Tiểu luận môn Các hợp chất tự nhiên có hoạt tính sinh học Nhóm chất Terpenoid



Bo co môn hc “cc hp cht t nhiên có hot tnh sinh hc”

 !"#" $
%&'( )*+ % ,-$ /012
-3"4%5 ,-$ /016
%&'( "4-!"78 % ,-$ /011
9:;$ 
-7: %<= $,>?"4*5-@ 
A0/.B

CDE
- FGC>
- HIJC>
- KLMNEAO-
PQML>
> FGC-R
.>:!"&STU;T *<
 !"#$%&'(
)*+, /0-123(1456-7$'89-:;<
-:==9%1>(*+.&-?)1@<$-AB,C@,
D/
)11-AE3()?15FD<)-1)
,<)).5>('-A5-1289-:<ED")G&1/
<H=I,<7+)J'K13(9-A)8LM")
%1.&05<N8'5'<EO(D$%1P-M/
AQRR<H15S?5<NL=6ND-AG)5J5<NTU*:
(&IVW!O(*AXVR/'5*AL=6ND18"C
"C-2 -25S5<N)1/0C(*AY
X

W
R
ZY[\Z-A
5<N5 *ATerpen. >(O(9L<O(C
=93('111].&*=18+A.&*S/////-A)BG(D
%10Y)Z5<N@*A<$*:(=9G(D(6E18:O(8C
$D(&^F(6K=.( _/
\
/


`91

.&C.&*=1
+A
a
-A4(*A5C"24*A=5^D+
T])#Gb"(186-7=/
*A)BG(Dc1G%1<V1*1-AG
=-A918G&*G;5<N)1KO(/0
<H@$DB$*A)&18/

0>V&!UWX5!TU;T *<
- d.ID(++! +-2-Ac1)*"'
5Ce
/
f

g)D(0%1)+V
gD(0%15<N+A="'N-71("^(h

5O(6-75(Ci 5(C6-75(C/ d.I^-2 
>(-2^*A-2!1&-2"b-A)*"'9(.3(#
=/
gb,V
   
j& βg`*
α
gd

k<-M&V*AENDc1WA8L"(18]>(
#Gb6-7"(18%1=c^8^(l8!CcY=g

X
Z

Y[\Z/
Y>"Z [*\!TU;T *<V\<7.*+
mP1+185^.*+V
n+!V1*O(1]/o**
O(G9/)NDA&5>(@$5 <*AE5$<$3(p
@C:<$*:(-APq///
nA+-2Vj*-AYO(8+AZ"C
E5<N5<1-A"r8)"5)Q///A2@5^5>('(6E1
8:
 mQ5^M:)*A)*"'#Gb=
c(<H1P1-A=6#Gb=5^.*+
9*\!TU;T *< "& %5]* ,^[7_ % "`<a
j Y=g
X
Z

\
s 
s
W
t

s
W
R

s
W
t

`3( Y=g
X
Z
a
X 
X
W
\f

X
W
\f

X
W
\\


 Y=g
X
Z
f
\s 
\s
W
a\

\s
W
a\

\s
W
as

 Y=g
X
Z
t
as 
as
W
Xs

as
W
Xs


1 Y=g
X
Z
R
fs 
fs
W
Xt
X
P1-A)*+#Gb=1.*+5<N)*+-Au*+
#Gb5>("(=<H18D5J/
a) Khung sườn Monoterpen Y
s 
Z5<N1AfV+"C-2
+L-2+\-2+a-2/
g)"C-2O*7"(\tg5&*1
)*++!b*AV
nj&V
s
W
t
nv1**
 

n1*V
s
W
R





n**1*
s
W
R
V*AAObO(8+5A1/
<N5>('K=P<DO(=9-AO(8+5A1
t
W
\
W
W
g)L-2VtD5<N?D&PV*
*
α
g
γ
g
α
 g**1
β
 g**1*/)D
A&*AAObO(%1-w1-w1-A.&8+A_//
v
α
g*
g)1-2VX*+ND(L1-2V(&1
11  d1  Y

α
g    -A
β
g  Z  11  Y81Z  =11  x1
=y1/)DA&-ABG(D%1O(.&8+5A.&C
O("7.&9<$____



=(&1αg81
b) Khung sườn Sesquiterpen:
11
z
g)`=3(V({=6-2.I5<N1Af/3(
#=a5$-J=*"'-71("^(5(C5O(+AL
`=3(+|-7f*"'5C/)+=1(V
n`=3(+!V)D<x1=
X
W
\f
x1=*-A
k*
X
W
\t

