INTERNAL MEDICINE Just the Facts pptx

INTERNAL MEDICINE
Just the Facts
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Editor-in-Chief
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Professor of Internal Medicine
Saint Louis University School of Medicine
Department of Internal Medicine
St. Louis, Missouri
Associate Editor
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Professor of Internal Medicine
Saint Louis University School of Medicine
Director, Division of Nephrology
St. Louis, Missouri
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INTERNAL MEDICINE
Just the Facts
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To Grandma Pauline for her divine
nurturing of education and spirit
And to our patients,
whom we have been given
the privilege of caring for
vii
CONTENTS
Section Editors xv
Contributors xvii
Preface xxvii
Acknowledgments xxix
Section 1
INTERDISCIPLINARY MEDICINE
1 Medical Professionalism Thomas J. Olsen1
2 Dermatology Timothy Rice 2
3 Nutrition Nora L. Porter and H. Douglas Walden 23
4 Preventive Medicine
Robert M. Heaney and Nora L. Porter 30
5 Perioperative Medicine H. Douglas Walden 38
6 Common Problems in Otorhinolaryngology
James Drake 45
7 Common Problems in Ophthalmology
Thomas J. Olsen51

8 Selected Topics in Men’s Health
Gina L. Michael, Margaret C. Hochreiter,
and Mona Bahl 54
9 Women’s Health Thomas J. Olsen 69
Section 2
ASSESSING THE MEDICAL LITERATURE
10 The Basics of Statistics Thomas E. Burroughs 73
11 Describing and Displaying Data
Thomas E. Burroughs 74
For more information about this title, click here
12 Overview to Inferential Statistics: Estimation
and Hypothesis Testing
Thomas E. Burroughs 78
13 Regression and Survival Analysis
Thomas E. Burroughs 84
14 Epidemiology and Study Design
Thomas E. Burroughs 88
Section 3
GERIATRIC MEDICINE
15 Geriatric Assessment John E. Morley 91
16 Geriatric Syndromes: The “I’s” of Geriatrics
Julie Gammack 100
17 The Confused Patient Seema Joshi 111
18 Frailty John E. Morley 115
19 Nutrition in Older Adults David R. Thomas 118
20 Geropharmacology Joseph H. Flaherty 121
21 Andropause Syed H. Tariq and Matthew T. Haren 128
22 Depression in the Elderly
Chinya Murali and George T. Grossberg 132
Section 4

ALLERGY AND IMMUNOLOGY
23 Asthma Mark S. Dykewicz 139
24 Immunologic Lung Diseases Raymond G. Slavin 146
25 Allergic Rhinitis Raymond G. Slavin 150
26 Sinusitis Raymond G. Slavin 152
27 Anaphylaxis Mark S. Dykewicz 155
28 Drug Allergies Mark S. Dykewicz 160
Section 5
CARDIOVASCULAR MEDICINE
29 Cardiac Structure and Basic Physiology
Steven C. Herrmann 169
30 Cardiac Diagnostic Testing Deryk McDowell 174
31 Electrocardiogram Basics Frank L. Bleyer 181
32 Arrhythmias Daniel Friedman 188
33 Atrial Fibrillation Frank L. Bleyer 199
34 Unstable Angina and Non–ST Elevation Myocardial
Infarction Frank L. Bleyer 201
35 ST–Elevation Myocardial Infarction
Jeffrey Ciaramita 210
viii CONTENTS
CONTENTS ix
36 Chronic Coronary Artery Disease
Richard E. Stewart 214
37 Aortic Stenosis Christopher R. Longnecker 217
38 Aortic Regurgitation Joseph Polizzi 220
39 Mitral Stenosis Jennifer Lash 224
40 Mitral Regurgitation Kevin Fitzgerald 226
41 Endocarditis Michael Forsberg 230
42 Heart Failure Stephen Kuehn 232
43 Aortic and Peripheral Vessel Disease

