Hiệu quả điều trị trúng đích trên bệnh nhân ung thư phổi không tế bào nhỏ giai đoạn muộn có và không có đột biến gen EGFR



!"#$%&%'#%( )
*+,-.(/012#034
56/,-5#4(.778%

9:;<=3>=?@ABCD=6E=,?F=?AB
CD=:;
?G=?AB#H#I=?JKBL?@=?6M=A

2N
OPQRSTU6VW56X4YUZ2NOPQRSTU6VW5[\]^_\T`4RVW2\TW\

aUbcd\edfUgchNihNjQRfkW\lX`YhlUbcd\edfUgchNi`mUZfnfOoWW\pQR`UQ\Wq\UbcrcsW\]tbQ\cQR
h\Od\uU[\vQRhwtX]Q\xZfyWtUbhhNzQQ\q`tbQ\Q\{QWqfYhtUwQR|Q}~€4R\UzQWpcQ\‚`feQ\
RUehƒlbfedpQRh]XQtY9„€€…mUlUbcd\edfUgchNihNjQRfkW\†\^UQ\q`tbQ\Q\{QcQRh\Od\uU[\vQR
hwtX]Q\xRU^Uf]TQ`cYQWq…X[\vQRWqfYhtUwQR|Q}~€…XfeQ\RUeh\PURU^Q‡ˆQRtbQ\[\vQRhUwQ
hNU‰Q9_Š…Xh\PURU^Q‡ˆQRh]XQtY9„Š‡^clUbcd\edfUgchNihNjQRfkW\†Q\q` tbQ\Q\{QcQRh\O
d\uU[\vQRhwtX]Q\xRU^Uf]TQ`cYQWq…X[\vQRWqfYhtUwQR|Q}~€7
tbQ\Q\{QcQRh\Od\uU
[\vQRhwtX]Q\xRU^Uf]TQ‹‹‹Œ‹ŽfOoWfUgchNifkW\t‚QR|Nl]hUQUteWfiQ\fYhtUwQ}~€t‚QR[h\c‘h
RUsUhN’Q\h“R|Q…XŠW]NdU]Q‡”€•Š~\UQ\‘QWeWfedpQRfUgchNi‡^c
–h\eQR…X
1h\eQR~\UQ\‘Q
…X‡]‡eQ\_Š…X„ŠW—^WeWQ\q` tbQ\˜whrcsQR\UzQWpc[\vQRR\UQ\‘QfOoWhNOPQR\odQX]
fedpQR\]XQh]XQ‡^c–h\eQR\]yW1h\eQRfUgchNifkW\3q™c\OmQRRUs` „€€†Q\q` fYhtUwQ
}~€9
]mUQ\q` fYhtUwQ}~93qWsUh\UbQWqQR\^h\QR[zWs_XQ\q`
fYhtUwQ}~9}Nl]hUQUtRUjd[]XUQRtbQ\Q\{QcQRh\Od\uU[\vQRhwtX]Q\xRU^Uf]TQ
`cYQWqfYhtUwQR|Q}~
?ĂÂÊ:=9Ô?ƠƯ?Đ>?ă=9Ôâê@ô=?ơưđÔê>â=9=78%B>:Ư?FƯđ>:ÔCGÔC=9đàả?

ẵ#ắ6#$

ặầẩẫấ ẩậè ẻẽ éẹềè ẩểễẩ
ếệầìéẩẻỉẻèậểìéẩẻỉẻĩẽ
ẻíẩềèịòẩẩỏềậéịậẻíẩõóọồổỗốộ
ấờìéởềịẻỡẩẩẻìộịớềèìéẩẻỉ
ẻợùợỉịèệ ủớéẩũọéèặịèéẻúì
ịụịẻẽẻừẩỏịửờìớẩẫữẻẻớẩủẻầẻớẩ
ẩẫứìéẩẻỉẻợỉịẩữệẫõựọỳổỗỷỹýỵỹ
ịớịẩẫỉ0éẻìéẩẻỉẻèẩẻứ1ẻ2éẩẽ
ĩèậẻũầị3ểèẩẻứẩẽĩèậẻũỗ4ẻớịềẹ
ịớị1ẻộìợ5ị1ẻớịầợẽặầề6ẫíẩ1ẻòẻớẩ
ẻ ủẹệ 1ẻộìé ẩẻỉ ẻầẻ7ì ẻẽẩịớị
ẩẫỉ0éẻ1ẻẻớẩẻợùẫụềèậéợậể

