liquid biopsy using blood test is latest weapon against cancer

`Liquid biopsy' using blood test is latest
weapon against cancer

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Contd..
In the usual cancer biopsy ,a surgeon cuts out a piece of the patient's tumor, but researchers in US labs are now testing a
potentially transformative innovation. They call it the liquid biopsy, and it is a blood test that has only recently become
feasible with the latest techniques. It is showing promise in finding tiny snippets of cancer DNA in a patient's blood.
The hope is that a simple blood draw -far less onerous for patients than a traditional biopsy or a CT scan -will en able
oncologists to figure out if a treatment is working and to continue monitoring the treatment in case the cancer develops
resistance. Failing treatments could be abandoned quickly . “This could change the way we follow up response to
treatments, and down the line could even be used for really early diagnosis,“ said Dr Jose Baselga of Memorial Sloan
Kettering Cancer Center. NYT NEWS SERVICE Researchers caution that more evaluations of the liquid biopsy's accuracy and
reliability are needed.
So far, there have been only small studies in particular cancers, including lung, colon and blood cancer.But early results are
encouraging. A National Cancer Institute study published in The Lancet Oncology , involving 126 patients with the most
common form of lymphoma, found the test predicted recurrences more than three months before they were noticeable on
CT scans. The testalso identified patients unlikely to respond to therapy .

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Oncologists who are not using the new test say they are looking on with fascination. “Our lab doesn't do it, but we are very
interested,“ said Dr Levi Garraway of the DanaFarber Cancer Institute.

Mary Susan Sabini, a teacher from Gardiner, NY, has lung cancer that resisted two attempts at chemotherapy and a round
of radiation. Her doctors at Sloan Kettering saw cancer DNA in her blood when she began taking an experimental drug in
October. Four days later, the cancer DNA shards had vanished, a sign, doctors hoped, that the treatment was working. But
they dared not tell her the good tidings. The blood test was so new that they were afraid to rely on it. Within weeks, Sabini
began to breathe easier. Months later, she had a CT scan, an X-ray test that uses a computer to assemble detailed images of
slices of tumor tissue. It confirmed her tumours were shrinking. The idea for the test grew out of a discovery made years
ago about fetuses. They shed little pieces of DNA into the bloodstreams of mothers-to-be. It turned out that all growing
cells, including tumours, shed tiny DNA fragments.

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