Robert Neumayr 237
44 Diseases of the Pericardium
Peter Mikolajczak and Frank Bleyer 241
45 Congenital Heart Disease in the Adult
Abhay Laddu and Aaron Tang 247
Section 6
ENDOCRINOLOGY AND METABOLISM
46 Diabetes Mellitus
Sahar Hachem and Marla Bernbaum 253
47 Disorders of the Pituitary Gland
Kenneth Patrick L. Ligaray 264
48 Disorders of Calcium Metabolism
Kent R. Wehmeier 271
49 Metabolic Bone Diseases Kent R. Wehmeier 276
50 Disorders of the Thyroid Gland
Alan B. Silverberg 283
51 Adrenal Gland Bahaeldeen A. Laz 290
52 Familial Hypercholesterolemia
George T. Griffing 297
Section 7
GASTROENTEROLOGY AND LIVER DISEASE
53 Diseases of the Esophagus
M. Louay Omran 303
54 Diseases of the Stomach
M. Louay Omran 310
55 Diseases of the Small Bowel
M. Louay Omran 319
56 Diseases of the Colon and Rectum
M. Louay Omran 329
57 Liver and Biliary Diseases

Adrian M. Di Bisceglie 338
58 Diseases of the Pancreas
Adrian M. Di Bisceglie 343
Section 8
HEMATOLOGY
59 Bone Marrow and Bone Marrow Failure
Catherine Iasiello 347
60 Red Blood Cell Disorders
Krishnamohan R. Basarakodu, Stephen L. Graziano,
Scott W. McGee, Rajesh R. Nair, Michael C. Perry,
Arun Rajan, Huda Salman, and Allison P. Wall 350
61 White Cell Disorders
C. Daniel Kingsley 377
62 Normal Hemostasis and Bleeding Disorders
Hans-Joachim Reimers 381
63 Thrombophilia Ganesh C. Kudva 390
64 Myelodysplasia Scott McGee 394
65 Myeloproliferative Disorders
Sri Laxmi Valasareddi 398
66 Acute Leukemias
Krishnamohan R. Basarakodu 405
67 Chronic Lymphocytic Leukemia
Krishnamohan R. Basarakodu 411
68 Hodgkin Lymphoma
Rami Owera 414
69 Non-Hodgkin Lymphoma
Osama Qubaiah and Paul Petruska 416
70 Multiple Myeloma and Related Disorders
Christopher N. Hueser 427
71 Transfusion Medicine

Marian Petrides and Allison Lisle 432
Section 9
ONCOLOGY
72 Oncologic Screening and Detection
Syed Huq 439
73 Cancer Treatment Overview
Michael C. Perry 443
74 Central Nervous System Tumors
Nancy F. McKinney 445
75 Head and Neck Tumors Huda Salman 452
76 Breast Cancer Joanne E. Mortimer 458
77 Lung Cancer
Vamsidhar Velcheti and Ramaswamy Govindan 464
78 Gastrointestinal Cancers Rami Owera 469
79 Genitourinary Oncology Noah M. Hahn 476
80 Gynecologic Cancers
Sara E. Crowder and Michael C. Perry 487
x CONTENTS
CONTENTS xi
81 Sarcomas Nancy F. McKinney 492
82 Carcinoma of Unknown Primary
C. Daniel Kingsley 497
83 Oncologic Emergencies
C. Daniel Kingsley 499
84 The Risk of Therapy-Related Organ Damage in
Long-Term Survivors of Cancer Treatment
Michael C. Perry 505
Section 10
INFECTIOUS DISEASE
85 Fever of Unknown Origin