Si^W\ãlUzQ\bá2NạQ{Q\eQ\Z2NcQRh{`4R\UzQWpc
~|Q
_N]h|UQZ2NOPQRSTU\VW56X4YU
}`^Ulá^Q[\^Q\8`ằ^\]]W]`
4RXằQ\Qá



4RXằfOoWW\ẳdh\cQá
7


1

ẩẽẩẫứẻậ5ị8ị9ỗố5ị8
ợùịòẫíẩẻúì
ẩẽ ĩ ẩẫậé ịớịẻỉụé ẩẻ
ịợúì ẩẫ
ẻỉ
ẻ6ìẩẻìẩầẻòẩẫ
ềèểẩẫ
ầẩủộéẩậèẩẻứ
ủì9ệ ịửĩẻẻừìéẩẻỉẻề6
ẫíẩẩẻíầịẻíó õóổỗẫậéẻởé9ệ
é7ợừặầặẻịợùẻớẩẻợỉịẻúìợịẻ
ẻừ ẩỏĩẻ ẻịẩúệ 9é ẩẫậé ìé ẩẻỉ
ẻầẩẻỡị ợặủ ẫ ợ0ịử ẻởé 8ỉị
ẻệ ệẹéỡ
ịịẻẽẻậểẩợéịửịẻỡéầ
1ậ8èẩẻ0éủộéềèừéịậịẻíẩỉé
ủộéịửéỉ0ĩẻỗòèịẻíẩ
ịịẻẽẻậểẩ
ẩẻẩặẫậủ1ủ4ủịửẩẻẩẻứặẽìẩộ
ẻớẩẩẫứĩứìệ2 ầ8ẫệéẫậ!ẩẻ
"ịẩậẫ ẫịẩậẫ é#ệ é"ẩĩ ềè ẫậẩĩầ
ợỉịéèìẻớợúìẩẫ
ẩẫỡéợịẻỗếẻúì
éẻấị
×îïÞÎ
ÃÐÖÁÃÎÖéÁÛÁÊÃê×ÅÃÞÎ5È
ÞÎ$ÐÁëÅîÈÜÁÏÃÐà ÒÑÁÖ
ÞîîíÙ

éẩẻìộịịử1ẻộìẩẫậéìẻớợúìẩẫ

ẩẫỡéợịẻỗ4ẻậ%éóỹýỳỹ ĩẻẻừìé
234356789





 "#$%&'()*+,'-./01*$)'234,'
56785.9:(3';<=>?@A.01*$)''+BCD
/: 'E' "F,3$' ;<=> ./ A$GH.CI' JK$
LM.0$NLFO0P.QR,0/*S''T'L'(
"#$%&'( ) *+, '- C:'( 01*$)' (3'
;<=> U'(0A"V'(MJK$LM.0$NLFO
0P. WXY?ZLB '$E'QI$[$S\:C . : ./
'$NL'($E'.VLJN$SL]L^.9:G$SL"A"
0$NLFOF_'(0P.FE'*S''T'L'( "#$
%&'()*+,'-($:$0,I'CL1'?`,0/Q0N
+$'($E'.VL0 a.H.$S'JK$Cb.$ELc
5?dA'($AeGS0A"V'(,+'*1fg>>h
JK$0$NLFO0P.2:$'/C *S''T'L'(
 "#$%&'()*+,'-($:$0,I'CL1'./
J+%&'(./01*$)'(3';<=>?
8?dA'($AU$($:'iM'(*S'%&'($)'
F$j'fk=lhJ+U$($:'iM'(,+'*1fglhi:L
0$NLFO0P.2'/C *S''T'L'( "#$
%&'()*+,'-($:$0,I'CL1'./J+%&'(
./01*$)'(3';<=>?

