canh giac duoc nghiên cứu khoa học

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<i>AI</i>

<i>.</i>

<i>.:.</i>

LEKETNAP

.

.

THANG 11 ..

SO

2

2020

A A A

TONG HQI Y HOC VI~T NAM

VIETNAM MEDICAL ASSOCIATION

68A Ba

Tri~u - Hoan Kie'm - Ha NQi;Tel:

024-39431866

Email: ; Webslte: tonghoiyhoc.vn

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.

_

.. - - ---

-1.

<b>MUCLUC</b>

•

•

T

~p

CHi Y HQC VII;T NAM T~P 496 - THANG 11 -

so

2 - 2020

VIETNAM MEDICAL JOURNAL N02- NOVEMBER - 2020

.. anh gia vai tro nQisoi

6

bunq trong chan doan va dieu tr] vet thu'dng tanq rang
Evaluation the role of laparoscopic in diagnostic and treatment of holow viscus
perforation wounds

Nguy~n Hoang Linh, Huynh Kim Khang, Ng_uy~nDuc Vd,

Duong Van Hai, Nguyen Cong Minh

Phl:lc hoi thanh cong rang ora sua sau va Ion bang chup Zirconia co san

Treatment anterior crown with pre-fabricated Zirconia

Nguy~n Anh DU'O'ng,Vo Truong NhU'Ngoc, Ngo Van Toan

Thl/c tranq hoat dQng tiem phong benh dai t9i tinh Gia Lai, giai dean 2015 - 2019
Situation of rabies vaccination in Gia Lai province, 2015-2019

Nguy~n Van Chuyen, Nguy~n Van Khai, Nguy~n Th] Minh Ngoc

B~c diem lam sang va ket qua dieu tr! nQisoi cam rnau mOi bang dong di~n

l:linical characteristicsand endoscopicelectrocauterytreatment outcomesof epistaxis

Ha Phuong Thao, Trin Thi Mai

5. Nghien cuu bao che vien nen Fexofenadin hydroclorid phan tan nhanh de tang hi~u

qua dieu tr] vlem mOid! ung

Preparation and evaluation of Fexofenadinehydrochloride rapid dispersible tablets to
increasethe effectiveness for treatment of allergic rhinitis

Vii

Van Tu~n, Nguy~n Van B~ch

Nghien cuu cai thien dQon d!nh thudc tlern Rotundin sulfat de tang tac dl,mgan than
Study on improving stability of Rotundine sulfate injection to increase sedative effect

Nguy~n Thi Ha, Nguy~n Van B~ch

Ket qua bu'ocdau nQisoi

0

bl:lng dieu tr! vet thu'dng<i>cd</i> hoanh

The initial result of laparoscopictreatment diaphragm wounds

Nguy~n Hoang Linh, Huynh Kim Khang,

Nguy~n Du-cVii, DU'ongVan Hai, Nguy~n Cong Minh

Nghien cuu d~c diem lam sang va c~n lam sang cua b~nh nhan viem gan B m9n tfnh
du'Q'cdi'eutr! bang thuac Tenofovir

l:linical characteristics of chronic hepatitis B cured by Tenofovir

Da Thi Quynh, Vii Van Nga, Bid Thi Thu Hoai

Banh gia rai lo~n chuyen hoa cald - phospho - PTH

<i>a</i>

b~nh nhan 19Cmau chu ky t9i
Khoath~n Tiet ni~u - L9Cmau, B~nh vi~n Huu Nghi

Evaluating the metabolism trouble in dialysis patients at neuphrourology - dialysis
department, Huu Nghi Hopital.

Trinh Thi Thanh H~ng, Nguy~n Van Tin, Nguy~n Th~ Anh

10. Khao sat sl/ tuan thu dieu tri Tenofovir tren b~nh nhan viem gan B m~n tfnh

Investigation of Tenofovir treatment adherence in chronJchepatitis B patients

Vii Van Nga, Do Thj Quynh, Vii Thj ThO'm,

Le Thj Di~m HAng, Bui Thj Thu Hoai

11. O'ng dl:lng

ky

thu~t multiplex PCRphat hi~n cac gen mcr-1, mcr-2 va mcr-5 khang

colistin

<i>a</i>

cac chung Escherichiacoli phan I~p tu cac trang tr9i ga

<i>a</i>

Ha Nam

Application of the multiplex PCRtechnology for detection of colistin resistant mcr-1,
mcr-2 and mcr-5 genes in the Escherichiacoli strains isolated from the chicken farms
in Ha Nam

Hoang Thi }\1aiHU'O'ng,Hoang Thj An Ha, Vii Nhi Ha,

Hoang Thj L~an, Phung The Khang, Ph~m Duy Thai, Trin Huy Hoang

12. Banh qia tlnh tranq nhiem virus viem qan B, C

<i>a</i>

b~nh nhan 19Cmau chu ky t9i khoa

Th~n tiet ni~u-19Cmau, B~nh vi~n Huu Nghi

Infection with hepatitis Band C virus in dinalysis patients at the nephrology-dialysis

department, Huu Nqhi Hospital ,

Nguy~n Van Tin, Trinh Thi Thanh Han!!. Hoan!! Manh Tron!!.

_• _• _x
X <i>I..</i>

Nguyen Le Hoa, Nguyen The Anh

2.

3.

4.

6.

7.

8.

9.

1

5

8

13

16

20

26

31

35

39

43

48

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- - - ---_

13. Thl/c tranq kern khoanq hoa men rang ham Ion - rang ctra 0 nhorn h9Csinh 12-15 51

tuoi t~i tinh Binh Dlnh narn 2019-2020

The current situation of molar incisor hypomineralistaton in group of 12-15 years old
students in Binh Dinh province in 2019-2020

_

Nguy~n Phuc Minh, Vo Truong NhU'NgQc

14. Mqt so d~c diem

dkh

te

hoc cac

ca tu vong do

benh

dai

tai

tinh<i>Sdn</i> La (2015 - 2019) 55

Some epidemiologicalcharacteristicsof human rabiesin Son La province (2015 - 2019)

Nguy~n Van Chuyen, Nguy~n Van Ba, Hoang Th] Thuan

15. Thay dOi tham my m~t nha voi ph§u thuat phoi hop dich chuyen tien ham va

tao

59

hlnh

cam

Simulataneuos premaxilla osteotomy and genioplasty on the facial profile
attractiveness of patients with convex face

DB

Tuin Ngoc, But Huu Phurrc,

ve

Hang Lie~, Hoang Tuin Anh

16. So sanh ke't qua dieu tr] dom nau anh sang cua Laser nano giay Q-Switched Nd: YAG 63

532 nm va Laser pico giay nd: YAG532 nm

Q-Switched double frequency Nd:YAG 532-nm nanosecond Laser vs. double
frequency Nd:YAG532-nm picosecond laser for the treatment of solar lentigines

Pham Thj Mai Trinh, Le Hfru Doanh,

ve

Thai Ha

17. B~c diem di can h~ch bach

huvet

vung co trong ung

thu

bieu ma tuyen giap bi~t

hoa

68
Characteristics of cervical lymph node metastasisin differentiated thyroid cancer

Nguy~n Van Nam, TrAn Xuan BQ

Vii Anh Hai, Le Thi Tuy~t Nhung

18. Mqt so d~c diem lam sang va c~n lam sang cua rang ham seraham tren co b~nh

1'1

71

tuy ho~i

tU

0

mqt nhom b~nh nhan den kham t~i B~nh vi~n Rang Ham M~t Trung
<i>L(dng</i> Ha Nqi nam 2019

Clinical and radiographic evaluation of primary upper molars with necrotic pulp of
young patients at Hanoi National Hospital of odonto-stomatology

Le NgQcDi~p, VOTruong Nhu NgQc,

Ph~m Hoang Tuin, Nguy~n Thi Van Anh

19. Mqt so d~c diem dich t~ h9Cvi khuan Rickettsia

0

Mien sac Vi~t Nam 75

Epidemiological characteristics of Rickettsia in North Vietnam

LuO'ngThi HAng Nhung, Nguy~n Vii Trung,

Le Thi HQi, Ma Thi Huyin

20. Thl/c tr~ng tai n~n thL(dng tfch cua tre nh~p khoa cap

<i>cuu</i>

t~i B~nh vi~n Nhi Trung 79

L(dng

tU'

7/2019 - 6/2020

Situation of children's injury admitted the emergency department at viet nam
National Children's Hospital from 7/2019 - 6/2020

Nguy~n Thi Huyin Sam, Truong Thi Mai HAng

21. Banh gia ket qua ph§u thu~t dieu tri h~p dqng m~ch canh ngoai S9 t~i B~nh vi~n Da 82

khoa Dong Nai

Results of extracranial carotid artery endarterectomy in Dong Nai Province Hospital