Musab U. Saeed and Donald J. Kennedy 509
86 Central Nervous System Infections
Musab U. Saeed and Donald J. Kennedy 510
87 Respiratory Tract Infections
Musab U. Saeed and Donald J. Kennedy 514
88 Cardiovascular Infections
Mary Abigail C. Dacuycuy and Donald J. Kennedy 519
89 Intraabdominal Infections
Mary Abigail C. Dacuycuy and Donald J. Kennedy 524
90 Hepatitis
Musab U. Saeed and Donald J. Kennedy 528
91 Genitourinary Tract Infections
Mary Abigail C. Dacuycuy and Donald J. Kennedy 530
92 Skin and Soft Tissue Infections
Mary Abigail C. Dacuycuy and Donald J. Kennedy 533
93 Bone and Joint Infections
Musab U. Saeed and Donald J. Kennedy 535
94 Sexually Transmitted Infections
Mary Abigail C. Dacuycuy and Donald J. Kennedy 538
95 Human Immunodeficiency Virus and Acquired
Immunodeficiency Syndrome
Musab U. Saeed and Donald J. Kennedy 542
96 Mycobacteria
Musab U. Saeed, Mary Abigail C. Dacuycuy,
and Donald J. Kennedy 547
97 Fungal Infections
Mary Abigail C. Dacuycuy and Donald J. Kennedy 549
98 Nocardia
Mary Abigail C. Dacuycuy and Donald J. Kennedy 554
99 Rickettsiosis and Ehrlichioses

Mary Abigail C. Dacuycuy and Donald J. Kennedy 554
100 Protozoan and Helminthic Infections
Musab U. Saeed and Donald J. Kennedy 556
Section 11
NEUROLOGICAL DISEASE
101 Cerebrovascular Disease
Paisith Piriyawat 559
102 Movement Disorders
Francis A. Mithen 563
103 Neuromuscular Disorders
Ghazala Hayat 567
104 Spinal Cord and Nerve Root Disorders
Florian P. Thomas and Robert M. Woolsey 572
105 Epilepsy Jayant N. Acharya 577
106 Headache David J. Walsh 584
Section 12
PSYCHIATRIC DISORDERS
107 Personality Disorders
Miggie Greenberg and Mehret Gebretsadik 589
108 Sexual and Gender Identity Disorders
Sundeep Jayaprabhu and George T. Grossberg 594
109 Mood, Anxiety, Sleep, and Eating Disorders
Stacy Neff 599
110 Schizophrenia and Other Psychotic Disorders
Harmeeta K. Singh and Jothika N. Manepalli 607
111 Substance-Related Disorders
Jeffrey Kao and George T. Grossberg 613
Section 13
PULMONARY MEDICINE AND CRITICAL CARE
112 Chronic Obstructive Pulmonary Disease

Joseph Roland D. Espiritu and
George M. Matuschak 621
113 Interstitial Lung Disease
George M. Matuschak and Ravi P. Nayak 627
114 Venous Thromboembolism
Wilman Ortega and George M. Matuschak 638
115 Pleural Diseases
Patricia A. Dettenmeier and George M. Matuschak 646
116 Acute Respiratory Failure and Acute Lung Injury/ARDS
George M. Matuschak 654
117 Sleep-Related Breathing Disorders
Joseph Roland D. Espiritu 662
xii CONTENTS
CONTENTS xiii
Section 14
NEPHROLOGY AND HYPERTENSION
118 Approach to the Patient with Kidney Disease
Kevin J. Martin 669
119 Fluid, Electrolyte, and Acid-Base Disorders
Paul G. Schmitz 673
120 Acute Kidney Injury Zhiwei Zhang 687
121 Chronic Kidney Disease
Marie D. Philipneri 696
122 Glomerular Disease
Rizwan A. Qazi and Bahar Bastani 702
123 Tubulointerstitial Disease
Alejandro C. Alvarez 711
124 Pathophysiology and Treatment of Kidney Stones
Rizwan A. Qazi and Bahar Bastani 721
125 Clinical Hypertension

Paul G. Schmitz 727
Section 15
RHEUMATOLOGY
126 Crystal-Induced Arthropathies
Katherine K. Temprano 733
127 Vasculitis Gideon Nesher 739
128 The Spondyloarthropathies
Rama Bandlamudi 748
129 Osteoarthritis Peri Hickman Pepmueller 754
130 Systemic Lupus Erythematosus
Terry L. Moore 758
131 Miscellaneous Connective Tissue Diseases
Thomas G. Osborn 762
132 Rheumatoid Arthritis Terry L. Moore 768
Index 773
xv
SECTION EDITORS
Cardiovascular Medicine
Frank L. Bleyer, MD
Assistant Professor of Internal Medicine
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Assessing the Medical Literature
Thomas E. Burroughs, PhD
Associate Professor of Internal Medicine and
Health Management & Policy
Executive Director, Saint Louis University Center
for Outcomes Research

