come by mixing old modes

Gregorio M. Katz: The trend in the
report, the Latin America biopesticide

lemon, fruit trees, grapevines, horticultural

Matias Santipolo: The actual market is

concept, in order to achieve environmental

ccording to Mordor intelligence'

in intensive regional productions; case of

today in the South American biopesticide

start to implement IPM as a mandatory

A

Gregorio M. Katz: We think that the
future opportunities for biopesticides are

of action with new modes of action, applying

of the first glyphosate resistant GM crop, it

demand for bio-products is increasing, not

more efficiently and using Biopesticides.

was what changed the agriculture model and

only in South America, but in the world; this

Biopesticides will help pesticides to increase

allowed us today to have high production

due to the constant restrictions of the allowed

control, avoid resistance breakdown and

levels, but in these more than 20 years is

MRLs of the requesting countries; as well as

increase crop yields.

becoming more frequent to find cases of

to the global demand on the consumption of

The biological compatibility and survival

What do you think are the biggest

challenges in promoting and
developing biopesticides in South
America? Why?
Matias Santipolo: Generally, the
registrations of pesticide patents are preferred

2023). Brazil is the largest market share

market is changing, we could not say that

resistance to chemical molecules, making

more sustainable products. In addition, the

of biopesticides are a determining factor

for the ministry of agriculture than those of

holder of biopesticides in Latin America with

it is only for one factor but that it is a set of

it difficult to control weeds, diseases and

markets seek to have greater competitiveness

since most microorganisms die in contact

chemical pesticides, mainly when it comes

the revenue USD 103.5 million in 2017 and is

interrelated factors.

insects. It is here where biopesticides along

at the global level, so they aim to look for

with chemicals or in environmental stresses.

to native microorganisms. Apologies I do not

with chemicals help to fight these pests and

productive alternatives to the conventional

Companies that manage to industrialize

have much knowledge of the regulatory area.

illnesses that are difficult to control.

one, for organic productions and to look

biopesticide have excellent opportunities in

Gustavo Herrmann: The biggest

for niche markets, which grow more and

expected to register a CAGR of 10.3% during
forecast period (2018 - 2023).

As in other parts of the world, society
looks more and more closely at agriculture

In Latin America, the biopesticides

and calls for greener technologies. This social

the market. Rizobacter has been working for

challenge in broad acre crops is to combine

market is witnessing a steady growth in the

pressure is generating changes in the demand

frontiers" such as the North Brazil region, the

more, and which pay another price for the

more than 40 years on the compatibility of

biopesticides with the traditional ones, in

past years. As more and more companies enter

for crop protection products, for instance,

Chaco Paraguay / Bolivia region and western

fruit (example: sugar, lemon, fruit trees,

microorganisms with chemicals and resistance

IPM programs that show more productivity

the Latin American biopesticide market, what

products with excellent agronomic efficiency,

Argentina, carrying out agriculture is really

vine, etc). Based on this, we think that the

to abiotic factors.

and less impact for the environment. And of

changes have occurred in this market, and

to regulate their use, even becoming banned.

challenging, the weather conditions are very

markets are looking for BIO alternatives over

what new opportunities and challenges have

For example, in Argentina the chemicals that

aggressive and the incorporation of beneficial

conventional products; This generates an

the biggest market, Brazil, the opportunities

emerged? What types of biopesticide products

can be used depending on their toxicity are

microorganisms help to make agriculture

expansion of a niche market, and we consider

are larger in row crops, like soybean,

are in strong demand in this market? I believe

delimited by regions.

viable.

that the trend is in that sense.

corn, cotton, sugarcane and others. At the

number of small growers and keep the high

these issues are of concern to every company

Another factor influencing the growth

Also in regions called "agricultural

In this context of a society that demands

Eduardo Perez: The improvement

Gustavo Herrmann: When we look to

course, at the same time do not increase costs
to the growers.
In the horti sector, to achieve a large

same time, the challenges are as big as the

level of quality within bioproducts can be

that wants to enter the Latin American market.

of the biopesticide market is the constant

agriculture with less environmental impact,

of effectiveness of the biological products

areas, because these segments are chemical

very challenging, so logistics is key for any

Therefore, we interviewed several companies

increase in cases of resistance to chemical

where we find increases in resistance to

over the chemical products has been the

intensive crops. In other countries like Chile

IPM program.

that performed well in the Latin American

active ingredients. Today in countries such as

agrochemicals and the need to increase the

main reason why the demand for biological

and Colombia, for example, the focus of

biopesticide market, they are Rizobacter,

Argentina, Brazil, Uruguay and Paraguay, it

surface in areas considered not optimal for

products has increased in the past five years.

