CONGENITAL DIAPHRAGMATIC HERNIA – PRENATAL TO CHILDHOOD MANAGEMENT AND OUTCOMES ppt

CONGENITAL
DIAPHRAGMATIC HERNIA –
PRENATAL TO CHILDHOOD
MANAGEMENT
AND OUTCOMES

Edited by Eleanor Molloy









Congenital Diaphragmatic Hernia –
Prenatal to Childhood Management and Outcomes
Edited by Eleanor Molloy


Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2012 InTech
All chapters are Open Access distributed under the Creative Commons Attribution 3.0
license, which allows users to download, copy and build upon published articles even for
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As for readers, this license allows users to download, copy and build upon published
chapters even for commercial purposes, as long as the author and publisher are properly
credited, which ensures maximum dissemination and a wider impact of our publications.

Notice
Statements and opinions expressed in the chapters are these of the individual contributors
and not necessarily those of the editors or publisher. No responsibility is accepted for the
accuracy of information contained in the published chapters. The publisher assumes no
responsibility for any damage or injury to persons or property arising out of the use of any
materials, instructions, methods or ideas contained in the book.

Publishing Process Manager Bojan Rafaj
Technical Editor Teodora Smiljanic
Cover Designer InTech Design Team

First published July, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from

Congenital Diaphragmatic Hernia – Prenatal to Childhood Management and Outcomes,
Edited by Eleanor Molloy
p. cm.
ISBN 978-953-51-0670-8

Contents

Preface IX
Section 1 Pre and Perinatal Issues
in Congenital Diaphragmatic Hernia 1
Chapter 1 Congenital Diaphragmatic Hernia with Emphasis
on Embryology, Subtypes, and Molecular Genetics 3
Bahig M. Shehata and Jenny Lin
Chapter 2 Diaphragmatic Paralysis -
Symptoms, Evaluation, Therapy and Outcome 19
Issahar Ben-Dov
Chapter 3 Evidence-Based Prenatal Management
in Cases of Congenital Diaphragmatic Hernia 29
Alex Sandro Rolland Souza
Section 2 Diagnosis and Investigation
of Congenital Diaphragmatic Hernia 45
Chapter 4 Rare Congenital Diaphragmatic Defects 47
Man Mohan Harjai
Chapter 5 Genetics of Congenital Diaphragmatic Hernia 59
Gabriele Starker, Ismini Staboulidou, Cornelia Beck,
Konstantin Miller and Constantin von Kaisenberg
Chapter 6 Diagnosis of Congenital Diaphragmatic Hernia (CDH) 93
Kotis Alexandros, Tsikouris Panagiotis, Lisgos Philip,
Dellaporta Irini, Georganas Marios, Ikonomidou Ioanna,

Tsiopanou Eleni and Karatapanis Stylianos
Section 3 Management of Congenital Diaphragmatic Hernia 107
Chapter 7 Congenital Diaphragmatic Hernia
and Associated Anomalies 109
Milind Joshi, Sharad Khandelwal, Priti Zade
and Ram Milan Prajapati
VI Contents

Chapter 8 Congenital Diaphragmatic Hernia
and Congenital Heart Disease 113
Katey Armstrong, Orla Franklin
and Eleanor J. Molloy
Chapter 9 Congenital Diaphragmatic Hernia: State of the
Art Reconstruction- Biologics Versus Synthetics 125
Anne C. Fischer
Section 4 Outcomes for Children with
Congenital Diaphragmatic Hernia 137
Chapter 10 Congenital Diaphragmatic Hernia Survivors:
Outcomes in Infancy, Childhood and Adolescence 139
Jennifer R. Benjamin and C. Michael Cotten
Chapter 11 Predictors of Mortality and Morbidity
in Infants with CDH 159
Hany Aly and Hesham Abdel-Hady

Preface

Congenital diaphragmatic hernia (CDH) remains a common malformation of the
diaphragm resulting in herniation of abdominal contents into the thoracic cavity and
associated pulmonary hypoplasia. Despite advances in antenatal diagnosis and
neonatal intensive care, a high morbidity and mortality persist in infants with CDH.
Each chapter provides an up-to-date consensus on definitions, embryology, antenatal
diagnosis, genetics, associated congenital anomalies, pathophysiology and long-term
outcomes. We hope that this book will appeal to pediatricians, neonatologists,
pediatric surgeons, pediatric intensivists, developmental pediatricians and other
healthcare professionals who are involved in the clinical management of children with
CDH.

Acknowledgements:
I would like to thank Bojan Rafaj, the publishing process manager, for his patience
and encouragement. In addition many thanks to all the authors who contributed their
expertise and time to make their excellent contributions.

Eleanor Molloy
National Maternity Hospital & Our Lady's Hospital for Sick Children
Royal College of Surgeons of Ireland
University College Dublin,
Ireland


Section 1
Pre and Perinatal Issues
in Congenital Diaphragmatic Hernia