Saint Louis University
St. Louis, Missouri
Gastroenterology and Liver Disease
Adrian M. Di Bisceglie, MD
Professor of Internal Medicine
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Endocrinology and Metabolism
George T. Griffing, MD
Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Psychiatric Disorders
George T. Grossberg, MD
Samuel W. Fordyce Professor
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
Infectious Disease
Donald J. Kennedy, MD
Professor of Internal Medicine
Division of Infectious Diseases
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri

Pulmonary Medicine and Critical Care
George M. Matuschak, MD
Professor of Pharmacological and Physiological
Science
James B. Miller and Ethyl D. Miller Professor
of Internal Medicine
Director, Division of Pulmonary, Critical Care,
and Sleep Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Copyright © 2008 by The McGraw-Hill Companies, Inc. Click here for terms of use.
xvi SECTION EDITORS
Rheumatology
Terry L. Moore, MD
Professor of Internal Medicine, Pediatrics, and
Molecular Microbiology and Immunology
Director, Division of Rheumatology and
Pediatric Rheumatology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Geriatric Medicine
John E. Morley, MB, BCh
Professor of Internal Medicine
Director, Division of Geriatric Medicine
Geriatric Research, Education and Clinical
Center
St. Louis VA Medical Center
Saint Louis University School of Medicine

St. Louis, Missouri
Interdisciplinary Medicine
Thomas J. Olsen, MD, FACP
Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Hematology and Oncology
Michael C. Perry MD, MS, MACP
Professor of Internal Medicine
Director, Division of Hematology and Medical
Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
Nephrology and Hypertension
Paul G. Schmitz, MD, FACP
Professor of Internal Medicine
Saint Louis University School of Medicine
Department of Internal Medicine
St. Louis, Missouri
Neurological Disease
John B. Selhorst, MD
Professor of Internal Medicine
Chairman, Department of Neurology
Saint Louis University School of Medicine
St. Louis, Missouri

Allergy and Immunology
Raymond G. Slavin, MD, MS
Professor of Internal Medicine and Molecular
Microbiology and Immunology
Director, Division of Allergy and Immunology
Division of Allergy and Immunology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
Jayant N. Acharya, MD, DM
Associate Professor of Neurology
Division of Neurology
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 105)
Alejandro C. Alvarez, MD
Assistant Professor of Internal Medicine
Division of Nephrology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 123)
Mona Bahl, MD
Assistant Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 8)

Rama Bandlamudi, MD
Assistant Professor of Internal Medicine
Division of Rheumatology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 128)
Krishnamohan R. Basarakodu, MD
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapters 60, 66, 67)
Bahar Bastani, MD
Professor of Internal Medicine
Division of Nephrology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 122, 124)
Marla Bernbaum, MD
Clinical Professor of Internal Medicine
Division of Endocrinology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri

(Chapter 46)
Frank L. Bleyer, MD
Assistant Professor of Internal Medicine
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 31, 33, 34, 44)
xvii
CONTRIBUTORS
Copyright © 2008 by The McGraw-Hill Companies, Inc. Click here for terms of use.
Thomas E. Burroughs, PhD
Associate Professor of Internal Medicine
and Health Management & Policy
Executive Director, Saint Louis University
Center for Outcomes Research
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 10–14)
Jeffrey Ciaramita, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 35)
Sara E. Crowder, MD
Assistant Professor of Clinical Obstetrics
and Gynecology
Department of Obstetrics and Gynecology

Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapter 80)
Mary Abigail C. Dacuycuy, MD
Fellow in Infectious Diseases
Division of Infectious Diseases
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 88, 89, 91, 92, 94, 96, 97–99)
Patricia A. Dettenmeier, ANP, MSN
Assistant Professor of Internal Medicine
Division of Pulmonary, Critical Care, and Sleep
Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 115)
Adrian M. Di Bisceglie, MD
Professor of Internal Medicine
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 57, 58)
James Drake, MD
Professor of Internal Medicine
Division of General Internal Medicine

Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 6)
Mark S. Dykewicz, MD
Professor of Internal Medicine
Division of Allergy and Clinical Immunology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 23, 27, 28)
Joseph Roland D. Espiritu, MD
Assistant Professor of Internal Medicine
Division of Pulmonary, Critical Care, and Sleep
Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 112, 117)
Kevin Fitzgerald, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 40)
Joseph H. Flaherty, MD
Associate Professor of Internal Medicine
Division of Geriatric Medicine
Department of Internal Medicine

Geriatric Research, Education and Clinical
Center
St. Louis VA Medical Center
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 20)
Michael Forsberg, MD
Assistant Professor of Internal Medicine
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 41)
xviii CONTRIBUTORS
CONTRIBUTORS xix
Daniel Friedman, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 32)
Julie Gammack, MD
Assistant Professor of Internal Medicine
Division of Geriatric Medicine
Department of Internal Medicine
Geriatric Research, Education and Clinical
Center
St. Louis VA Medical Center
Saint Louis University School of Medicine

St. Louis, Missouri
(Chapter 16)
Mehret Gebretsadik, MD
Resident in Psychiatry
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 107)
Ramaswamy Govindan, MD
Associate Professor of Internal Medicine
Division of Medical Oncology
Alvin J. Siteman Cancer Center
Washington University School of Medicine
St. Louis, Missouri
(Chapter 77)
Stephen L. Graziano, MD
Professor of Medicine
Regional Oncology Center
Upstate Medical University
State University of New York
Syracuse, New York
(Chapter 60)
Miggie Greenberg, MD
Assistant Professor
Director of Adult Psychiatry Inpatient Unit
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri

(Chapter 107)
George T. Griffing, MD
Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 52)
George T. Grossberg, MD
Samuel W. Fordyce Professor
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 22, 108, 111)
Sahar Hachem, MD
Fellow in Endocrinology
Division of Endocrinology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 46)
Noah M. Hahn, MD
Assistant Professor of Medicine
Division of Hematology and Oncology
Department of Medicine
Indiana University Cancer Center
Indiana University School of Medicine
Indianapolis, Indiana
(Chapter 79)

Matthew T. Haren, PhD
Post Doc Fellow
Division of Geriatric Medicine
Department of Internal Medicine
Geriatric Research, Education and Clinical
Center
St. Louis VA Medical Center
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 21)
Ghazala Hayat, MD
Professor of Neurology
Division of Neurology
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 103)
Robert M. Heaney, MD
Professor of Internal Medicine
Associate Dean, Graduate Medical Education
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 4)
Steven C. Herrmann, MD, PhD
Adjunct Assistant Professor
Department of Pharmacological and
Physiological Science
Saint Louis University School of Medicine

St. Louis, Missouri
Director of Cardiovascular Services
Bradford Regional Medical Center
Bradford, Pennsylvania
(Chapter 29)
Margaret Hochreiter, MD, PhD
Associate Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 8)
Christopher N. Hueser, DO, MS
Fellow in Hematology and Oncology
Division of Hematology and Oncology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 70)
Syed Huq, MD, MS
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapter 72)
Catherine Iasiello, MD
Fellow in Hematology and Medical Oncology

Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapter 59)
Sundeep Jayaprabhu, MD
Resident in Psychiatry
Division of Neurology
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 108)
Seema Joshi, MD
Fellow in Geriatric Medicine
Division of Geriatric Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 17)
Jeffrey Kao, MD
Resident in Psychiatry
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis Missouri
(Chapter 111)
Donald J. Kennedy, MD

Professor of Internal Medicine
Division of Infectious Diseases
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 85–100)
C. Daniel Kingsley, MD
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapters 61, 82, 83)
Ganesh C. Kudva, MD, MRCP (UK)
Assistant Professor of Internal Medicine
Division of Hematology and Oncology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 63)
xx CONTRIBUTORS
CONTRIBUTORS xxi
Stephen Kuehn, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri

