Major pathways of glucose utilization
CELLULAR RESPIRATION
STAGES OF CELLULAR RESPIRATION
• Glycolysis
• The Krebs Cycle
• The Electron Transport Chain (ETC)
OVERALL EQUATION FOR CELLULAR RESPIRATION
C6H12O6 + 6O2
6CO2 + 6H20 + ATP
WHERE DOES CELLULAR RESPIRATION TAKE PLACE?
It takes place in two
parts of the cell
Glycolysis occurs in
the Cytoplasm
Krebs Cycle & ETC
take place in the
Mitochondrion
Mitochondrion
CELLULAR RESPIRATION PROCESS
Occurs across
Cristae
Occurs in
Cytoplasm
Occurs in
Matrix
Aerobic Cellular Respiration
COENZYME A
Co-Enzyme A – Carrier for Acetyl units in intermediate
metabolism, fatty acid synthesis and oxidation acetyl
coA
Glycolysis
Glycolysis
The glycolytic pathway consist of ten enzyme-catalyzed reactions that
begin with a glucose and split it into two molecules of pyruvate
Pyruvate kinase
Overall equation for glycolysis
GLYCOLYSIS SUMMARY
Takes place in the Cytoplasm
Glucose splits into 2 molecules of Pyruvate
produces a net gain of 2 ATP molecules &
2NADH (2x3 ATP)
Product: pyruvate
Pyruvate is oxidized to Acetyl CoA and CO2 is
removed
1. Phosphorylation of Glucose
2. Conversion of Glucose 6-Phosphate to Fructose 6-Phosphate
The phosphohexose isomerase reaction
3. Phosphorylation of Fructose 6-Phosphate to Fructose 1,6-Bisphosphate
4. Cleavage of Fructose 1,6-Bisphosphate
5. Interconversion of the Triose Phosphates
6. Oxidation of Glyceraldehyde 3-Phosphate to
1,3-Bisphosphoglycerate