αgx1=
n`=3(L-2VA&f*+`=3(L
-2 -7u )D ")1(V8=18*1 *1
((*1-A11

n`=3(181-2VA&D(+c+<H )
D<V11(=1__
c) Khung điterpenoid: 5<N+AKf5$-J=/kA&])D
(8^(<Vd&*1})1GP1//

1}

d) Cc triterpenoid:)<H <7+=*&~ !
+)P
5^?*A`3(1*V
as
W
aX


R
e) Tetraterpen:1&24*A1*AEDA(-A(]6
K5L-M/0+A(%1A(1A6*5wc_
]1+|Yv&GZ-A1L-2-A\-2/
Y1o1&G1//Z

v&

αg1
o1&*
Như v-y:
*A)D&18>(P-MD(+)4=
-A5<N4*A)D1&
5$-J=*A
X

W
R
 >(

)*+O(5 8'*A)*+1($3(1
A&*A<Vj*(*&*1-A==3(
<1=~*8*)DA&515<N=I,-Ac,LS
Pq-A<Nq
b>9c!` "$
*AD*wA(-A=(6r$<7"C1<7
^1L^b]Rs5L/
•
€G•->*bb%11<HG•5'*pb%1)*+
5^?
1ZjV
nj*VvADA(-A+$61*/
‚^#!:5L2/^"CA(@8+Ab=)@/
k:5L9&Vf\ƒfX
=
s
e\\„b1Vb1
nj&VD*w"CA(/k:5L=CVtt/ssgtR/ss„/!zts/ssW/
b.PVR/RX…s/Xsg\fa
b1V†1<7Y\X‡*!\XsZ1<N((CE(
$/j@<$b"bb1"(&')=I,!]5LˆX‰
n11*V=C!ssg\
s
-J#@$lJ(O(=9
O(1
n1*V*AD#"'?""CA(-J#9&!R\

s
/
8ZV
g`3(1*<H <7+=*&~ !+)P/4
*<N.IVfs/zR‡*/k:5L9&Vgss„/k:5L=CY!\X
WZV\RX„/€C1<7
> HIJC>
k(&#g$=!%1=P'V
P1$=!=P.86gA1")1(%1D.bYNDZ
-A\(C"CL*B-A1(/YD.b16(
CA&<*+"C16(C"1Z"'3(9*D&5<NDO.
b1"w1B(815O(=1(5(&^-A1c\Y(CZA0
1(6àG)5JD.b(CA&8TE<$
),^///
^))D1"wP-M^5<N'A8T>()")1(
<V•*D&O(8•*C(68T$<75^))O(.'8T
s
(CE($_(&\<$)F8'$95^))D
1"wP-M/
)V<7'8T(C<N(g<75^)O(')D1
"wP-M/`1(5'=1*48T)(CK"C.P5'
.P/)(C'c1)NDE($5L.PO1(=Š
5<ND5<F(C/
)\V'-A.*M)DB(P-M8T)*+(CK
"C.P5')(C5L.PQOVgG1*y
&*1G1g8(1*1*1*g<7/
"d!e* *!TU;T +fTfg&!TU;T $
k(&*p(V'8T<$)D"•$<7=1(5<D5^
(O(Y'8T)(CE($VO(9G18~_ 
5Jb1&5J*<N8T))&'8J:5+<=#"p"bYZ

=#"p"b"6FYgj`Z
b,'*D&O(K-w8<!51@V
<!1W@(+->8F-A)*D&-w*‹5'8'A5](6
+@5^Q<$2-w?@1*48w@#/w2*+?5)
w?-(C G1&(&l<DP'-7<7-7Œ*:*Aass-w‡
Xss*<7/`1(fH<D(5<Ns/t*O(56-7(&*:()
w-A/t\*O(56-7(&*:(G1&(&l/`1(5*+<72*+
O(8Tk1
\
`
f
"1 *A5C*+5^)<7/o)5J)
U=6-M*p%1O(kR•g••a-7"'3(9<=1(VŒ4!
\s
s
Vs/Ra•XU=6"0G+V/fz\s3(1&P•VRf
s
a\ŽA(=#%1O(V
jA(#$5,/^G)5J)D(I%1O((<$)=#"p
•"6Fgj`(5<NaRD(I5*g *Vt\/sf‰ •g
&V•/\•‰1*V\/R‰ •g*V/R•‰\•gV/R\‰•g1*V
/ta‰1=g1*V/aR‰/