biologicals are more related to high value

challenges lie in the regulations of the

Koppert Brazil, TENSAC and Biotrop.

has been more than 20 years since the launch

agriculture, the growth of the market for

crops, like berries, tomatoes, flowers, etc.

different countries, in being able to register

42 2020 Biologicals Special

More and more biopesticide

Gregorio M. Katz: The greatest

2020 Biologicals Special 43


VIEWPOINT

VIEWPOINT
them in the State institutions with often

LEADING WITH YOU
As the leading provider of biopesticides for conventional
and organic producers, our mission is to drive the most
effective solutions and product innovations for the industry.

exorbitant tariffs; This is because many
times the requirements that a biopesticide
has to pass at the time of registration,
are the same as that of a conventional

Partnering with industry leaders
and growers to successfully
commercialize biopesticides in
several markets while
innovating the industry with
new technologies including the
very first biological plant
activator, LifeGard®.

BROAD
PORTFOLIO

Committed to providing a strong
product portfolio to combat resistance,
fight agronomic crop disease
and pest challenges today
and for the future.

RELIABILITY

KNOWLEDGEABLE
REPRESENTATIVES

A passionate team comprised
of over 20 technical, sales,
and marketing professionals
focused daily on leading
biopesticides forward in
the industry.

high temperatures, salinity and resistance
to drought. This new inoculant resists very

relies in the ability to introduce these

Beauveria Bassiana, Trichoderma Spp,

stressful conditions, together with new

products in extensive crops like corn,

Paecilomyces fumosoroseus .

varieties of Soybeans will allow agriculture in

There are products on the market with the

improve their performance, but also as

efficiency. This difference in the efficiency of

Challenger, the first bioinsecticide registered

bioinsecticides and biofungicides.

the products is due to the artificial selection of

for the control of ACP (Asian Citrus Psilid),

microorganisms, it is also possible to see notable

the vector of greening disease in citrus crops.

differences in the concentration, shelf time

The product can be used in combination with

and formulation between products of the same

most of the recommended chemicals for

microorganisms.

the pest, specially in flowering and harvest

In terms of registration
supervision, do South
American countries have
special requirements for the
registration of biological

pesticides?
Matias Santipolo: Generally,
biopesticide patent registrations are

Gustavo Herrmann: Most of the
countries includes biologicals in the
same regulation of chemical pesticides.

Gregorio M. Katz: The BIO products that

different in one country than the other,

seasons, reducing the residues of pesticides

are most in demand belong to the order of the

in the end product (fruit or juice). This

Biologicals (microorganisms) mainly.

product was developed in partnership with

Eduardo Perez: Nowadays, biopesticides

Fundecitrus (Citrus Industry Research Center)

are mainly required in intensive crops but day by

and ESALQ/USP (University of São Paulo)

day are beginning to be used in extensive crops

and it is now available for Brazil.

as well.

In the pipeline, we intend to launch a
new Bacillus based product with nematicidal
effect, EPNs (entomopathogenic nematodes)

At present, what biopesticide
products has your company launched
in South America? What new
products will enter the market in the
future?

There are some peculiarities that may be

as bioinsecticides and new macro organisms,
like Telenomus podisi , a parasitic wasp to
control the soybean stink bug.
Gregorio M. Katz: Those that TENSAC
promotes are the Esten 80 and Esten 80 H.
Plus, Bioinsecticides. The plan is to launch a

Matias Santipolo: Currently Rizobacter

bio Herbicide and a specific phyto regulator

but in general everyone has to follow

launched Rizoliq LLI, which is the only

the PPP (plant protection products)

liquid inoculant registered in Brazil based on

registration path.

Bradyrhizobium spp, that can be in contact with

that the ESTEN 80 product was nominated

Gregorio M. Katz: In some cases,

to tobacco.
Referring to this question, we inform you

agrochemicals in the seed for 60 days, currently

for the Innovation Award “Bio-based Material

the regulatory entities of each country

most of the products on the market do not resist

of the Year 2020’’ at 13th International

have some differential biopesticide

contact with agrochemicals. Rizoliq LLI is a

Online-Conference of Bio-based Materials in

treatment, what happens is that from

great advantage for the seed treatment industry

Cologne Germany, 12-13 May 2020.

the point of view of technical analysis,

and for the farmer who does not have to damage

beyond physicists, chemists and

his seed by re-treating with inoculants before

company already launched biofertilizers,

toxicologists, a lot of study or testing time

planting.