Tr~n Quy~t Ti~n, Nguy~n Anh Diing

22. Hi~u qua rna hinh phl:1Choi chuc nang dl/a vao cQngdong cho ngL(Oikhuyet t~t v~n 86

dQngt~i huy~n Thong Nhat tinh Dong Nai

The effectiveness of community-based rehabilitation for people with mobility
disabilities in thong nhat district Dong Nai Province

Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng

23. Ket qua ph§u thu~t nQisoi cat rUQtthLtaqua dL(ongam d~o 90

The results of laparoscopic appendectomy through vaginal route

DB

Tit Thanh, Tr~n Binh Giang

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24. Kha nang cung ung dich vu cham soc tre so sinh tal Trung tam Y te huyen Kim Boi, 93
tinh

Hoa

Binh, narn

2019

Infant care service delivery providing at Kim Boi District health center in Hoa Binh
Province in

2019

Ngu

y

~n QuAc Ti~n

,

Ngu

y

~n Quang T,!, Nguy~n Dang Vtmg,

Pham H

a

i Thanh, Nguy~n Huu Thing

25. Cck yeu to dlj bao ket cue

<i>d</i>

benh nhan dQt quy thleu rnau nao cec bQ cap tfnh du'<;>'c97
dieu tr] tai tu'oi mau bang lay huyet khoi <i>cd</i> hoc ket hop d~t stent cap ciru thuoc tuan

hoan

nao

truce

Outcome forecast factors in patient with acute ischemic stroke received reperfusin
treatment using mechanical thromboembolism combined with anterior cerebral
circulation emergency stent

Nguy~n Van Hu

y

, Mai Duy Ton,

Le

HAng Trung

Dito Vi

~

t Phuong

,

Vii Dang LU'U, Tdn Anh Tu~n

26. Tinh hinh tang ap luc

0

bunq

va mQt yeu to nguy co 0 benh

nhan

n~ng nh~p vi~n 102
khoa Hoi

sire

Tfch

cue

Intra-abdominal hypertension and some risk factors in patients who admitted to the
intensive care unit

D~ng Th] Huong, Dao Xuan CO'

27. Hoi tu'dng quan giG'aap

luc

nQi SQva diem glassgow

<i>d</i>

b~nh

nhan

xuat huyet nao

5

105
ngay dau

Correlation between the intrcranial pressure and glassgow score in patients with
brain hemorrhage for the first

5

days

Le

Thi Bich Thii

y

, ~guy~n Van ChU'O'llg

28. KhilO sat cac yeu to lien quan den

<i>muc</i>

dQ n~ng cua b~nh gan nhiem ma khong do ru'<;>'u 109
Related factors of severe nonalcoholic fatty liver disease

Vo Duy Thong, D6 Duc Minh

29. Tinh tr~mg trCing qua huyet ap Iu'u dQng

<i>d</i>

b~nh nhan IQcth~n 113
Dipper pattern on ambulatory blood pressure monitoring in the hemolysis patients

Chau Huu HAu, Nguy~n Minh Tri

30. KhilO sat ta du'Q'cdong kho cho cong thl)'C bao che thuoc tiem dong kho liposome 117
amphotericin B

Investigation lyophilized excipients for the preparation formulation of liposomal
amphotericin B for lyophilized injection

Nguy~n Tu~n Quang, Ph~m Thi Minh Hu~, Nguy~n Thai SO'll

31. HQt so yeu to lien quan toi thai gian dieu trl cua ngu'ai b~nh viem loet giac mi;lc 120
Factors related to treatment duration in patients with corneal ulcer

D~ng Thi Hai Hit, Ph~m HAng Van

32. Banh gia hi~u qua kiem soat ho hap cua phu'dng phap thong khf ap Iljc du'dng ngat 123
quang dau trung tam ket h<;>'pngoi;li vi trong ph§u thu~t ti;lo hinh khf quan

Evaluate the effectiveness of airway management using distal tracheal intubation
and intermittent positive pressure ventilation for tracheal resection and
reconstruction surgery

Dinh Thi Thu Trang, Nguy~n Minh

Ly,

Cong Qu

y

~t Thing, TAng Xuan Hung

33. Thljc tri;lng dam bao thuoc thong qua hinh thuc dau thau ti;li B~nh vi~n Quan

Y 105

128

tlt

nam

2015 - 2018

Current situation of drug security through drug bidding at

105

thmilitary hospital from

2015

to

2018

HA CanhH~u, Ngu

y

~n Minh Chinh,

Hoang Hai, Ngu

y

~n CAm Van, Vii NgQcMai

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34. Nghien

cuu

d~c diem lal}l sang due the thuv tinh sau chan thu'dng va mQt so yeu to
tien hrono thi nrc sau ohauthuat dieu tri

Clinical characteristics and prognostic factors for visual outcome of traumatic cataract

Pham Phuong Dung, Th§m Truong Khanh Van

35. 8anh gia ket qua phuc hoichuc nang nh~n tmrc cho benh nhan chan thu'dngS9 nao
tal B~nhvi~n Phuc hoiChuc nang Ha NQinarn2019 - 2020

Functional cognitive assessmentof the patient after traumatic brain injury

Phan Thi Ki~u Loan, Ph~m Van Minh

36. Banh gia hi~u qua phuc hoi chirc nang thang bang tren ngu'oi benh nhoi rnau nao t1;li

B~nhvi~n Lao khoa Trung u'dng

Assessment the effectiveness of balance rehabilitation for patients after cerebral
infarction at National Geriatric Hospital

aa

Thi HUiYDgMinh, Cao Minh Chau

37. B~c diem lam sang va c~n lam sang cua benh nhan tnrot dot song don tang do
khuyet eo

Clinical and subclinical of patients with one-level lumbar spondylolisthesis

.Tdn HBng Vinh, Nguy~n Van Thach, Vii Van Hoe

38.

Khao sat chi so FIB-4 trong dl,( doan gian

tinh

mach

thirc

quan

<i>d</i>

b~nh nhan<i>xd</i> gan
co chu'ang

Investigation apri indicator to predict esophageal varices in cirrhosis patients with
ascites

ve

Duy Thong, HAThi Van Anh

39.

Thl/c tranq ngu'oi khuyet t~t v~n dQng va phuc hoi chirc nang cho ngu'oi khuyet t~t
v~n dQngdl/a vao cQngdong tc;lihuy~n Thong Nhat tinh Dong Nai

The current situation and community-based rehabilitation for people with mobility
disabilities in Thong Nhat district Dong Nai Province

Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng

40.

Danh gia chat 1u'Q'ngkhOitieu (au trong qua trlnh bao quanva moi lien quan giO'acu'ong
dQhuynh quang vai doi song cua tieu cau du'Q'csan xua'tbang phu'dngphap buffy coat
Assessment the quality of platelets during storage period and the colleration
between the fluorescence intesity and the lifetime of platelets produced by buffy coat
method

Nguy~n Thj Lan, Luu Thj Thu Phuong,Tr§n Van Tinh,

. Nguyin Dac Thao, Tr§n Thj Thanh Tam

41. Nhu cau cham soc dai hc;lncua ngu'oicao tuoi

<i>d</i>

mQt so xa thuQc huy~n Soc Sdn, Ha
NQinam

2018 - 2019

.tong-term care need of elders in some wards in SocSon district, Ha Noi in

2018 - 2019

Nguyin Thi Thu Huy~n, Ph~m Le Tuin

42.

Phau thu~t ung thu'tuyen giap

<i>d</i>

ngu'Oib~nh Basedowtc;IiB~nhvi~n NQitiet Trung<i>u'dng</i>
Thyroid cancer surgery in patients with Basedowdisease at the National Hospital of
endocrinology

"

' ,

Ph~m Quyet Thang, Tran NgQc Luong

Da

Thanh Cong, Truong Quang Huy

43. Banh gia cau truc vi the va dQ ben cua ma van tim lQ'nsau bao quan Ic;lnhsau

Evaluation of the microstructure and tensile strength of the cryopreserved porcine

heart valve

Cu Thj Bich Thuy, Ngo Duy Thin, Duong Cong Nguyen,

Le Thj HAng Nhung, M§u Van Cal!h

44. Kinh nghi~m bu'ac dau sU'dl,lng du'ong lIlo it xam Ian qua

<i>md</i>

ngl/c phai trong ph§u
thu~t thay van hai 113tc;liB~nh vi~n ChQ'Ray

Early experience of minimal invasive surgery by the right thoracotomy in mitral
valve replacement at the cardiac surgery deparment of Cho Ray Hospital .

Lam Tri~u Phat, TrAn Quy~t Ti~n

132

136

139

142

145

149

153

157

160

164

168

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45. U'ng dunq thuc nqhlern phau thuat n9i soi qua duang am dao tren lon giai doan 173
2011- 2014

Applying experimental laparoscopic appendectomy throu~h vaginal route on pig

D6 Tat Thanh, Trin Blnh Giang

46. Kha nang cung lIng dich vu cham soc SlICkhoe so sinh tal cac Tram Y te xa, huy~n
Kim BOi,tinh Hoa Blnh, nam 2019

Ability to provide neonatal medical health care services at commune healthcare
stations at Kim Boi Provine,Hoa Binh District, 2019

Nguy~n Qu6c Ti~n, Nguy~n Quang Tu,
Nguy~n Dang Vu'ng, Pham Hai Thanh, Nguy~n Hfru Thi~g

47. Banh gia ket qua phau thuat cat amidan bang dao Ligasure
The evaluation results of tonsillectomy method with Ligasure

Nguy~n Phuong Thao, Nguy~n Quang Trung

48. Nghil~n ClIUsir thay doi the tfch the chai tren hinh anh c9n9 hu'ang

tir

a benh nhan
nghi~n

ruou

Research on change in volumes of corpus callosum on magnetic resonance imaging
of the alcoholic patient

Le Phi Dlili, Nguyen Thi Sinh, Tran Ngoc Anh, D~ng Ti~n Truong

49. B~c diem lam sang, chan doan hinh anh b~nh

Iy

do d!ch nao tuy do vo nen S9 sau
chan thu'dng S9nao t~i B~nh vi~n Vi~t £)lIC

«;Iinical characteristics and imaging evaluation of cerebrospinal liquid leak (csf)
caused by skull base fracture post traumatic injury in Viet Duc Hospital .

_ Ngo Manh Hung, TrAn Blnh Ngoc, Nguyjn Duc Dong

50. Banh gia tinh tranq nhiem khuan b~nh vi~n a b~nh nhan du'qc dieu tr! ECMOt~i
B~nhvi~n B~ch Mai

Evaluate hospital associated infections in patients who were on ECMOat Bach Mai
Hospital

Trin Duc Trung, Dao Xuan CO'
5!. C.c3cyeu to anh huang ket qua dieu tr! viem loet d~ day ta trang helicobacter pylori

du'dng tfnh bang phac do 3 thuoc Amoxicilin,Levofloxancin, PPI t~i B~nh vi~n Trung
U:dnaThai Nauven

Clinical factors influencing the efficacy of H.pylori eradication of triple therpy
(Amoxicilin, Levofloxancin, PPI)in Thai Nguyen General Hospital

Ngo Duc hQ'P, Duong HAng Thai, Nguy~n Thj Thu Huy~n

52. Tinh hinh nhi~m nam Malasseziatren benh nhan viem da <i>cd</i> dia tai Benh vien Da

Ii~u Trung u'dng . . .. .

Malassezla infection in patient with atopic dermatitis at National Hospital
dermatology and venerology

Nguy~n Van Hi~u, Trin CAm Van, Phlilm 'fhi Minh Phuong

53. Banh gia ket qua hoax~

tri

dong thai tjen phauungthu' bieu rna thl/c quan 1/3 giO'adu'Oi
Assessment of the rusults of preoperative chemoradiotherapy for esophageal cancer

Phlilm Quang Anh, VO Van Xuan

54. Banh gia d9C tfnh ban tru'ang di ~n tren h~ t~o huyet cua vien nang ClIng Fucolen
sau bao che tren d9n9 v~t thl/c nghi~m

Examines the semi-chronic toxicities of Fucolenon experimental animals

Trin Thanh Huong, TrAn Van Thuin, Vii Mlilnh TuAn,
Nguy@n Van Khiem, Dao Van Tu, Nguy~n Ti~n Quang

55. Nh~n xet ket qua sau 2 tuan dieu tr! Esomeprazoletrong viem diil day khang kern
theo loet a tre nhi~m Helicobacter Pylori tiili B~nhvi~n Nhi Trung u'dng

Assesment of treatment result with esomeprazole after 2 weeks for non- ulcer
gastritiS combined Helicobacter Pylori infection in vietnam national Hospital'S Childr~n

DilO Thj Ngoan, Phan Thj Hien

176

179

182

185

188

193

197

201

205

210

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56. B~c diem lam sang c~n lam sang va thai gian song them khang benh ung thir bieu 214

ma tuyen che nhay de day giai doan II, III

Clinical characteristics and complementary examination, disease free survival and
some factor affect disease survival of mucious gastric cancer stage II-III

Nguy~n Thi H~ng, Trinh

Le

Huy,

Le

Van Th

i

mh

57. B~c diem lam sang va m9t so yeu to lien quan den b~nh vlem da dau tal B~nh vi~n 218

Da Ii~u Trung u'dng

Clinical manifestations and several factors relating to seborrheic dermatitis in
National Hospital of Dermatology and Venereology

Truong

Th] Thanh Huong, Ngu

y

~n Huu Sau, Trin

cim

Van

58. B~c diem lam sang va nhu cau cham soc dieu du'ong trong ngay dau cua ngu'ai benh 221

c6 h9i chung cai nrou

Clinical characteristics and needs for carein the first day of of patients with alcohol
withdrawal syndrome

DB

Thi Ho

a

, Ngu

y

~n Doan Phuong,

Le

Thi Thu Ha

,

Ngu

y

~n Th] Hila

,

Pham Xuan Thing

59. Ket qua sam ph§u thuat teo ruot non bam sinh tal B~nh vi~n HO'unqhl Vi~t

<i>Duc</i>

giai 225

doan 2017 - 2019

Results of surgical treatment for jejunoileal atresia in infant at Viet Duc University
Hospital from 2017 to 2019

Chu Minh Phuc, Nguy~n Vi~t Hoa, Vii Hang Tuan

60. Bi~u qua dieu tri cua colchcin trong may day man tfnh

til

phat

Colchicine in the treatment vietnamese patient with chronic spontaneous urticaria

Ngo Th] Minh Nguy~t, Pham Thj Lan

61. Banh gia ket qua dieu tr] Erlotinib bu'ac m9t tren benh nhan ung thu' phoi khang te
bim nho giai dOe;!niv c6 d9t bien EGFR

Assessment treatment outcome of first-line Erlotinib in patients with advanced EGFR
mutation-positive non-small-cell lung cancer

Nghiem TrAn VU'Q'Ilg,

Nguy~n Ti~n Quang, Le Thi Y~n

62. Trai nghi~m cua giang vien ve chu'dngtrlnh giao dl,lc dieu du'ong dy'a vao nang h!c
Perceived experiences of nurse educators in a competency - ba.sed nursing
curriculum: a qualitative descriptive study

Ngu

y

~n Thi HAng Anh, Ph~m Thi Thu

y

Dung

63.

Thl/c tre;!ngtiem chung day du va dung lich cua tre em du'ai 1 tuoi t9i huy~n Tr9m

Tau, tinh Yen Bai nam 2019

The fully and scheduled immunized situation among under 1-year-old children in
Tram Tau district, Yen Bai province in 2019

Cao Bach, LQCThi Mai

,

Le Thi Thanh Xuan

64. Ket qua dieu tri soi ni~u quan 1/3 du'ai bangTamsulosinti;liB~nhvi~n De;!ihQcY Ha N9i
Results of therapy of therapy of under 1/3 by Tamsulosin treatment in Hospital

University of Hanoi

Trinh Anh Tu§n, Vii Nguy~n Khai Ca

65.

Gia

tri cua

tY

I~ dau ra nang noan (FORT)vai ket qua kfch thfch buang trung

Use of follicular output rate (FORT)to predict ovarian stimulation outcome

Ph,m Thi Anh, Nguy~n Lien PhU'ong,

LU'UQu

y

nh HU'ong

,

HA

S

y

Hung

66. Khao sat cau truc vi the thanh tinh machtinh cua nhO'nqbenh nhan qian tinh mi;lchtinh
Evaluating the microstructure of veinous walls inpatients with varicocele

Ngu

y

~n Hoai Bic, Dinh Van Toan,

Ph,m ThuAn M,nh, Hoang Long

229

233

237

241

245

248

252

Trung

tâm

DI&ADR

Qu

ố

c

gia

- Tài

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ệ

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67. Hi~u qua khU'te bao mang nqoel tim bo bang Sodium Dodecy Sulfate 256
Decellularized effect and extracellular structure of bovine pericardium after treatment
with Sodium Dodecy Sulfate

Nguy~n Van Hoang, Ngo Duy Thin,

i.e

Thi HAng Nhung, Miu Van Canh

68. "~c diem lam sang, nQisoi

va

mo benh hoc

0

benh nhan dieu tr] cat tach nlem mac 259

dai true

trang

Clinical, endoscopic and histopathological features in patients undergoing endoscopic
submucosaldissection

Le Phu Tai, Nguy~n Cdng Long

69. Khao sat tinh tri;!ngnhiemkhuantiet ni~u

0

benh nhantrong

3

thang aau saughepth~n 263
Investigationof the urinary tract infections in kidney transplant recipents in the first

