Tải bản đầy đủ (.pdf) (63 trang)

Định lượng đồng thời amoxicillin và cloxacillin trong chế phẩm bằng phương pháp quang phổ đạo hàm

Bạn đang xem bản rút gọn của tài liệu. Xem và tải ngay bản đầy đủ của tài liệu tại đây (26.36 KB, 63 trang )

ĈҤ,+Ӑ&48Ӕ&*,$+¬1Ӝ,
75ѬӠ1*ĈҤ,+Ӑ&.+2$+Ӑ&7Ӵ1

----------------------------

9NJ7QJ/kP

Ĉӎ1+/ѬӦ1*ĈӖ1*7+Ӡ,
A02;,&,//,19¬&/2;$&,/
7521*&+ӂ3+Ҭ0%Ҵ1*
3+ѬѪ1*3+È33+ӘĈҤ2+¬

/8Ұ19Ă17+Ҥ&6Ƭ.+2$+Ӑ&

+j1ӝL
- 2014
1


,
+&48&*,$+ơ1,
751*,+&.+2$+&71

----------------------------

97QJ/kP

1+/1*1*7+,
$02;,&,//,19ơ&/2;$&,
7521*&+3+0%1*
3+1*3+ẩ33+2+ơ



&KX\rQQJjQK+yDSKkQWtFK
0mV
: 60440118

/81917+&6.+2$+&

1*,+1*'1.+2$+&
: 7691*+2ơ
AA
76/ầ7++1
A

+j1L
- 2014


/Ӡ,&Ҧ0Ѫ1

1KkQ GӏS KRjQWKjQK OXұQ YăQ 7KҥF

OzQJELӃWѫQVkXVҳFY
jOӡLFҧPѫQWӟLFiFWKҫ\

QKӳQJQJѭӡLÿmJL~SÿӥW{LWURQJWKӡ

7UѭӟFKӃWW{L[LQEj\WӓOzQJNt
TS. 9NJ

ĈһQJ +RjQJ

QJѭӡL WKҫ\
KѭӟQJ
NtQK PӃQ
GүQ
ÿm
JL~S ÿӥ

NLӋQWKXұQO
ӧLÿӇW{LKRjQWKjQKOXұQYăQQ

7{L[LQWUkQWUӑQJFҧPѫQ
TS. /r7Kӏ+ӗQJ+ҧR
- 9LӋQ
3Ky
9LӋQ9Ӌ

6LQK$Q7RjQ7KӵF3KҭP4XӕF*LD
QJѭӡL
ÿm
WұQWuQKFKӍEҧR

WURQJVXӕWTXiWUuQKWKӵFKLӋQÿӅWj

7{L[LQJӱLOӡLFҧPѫQFKkQWKjQK
FiF
WK̯\F{WURQJ%͡
+yD

3KkQ7tFK
ÿm

KӃWJL~STXDQWkP
JL~Sÿӥ
W{L
WURQJTXiWUuQKK
KLӋQOXұQYăQ

7{L[LQWUkQWUӑQJFҧPѫQ
%DQJLiPK
L͏X3KzQJĈjRW̩R

Yj
FiFWK̯\F{JLiRWU˱ͥQJ
.KRD+͕F7͹1KLrQ+j1͡L
ÿmJLҧQJGҥ\
o

ÿLӅXNLӋQWӕWQKҩWFKRTXiWUuQKKӑF

T{L
FNJQJ
[LQJӱLOӡLFҧPѫQ
FKkQWKjQKQKҩW
WӟLQKӳQJQJѭӡ

OX{Q
ViWFiQKÿӝQJYLrQW{L
WURQJKӑFWұSFNJQJQKѭWU
.

9jFXӕLFQJW{L[LQEj\WӓOzQJ

kXVҳFQKҩWWӟL

\rXQKӳQJQJѭӡLÿmOX{QӣErQFҥQK

+j1͡LWKiQJ
4
+͕FYLrQ

9NJ7QJ/kP

1


0Ө&/Ө&

7UDQJEuD
0өFOөF
'DQKPөFFKӳYLӃWWҳW
'DQKPөFFiFEҧQJ
'DQKPөFFiFKuQK
/Ӡ,&Ҧ0Ѫ1
0ӢĈҪ8
....................................................................................................................1
&+ѬѪ1*7Ә1*48$1
.....................................................................................3
7Ә1*48$19ӄĈӔ,7ѬӦ1*3+Ỉ17Ë&+
..........................................3

0ӝWVӕÿһFÿLӇPKyDFӫD$PR
...........3


 ĈһF ÿLӇP GѭӧF ÿӝQJ KӑF Yj ÿӝ
Cloxacillin [5] .....................................................................................................4
1.1.2.2. Cloxacilin [5]. ........................................................................................5

1.27Ә1*48$19ӄ3+ѬѪ1*3+È33+Ỉ1
...............................6

&iFSKѭѫQJSKiSÿӏQKOѭӧQJDPR
6

.ӃWOXұQYӅFiFSKѭѫQJSKiSSK
.................................7

 7Ә1* 48$1 9ӄ  3+ѬѪ1*
48$1* 3+Ә
 3+È3
ĈҤ2 +¬
(Derivative spectrophotometry)...........................................................................7
.KiLQLӋP
.................................................................................................7

 &iF SKѭѫQJ SKiS ÿӏQK OѭӧQJ Kӛ
ÿҥRKjP
.............................................................................................................15


J3KѭѫQ
SKiS ÿҥR KjP JLDR
-crossingLP

derivative NK{Q
spectrophotometry) ...........................................................................................16