PGPRs, inoculants and nematicides products.

is required (similar to a conventional one)

In Argentina we launched a Rhamnolipids-

Eduardo Perez: At present, our

In the next few years, we will follow with

requiring a lot of information, which is

based Bio-surfactant, it was an innovative launch,

the introduction of bioinsecticides and

sometimes unnecessary and unjustifiable.

it is an adjuvant for tank mix use that replaces

biofungicides.

problem in South America is that, in
general, there is no specific legislation

www.CertisUSA.com

Gustavo Herrmann: We’ve launched

same microorganism, but not all have the same

Eduardo Perez: No. The big

Discover the biopesticide solutions you need, learn from our thought
leadership & industry expertise, connect with our world-class field support
team and access labels & certifications.

regions considered to be marginal.

of not only using them as PGPR to

area.

Certis owns and operates three stateof-the-art production facilities, two of
which are based in the United States
for fermentation and a facility in
India for plant extraction of
neem-based products.

bacteria, we obtained an inoculant that resists

spp, Bacillus Subtilis, Bacillus Thuringiensis,

Eduardo Perez: The major challenge

have much knowledge of the regulatory

Our portfolio features sustainable alternatives for organic and
conventional use including the broadest offering of over 30 OMRIListed Products, most of which are Residue Exempt and have short
re-entry and pre-harvest intervals.

44 2020 Biologicals Special

Matias Santipolo: The main microorganisms

native microorganisms. Sorry I do not

MANUFACTURING
EXPERTISE

Dakar, an inoculant based on Bradyrhizobium
spp, for inoculation in soybeans, which
due to the artificial selection of resistant

privileged, especially when it comes to

Trusted to protect crops time
and time again with the broadest
line of biological products tested
in 6,000+ field trials for over three
decades.

Paraguay, Uruguay and Brazil will be Rizoliq

used in South America are Bradyrhizobium

product.

soybean and wheat with the purpose

MARKET
SHAPERS

At present, what kind of biopesticides
products in South America are in
high demand?

traditional adjuvants.
In Paraguay, Argentina and Bolivia we
launched Rizoderma which is a fungal Bio-

for biological products. And this is an

controller based on Trichodema , specifically

important issue to be resolved in different

developed for seed treatment.

countries.

The new launch in Argentina, Bolivia,

1–800–250–5024
2020 Biologicals Special 45


VIEWPOINT

VIEWPOINT

The combined use of insect viruses with chemical
pesticides to increase mutual synergy reduces the use
of chemical pesticides, and the resistance of insect
pests to chemical pesticides.
Cheng Qingquan

General Manager of Keyun Biotechnology

such as pome fruit or citrus production, but

PxGV and CPV, which are mainly used for

insecticidal spectrum via recombination,

since some years also in row crops such as

control of plutella xylostella, beet armyworm,

such that viral products can be accepted in

cotton, sorghum or soybean. We also should

cotton bollworm and plusia agnata.

more market applications. In the process of

not forget that some insect viruses have been

Viral Insecticides: Technological Innovation,
A New Blue Ocean of Future Pesticides

V

iral Insecticides for Biological
Control focuses on the basic

as well as applied aspects of viral

Could you give a briefing of the
development status and major
applications of viral insecticide?

insecticides, which have the potential

According to the outcome in the eighth

viral recombination, not only the insecticidal

very successfully applied to control important

report of the International Committee on the

spectrum is expanded, but also some viruses

forest pests.

Taxonomy of Viruses in 2005, the recognized

are found to have a synergistic effect against

At present, more than 1,670 insect

5,000 virus species was split into 73 virus

other viruses, which improves the lethality

viruses have been discovered in more than

families, of which 230 species are insect

of products and achievement of a better

1,100 kinds of insects worldwide, which

viruses (definitely pathogenic to insect),

insecticidal effect.

involve hosts of 43 families in 11 classes.

being classified and included in the 18 virus

On the other side, in order to improve the

In China, 291 kinds of insect viruses have

families, including rhabdoviridae , roniviridae ,

effect of control of insect virus on older larva,

been discovered. Although the research and

biscistravirus, infectious PVA, ascoviridae ,

researches are made into recombination of

development of viral insecticide started

baculoviridae , birnaviridae , iridoviridae ,

insect viruses with some chemical pesticides.

