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Downstream Processing
Novasep Solutions for the Industrial Biotech Industry:
Process development and engineering capabilities
combined with an unparalleled technological portfolio
to maximize your return on investment
Manuel Fernandez
Process Design
Industrial Biotech
At Novasep, we can
develop and supply
your optimized
purification process.
www.novasep.com
A Solution Provider Adapted to Your Project Strategies
At Novasep, we strive to understand your manufacturing needs in order to propose the most cost-effective process
solutions. We will partner with you to make your project a joint success.
Based on our large palette of separation technologies, Novasep can:
Design and develop optimized processes.
Supply systems and equipment for the purification of food and functional ingredients as well as bio-industrial
chemicals and ingredients.
Produce development and validation lots for your functional ingredients in our facilities through our contract
manufacturing services.
Our facilities and experience in a broad range of applications enable us to adopt appropriate manufacturing standards
including food GMP or pharmaceutical cGMP.
Starting at early stage development, we design optimized solutions suited to your needs.
We engineer and supply turnkey purification processes and systems with guaranteed performance.
We can provide contract manufacturing services of functional ingredients should you consider interim
or long-term outsourcing.
A Unique and Flexible Business Model for Numerous Applications
Your Process
and/or

Manufacturing
Needs
Technical
Package
Outsourcing
Solution
Insourcing
Solution
Novasep Process
Development
R&D
Pilot Scale
Industrial Scale
Novasep Equipment
& Turnkey Systems
Novasep Customer Service
Novasep CMO Services
Food Ingredients Bio-Industries Functional Ingredients
Sugars
Starch Derivatives
Milk & Whey Derivatives
Vitamins
Antibiotics
Organic Acids
Amino Acids
Polyphenols
Anthocyanes
FOS
Sweeteners
A Unique Palette of Technologies and an Unparalleled Breadth of Key Unit

Operations
High, Medium and Low
Pressure Batch
Chromatography
- Normal/reverse phase HPLC
- Selective elution
- Complex mixture fractionation and
separations
Membrane Processes
- Microfiltration
- Ultrafiltration
- Nanofiltration
- Reverse osmosis
- Pre-treatment
- Concentration
- Desalting
- Applexion
®
NAP process
- Polymeric and mineral membranes
Adsorption & Ion Exchange
- Salt conversion
- Demineralization
- Decolorization
- Adsorption/desorption
- Applexion
®
XA resins
Evaporation/Crystallization
- Plate/tubular evaporators

- Multiple effect mechanical vapor
recompression
- Falling films
- Forced circulation
- Draft tube baffle continuous
crystallizer
Reactions
- Enzymatic:
> Isomerization, hydrolysis
- Catalytic:
> Heterogeneous, chemical,
homogenous
Continuous Low Pressure
Chromatography
- Applexion
®
SSMB (Sequential
Simulated Moving Bed)
- NS2P/FAST (Danisco Alliance)
- Proprietary chromatography
simulation software
A Proven Track Record in Process Solutions Including:
Flexible whey demineralization processes
Cost-effective solutions for refined and industrial liquid sugars
Environmentally friendly solutions for beet sugar factories
Original process for the production of glucose and high fructose syrups
High-purity antioxidant and protein extraction & purification
Production of Fructo-Oligo-Saccharides (FOS)
Efficient purification process for amino acids (glutamic acid, threonine, lysine, tryptophan, etc.)
Production of bulk antibiotics (erythromycine, cephalosporin C, vancomycin, clavulanic acid, etc.)

Purification of enzymes and yeast extracts
Purification of organic acids and green biochemicals
Production of bioethanol and biodiesel valuable co-products
Electrodialysis
- Mega ED RALEX
®
technologies
- Demineralization
- Desalting
From Process Development to Industrial Systems - Guaranteed
By the diversity and complexity of the projects handled, Novasep has acquired great expertise and knowledge
enabling us to offer a high level of service and assistance to our customers. We are flexible and adapt to your
requirements in terms of quality, design and construction. Our engineers design customized units, equipment or
systems ideally suited to your facilities and specific process needs. We can supply the purification system to your
required scale and transfer the process with an unrivalled reliability and speed. Our expertise lies in bringing
together different extraction and purification technologies.
R&D scale: a strong focus on your
process
Novasep’s R&D team designs a single unit operation
or a complete process combining different techno-
logies adapted to your requirements. We have
developed an advanced methodology using our
proprietary computer simulation software.
Novasep provides process development services
including:
Analytical method transfer/development
Resin and membrane screening
Extensive process modeling capabilities
Piloting: a key step towards industrialization
Novasep offers multiple services at the pilot scale including:

Process optimization
Process scale-up
In-house piloting
Customer site piloting
Industrial design of your unit
Process validation
These activities enable us to provide you with:
Process performance guarantees
Complete process and guaranteed
performances at industrial scale
Novasep supplies complete industrial processes :
Design of cost-effective solutions
Basic process engineering
Supply of process equipment with cost-effective local
sourcing and engineering where applicable
On-site assistance for commissioning
Customer service
Continuous improvement
Enhanced process solutions
Membrane
CMO Services
Ion Exchange
Decolorization
Chromatography
Electrodialysis
Process Optimization
SSMB
Demineralization
Evaporation/Crystallization
Piloting

CMO Services: Our Unique Expertise at Your Service
With Novasep, you benefit from a unique expertise acquired
by our teams in both designing and using our patented
chromatography solutions, ion exchange and cross-flow
filtration technologies at Novasep’s own production facilities.
As part of our global outsourcing solution for functional
ingredients, we ensure a smooth transfer of the process
package from lab to production. Our broad range of
applications enable us to adopt the appropriate quality
standards including food GMP or pharmaceutical cGMP.
Novasep provides a global and cost-effective solution
integrating your specification and your timelines.
Our responsive customer service teams in Europe, the USA and China provide optimum process and equipment
performance to our local & regional customers, ASAP!
Extensive Technical Support Service to Answer your Questions
Our customer service teams provide on-going technical assistance and are dedicated to addressing your
challenges, when and where you need it.
Training to Keep Optimum Performance
Optimum performance is achieved with well-trained operators for all the different purification processes. Our
experienced technical staff provides on-site training tailored to your needs.
Spare Parts Services to Maintain Productivity with Minimum Downtime
We maintain an inventory of standard parts for quick deliveries. Based on your process, we select spare parts
which have been subject to in-depth evaluation and establish your basic on-site inventory. They are perfectly
adapted to the process steps and meet applicable international and local standards.
Upgrade to Extend the System’s Operating Life
Our engineering and service teams can extend your equipment operating life without the capital expense of
purchasing new equipment. Upgrades may also be a cost-effective alternative to new equipment and our team can
provide custom solutions to meet your new requirements.
Technical Expertise with On-Site Auditing
Our customer service team strives to offer you customized solutions by auditing, improving and optimizing the

throughput of new or existing equipment, reducing operating costs and guaranteeing optimum performance.
billiotte.fr • 8114 - 02/2011
Printed on recycled paper
www.novasep.com
REST OF THE WORLD - Novasep Process
Phone: +33 (0)4 72 01 27 27

EUROPE - Novasep Process
Phone: +33 (0)4 72 01 27 27

NORTH AMERICA - Novasep Inc.
Phone: +1 610 494 0447

ASIAN COUNTRIES - Novasep Asia
Phone: +86 (0)21 3895 0252

INDIA - Novasep Partner, Nishotech
Phone: +91 22 41515151

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