 3KQJ SKiS R KjP SK W
Spectrophotometry) ..........................................................................................17

QJGQJTXDQJSK
RKjPWURQJQKOQJW
9LW1DP
...........................................................................................................19

&+1*,71*9ơ3+1*3+ẩ31*+,
...................22
,71*1*+,ầ1&8
....................................................................22
7+,7%1*+,ầ1&8
..........................................................................22

ii


1,'81*1*+,ầ1&8
........................................................................23

;k\QJSKQJSKiSQKO
SKQJSKiSTXDQJSK89
-9,6YjVFNờOQJKLXQ
.....................23



GQJ
QJ QK OQJ QJ WKL $
Faclacin 2 ..........................................................................................................24
;OờNWTXWKFQJKLP>@
................................................................24
&+1*.7489ơ7+2/81
.........................................................25

 3+1* 3+ẩ3
* 3+Ә
48$1
;È& Ĉӎ1+ ĈӖ1* 7+Ӡ,
CLO ......................................................................................................................25
&KXҭQEӏPүXQJKLrQFӭX
.......................................................................25

;k\GӵQJSKѭѫQJSKiS[iFÿӏQK
.......................26
ĈӝOһSFӫDSKѭѫQJSKiS
.........................................................................34
Ĉӝÿ~QJFӫDFiFSKѭѫQJSKiS
...............................................................36

3+ѬѪ1*3+È36Ҳ&.é/Ӓ1*+,ӊ81Ă1*
...........................37
&KXҭQEӏPүXQJKLrQFӭX
.......................................................................37

ҥL
.LӇP

SKѭѫQJ
WUD OSKiS VҳF
&{QJ
Nê OӓQJ
W\ &ә
iS
S
'ѭӧFSKҭP7UXQJѭѫQJ
................................................................................37

.KҧRViWWtQKWtFKKӧSFӫDKӋ
......................................................41

.KҧRViWÿӝOһSFӫDSKѭѫQJSKi
..........................................................42

.KҧRViWÿӝÿ~QJFӫDSKѭѫQJSK
.......................................................43
.ӂ748Ҧ3+e3Ĉӎ1+/ѬӦ1*
..............................................................44
&+ѬѪ1*.ӂ7/8Ұ19¬Ĉӄ;8Ҩ7
.............................................................46
7¬,/,ӊ87+$0.+Ҧ2
......................................................................................47

iii


'$1+0Ө&&+Ӳ9,ӂ77Ҳ7


AMO

: Amoxicilin

CLO

: Cloxacilin

HPLC

: 6ҳFNêOӓQJKLӋXQkQJFD

3Ĉ+

3KәÿҥRKjP

3Ĉ+7Ĉ

: 3KәÿҥRKjPWӹÿӕL

TLTK

: 7jLOLӋXWKDPNKҧR

VKNTW

9LӋQ.LӇPQJKLӋP7KXӕF

iv



'$1+0Ө&&È&%Ҧ1*

%ҧQJ  0ӝW Vӕ ÿһF ÿLӇP KRi Oê Fӫ
CLOXACILLIN NATRI .............................................................................................3

%ҧQJӬQJGөQJTXDQJSKәÿҥRKjPӣ
...........20

%ҧQJ.ӃWTXҧNKҧRViWNKRҧQJWX\ӃQ
................................................32

%ҧQJ.ӃWTXҧNKҧRViWNKRҧQJWX\ӃQ
..............................................33

%ҧQJ.ӃWTXҧNKҧRViWNKRҧQJWX\ӃQ
-VIS.
...................................................................................................................................34

%ҧQJĈӝOһSFӫDFiFSKѭѫQJSKiSTXD
-VIS...........................................35

%ҧQJ.ӃWTXҧÿӏQKOѭӧQJKӛQKӧSPү
EҵQJFiFSKѭѫQJSKiSTXDQJSKә
.............................................................................36

%ҧQJ.ӃWTXҧNKҧR
ViWNKRҧQJWX\ӃQWtQKFӫD$02
...............................38


%ҧQJ.ӃWTXҧNKҧRViWNKRҧQJWX\ӃQ
.................................39

%ҧQJ.ӃWTXҧN
KҧRViWNKRҧQJWX\ӃQWtQKJLӳD
$02Yj&/2
............................................................................................................40

%ҧQJ.ӃWTXҧNKҧRViWWtQKWKtFK
............................41
%ҧQJĈӝOһSFӫDSKѭѫQJSKiS+3/&
..............................................................42

%ҧQJ.ӃWTXҧÿӏQKOѭӧQJKӛQKӧSP
.......43

%ҧQJ.ӃWTXҧÿӏQKOѭӧQJ$02WURQJ
.....................44

%ҧQJ.ӃWTXҧÿӏQKOѭӧQJ&/2WURQJ
......................45

v


Danh mục các hình

+uQK3KKSWKYjRKjPFDG
...9


+uQK3KKSWK D
SKәÿҥRKjP
 F
 GҧL

FӫDFKҩWFyFQJYӏWUtYjFQJÿӝFD

trans ±VWLOOEHQWURQJF\FORKH[DQ G
YjSKә
 H
EұF I
...................................................................................................................................10

+uQK
ҦQKKѭӣQJFӫDWiQ[ҥiQKViQJO
ҩSWKөYjSKәÿҥR
11

+uQK3KkQELӋWFiFGҧLSKәEҵQJSK
........................................12

+uQK3KