Nano huu co FINISH

Ho Chi Minh City University of Technology
Chemical Engineering

Polymeric nanoparticles for oral drug delivery

Advisor

: Dr. Le Thi Hong Nhan

Postgraduate Student: Huynh Kim Ngan
Nguyen Thi Kim Hang
Nguyen Hoai Thuong
4/20/16

Le Thi Bich Phuong

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ROUTES OF DRUG ADMINISTRATION


Oral Drug System
Advantages

 Safes
 Most convenient
 Most economical
Disadvantages

 Poorly absorption of large

 Highly charged molecules
 Degradation of drug by stomach acid


Parenteral Administration
Intramuscular





Patient can administer the drug himself
Larger volume than subcutaneous
By-pass first pass metabolism





Invasive – patient disconfort
Irritation, inflamation
May require some training


Transdermal administration

• Advantages
Solution for drug that can not be administered by
oral delivery

Reliability, precision of dosage
• Disadvantages
Discomfort
Possibility of infection
Tissue damage


Global drug delivery market by administration mode


Oral Delivery
(Gastrointestinal Administration)


Gastrointestinal Administration


Gastrointestinal Administration
 Saliva?
pH = 5.5 – 7

 Oral cavity : water rich environment
 selection of hydrophylic matrices as
drug carriers


Dosage forms
 Liquid
 Dispersed system
 Solids

Controlled Release


Targeted Delivery


Nanoparticle for Drug Delivery System


Polynmeric Drug delivery system


Prodrug


Prodrug
Prodrug = Drug + Drug delivery system
Types of Prodrugs


Comparison oral drug delivery and oral nanoparticles delivery


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6

5

4

•

Dosage Form
3

•

Dose
2

•

Drug Release
1

•
•

Freeze-Drying

Nanoparticle formulation
Stabilizers for NPs


Materials for Preparing NP Matrix

Polymers

Natural polymers

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Synthetic polymers

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Natural polymers

Advantages
- Low cost.
- Biocompatibility.
- Aqueous solubility.

Disadvantages
- The presence of impurities.
- Batch-to-batch varibility.
- Low hydrophobicity.

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Synthetic polymers

Advantages
- More reproducible.
- Degradation rates.
- Molecular weights.
- Copolymer compositions.

Disadvantages
- Limited solubility.
- Soluble only in organic solvents.

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Natural polymers

•
•

These are the polymers obtained from natural resources and are generally non-toxic.
Natural polymers are formed in nature during the growth cycles of all organisms.

Proteins

Natural polymers

Collagen

Agarose

Albumin

Alginate

Gelatin

Carraheenan

Polysaccharides

Hyaluronic acid

Dextran

Chitosan

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Cyclodextrins

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Synthetic polymers
Poly(lactic acid) (PLA)

Polyesters

Poly(glycolic acid) (PGA)

Poly(hydroxy butyrate)

Synthetic polymers
Polycaprolactone (PCL)

Polyanhydrides
Poly(adipic acid)

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Miscellaneous
 Stearic acid and
Gliadins.

Hydroxypropyl methyl
cellulose phthalate.

NPs are also prepared
by utilizing simple organic or
inorganic compounds.

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Stabilizers for NPs

Stabilizers are used to
prevent the aggregation of
particles by conferring a
surface charge.

 The higher the surface
charge the greater is the
stability.

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