mnopqrsptu

vmwxyz{y|}wx~|€‚$)'.VLQC&^
G,IFU'( a"Q./ 3, Rƒ$R„.U$($:'
iM'(EC?
…mn†xz‡ˆ|}
6‰*S''T'L'( "#$%&'()*+,
'- ($:$0,I' ŠŠŠ‹ŒŠ[ 0 a. 0$NL FO*'(
Ž‘’“”“•I$*S'J$E'–:,J+*S'k#$ZFL'(
—'(Q*S' J$S' ˜ ZFL'( —'(Q*S' J$S'
™šL\(OJ+*S'J$S'‹I.›:$?‹S''T'
0 a..œ'0,A'4A.0O'RH:J+,%)]L^C&
*S' „.J+%&'(C.L'( '+,%A.?
@A.CžLC&L'( "#$0_.F,'(":F:Ÿ$'Q
0 a.G+C 4 '($SC ¡C 01*$)'(3';<=>
I$FL'( TC '($E' .VL <3' 7 kF,3$'Q
ZFU'(dI$„.¢™+\1$?
£mw‡¤|}¥w¦¥
ZL§".A.&'($'JNGTCi+'(J+.§'
GTCi+'(.9:*S''T'c¡'FI'(,+'T'Q
234356789





F$SL.V'(GTCi+'(Q%P. K.LQI.Q.A.
#' '(R$.â'RH:FE'%AC GTC i+'(Q
.A.4'($SC.Đ'GTCi+'(J+Ă'^'.?
ê$*S' 'T' iô 0 a.3, R$R.F,'(
iLMU$($:'0$NLFOQ*0ơLưG_.$)"'Đ'
0$NLFO0P..,0)'%$đJ,'(QC3,R$

,.%)_.'($E'.VL?
$SL "A" 0$NL FOF_'( 0P. (C R a.
.5XC(J$E'QR'(0 U'(LM'(5
J$E''(+BQG$E'b.Cê$'(+B.,0)'%$*S'
'T' ./ RL $SL $)' F$j' *S'Q4L$S'
01.P'%&'(."'Đ'0 a.Q4$'F:%-$
'($E'.VL,.đJ,'(?
S''T'0 a..$:+'8'/C 3,
Ă'FI'(01*$)'(3';<=>c'/C ./01
*$)'f;<=>fhhJ+'/C %&'(./01*$)'
f;<=>f7hh?d1*$)'(3';<=>0 a.4A.0O'
*'( %LĐ($^$FĂ' H (3' J+ %LĐ
l.,F"$,'à>lJK$01'IBGơ'GaG+ảã
WáYJ+5ã WạYJ+010.$SLG+5ã .,.^8
%LĐ?
ZF,'(]LAFĂ'3,R$0$NLFOQ*S''T'
iô0 a.c
dA' ($A 0A" V'( ,+' FI'( fRH: FE'
'Đ' 0O' .9: *A.i0$NL FOh3, .iM
:F',i%Bi:L ảA'(QáA'(f*^'(5h?
dA"V'(,+'FI'(0 a.0A'($A+'8
CV.c#' 0O'â'( f.iM :F',i%B ($
'(LBE',.â'(GE'i:LU$($:'0$NLFOhJ+
($^C f.iM :F',i%B($^C i:L U$($:'
0$NLFOh?
dA'($A0A"V'(H.j3,$EL.L'
>;@lZW6Yi:LảJ+áA'(f*^'(8h?ZeGS
0A" V'( ,+' *1 fg>>QgJ3F:GG>3i",'i3
>:3h0 a.P'*'(#'(.9:eGS0A"V'(
,+' ,+'f@>hJ+eGS 0A"V'(C1"ơ'

fk>h?
<$'Đ'U$($:'iM'(*S'%&'($)'
F$j'fk=lQkF,(F3ii$J37=F33lLFJ$J:GhfA'(hc
8



 !#$%!&'()!*+,-./-#*0%!12#3).).4#+- Q.*-./-!.I*?*R-SF-?!.CK!4D-TUVWX
5.*6-.)789%.*6%!*+-!1*:-;6-.-.<-!= V>L1R''W%1>*>R'YU!.Z-?YX !#$%!&'()!*+,
>4-?>@9!5A-?%BC--.<--D4;)7!.E-?!*- -./-#*0%!12#3).).4#+-5.*6-.-.<-!=
)%F*)G-?!14-?!1HI-?.J,K9!!.L48M*.4N) >4-?;)7!.E-?!*-)%F*)G-?!14-?!1HI-?.J,
K9!!.L48M*.4N)5+!!.()-?.*C-)O%P
5+!!.()-?.*C-)O%P
[\]^_`ab]c^dbefg]ehi]^ecjfkclmnoph]fqmrs
adtu
vwkcfiexy]^
z{{| }.E-?)7!1*6%).O-?1M1D-?)~R6-.;5.--?.4!#T-?K-.
{| }.--?.4!#T-?@-.!.HI-?;!1*6%).O-?6-.!F*!.*:%
{| }.--?.4!#T-?@-.!.HI-?-.H-?,.*)F? -?P7KN!)~R!1*6%).O-?6-.
E-?)75.--?.4!#T-?@-.!.HI-?.4N)'DK >*6)-.H-?)-!,.)>!F*
{| }.
!.*:%#HJ)
{| $-)7S?*(,#)$-!.*+!>D#HJ)).KS7)B!+
{| $-)7S!1J?*(,19!'->D#HJ)).KS7)B!+!.HI-?%BC{| }.E-?!,.)>!F*!.*:%;)$-)7S!1J?*(,'*C-!)>D#HJ)).KS7)#N)*C!
{| *6!?*HI-?;-K>*6--.H-?).HR)7-?%B)!=>4-?
{| 6-.-N-?).KS7)#N)*6!6-.>*6z{| 9,.F*
{| =>4-?
[\]^`dkc]xb]c^dbxbw]^eckectecjfĂÂÊÔƠ
[Đ]cxb
cƯ]^mnxb]c^db w]^cfg

]
efg]Ơ
ơHI-?53-.'F*%#3).
-.9!)~R5.F*%!1C- }.

*
+-K9!
.4N)ưđ-?)
-?#T).9!). 1>0@-.
#*:K%-?!.HUàảY !.HI-?
ã-!.H-?
*+-K9!
!.O,.Z!
.4D-!4D1

dkc]xb]c^dbxbw]^eckect
[Đ]cxbw]^ [Đ]c]^â]^ [Đ]cedê]ehdt]
uyecă]Ơ edê]ehdt]ĂôƠ
ôƠ
K{| -?{|S4
Q*K{|S4 Q*
.
>*!1H)#*0%!12 4N){!|-? >*!1H)#*0%!12
}.E-?!-?U-.H-?).HR!1>0 *+,!)!-?
-?H-?@-.!.HI-?Y
ạ%9!.*6-!.CK
-!*8R*8á-?-.H-?5.E-?%9! KT
4N)-.*0%
.*6-!.CK!ã-!.H-?K* !ã-!!..H?K*
2343561789

9




 !"$"%&'()*+,)-./0.1023& 45&$ 0E2}&$0j&$~L4B& & I&2tLz4B& *"B&
6 .7&$6 869%6:%&;<="=>?)@A 804"B2*C 2% F|& 2"Sc 0 c& 0h& Fc -./0& &
2!"$"%&'()*+,)0D%080& EF GH-./0 *+J&$ "S&0bc?l0-"F0D%0804B& & I&
6 I&230 45&$2=G2:J$>%&A*1"6KLMLN-./0 -./02>& 4+e2>J&$4&${?E{4B& & I&
-./0O80-& 0E-j24"y&$=&( 2>J&$
O=F:+0EP&$ Q%2R&$AS?
TUVWXY Z[\]^ZYX_`a$ "S& 0bc 2cI& A R"c*+zz4B& & I&A&$0E-j24"y&$=&
2D -de -D 080 &$ceS& 2f0 -gJ -b0 2>J&$ &+e 4&$ z?lj 2c}"2>c&$ 4& 0c&$ :+
wMxwMw?:B&26 7&&%F0w
&$ "S& 0bc e h0-./0ij"-k&$ -gJ -b0
F 0E*+A &$0E-j24"y&(?9 &$
2>J&$&$ "S&0bceG"& >.!&$lg" h0mi+ &E
22cR0J0-|&$.&$ 22cR0xL&F
aj"6 SnceB2?
0"yF 2:B0%J 7&0w& EF 0E:HnJ-%
GR0804B& & I&-|0%J2c}"?<4B& h0
opqrs
A R"c0D%2204B& & I&-Cc:+ng&$c&$
t28&$LuvwLxx-y&28&$LzvwLx{-| 2.4"cF2cey&?
Z[oTYW]ĂÂZ[YÊÔƠ_ƯZĐ\Z[\]^ZYX_
TYW]
_ả]&F
]ã]ĐáZ\
&Ž¹
a%F

a“
]ºZ¡»\¼§§\_½Y
&Ž¹
i–2
9 &$ –2 ŽJƒ0 -|
&$.&$—xL&˜F
¾¿žÀÁÂZ\\ÃY
&Ž¹
‡%>0"&JF2cey&
‡%>0"&JF*†e
‡%>0"&JF2y4+J:1&