3

months after transplantation in bach mai hospital

Hoang Thi Nhan, Mai Thi Hiin

,

Nguy~n Thi Hmrng

70. Hi~u qua cua phu'dng

thirc

AVAPS0

benh

nhan d<;1tcap b~nh phoi tac nghen man 266

tlnh

(COPD)du'<;1Cthong kh(

nhan tao

khong

xam

nh~p

Effectiveness of AVAPS in acute exacerbation of chronic pulmonary obstructive
diseasepatients on non invasive mechanicalventilation

Vii Trung Kien, B&NgQcSan

71. Cd cau benh tai mOi hQng0ngu'oi lao dQngcua t~p doan Viettel qua kharn

srrc

khoe 270

dlnh

ki nam 2019 - 2020

Structure of ear, nose and throat disease among employees of Viettel group through
periodic health examination in 2019 - 2020

Nguy~n L,p SO'n,Pham Huy Tin

72. Nghien cru d~c diem lam sang, c~n lam sang

0

benh nhan tang triglyceride mau cao

Study on clinical and subclinical characteristics in patients with high degree of
hypertriglyceridemia

Nguy~n Vi~t Hung, Nguy~n Khoa Di~u Van

73. ~hi)Q sat d~c diem tinh dich do cua nam gioi c6 chuc nang sinh san binh thu'ong

Evaluation of semen parameters in fertile men

Nguy~n Hoai B~c Nguy~n Cao Th~ng, Hoang Long

74. Gia trl cua thang diem hacor de dl,( doan ket qua cua tho may khong xam nh~p tren

b~nh nhan suy ho hap cap

The value of the hacor scale in predicting result of non-invasive mechanical
ventilation in patients with acute respiratory failure.

Ph an Thi Lan HUO'ng,BB NgQcSO'n,Phung Nam Lam

75. Banh gia ket qua dieu trl ph§u thu~t ung thu' phan con Ii;!idi;!day

Efficacy of surgical management of gastric stump cancer

Phan Hfru Huynh, Ha Hili Nam

Trin Blnh Tan, Ph~m Vii Minh Hoang

76. B~c diem lam sang va hinh anh hQC

0

b~nh nhan nhoi mau nao h~ song - nen

Clinical and imaging features of vertebrobasilar ischemic stroke patients

Nguy~n Thi Tuyit Trinh, Nguy~n Van HUOng,Le Tu§n Linh

77. Ket qua ph~u thu~t cattoan bQ di;! day do ung thu'

0

b~nh nhan cao tuoi t<;liB~nh

vi~n

K

Trung u'dng

The results oftoltal gastrectomy in olderly patients with gastric cancer in National
Cancer Hospital

Nguy~n Van Tung, Ph~m Van Binh, Vii Thi Hang Anh

274

279

283

288

291

294

Trung

tâm

DI&ADR

Qu

ố

c

gia

- Tài

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78. Khaa sat dQ dai co

tU'

cung 0 1000 thai phu c6 tuoi thai

tir

20-24 tuan bang sieu am 298

qua du'ang am

dao

Evaluatian of the cervical length at 20-24 week' gestatian in 1000 pregnancies by
transvaginal ultrasound

H~ Van Quy

, V

ii Ba Quy~t, Ngu

y

~n Xuan Hq

'

i,

_

Dao Thi Hoa, Phan Thi Thu Nga

79. Ket qua dieu tr] naa LIng thuy bam sinh bang phau thuat nQi

sot

pha san naa that III 302

ket hop dot dam roi mach mac

Outcames of treatment cangenital hydracephalus by endoscopic third
ventriculastamy withcharoid plexus cauterizatian

.

Dao Th] Mo, Cao Vii Hung, 1)8 Thanh Huong

80. Banh gia ket qua dieu tr] ung thu' phoi khong te baa nh6 giai doan III tren ngu'ai caa 305

tuoi bang h6a X<;I tri dong thai

Assess the treatment results af concurrent chemaradiatian in elder patients with
stage III nan - small cell lung cancer at

K

Hospital

Ph~m Van Phat,

ve

Van Xuan

81. B~c diem rOi loan cu'dng du'dng va mQt s6 yeu to lien quan 0 benh nhan benh th~n 310

man giai doan IV tal khoa Than - Tlet nieu B~nh vi~n Bach Mai

Characteristics af erectile dysfunctian and same related factars in patients with stage IV
chranic kidney disease at the department af nephran - urolagy af Bach Mai Haspital

D8 Cong Huan, Nguy~n Quang

82. Nghien

<i>diu</i>

dQc tfnh va anh hu'ong cua la ng6n va hi;lt cay C9Craa len mQt so chi tieu 313

h6a sinh tren dQng v~t thl/c nghi~m

Studying an taxi city and efectiveness af the gelsemium elegans and jatropha curcas
seed extract an biachemistry af animal madel

Hoang Anh Tuin, Hoang Gia Bao

83. U'ng dl:lng thang diem radnan cai tien trang danh gia ton thu'dng da 0 b~nh <i>xd</i> cung 318

bi h~ thong

Using the madified radnan skin scare to. assess skin lesians in patients with systemic
sclerasis

Hoang Vi~t Tai, Bui Hai Binh

84. Tong ket cac baa caa lien quan den phan v~ trong <i>cd</i> so dCi'li~u baa caa

<i>W</i>

nguy~n 323

Vi~t Nam giai da~n 2010-2019

Anaphylactic reactians in spantaneaus reparting database af vietnam from 2010 to.2019

Truong Thi M§n, Nguy~n Phuong Thuy, Nguy~n Hoang Anh,

D~ng Bieh Vi~t, Cao Thi Thu Huy~n, Nguy~n Hoang Anh,

Vii Dinh Hoa, Nguy~n Van Dinh

85. B~c diem ngu'oi b~nh suy tim mi;ln,tinh tri;lng 10.au va ket qua cham soc ngu'oi b~nh 328

ti;li khaa tim mi;lch lao. h9C - b~nh vi~n tim mi;lch an giang nam 2020

Characteristics af chronic heart failure and results take care patien at department tim
mach lao. hac - an giang cardiovascular haspital

Nguy~n Cong Thanh

86. Thl/c tr<;lngtuan thu quy trinh do de thu'ong cua hQ sinh t~i khaa san B~nh vi~n San 333

- Nhi Tra Vinh nam 2020

The current situattian af camplying with narmal delivery pracedures af midwives at
the department af abstetrics in Tra Vinh Obstetrics and Pediatrics Haspital, 2020

Huynh Thi Tuy~t Minh, Truong Quang Ti~n, T~ Van TrAm

87. Banh gia anh hu'ong tren huyet dQng cua phu'dng phap gay te tuy song - ngaai 337

mang cung phoi hc;1pde mo lay thai tren sim phl,l c6 nguy <i>cd</i> caa tl,lt huyet ap

Hemadynamic effect af cambined spinal epidural anesthesia far cesarean delivery in
patients with risk af hypatensian

Nguy~n Thi Thu Ba, Ngu

y

~n Due Lam, Ngu

y

~n Duy Anh

Trung

tâm

DI&ADR

Qu

ố

c

gia

- Tài

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TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 -

56

2 - 2020

f>i;lihoc Y Ha NQi,Ha NQi,

2. K. M. Matsuda et al., 2019, Skin thickness score
as a surrogate marker of organ involvements in
systemic sclerosis: a retrospective observational

study, Arthritis research & therapy, 21, 1, 129-129

3. 1. Varga, 2014, Overview of the clinical
manifestations of systemic sclerosis (scleroderma)

in adults, UpToDate. Waltham, MA. Retrieved

August,4, 2014

4. V. Leroy et al., 2019, Association of skin
hyperpigmentation disorders with digital ulcers in
systemic sclerosis: Analysis of a cohort of 239
patients,JAm Acad Dermatol,80, 2,478-484

5. S. Amjadi et al., 2009, Course of the modified

Rodnan skin thickness score in systemic sclerosis

clinical trials: analysis of three large multicenter,
double-blind, randomized controlled trials, Arthritis
and rheumatism,60, 8, 2490-2498

6. T. L. Moore, M. Lunt, B. McManus, M. E.
Anderson, and A.L.Herrick, 2003,
Seventeen-point dermal ultrasound scoringsystem-a reliable
measure of skin thickness in patients with systemic
sclerosis, Rheumatolo~y (Oxford), 42, 12, 1559-63
7. L.P. Lan, 2015, f>ac diem lam sang, can lam
s,~ngv~ c~u'cDang t~on~ kh.iyh~i(1benh nhan xo
cl1ng bl h~ thong, LUi;lnan tien Sly hoc, f>ai hoc Y

Ha NQi, . . .

8. N.S.Gohet al., 2008, Interstitial lung disease in
systemic sclerosis: a simple staging system, AmJ
RespirCrit Care Med,177,11, 1248-54

,.." "., , , ,,.. ,..,? A'

TONG KET CAC BAO CAO LIEN QUAN DEN PHAN VE TRONG CO'

<i>sa</i>

,nCr LIEU BAo cAo TU' NGUYEN VIET NAM GIAI DOAN 2010-2019

_.

_...

_.

Truong Th] Mint, Nguy~n Phuong Thuy\ Nguy~n Hoang Anh2,

D~ng Bieh Vi~t2,Cao Thj Thu Huy~n2, Nguy~n Hoang Anh',

,

Vii Dlnh Hoa2, Nguy~n Van Dinh3

T6MTAT.

Nghien oru du'gc tien hanh nham tong ket thong
tin ve cac phan<i>ung</i>phan v~ du'gc ghi nh~n tlt cac bao
cao tlj nguy~n trong <i>cd</i> so dO'Ii~u canh giac du'dc t~i
Vi~t Nam tlt nam 2010 den 2019. Cac bao cao tv'
nguy~n du'gc sang IQ.cdu cac thong tin yeu cau cho
qua trinh danh gia phim ung theo tieu chuan dinh
tru'ck. f>~cdiem cua hOi;ltdQng bao cao, d~c diem cua
thuoc nghi ngo va phim <i>ung</i> phim v~ du'gc ghi nh~n
cling voi t~o.ng tin ve

<i>xu</i>

tri ti;li<i>ddn</i> vi dieu tri <i>du'gc</i>

tong ket va mo ta. Ket qua cho thay phan v~ chiem
13,7%so bao cao tv' nguy~n ADR ti;li Vi~t Nam. f>dn vi
bao cao chu yeu thuQc khoi cong I~p(94,5%). Du'qc

59

la doi tu'gng bao cao phan v~ nhieu nhat(41,4%).
Co81,8%bao cao ghi nh~n thong tin khai thac tien sU'
di<i>ung</i>trong do co 1,6%b~nh nhan co tien sU'di ((ng
voi thuoc nghi ngo va 2,0% b~nh nhan co tien su di
U'ngthuoc cling nhom vOi thuoc nghi n90. Khang sinh
cephalosporinva carbapenem(51,5%tong so bao cao
phan v~), khang sinh penicilin (9,5%), thuDc can
quang(5,3°~o),N~,!\IDst5,oo/~}la.~hO'n~nhom}h~§c
du'gc bao cao nhlE:~unhat. Cac tn~u chl1ng pho bien
nhat cua phan v~ la tren tuan hoan ~75,2%},ho hap
(74,6%), da/niem mi;lc(55,6%). Co 38,4% tru'ong

hgp co bieu hi~n hi;l huyet ap nghiem trQng, 67,9%
tru'ong hqp<i>du'gc</i>can bQy te danh gia la nghiem trQng
va co1,6%tru'ong hgpt(tvong. Corticoid(72,7%)va
adrenalin(68,2%) la2thuDCdu'gc su dl,mg pho bien

<i>) Tfllt7ng Cao Dang DI.I(fc</i>7W<i>Hai Dl.ldng</i>

<i>2Trung tam DI&ADR QG, Trl.lt7ng D~i h9C DI.I(fc HaN9i</i>

<i>3Mnh</i> <i>v$n</i>

<i>Quifc</i>

<i>te'Vinmec TimesCity,</i>

<i>D9i</i>

<i>t'9C VinUniversity</i>

Chiu trach nhi~m chinh: Tru'dng Thi Man
Email:

Ngay nh~n bai:24.9.2020

Ngay phan bi~n khoa hQc:30.10.2020
Ngay duy~t bai:11.11.2020

nhat de xU'tri phan v~.Ket qua nghien ciru cung cap
thong tin can thiet cho hoat dQng theo doi va xU' tri
phan v~ ti;li cac don vi dieu tri cung nhu' gqi y cho cac
giai phap can thi~p cua cac cac<i>cd</i> quan quan Iy doi
voi bien cO'y khoa nghiem trQng nay.

<i>Til'khoa:</i> phan <i>ung</i> phan v~, bao cao ADR, ti Ie

bao cao, xII tri phan v~, adrenalin. .

SUMMARY

ANAPHYLACTIC REACTIONS IN
SPONTANEOUS REPORTING DATABASE OF

VIETNAM FROM 2010 TO 2019

The current study analyses information of
anaphylatic reactions (AR) based on spontaneous
reports to National Pharmacovigilance Center from
2010to 2019. Individual Case Safety Report (ICSR)
were screened for essential information and the AR
was assessed followed a prespecified criteria. The
characteristic of reporting activity, suspected
medications and reported reactions were summarized
and described. The reported AR were in 13,7% of
spontaneous ICSR in Vietnam. The public sector had
major contribution, accounting for94.5%. Pharmacists
were most active reporters contributing to 41,4% of
ICSR.The history of allergy was reported in81,8%of
cases. Of those, allergic to suspected medications or
allergiC to medications which might cross reactivity
with the suspected one were 1,6%· and 2,0%
respectively. The leading suspected medications were
cephalosporins and carbapenems (51,5%), penicilin
(9,5%), contrast media agents (5,3%) and NSAIDs
(5,O%).The manifestations of

RA

occurred mainly in
cardiovascular, repiratory and subcutaneous systems
with prevalence of 75,2%, 74,6% and 55,6%,
respectively}. Severe hypotension was reported in
38,4% of cases. Servere reactions have been
identified by reporters in 67,9% of reports, and the

fatality rate was of1,6%.Adrenalin and corticoid were

323

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VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020

used to manage AR in 72,7% and 68,2% of patients,
respectively), This study provides information for the
management of anaphylatic reactions in healthcare
centers and suggests for the intervention of authority,

<i>Keywords:</i> Anaphylactic reaction, ADR report,

reportingproportion,anaphylaxismanagement,adrenalin

v '" '"'

I. £>AT VAN £>E

Philn v~ la mQt phan ((ng di ((ng toan than,
cap tinh xily ra sau khi tiep xuc voi di nguyen.
Day du'qc coi la mQt trong nhG'ngphan ((ng nguy

hiem nhat tren lam sang do thai gian khoi phat
nhanh, c6 the gayt((vong va khong the dl/ doan
du'qc. Trong cac nguon dG' Ii~u ve philn v~, bao
cilO tl/ nguy~n ve philn ((ng co hc;licua thuoc
(ADR) du'qc coi la n~uon thong tin quan trQng
giup danh gia d~c diem cGng nhu' sl/ hinh thanh
tin hi~u philn v~.Ti;!i Vi~t Nam, theo nghien c((u
cua Le Thi Thuy Linh, so Iu'qng bao cao philn v~
giai dOc;ln2010-2014 ta 2.161 ca, chiem 10,55%
tong so bao cao ADR [2]. Trong giai
dOc;ln2010-2016, Nguyen Khac DGng va cQng sl/ ghi nh~n
55 bao cao philn v~ gU1ve Trung tam DI&ADR
QUocgia la 4.873 ca, chiem 13,2% tong so bao
cao ADR [4], trong do co 111 ca t(( vong (chiem
82% so Iu'qng ca t(( vong trong 7 nam cua toan
bQ<i>cd</i> so dG'Ii~u ADR), trong khi do b~o cao lien
quan den philn v~ chi chiem 0,9% tong so bao
cao trong <i>cd</i> so dG' li~u bao cao ADR toan cau
cua To ch((c

Y

te the gioi (Vigilyze) [5], Xuat
phat tu thl/c te tren, nghien c((u du'qc thl/c hi~n
nham tong ket d~c diem bao cao lien quan den
philn ve trong <i>cd</i> so dG' li~u bao cao

tl/

nguy~n
Vi~t Na'm giai dOc;ln2010-2019 de h~ tr$1cong
tac bao cao,x((tri, dl/ phang va giilm thieu nguy
co cua philn v~.

11.001TlIQNG VA PHlfO'NG PHAp NGHIEN

c(J'u

1.D61tu'dng nghien cuu. Tat cil cac bao
cao tl/ nguy~j, ve philn ((ng co hc;licua thuoc

(bao cao ADR) do can bQ y te tren phc;lmvi cil
nu'oc gU1ve Trung tam DI&ADR QUoc gia giai
doan 2010-2019.

'Du'a vao tieu chuan chan doan cac tru'ong
hdp 'philn v~ du'qc quy dinh trong Thong tu'
si/2017/TT-BYT [1], cac bao cao philn v~ du'qc
du'a vao nghien c((u neu thea man 1 trong 2
dieu ki~n sau:

<i>- £)u'qc</i>can bQy te me til la soc philn v~ ho~c

philO ((ng philn v~

- ADRxuat hi~n trong yang 1 ngay tinh,tu Ian
dung thu5c cu5i cung va co it nhat mQt bieu hi~n
tren 2 trong 4 h~<i>cd</i> quan da/niem mc;lc-hohap
-tieu hoa-tim mc;lchho~c co bieu hi~n hi;!huyet ap
nghiem trQng.

