childrenwithchromosomalabnormalitiesand
congenitalheartdefects.PediatrCardiol.
2014;35:536–541.
59.YiJJ,TangSX,McDonald-McGinnDM,etal.
Contributionofcongenitalheartdiseaseto
neuropsychiatricoutcomeinschool-agechildren
with22q11.2deletionsyndrome.AmJMed
GenetBNeuropsychiatrGenet.2014;2:137–147.
60.HomsyJ,ZaidiS,ShenY,etal.Denovo
mutationsincongenitalheartdiseasewith
neurodevelopmentalandothercongenital
anomalies.Science.2015;350:1262–1266.
61.FullerS,NordAS,GerdesM,etal.Predictorsof
impairedneurodevelopmentaloutcomesatone
yearofageafterinfantcardiacsurgery.EurJ
CardiothoracSurg.2009;36:40–47.
62.GaynorJW,NordAS,WernovskyG,etal.
ApolipoproteinEgenotypemodifiestheriskof
behaviorproblemsinpreschoolchildren
followingneonatalandinfantcardiacsurgery.
Pediatrics.2009;124:241–250.
63.BurnhamN,IttenbachRF,StallingsVA,etal.
Geneticfactorsareimportantdeterminantsof
impairedgrowthafterinfantcardiacsurgery.J
ThoracCardiovascSurg.2010;140:144–149.
64.NewmanFM,CroughwellND,BlumenthalJA,et
al.Predictorsofcognitivedeclineaftercardiac
operation.AnnThoracSurg.1995;59:1326–
1330.
65.TagarakisGI,Tsolaki-TagarakiF,TsolakiM,et
al.TheroleofapolipoproteinEincognitive
declineanddeliriumafterbypassheart
operations.AmJAlzheimersDisOtherDemen.
2007;22:223–228.
66.YadavA,RadhakrishnanA,BhanotG,SinhaH.
Differentialregulationofantagonisticpleiotropy
insyntheticandnaturalpopulationssuggestsits
roleinadaptation.G3(Bethesda).2015;5:699–
709.
67.KimDS,KimJH,BurtAA,etal.Patient
genotypesimpactsurvivalaftersurgeryfor
isolatedcongenitalheartdisease.AnnThorac
Surg.2014;98:104–110.
68.BellingerDC,JonasRA,RappaportLA,etal.
Developmentalandneurologicstatusofchildren
afterheartsurgerywithhypothermiccirculatory
arrestorlow-flowcardiopulmonarybypass.N
EnglJMed.1995;332:549–555.
69.BellingerDC,WypijD,KubanKCK,etal.
Developmentalandneurologicalstatusof
childrenat4yearsofageafterheartsurgerywith
hypothermiccirculatoryarrestorlow-flow
cardiopulmonarybypass.Circulation.
1999;100:526–532.
70.NewburgerJW,JonasRA,WernovskyG,etal.
Comparisonoftheperioperativeneurologic
effectsofhypothermiccirculatoryarrestversus
low-flowcardiopulmonarybypassininfantheart
surgery.NEnglJMed.1993;329:1057–1064.
71.BellingerDC,WypijD,duPlessisAJ,etal.
DevelopmentalandneurologiceffectsofalphastatversuspH-statstrategiesfordeep
hypothermiccardiopulmonarybypassininfants.
JThoracCardiovascSurg.2001;121:374–383.
72.GoldbergCS,BoveEL,DevaneyEJ,etal.A
randomizedclinicaltrialofregionalcerebral
perfusionversusdeephypothermiccirculatory
arrest:outcomesforinfantswithfunctional
singleventricle.JThoracCardiovascSurg.
2007;133:880–887.
73.HirschJC,JacobsML,AndropoulosD,etal.
Protectingtheinfantbrainduringcardiac
surgery:asystematicreview.AnnThoracSurg.
2012;94(4):1365–1373.
74.GreeleyWJ,KernFH,UngerleiderRM,etal.
Theeffectofhypothermiccardiopulmonary
bypassandtotalcirculatoryarrestoncerebral
metabolisminneonates,infants,andchildren.J
ThoracCardiovascSurg.1991;101:786–794.
75.KernFH,UngerleiderRM,RevesJG,etal.
Effectofalteringpumpflowrateoncerebral