RESEARCHING TO SYNTHESIZE NANO DENDRITIC POLYMER

RESEARCHING TO SYNTHESIZE
NANO DENDRITIC POLYMER
Laboratory of organic and polymer chemistry,
Institute of Chemical Technology, VAST
1 Mac Dinh Chi, Dist.1, Ho Chi Minh City
Email:
Ha Noi - 2009
INTRODUCTION
DENDRITIC POLYMER
Dendritic architecture class
dendrons and dendrimers
dendrigraft or dendronized polymers
randomly hyperbranched polymers
and star polymers
DENDRIMERS
•
most size-controlled macromolecules
•
geometrically restricted structures
•
well-defined and highly branched structure with a high degree
of control over their size and shape in three dimensions
•
very low polydispersities
•
a wide variety of functionalization on their multiple functional
groups on the exterior as well as interior.
Structure of Dendrimers
Figure 1. Structure of a dendrimer includes core, branched interior layers
known as ‘generation’ and periphery (surface group)
Characteristic features of dendrimers

•
isolated as a monodisperse single compound
•
the properties of dendrimers (e.g., solubility, chemical reactivity,
glass transition temperature) are dominated by the nature of the
end groups
•
dendritic growth is mathematically limited linear polymer
growth that theoretically can continue ad infinitum
•
Viscosity: decrease in dependence with increase in dendrimer
generation after a maxima is reached
APPLICATION OF DENDRIMERS
Dendrimers are application in many fields such as catalysis, materials,
biological (delivery devices)…
Figure 2. Dendrimer as drug carrier agent
Drug molecules can be loaded both in the interior of the dendrimers as
well as attached to the surface groups by covalently or non-covalently
bounds.
OUR LAB’S RESULTS
1. Synthesis PAMAM (polyamidoamine)
PAMAM: a popular dendrimer
By using ethylenediamine (EDA) and amonia as cores, we synthesized 2 kind
of PAMAM.

PAMAM using ethylenediamine (EDA) core: up to G(3,0)
Figure 3. Structure and TEM image of PAMAM G(2,0) core EDA
Figure 4: Structure and TEM image of PAMAM G(2,5) core EDA

PAMAM using NH

3
core:
G(1,0)
G(1,5)
G(2,5) G(3,5)
G(4,0)
Figure 5. Structrure and TEM images of PAMAM
generations (NH
3
core)
G(1,0)
G(2,0) G(3,0)

Initial applied research: making silver nanoparticle in dendrimer:
Figure 6. TEM images of Ag-PAMAM generations (EDA core)
Figure 7. UV-vis spectrum of Ag-PAMAM
The absorption spectra of the obtained silver particles system were measured at
different shelf time so as to investigate its stability. The result shown that the silver
nanoparticles could remain stable at least 3 month.

Forthcoming plan
synthesize
PEG-PAMAM as 5-
flourouracil carrier agent
PAMAM - cis-platin
complex
Test biological
activities
2. Hyperbranched polyester


their properties are similar to those of dendrimers

synthesized via one-step reactions
Hyperbranched polyester: 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (TMP)
as a core, interior branching: 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)

Initial applied research:
•
Substituting the terminal hydroxy groups with benzoyl chloride, propionyl chloride,
stearic acid.
•
Researching about influence of dendrimer on vitamine C preserve.
The initial result shown that polyester can make to increase the time of vitamine C
preserve about 10%.
Figure 9. TEM images of
vitamine C in stearate-modified
hyperbranched polymer
Figure 8. TEM images of
benzoyl-modified
hyperbranched polymer
THANK YOU FOR YOUR
THANK YOU FOR YOUR
ATTENTION!
ATTENTION!