324

<i>Tieuchuanloai tnn</i> Cac bao cao ADR thieu

thong tin ve thucc'nghi ngo va bieu hi~n ADR.
2. Phu'dngphap nghh1!ncuu. Mo ta thong
qua hoi cuu cac tru'ong hop phan v~ du'qc bao

cao

ve Trung tam DI&,ADRQuoc gia trong giai
doan 2010-2019 voi cac chi tieu: So IWng,

tY

I~
bao

cao

phan v~ trong <i>cd</i> so dG'Ii~u theo

nam:

thong tin hanhchinh ghi nhan tu bao

cao

phan
v~; <i>D~c</i> diem b~nh nhan ghi nhan

<i>tu</i>

bao cao
phan v~;<i>D~C</i>diem cua thucc nghi ngo gay phan
v~; <i>D~c</i> diem cua phan v~, cach xU' tri va ket
qua sau xU'tri

Nhom thuoc c~a cac hOc;ltchat nghi ngo gay
phan v~ du'qc phan 10c;lidl/a tren<i>cd</i> so phan 10c;li
rna ATC).Thai gian tiem tang xuat hi~n philn v~,
bieu hi~n cua philn

1~

tren cac h~<i>cd</i> quan (phan
10i;!itheo Hu'ong dan WHO - ADR Terminology
2012) [6], m((c dQ nghiem trQng cua cac tru'ong
hdp philn v~ phan10c;litheo Brown [3] va Hu'ong
d§n QUocgia ve Cilnh giac<i>Du'qc.</i>

3.

xU'

Iy dU' Ii~u.Toan bQ dG' Ii~u du'qc
nh~p, xU'1'1'tren phan mem Microsoft Office
Excel 2016 va SPSS22.0. Cac bien du'qc thong
ke theo tan suat va

tY

I~ phan tram.

III.

KET

QuA

NGHIEN CU'U

<i>Tu</i>

73447 bao cao

tl/

nguy~n Iu'utrG'ti;!i trung
tam 01 & ADR Quoc gia giai dOc;ln2010-2019,
sau khi 10i;li1971 bao cao, co 10027 bao cao
philn v~ da du'qc du'a vao nghien c((u.

Sc)Iu'qng,

tV

I~ bao cao phim v~ thf!o nam

2500 20

18

,,po2000 16

>

c 14

-III

12

'i

"E.1500

0 10 ...

-III _:!!'

u

o 1000 8

?:

-III

.0 6

~ 500

0 0

20102011 2012 2013 20142015 2016 20172018 2019

... 56bao,aoph"nv~ _ <i>TV</i>I~vOlt6ngsobaD cao nghlen c(I'U(%)

<i>Hinh</i>1:<i>So'lutlng va</i>

<i>tY</i>

<i>I~ bao caophan v~</i>

<i>theo tung nam</i>

So Iu'qng bao cao philO v~ tang aan qua cac
nam

tlt

155 bao cao (nam 2010) len 2235 bao
cao nam 2019 (hinh 1). T'1 I~ bao cao philn v~
tren tong 55 bao cao ADR cua tung nam dao
dQng trong khoilng 9,1%-17,3% quanh gia tri
trung binh la 13,7%

D~c diem cua ho~t dQng bao cao.<i>Ddn</i> vi
bao cao chu yeu thuQc khoi cong I~p (94,5%)

</div>
<span class='text_page_counter'>(12)</span><div class='page_container' data-page=12>

TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 -s62 - 2020

trong do benh vi~n tuyen tinh/thanh pho la don

v] tham gia bao cao nhleu nhat (chiem 44,8%),

khoi benh vlen tu'nhan chi chiem 5,5%. Ducc

s9

va bac

s9

la 2 doi W<;1ngbao cao phan v~ nhieu

nhat, fan 1u'<;1tchlern 41,4% va 32,9%, dieu

du'ong (19,2%),cac doi tu'<;1ngkhac (3,0%).

<i>Bang</i>1:<i>S~c diem thong tin hanh chinh</i>

A • , , • A

<i>ghi nhan tv bao cao phan ve</i>

TYI~
Thong tin himh ehinh ghi Solu'qng (%)

nh~n

<i>tit</i>

bao efto phim v~

~c

phim v~ (n

=

10027'
Oan vi bao e,ao

Benh vien tuyen'Trung u'dng 1228 122
B~nh vi~n tuyen tinh/thanh ₄₄₉₃ _44,8

pho

Benh vien tuyen quan/huyen 3317 33,1
Benh vien tu' nhan 552 55

Be'nh vien nganh 241 2,4
Tru'ong f)ai hoc Y Du'dc 196 2,0

001

tu'ang bao eao

Bac Sy 3301 329

Du'dc Sy 4153 414

f)ieu dtiong 1923 19,2

Khac 296 3,0

Khong co thong tin 354 35

Thai gian bao eao

< 1 tuan 2631 26,2

1 tuan - 1 thanq 3688 36,8

>

1 thang 3640 36,3

Khong co thong tin

I

68

I

0,7

I

Cacbao cao phan v~duoc glri den Trunq tam
trong vonq 1 tuan chiem 26,2%, tu 1 tuan - 1

thanq (36,8%), tren 1 thang (36,3%). Co 0,7%
bao cao khong xac dinh du'<;1ckhoimg thai gian
bao cao. Tronq 8205 bao cao (chlern 81,8% tong
so bao cao phan v~) co ghi nh~n thong tin ve
vi~c khai thac tien SlI d! lIng, co 162 benh nhan
(1,6%) co tien SlI d! lIng vOi chfnh thuoc nghi

ngo gay phim v~, 202 b~nh nhan (2,0%) co tien
SlI d! lIng vOi thuoc cling nhom voi thuoc nghi
ngo gay phim v~.

f)~e diem ella thuoe nghi ngo gay phan

v~. Phim v~ du'<;1cghi nh~n vOi hau het cac nhom
thuoc, trong do nhG'ng nhom thuoc du'<;1Cbae
cao nhieu nhat bao gem: nhom thuoc khang
khuan tac dl:mg tean than (J) chiem 76,7%,
nhom thuoc tac dl:mg tren h~ than kinh (N)
chiem 8,82%, mau va <i>cd</i> quan t<;le mau (B)
chiem 6,6%, h~ <i>cd</i> -xu'dng (M) chiem 6,28%,
thuoc can quang chiem 5,3% (bang 3). NhG'ng
hQ du'<;1cIy hay g~p trong cac bao cae phan v~
bao gem: khang khuan' nhom cephalosporin va
carbapenem (chiem 51,5%), khang khuan nhom
penicilin (chiem 9,5%), thuoc can quang (chiem
5,3%), NSAIDs (chiem 5,0%). Trong 566 thuOc
nghi ngo khac nhau da du'<;1cghi nh~n trong cac
bao cae phan v~ co 10 thuoc nghi ngo co tan
suat gay phan v~ cao nhat du'<;1ctrinh bay trong
Bang 2.

<i>Bang</i>2.<i>Sac diem thuoc nghi ngtYgay phan ve</i>

Nh6m thuoe - ma ATe Sobao eao_{phan ve} _(n=10027)Ty Ie0/0

Khang khuan tac dung toan than (J) 7687 76,7

1 J01D - khang khuan beta-Iactam khac 5166 515

2 J01C- khang khuan nhom beta-Iactam he penicilin 949 95
3 J01M- khang khuan nhom quinolon, khang khuan khac 1572 157

He than kinh (N) 884 88

1 N02-thuoc giam dau 338 3,4

2 N01-thuoc gay me va gay te 401 4,0

3 cae loai thuoc khac 145 1,5

Mau va<i>cd</i> quan tao mau (B) 665 66

1 B05-chat thay the mau va dich truyen 435 4,3

2 B02-thuoc cam mau, cae thuoc khac 230 23

He cd-xu'dnq (M) 630 6,3

1 M01A-NSAIDs 503 50

2 M03-thuoc qian <i>cd</i> 'M04-thuoc chonq qout 127 1,3

V08-thuoc can quanq 534 5,3

Cac nhom thuoc khac 1073 107

Mltai hoat chat nghi ngo gay phan ve nhieu nhat

1 Cefotaxim 1668 16,6

2 Ceftriaxon 955 9'5

3 Ceftazidim 720.,. 7,2

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<span class='text_page_counter'>(13)</span><div class='page_container' data-page=13>

VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020

4 Diclofenac 289 2,9

5 Cefuroxim 254 2,5

6 Iobitrldol 251 2,'5

7 Ciprofloxacin 247 2;5

8 Cefoperazon 241 2',4

9 Paracetamol 216 22

10 Cefoperazon/sulbactam 213 2,1
f)u'ong dung cua cac thuoe nghi ngo gay phan ve

1 Tinh mach 7850 78,3

2 Uong 1794 17,9

3 Tiem bap 1011 10,1

4 Du'ong dung khac 686 6,84

-

, , A

.-

N , A , ,

-

,

Nhung du'ong dung pho bien nhat trong cac bao cao phan

<i>ve</i>

la du'ong tmh mach (78,3%), du'ong
uong (17,9%), du'ong tiem bap (10,1%). Cac du'ong dung khac (bao gam: gay te, tiem du'oi da, d~t
h~u mon, khf dung, ng~m du'oi Iu'Oi,du'ong dQngmach, born vim

tlt

cung, thuy cham, nho mat, nho

mUi) chiem 6,84%.

f)ije diem ella phim v~ ghi nh~n trong bao cao. Da so cat baocao phanv~ co thai gian tiem
tang du'oi 10 phut (49,2%), 32,5% phan ltng xay ra trong yang tU' 10 phut den 1 giO va chi co 7,7%
cac tru'ong hcp xay ra sau 1 gia. Co 10,6% bao

cao

khong ghi r6 thai gian tiem tang xuat hi~n phan v~.