\_Z[©Zª«¬­
ˆwMˆ‘xwMwˆ

\®ž¯°±©²­
©Zª›³­

\®ž¯°±©´­
©Zªµµ­

zNŽNˆMw¹
{NŽz{M~¹

xuŽNwM~¹
xŽzMw¹

wˆŽNuMx¹
x~ŽzLMu¹

wNŽ{xM{¹
NNŽˆ~M¹

~ŽwwMw¹
w~ŽM~¹

xŽ{~Mˆ¹
wŽˆxMz¹

~LŽxLL¹
L
L

{ˆŽxLL¹
L
L

zzŽxLL¹
L
L

’:B-j24"y&$=&Š‹(Œ2>J&$Äcd&2„&$ "S&0bc:+zN¹ Ž{ˆv~LM2>J&$-E0 Deyc:+-j2
4"y&ŌŠÆŽ-j24"y&OE%-Jg&-"„& …& A &$:+F:B0 A c&$n‰0 F|•=OJ&xuŽ0"yFNNMˆ¹
*+-j24"y&-"„F Å~N~Œ•=OJ&wxŽ0 "yF {~Mu¹?a$J+">%0Ç&6 82 "B&Fj2GR-j24"y&0E
&$ Q%A 80*1"2’:B2”6 7&& .-j24"y&-"„F‹xu)•=OJ&x~ŽwM~¹*+-j24"y&OE%-Jg&
A &$-"„& …& •=OJ&xuŽwM~¹?9 &$6 82 "B&2>.!&$ /6&+JF%&$-j24"y&$IeA 8&$
9ÈGŽ4†&$z?
234356789








 !"#$%&'() *+,-.!/-0'12&!"3!456
7!/'89!"-0'12&!
4*:!-0'12&! ;<=>?!"@!">A2BCD
EFGIJKLMNOPQRS
TTUVWQXXYS
EFGIJKLMNOPQZS
[\UVWQTXYS
EFGIJKL]PM^
_`
aWU[\QXXb\YS
EFGIJKL]VXVP
a_
_TU[\Q[Vb`YS
EFGIJKLNc_`d
_V
_U[\QabVYS
EFGIJKLefghijLklmLnhJoLlpLl
_`
_U[\QabVYS
EqJrsJhtu vLn Glwx GlobLnlJyL xvz xaGlJhJogzhJzG~LyzG~yLQ[GltLn
klmLn nlJLl{L h|}xG~|Ln l}u Li htu PP_b[[Ă`XYÂWb\_Rab_ar\GltLnPP
vLnliLGiLgz[GltLnlix\GltLnhJz TĂ`XYÂR_bT`R_Tbc[SƠyLxjLlhfbnlJ
G~hxlfezl|sLnnJGhtuvLnGiL Ll{LxtxhtuvLnGiLG~jLnxƯgILlLlĐL
IF PP Llf hFGIJKL MNOP QRSi rsJ xliGlăxlâqêg~LiôkÔLhLlUGơLngzW[

Llf hFGIJKLMNOPQZSPPgzW[GltLn GltLnrW\GltLnhJzG~Llf hFGIJKL
rW\GltLnLlf hFGIJKLMNOPQZSL MNOPQZSL|}G\`bTTY rVWY irsJ
|}G[[b[[Y raWY irsJLlf hFGIJKL Llf hFGIJKLMNOP QRSXabacY rTWYb
MNOPQRSaXY rXY QILnXSzLlJyLb xliGlăxlJzl|sLnxJGlJLGiLG~jLnr
wxlyLlxlLklmLnxfLnlgGlqLnky xưLơLnGqGlưLLlfxfhFGIJKLMNOPQZS
 !"đ$=,+,-+!"'/,'/B'/3:64;D
;)'/+!"
;)'/+!"
:92-+!" 456BDQL[\S 456BDQLTTS 456BDQLaWS 456BDQLaWS
P
W
W
W
W
P
_aU[\Q[[b[[YS __UTTQaXYS WTUaWQaWYS
W_UaWQXYS
d
_XU[\QT_b\cYS _TUTTQ[_bVaYS _TUaWQcWYS _TUaWQcWYS

W`U[\QaXYS _`UTTQT[b_VYS WaUaWQ_WYS WXUaWQaXYS
_UaWQXYS
PPPZP _aU[\Q[[b[[YS __UTTQaXYS TUaWQaWYS
PP_b[[Ă`XYÂWb\_Êab_a
PPTĂ`XYÂR_bTV\Ê_Tbc[
QPhtuvLnliLGiLĂPhtuvLnFGulLĂdILlÔLhLlĂILlGJKLG~JoLĂPP
htuvLnGiLIFS

12

34546789

21



 !"#$%&'(')(*+ !,-. ,/0 !1,23-'245678/-95:;<
@8AB,2( !
@8A",2( !
>-0?)(*+ ! CDE1FRHSTHUVWXHY PZVKLGL[\OO]M PKVOOGZP\P^]M _LVPQG`Q]M
Q`VPQGOQ]M
abcd
__VKLGKQ\ZL]M P_VOOGO^\PK]M QOVPQGPQ]M
_PVPQGLQ]M
efbghbWUibYbjHkfHYWUld\mnkomcbWUbpHmnqHYUrjWUfHYsltmcuvwgxywtHUndSzW
{b|H}av~GM€‚ƒHYgTuvwtHUndSzW{b|H}av~GMk„ghbHUndSzW{b|H}av~G…M†‡H†ˆ‰W
†x^\ZWUŠHYgxO\PZWUŠHYG‹JQ\Q_ZM€ˆŒHYWo\W‚ƒHYgTywtHUndSzW{b|H}av~GMk„ghb
HUndSzW{b|H}av~ G…M†‡H†ˆ‰W†x_KWUŠHYgx`WUŠHYG‹JQ\QO_MG{cHY^M€
 !#2Ž?!?8 56 !D@.@‘’ 2“”•& 2 2–
/A !— 2“”CDE1F< 2“”CDE1N<
uvwGWUŠHYM
˜~JP\P_G[Z]™šJ_\_^›O\_`Mœ
^\Z
O\PZ
GHJ`QM
‹JQ\Q_Z
˜~J_\LKG[Z]™šJ_\QL…P\^LMœ
ywGWUŠHYM
_

K
`
‹JQ\QO_
GHJ`QM

?A)žŸ#?A)ž78*%8 N 3?3/,22?& ,2Ž?!?8 56 !,2¡”,-. •¢1@<
.,2Ž?!?8 56 !•& 2:2£ !,?¤ ,/? 1D@<'¥8’ 2“”•& 2 2– '“.:2£ !'“
)¢,•?¤ !3 CDE

234356789









 !"#$

%&'(*+, -&./(01234(0-1.3156718(0
-9:;<(1=716>.2?31@-16A(>BC06D6>-69( FD GHHHIJHKLM(0./6:A(1 718(0 ?N( 71O
(P(031Q4-14R-M?N(S6A431@31TD-&U?5>6V(
79-1231D6-14W?G3SD-6(4X Y;Z<?[-DF[SL>B
>E->9(\-&](^?_D16A4`4O>6a4-&UYb6-cSA
dW(0 e (PX S; ff, Y; g (PX S; ee, hijk
%&<(0:W6?O(1>TM[&S<-6(6:Y;0[l6-6(6:>B?1<
-1mn16A4`4OY.2--&o6d

-1W(0>p?:6A--&'((1TX :A(1(1q(?T>o:69(0[(rstuvw6A4`4O(;n>B>.2??1x(0
X6(1 `4D (16a4 31q( -y?1 1z6?x4 Y; -1{
(016AX SqX d;(0 he+|eejv}016'( ?x4 (;n
-1[:;<(1=06D6><E(X4o(-E6K6A-}DX >.2?
>6a4 -&U>y?1 :€(0 [&S<-6(6:M-&<(0 >T ?T f
:A(1(1q(?T>o-:69(rstu(1En?OX Yb6
%‚HdM?1?@<-&.b?-&'(-1906b6v
„@3x(0?_D(0./6:A(1>W6Yb6S6A431@3
>6a4-&U-&…(0>y?1>.2?-1[0zX >@3x(0-1†?-1VG-1[<ur‡Hˆ%LY;>@3
x(0-<;(-&E(0G-1[?x4016(1R(>.2?F41.b(006OX -cSA>@3
x(0-<;(:oŠuuC(1TX >o-:69(rstuG‹L
d<Yb6(1TX >o-:69(rstuGŒLŠuudD4+f
-1@(0Y;+-1@(0C(1TX>o-:69(rstuGŒL
S](S.2-S;ffMff, Y;g+, d<Yb6(1TX >o:69(rstuG‹LS;gŽ, Y;Ž,v%4n(16'(Md†
?1'(1SA?1(;n718(0?T(01D-1W(07'?T
-1VZ<:A(1>BY;<06D6>71W64>BSb(Y;?1<Z6?P(('(-cSA>@3x(0
1<;(-<;(Y;Xo-31](718(0?DY.2--&o6&~&A-C(1TX ?T>o-:69(G:O(0ŽLv
‚16F‘->@3x(0-<;(-&E(0M-cSA5(>U(1J-P(0
?1‰dW‚D&(<ld76C(1TX >o-:69(rstuGŒL
>a4?D<1’((1TX 718(0>o-:69(C?O-1/6
>6VX f -1@(0 Y;  -1@(0 G-cSA S]( S.2-S;
iM““, Y;+, d-1mn (1TX :A(1 (1q( ?T >o-:69( >.2?
12