(Chapter 42)
Abhay Laddu, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 45)
Jennifer Lash, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 39)
Bahaeldeen A. Laz, MD
Staff Physician, St. John’s Hospital
Department of Internal Medicine
Division of Endocrinology
Lake St. Louis, Missouri
(Chapter 51)
Kenneth Patrick L. Ligaray, MD
Fellow in Endocrinology
Division of Endocrinology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 47)
Allison Lisle, MD
Resident in Pathology

Department of Pathology
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapter 71)
Christopher R. Longnecker, MD
Assistant Professor of Internal Medicine
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 37)
Jothika N. Manepalli, MD
Associate Professor of Psychiatry
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 110)
Kevin J. Martin, MB, BCh, FACP
Professor of Internal Medicine
Saint Louis University School of Medicine
Director, Division of Nephrology
St. Louis, Missouri
(Chapter 118)
George M. Matuschak, MD
Professor of Pharmacological and Physiological
Science
James B. Miller and Ethyl D. Miller Professor

of Internal Medicine
Director, Division of Pulmonary, Critical Care,
and Sleep Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 112–116)
Deryk McDowell, MD
Fellow in Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 30)
Scott W. McGee, MD
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapters 60, 64)
Nancy F. McKinney, MD
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School

of Medicine
Columbia, Missouri
(Chapters 74, 81)
Gina L. Michael, MD
Assistant Professor of Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 8)
Peter Mikolajczak, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 44)
Francis A. Mithen, MD, PhD
Professor of Neurology
Division of Neurology
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 102)
Terry L. Moore, MD
Professor of Internal Medicine, Pediatrics, and
Molecular Microbiology and Immunology
Director, Division of Rheumatology and
Pediatric Rheumatology
Department of Internal Medicine

Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 130, 132)
John E. Morley, MB, BCh
Professor of Internal Medicine
Director, Division of Geriatric Medicine
Geriatric Research, Education and Clinical
Center
St. Louis VA Medical Center
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 15, 18)
Joanne E. Mortimer, MD
Professor of Medicine
Deputy Director for Clinical Affairs
Division of Hematology and Oncology
Department of Internal Medicine
Moores Cancer Center
University of California—San Diego School
of Medicine
La Jolla, California
(Chapter 76)
Chinya Murali, MD
Staff Physician, Department of Psychiatry
St. Louis VA Medical Center
St. Louis, Missouri
(Chapter 22)
Rajesh R. Nair, MD
Fellow in Hematology and Oncology
Division of Hematology and Oncology

Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 60)
Ravi P. Nayak, MD
Assistant Professor of Internal Medicine
Division of Pulmonary, Critical Care, and Sleep
Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 113)
Stacy Neff, DO
Resident in Psychiatry
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 109)
xxii CONTRIBUTORS
CONTRIBUTORS xxiii
Gideon Nesher, MD
Head, Department of Internal Medicine and
Rheumatology Service
Shaare-Zedek Medical Center
Jerusalem, Israel
Clinical Associate Professor of Medicine
Hebrew University Medical School
Jerusalem, Israel
Adjunct Professor
Division of Rheumatology

Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 127)
Robert Neumayr, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 43)
Thomas J. Olsen, MD, FACP
Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 1, 7, 9)
M. Louay Omran, MD
Assistant Professor of Internal Medicine
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 53–56)
Wilman Ortega, MD
Assistant Professor of Internal Medicine
Division of Pulmonary, Critical Care, and Sleep
Medicine
Department of Internal Medicine

Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 114)
Thomas G. Osborn, MD
Associate Professor of Medicine
Division of Rheumatology
Department of Medicine
Mayo Clinic College of Medicine
Rochester, Minnesota
(Chapter 131)
Rami Owera, MD
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapters 68, 78)
Peri Hickman Pepmueller, MD
Associate Professor of Internal Medicine and
Pediatrics
Division of Rheumatology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 129)
Michael C. Perry MD, MS, MACP
Professor of Internal Medicine and Director

Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapters 60, 73, 80, 84)
Marian Petrides, MD
Associate Professor of Clinical Pathology
Medical Director, Transfusion Service and
Coagulation Laboratory
Department of Pathology and Anatomical
Sciences
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapter 71)
Paul Petruska, MD
Professor of Internal Medicine
Division of Hematology and Oncology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 69)
Marie D. Philipneri, MD, MPH
Assistant Professor of Internal Medicine
Division of Nephrology
Department of Internal Medicine

Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 121)
Paisith Piriyawat, MD
Assistant Professor of Neurology
Division of Neurology
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 101)
Joseph Polizzi, MD
Fellow in Cardiology
Division of Cardiology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 38)
Nora L. Porter, MD, MPH
Associate Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 3, 4)
Rizwan A. Qazi, MD
Assistant Professor of Internal Medicine
Division of Nephrology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri

(Chapters 122, 124)
Osama Qubaiah, MD
Fellow in Hematology and Oncology
Division of Hematology and Oncology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 69)
Arun Rajan, MD
Fellow in Hematology and Oncology
Division of Hematology and Oncology
Department of Medicine
Upstate Medical University
State University of New York
Syracuse, New York
(Chapter 60)
Hans-Joachim Reimers, MD, PhD, FAHA
Professor of Internal Medicine
Division of Hematology and Oncology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 62)
Timothy Rice, MD
Associate Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 2)

Musab U. Saeed, MD
Fellow in Infectious Diseases
Division of Infectious Diseases
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 85–87, 90, 93, 95, 96, 100)
Huda Salman, MD
Assistant Professor of Internal Medicine
Division of Hematology and Oncology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 60, 75)
Paul G. Schmitz, MD, FACP
Professor of Internal Medicine
Saint Louis University School of Medicine
Department of Internal Medicine
St. Louis, Missouri
(Chapters 119, 125)
xxiv CONTRIBUTORS
CONTRIBUTORS xxv
Alan B. Silverberg, MD
Professor of Internal Medicine
Division of Endocrinology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 50)
Harmeeta K. Singh, MD

Resident in Psychiatry
Division of Psychiatry
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 110)
Raymond G. Slavin, MD, MS
Professor of Internal Medicine and Molecular
Microbiology and Immunology
Director, Division of Allergy and Immunology
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 24, 25, 26)
Richard E. Stewart, MD
Associate Professor of Medicine
Division of Cardiovascular Medicine
Department of Internal Medicine
University of North Texas Health Science
Center
Fort Worth, Texas
(Chapter 36)
Aaron Tang
Senior Medical Student
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 45)
Syed H. Tariq, MD
Associate Professor of Internal Medicine
Division of Geriatric Medicine

Department of Internal Medicine
Geriatric Research, Education and Clinical
Center
St. Louis VA Medical Center
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 21)
Katherine K. Temprano, MD
Assistant Professor of Internal Medicine
Division of Rheumatology
Department of Internal Medicine
University of Kentucky School of Medicine
Lexington, Kentucky
(Chapter 126)
David R. Thomas, MD
Professor of Internal Medicine
Division of Geriatric Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapter 19)
Florian P. Thomas, MD, MA, PhD
Professor of Neurology and Psychiatry
Associate Professor of Molecular Virology and
Molecular Microbiology and Immunology
Division of Neurology
Department of Neurology and Psychiatry
Associate Chief of Staff, St. Louis VA Medical
Center
Saint Louis University School of Medicine

St. Louis, Missouri
(Chapter 104)
Sri Laxmi Valasareddi, MD
Fellow in Hematology and Medical Oncology
Division of Hematology and Medical Oncology
Department of Internal Medicine
Ellis Fischel Cancer Center
Columbia School of Medicine
University of Missouri—Columbia School
of Medicine
Columbia, Missouri
(Chapter 65)
Vamsidhar Velcheti, MD
Department of Internal Medicine
Division of Oncology
Department of Internal Medicine
Washington University School of Medicine
St. Louis, Missouri
(Chapter 77)
H. Douglas Walden, MD, MPH
Professor of Internal Medicine
Division of General Internal Medicine
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri
(Chapters 3, 5)