8 tumor markers

TUMOR MARKER
Ng HN Tuan, MD, PhD



NON SMALL CELL LUNG
CANCER







Sharma et al. Nature Reviews Cancer 7, 169–181 (March 2007) | doi:10.1038/nrc2088



OPTIMAL trial


HEPATOCELLULAR
CARCINOMA







AFP

A glycoprotein that is
normally produced
during gestation by the
fetal liver and yolk sac.


AFP
• Elevated serum AFP occurs with tumors of gonadal origin & in a
variety of other malignancies.
• Elevated serum AFP may also be seen in patients with chronic liver
disease without HCC such as acute or chronic viral hepatitis.


AFP – clinical values
• A rise in serum AFP in a patient with cirrhosis or hepatitis B should
raise concern that HCC has developed.
• Patients with cirrhosis and persistently elevated AFP values have an
increased risk of developing HCC compared with those who have
fluctuating or normal levels.
• It is generally accepted that serum levels greater than 500 ug/L
(normal in most laboratories is between 10 and 20 ug/L) in a high-risk
patient is diagnostic of HCC.