quite late, it has moved forward rapidly in

metaviridae , nimaviridae , nodamura

In this aspect, a breakthrough has been

viruses compared to the overall microbial

recent years. There have been more than 60

virus, orthomyxoviridae , parvoviridae ,

achieved. The method is, during the field

plant protection market is relatively low,

kinds of viruses filed in various countries for

multicomponent virus, polyviridae ,

spraying, to mix viral insecticidal products

since the use of each product is restricted

registration which are now in the process of

pseudoviridae , reoviridae and tetravirus.

with some chemical pesticides for application

to a single or relatively few numbers of

field trial while more than 30 kinds of viruses

Insect viruses commonly used in crop control

as in a form of “combo” product. It is

target insects. If we estimate a yearly annual

have been registered, produced and applied

are mainly NPV and GV of baculoviridae,

found upon application that some chemical

reliance on chemical pesticide

insecticide around the world is mainly used for

turnover of 70 m US$ for this product

worldwide.

CPV of reoviridae. Viral insecticide has

pesticides have an obvious synergistic effect

technology. Compared with traditional

control of cotton bollworm, soybean worm,

category, this represent only 3 % of the global

Chen Jiao: Since 1993 when HaNPV

the superior properties of high safety, non-

against insect viruses, which can speed

pollution, non-residue and non-resistance,

up the death of insect pests infected with

having gradually attracted user’s attention.

viruses, causing a higher death rate of insect

to significantly reduce the current

Cheng Qingquan: At present, viral

chemical insecticides, viral insecticides

spodoptera frugiperda , codling moth, prodenia

microbial plant protection market. The market

wettable powder, the first viral insecticide,

are highly targeted, environmentally

litura as well as the resistant beet armyworm

can surely accept many more insect virus

was granted registration in China, there have

friendly, and have been rapidly

and plutella xylostella . Its market share has been

products, as they are highly efficient, safe and

been 74 viral biopesticide products being

pests. This has significantly increased user's

developed in the past few years,

growing constantly.

compatible with many production strategies.

granted registration by 2019, covering mother

acceptance of this kind of product due to its

The challenge lays in the high investment

liquid and formulations. There are 26 HaNPV

especially in organic agriculture. What is

Kessler Philip: We are happy to recognize

the current status of the development of

a general increase of biological plant protection

in registration for products to control single

products, which accounts for the majority of

viral pesticides, what new products and

tools in agriculture, particularly of microbial

pest species, as it is clearly disproportionate

the registrations. There are 12 insect virus

technologies are there, and how will they

biocontrol technologies. Insect viruses, namely

to its market potential. As a consequence,

varieties, eight of which are registered by

Could you tell us about the status
of research of viral insecticide
(recombination of insect viruses
or combined with small amount of
chemical pesticide)?

satisfactory control effect.
In fact, in terms of chemical pesticides,
especially some patented chemical pesticide
products, the combined use of insect viruses
with chemical pesticides to increase mutual

develop in the future. To this end, we

the baculoviruses, have been successfully applied

there are very few virus species that have

Chuqiang Biotechnology, a wholly-owned

interviewed several leading companies

for decades, as their high efficacy and safety

become global success stories like the insect

subsidiary of Wuhan Unioasis Biological

in virus pesticides. They are Cheng

has been recognized from early on. Several

viruses against Cydia pomonella (CpGV)

Technology. So far, more than 20 virus

Qingquan, General Manager of Keyun

international biocontrol companies successfully

and Helicoveropa armigera (HearNPV).

insecticide products have been registered

of recombination of viral insecticides. The

the resistance of insect pests to chemical

first is the recombination between different

pesticides, thus extending the product life

Cheng Qingquan: There are two kinds

synergy not only reduces the use of chemical
pesticides, but also significantly reduces

Biotechnology, Philip Kessler,Director

develop and globally market products based on

Insect viruses are used in organic crops and

in the United States, France, Switzerland,

International Market Development of

baculoviruses. There are also locally operating

conventional IPM strategies to manage MRL

Russia, Brazil, Spain, Japan, South Africa,

insect viruses, including recombination

cycle of chemical pesticides while pesticide

Andermatt Biocontrol, Chen Jiao, Wuhan

companies developing virus-based plant

and resistance issues. So far virus insecticides

India and Australia. The main insect viruses

of two or more different kinds of insect

residues are greatly reduced.

Unioasis Biological Technology Co. Ltd.

production products. However, the use of insect

find their way in strategies in high value crops

used for biological control include NPV,

viruses. The purpose is to broaden product’s

46 2020 Biologicals Special

Chen Jiao: At present, there are two

2020 Biologicals Special 47