"d!!U!TU;T $
k(&*p(V'<7YP' 8TY'8T
‘WasgRs‰'8T*15^*++=1(5'8TjW1
'5<N'5<N'*+:(Cg(1*VW
\

'8J8L=G*@5^'V

%1€'A&\*+*AV
/):' `G*<H-A
5$9-MA8T1&/
\/  )  :  '  `G*  P  5L
Y}(g`G*Z-MAP5L/

€’(M'A&<H=I,5^
'))DE($T
B(!+#1&+8L1&
9w1&)-M*:(B("C/
"d!T!U5!TU;T     
)(C<H5<N=I,*A11VgG1YfVtZg
G1V=1*YaV\Z/
"78 %;"h;;"Z !`"i4 "!` "i4 "[7_ %h"_;"V!!TU;T *<$
gd.b)O(8T)'8JVgj`/
\
gjL=6)ND")<V1@=#"p89
wYvZ=#"p*w:(Q1Wdv=#"p*w"6Fvgj`_
jh;"78 %;"h;khi4 "V&!UWX5!TU;T *<
.>"78 %;"h;"*h"$
g`1("'ND5<NG)5JCc.I8T<$)
"5^V.b(&6)4-AG)5J"6*<N.I8T<$
)"6F
go)5J)T=6-M*b5 <U4-A:5L9&:5L=C
U=6"0G+-AQ=(D3(1&P/b3(1+5<NG<*ALbD
5 <).ID(08D56Gc/
g)bD)45 <%1)c.IND
c(5<Nb:5^G)5J)cWWe*"'5C
___
gd<$)G)9D*ALC,E(:(5^G)5JD(0%1

/).G)<H(*A~€j
f
 1GW
a
-A
k1_
gLH1A5L"0G+.I*3(15'"(+185S
5<Nb)P1U=6"0G+5^G)M)9(&'D(0/
g`PFNAO)•"|5JD(05S'*M/
0>"78 %;"h;l![c$
`I,)<$)-M*p:5+FI+F]+FL
<!K+.F"6•G)5J1)c
ND/
a
ndFL<!+.kj“•'M89D)4%1)
ƒWgW
\
gW
a
//5>(A&0-:G)5JD(05<NbG)5]
H)<$)A&;•.8:5<N)5].*M^/
ndF"6*<Nj`<HG(&5<N@5^G)5JD(0%1)
/d<$)A&8'"6*<N.I-A)9.I%1
5>(A&•G)5JCc.I89D)'-A-Jb<$56
%1)*"'5C/
n€"'N9\<$)=#"p"b-AF"6•G)5JA
O)4)D(IuNO(
nd<$)l(G+1o•G)5JbG)D(0-A)*M
^%1)ND/
>MNEAO-PQM

L>
)c1>(P-M<=(-A
c1O(P1%1P-M8M1*&*AAOb%1)
1=(P/b-? 5^D(+%10)),
*AC+-A*AQ5L5A]%1$-AA+/
)11-AE3()?15FD<)-1),<
)).5>('-A5-1289-:<ED")G&1/<H
=I,<7+)J'K13(9-A)8LM")%1.&
05<N8'5'<EO(D$%1P-M/
hU!TU;T $)J&4*A)+Db%1.=.>(
=.’-:1_-A1D*).&5*Q5>(*A)D<7+
)=1
)D%1191();*A)D=1/
)DA&),6G)D+-A),2-A5>(J(
<5<H()-A(<(&'>*:/
15<Nc,LS5q=9G(D)=9q8FG(<”),
6G)6*S)Q<H"9QlJ$^.1=c
"•
f
)>(c,V
gC:<NqV(6E18:8Q)).O(Gc////
n`3(1*YasWXsZO(1)
n“*Y-1}
\s
W
\•
WZ*25wcO(1)_
g   C  :  P  qV8) "rO(
Q=E1<79")///
g1-A*YfsWXtZ*A=#6A(5w%1A6-AA(1b

gC:’qV<71"5)Q///

mC:=9G(D<NqO(8C$D(&^F(6K=.( /
X
O(8C$<Nq
+[&!"5en"o*$
–—/k(&l€dd,Y\sszZ !"#$%&'()*+
,-.d/Wj/
–\—/k(&l€#˜({cY•••Z)/0$#1)2!#1
*W™g<Nd/WCbjfXg•z/
–a—/uJW1Y\s\ZA9C #$3456
7819':+;<*+) =+/'
–f—/V‡‡ššš/(*(/‡\s‡‡g1gg((g1g1g1g/*
–X—/V‡‡ššš/-18"/‡"&g(1ggG(1g(g*(gas\s\/*
t