1.C(0S26-”d†?O6-16A(-<;(-&E(0(16a41’(
(1TX718(0>o-:69(v
„W6Yb6-1/606D( dW(0 -1'XM?T d† ?O6
-16A(?T(01D-1W(07'C?O•tˆY;ŠˆC
(1TX >o-:69( rstu GŒLv%&4(0 YU•tˆ C
(1TX>o-:69(rstuGŒLd<Yb6(1TX>o-:69(
rstuG‹LS](S.2-S;*MŽ-1@(0Y;“MgŽ-1@(0
G3 – +M+eŽL|-&4(0 YUŠˆ C (1TX >o-:69(
rstuGŒLd<Yb6(1TX>o-:69(rstu G‹LS](
S.2-S;ef-1@(0Y;-1@(0G3–+M+“eLv‚9`4O(;n?1<-1mnd†16A(Z6A(?_D>o-:69(
0[( rstu 06…3 7‘< Z;6-1/606D( dW(0 ?1<
(1TX:A(1(1q(Zƒ(0S6A431@3>6a4-&U-&…(0
>y?1M1<;(-<;(31ƒ123Yb679-`4O?_D-1{
(016AX ‡—˜sIhegjv%4n(16'(M-&4(0YU•tˆ
Y;Šˆ-&<(0(016'(?x4>a4(0™(1’(-&<(0
-1{(016AX ‡—˜IsGS](S.2-S;*MŽ-1@(0Y;
ef-1@(0d-6'4 ?14š( ?1›( XQ4 >a4 S; 4(0 -1. 3156
718(0 -9 :;< (1= 06D6>(1q(?TSœZ<(016'(?x4?1.D31q(>U(1S6A4
31@3>6a4-&U-&…(0>y?1:.b?e1-&<(0716-1{(016AX‡—˜Is?1‰?1›(31@?>z
[&S<-6(6: :.b? e -&'( :A(1 (1q( 718(0 1…-14W?S@MYW(S;>W6-.2(0(1En?OX Yb6S6A4
31@3>6a4-&U-&…(0>y?11’(v„qnS;Ym(>a
?1.D 06O6`4n9->.2? ?_D (016'( ?x4d<
d@(1 16A4 `4O S6A4 31@3 >6a4 -&U-&…(0 >y?1
:.b?e14(0-1.3156718(0-9:;<(1=06D6>?T Y; 718(0 ?T >o-:69( 0[( rstuv%4n

(16'(MZ<-1†?-9>6a4-&U4(0-1.(T6?14(0Y;
4(0-1.3156718(0-9:;<(1=(T6&6'(0-E6
K6A-}DX ?N((16a4-&D(1 ?B6M(1m-S;>x(0
-&.b?Xo-S6A431@3>6a4-&U-&…(0>y?1XD(0
SE616A4`4O(1.(0?N(Xb6XMXo-:o31R(
:A(1(1q(YQ(31O6?1U40@(1(p(076(1-9716
-1[<>456S6A431@3>6a4-&U(;nM('(Y6A?S†D
?1›(:A(1(1q(?1<?@?(016'(?x4>@(106@
S6A431@3>6a4-&U-&…(0>y?1?N(&m-71T71P(v
%&<(0 -.’(0 SD60](M716S6A4 31@3 >6a4 -&U
34546789
2