<i>B'ang</i>3 8

.

.

<i>ac</i>v <i>tlt</i>

<i>tem</i>

<i>A'</i> <i>cuap, an•</i> <i>h'</i>

<i>ve</i>

Agj<i>h'In an trong aocao</i>hA <i>b"</i>

SoBC phan Ty I~(0/0)

NQidung (n=

v~

₁₀₀₂₇₎

Bieu hien eua phan ve

H~ tim m~eh: h~ huyet ap, m~ch nhanh, nhip tim nhanh, lo~n nhip, m~d ₇₅₄₂ _75.2
cham khonQ bat du'dc, dai tieu tien khong tu' chu, nQat

H~ ho hap: suy ho hap, kho tho, co that phe quan, tho khe, tho rft, thanh ₇₄₈₁ _74.6
Quansu'ng, phu du'onQho hap

Da/niem mac: ban do, me day, phu mach, nglta da, do va nglta mat 5576 55.6
He tieu h6a: dau thu'dng vi, tieu chay, non lien tuc, dau bl,lng dG'd6i 2729 27.2
Bieu hi~n khae: v~t va, va rna hoi, suy da t~ng, ret run, sot cao, hoa ₂₉₆₆ _29.6

mat, chong mat, gong cltng ngu'ai

Mlte do nghiem trong ella phim ve phan loai theo Brown

[3]

Nghiem trong mlte do

1

5376

53.6

Ha huyet ap nghiem trQng 3851 38.4
Bieu hien thieu oxY mau 1701 17.0
Bieu hien tren he TKTW 1367 13.6
Nghiem trong mlte do

2

4632

46,2

Khong xae dinh du'de

19

<i>0l_2</i>

Mlte do nghiem trong e(la phim ve phan loai theo bieu mau bao eao ADR

Tuvong 156 1,6

De doa tfnh mang 5069 50,6
Nhap vien/keo dai thoi Qian nam vien 1697 16,9
ran tat vinh vien/nanQ ne 43 0,4

Khong nghiem trong 2021 20,2

Khong r6 13 0,1

Kh6ng co thong tin 1028 10,3

.

A , .A .A .'" _'" A A ,

,.

A

'"

Phan v~ thu'ong du'c;1cbleu hl~n pho bien nhat tren h~ tim m~ch (75,2%) va h~ ho hap (74,6%) .
Tri~u ch((ng tren da ho~c niem m~c du'c;1cghi nh~n tren 55,6% so bao cao, tren tieu hoa (27,2%),cac
bieu hi~n khac (29,6%). Cac bao cao co bieu hi~n nghiem trQng mltc 1 chiem 53,6% voi tl,lt huyet ap
nghiem trQng 113bieu hi~n pho biet nhat, chiem 38,4%. Bieu hi~n thieu oxy va thieu mau chiem ran
1u'c;1t17,0% va 13,6%. Da so phan v~ du'c;1ccan bQy te danh gia la nghiem trQng, chi co 20,2% phan
v~ du'c;1Ccoi 113kh6ng nghiem trQng.

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<span class='text_page_counter'>(14)</span><div class='page_container' data-page=14>

TAP CHi Y HOC VIET NAM TAp 496· THANG 11·562·2020

<i>Bang</i>4. <i>Dac diem ve xu</i>

<i>tri</i>

<i>phan ve ghi nhan trona bao</i>

<i>ceo</i>

each

xU'tri

<i>Sa</i>

Be

Ty I~(%) Kit qua sau xU'tri

<i>Sa</i>

Be

jry I~(0/0

phi,"v~ (n= tOO27) phan v~ (n=

tOO27)

Corticoid 7294 72,7 TU'vong 163 f,6

Adrenalin 6834 68,2 Chua hoiphuc 253 2',5

Lieu phap oxy 4710 47,0 Dang hoi phuc 3203 31;9

Khang histamin Hl va H2 4658 46,4 Hoi phuc co di chunq 92 0,9

Truven dich 4159 41;5 Hoiphuc khong co di chung 5383 53,7

Thuoc khac 790 7,9 Khong ra 200 2,0

Kich

thich

beta 2 400 4;0 Khonocothong tin 733 7,3

Van mach_, khac _, 366 _, 3,7

A

.

~

~ A , , A ~ .~

C~rtlcold va,adrenal,1nI~ du'Q'c

<i>~u</i>

dunq p~o bien nhe~de

<i>xu</i>

tnAphan,v~, la~ 1u'Q'tchlern72,7% va

68!! <i>Vo.,</i>K:t 9ua s~u

<i>~u</i>

tn ch? thay ca~ tru'ong hop hOIphuc khong co di chung va dang hoi phuc

chiem

tV

I~ Ion nhat, Ian 1u'Q'tla 53,7% va 31,9%. Co 163 ca ghinhantu vong<i>ung</i>vai 1,6%. .

IV. BAN LU~N .

cac

tru'onghopnhi~m khuan n~ng. Ngu'Q'clC;lithi

Nghien CtIUda cho thay so 1u'Q'ngbao

cao

lien penicilin la mQt thuoc da du'Q'ccanh baonhieu ve

quan den phsn v~ ghi nh~n du'Q'ctang theo thai c~c tru'ong hQ'pphsn v~ do do ft du'Q'ccan be?y

gian trong 10 nam khso sat. Khang sinh trong do te h/a chQnsu dl,Jngtrong dieu trio

nhom cephalosporin va carbapenem du'Q'cghi Nhom thu5c co so bao cao phsn v~ CqOthu'

nh~n la cac thuOc pho bien nhat lien quan den hai trong <i>cd</i> so dCi' Ii~u la thu5c csn quang

phsn <i>ung</i> phsn v~. Bh~uhi~n cua phsn v~ da (5,3%)" trong do dung dau la iobitridol (2,5%).

dC;lngva xuat hi~n chu yeu tren h~ ho hap va tim Theo ca:: nghien nay, iopromid la thuoc csn

mC;lch.Phan Ian cac phsn ung

0

<i>muc</i>

de?nghiem qu~ng lien quan den nhieu tru'ong hQ'pphsn v~

trQng va du'Q'CxU' trf bang adrenalin cung nhat, trong khi nghien cuu cua ch(mg toi

corticoid. Da co 1,6% so bao cao ghi nhan benh iopromid chidung thu 2 vai 1,1%. Su' khac biet

nhan tU'vong. . . nat co the den tlt vi~c iobitridol du'~c sU'dl,m'g

So 1u'Q'ngbao cao phsn v~ tang dan theo tltng nhieu hdn i<?promid.Nghien cuu cua ch(mg toi

nam,

tY

I~ bao cao phsn v~ cung co xu hu'ang cho thay, bieu hi~n tren tuan hoan la thu'ong g~p

tang va dao de?ng quanh gia tri trung binh nhat (75,2%) sau do den bieu hi~n tren ho hap

13,7%.

TV

l~

nay cao hdn

tY

I~

10,5% trong (74,6%), da/niem mC;lc (55,6%), tieu hoa

nghien cuu cua Le Thi Thuy Linh giai dOC;ln2010- (27,2~0).:.MQt nghien cuu hoi cuu thl/c hi~n tC;li

2015 [2]. So sanh vai <i>cd</i> so dCi'lieu bao cao tu' An DQcung cho ket qus vai ket cau tu'dng tu'vai

nguy~n Vigilyze cua To chuc Y te the giai (2010~ bieu hi~n tren tuan hoan chiem 98,15%; ho

2019) thi

tY

I~ nay la 0,9%[5]. Ket qus nay mQt h~p(81,48%), da (72,2%), tieu hoa (9,26%) [7].

m~t cho thay nh~n th((c cua can bQ y te trong Ty I~ ~ay cao hdn trong nghien cuu cua chung toi

vi~c phat hi~n va bao cao nhCi'ngphsn ung nay co the do can

be?

y te thu'ong mo ts ngan gQn

tai Trung tam 01 & ADR Quac Gia da du'dc cai phan v~ chu khong mo

til

chi tiet cac bieu hien

thi~n, m~t khac phsn anh thoi quen sU"dung tren tat ca cac h~<i>cd</i> quan. .

thuoc tren lam sang cua can bo y teo . Nghien cU'Ucung ghi nh~n 53,6% phim v~

Cephalosporin va carbapenem (chu yeu la xay ra

<i>muc</i>

de?nghiem trQng va co 1,6% tru'ong

khang ~nh cephalosporin) c~

tY

I~ gay phsn v~ h9P t~ vo~g I~en

9

uan denAphanv~.,

sy

k~ac bi~t

cao nhat (51,52%) - cao gap hdn 5 Ian nhom nay co the den tIf hOC;ltdQng canh bao tlch cl/c

penicillin (9,5%) trong nghien cuu cua chung toi. trong h~ thong y te tru'ac do ve h~u qua dang

Ket qua nay khac vai me?tsO'nghien cuu

0

Chau ti~c cua phan v~ neu khong du'Q'cxU'trf kip thai

Au da du'Q'ccong b5 tru'ac do khi ma khang sinh cung nhu' vi~c tang cu'ong cong tac quan IV,

penicillin luon du'Q'cghi nh~n la thu5c co

tY

Ie giam sat phan v~ trong cac<i>cd</i> so y te nen cac

gay phan v~ cao nhat nhu'ng tu'dng tl/ vai mot can be?y te da

<i>V</i>

thU'c hdn trong vi~c dl/ phong

nghien cuu hoi cuu

0

Trung Quac vai 34,5

0

/0 va xU' trf phan v~. Phan v~ Iii phan ung co the

cephalosporin va 7,9% penicillins. Nguyen nhan phong tranh du'Q'cneu tim hieu ky tien sU'di ung

co the do xu hu'ang va thoi quen sU'dl:mg khang c~a b~nh nhan nhu'ng tren thl/c te, can bo y te

sinh cua can bo y te

0

Viet Nam khi nhom van chu'a chu trQng den dieu nay do do v§n co

cephalosporin dJQ'c dung ph6 bien hdn dOi vai mQt

tY

I~nho b~nh nhan g~p phsn v~ vai thuoc

327

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<span class='text_page_counter'>(15)</span><div class='page_container' data-page=15>

VIETNAM MEDICAL JOURNAL N2 ã NOVEMBERÃ 2020

dĐ tung gay di ((ng (1,6%) ho~c thuoc cling

nhorn voi thuoc gay di ((ng (2,0%).

Nghien cuu cua chung toi cling ghi nhan
72,7% tnJ'ong hop str dunq corticoid, 68,2% sU'

dunq adrenalin.Con ket qua trong nghien ciru

<i>a</i>

Trung QUoc,

tY

I~benh nhan sU'dunq adrenalin
la 59,5%. Trong mQt so nqhlen cuu khac, bien
phep dlJ'qc sU' dunq nhieu nha't la corticoid va
khanq histamin Hl, tuy nhien ngoai adrenalin
cac bi~n phap tren phI,!thuQc vao bieu hi~n phan
v~ va cach xU' tri clla bac si nen

tY

I~ giiIa cac
nghien c((u chenh I~ch nhieu. NhlJ'v®y, vi~c dao
t~o dinh ky nham giup can bQ y te t~i cac<i>cd</i>

<i>so</i>

kham chiIa b~nh nam viIng kien th((c ve phat
hien va xU'trf la van de can thiet neu muon tang

tY

'I~ xU'trf phu h<;1ptren thl/c teo

v.

KET LU~N

Nghien c((u d§ cho thay hinh imh ve thl/c
hanh bao cao lien quan den cac trlJ'ong phan v~
ghi nh~n tls' h~ thong bao cao tl/ nguy~n clla Vi~t
Nam giai do~n 2010-2019 ve d~c diem clla ho~t
dQng baa cao, d~c diem clla thuoc nghi ngo va
phan lfng phan v~ dlJ'<;1cghi nh~n cung voi thong
tin ve xU'trf t~i ddn vi dieu trj. Ket qua tls' nghien
clfu d5 cung cap nhiIng thong tin hiIu fch giup
cho vi~c dl/ phong va xU' trJ phan v~ tren lam
sang, tuy nhien day la cac bao eao tl/ nguy~n
nen khong the tranh du'<;1ehi~n tu'gng bao ca,o
du'oi mlfc thl/e teo Can tiep tl,!Cdjnh ky tong ket
cae bao cao tl/ nguy~n de cung cap cae bang
ch((ng cho thl/e hanh gii~mthieu nguy<i>cd</i>tai bien

do phan v~ tat cac don vi dieu trio
TAl LIEU THAM KHAo

1. BO

Y

te(~017~,Thanatu'sO51/2017{1T-BYTve vi~

"HtJ'angdan phong,chandeanva xU'trlphan v~".

2. LeThj Thuy Linh (2015), "Danh gia sl/ hinh
thanh tin hi~\.Jva cacf xU'tn cac tnlonq hop phan
v~ nr dO',li~l!,bao cao ADR tl/ nguy,~ntal Vi~t
Nam", Luc;tnvanthac siduoc hoc,TrtJ'dngDc;tihoc

Duoc Ha Nai.

3. Brown S: G. (2004), "Clinical features and
severity grading of anaphylaxis", J Allergy Clin
Immunol, 114(2), pp. 371-6.

4. Nguyen K. D., Nguyen H. A.,et al. (2019),

"Drug-Induced Anaphylaxis in a Vietnamese
Pharmacovigilance Database: Trends and Specific
Signals from a Disproportionality Analysis", Drug
Saf, 42(5), pp.671-682.

5. Uppsala Monitoring Center(2019), "Vigilyze
-an inst-ant graphical overview of global data to
support evaluation of domestic data (avaiable for
National PharmacovigilanceCenters participating in
WHO Programme for International Drug
Monitoring). Retrieved in Oct 1st 2020 at
pp.

6. WHO/Uppsala Monitoring Center (2012),

"WHO Adverse reactions Terminology", pp. 8-178.

7. Patel Tejas K, Patel Parvati B,et al. (2014),

"Drug-induced anaphylactic reactions in Indian
population: A systematic review", Indian journal of
critical care medicine: peer-reviewed, official
publication of Indian Society of Critical Care
Medicine,18(12), pp. 796.

8. Ye Young-Min, Kim Mi Kyeong, et al. (2015),

"Predictors of the severity and serious outcomes of
anaphylaxis in Korean adults: a multicenter
retrospective case study", Allergy, asthma &
immunology research, 7(1), pp. 22-29.

DAC DIEM NGUCYIB~NH SUY TIM M~N, TINH T~NG

LO

Au vA

KEi

QuA

CHAM SOC NGUCrI B~NH T~I KHOA TIM M~CH LAo HQC

-BENH VIEN TIM MACH AN GIANG NAM 2020

.

.

_.

T6MTAT.

Nghien cltu me ta cat ngang tren 209 ngtJ'oi~nh
suy tim mc;tnnh~p vi~n tc;tiB~nh vi~D Tim mc;tchAn
Giang (BVTMAG),tu thang 01/2020 den 06/2020. Ml,1c
dfch cua nghien cU'utim hieu cac yeu to lien quan den

10au va danh gia ket qua cham soc cua b~nh nhan
suy tim nh~ vien tai BVTMAG.Ketqua: Nhom tren
60 tuoi chiem (85,60/0),tuoi trung binh72 :I:: 12, nO'

<i>*Tru'ifng Dai Hoc TMng Long</i>

Chiu trach nhiem chinh: Nguy~n Ceng Thanh
Email:

Ngay nh~n bai: 28.9.2020

Ngay phan bi~n khoa hQc: 30.10.2020
Ngayduy~t bai: 10.11.2020

328

Nguy~n Cong Thimh*

chiem (63,2%), trinh dQ hQc van < cap 1 (59,8%),
nghi htJ'u (85,6%), song 0 nang then (74,6%), thu
nh~p < 2 tri~u dang/tnang (80,4%), tien sU'suy tim
(60,8%). Tinh trc;tngnh~p vi~n co kho tho (54,1%1,
nang ngtJ'c (44,5%), phu chi (22%), tinh mc;tchnoi
(35,4%).' Hong cau (4,2 :I:: 0,7), Ure (6,8 :I:: 4,8)
Creatinin (112,8 :I::156,9), Natri (135:I::5,3), Kali (3,4
:I::0,4), NT ProBNP(2721,7:I::384,5. Suy tim nh~ (I +

II) 68%, suy tim n~ng (III

+

IV) 32%.

TV

I~ngtJ'oi
benh10au trong nghienCIIU55,5%. Sau dfeu tri va
cham soc diem trung binh cua tnang diem DASSgiam

tU' 9,1 :I::0,4 xuong con 3,61 :I::0,2 (p < 0,001). Cac
yeu to co anh htJ'ongden 10 au bao gam: thu nh~p
thap (OR = 2,06; KTC95% = (1,0 - 4,0); P = 0,046),
thai gian suy tim > 1 nam {OR = 2,57; KTC95% =
(1,4 -4,5); P= 0,001), co mOt dQST n~ng (OR=2,04;

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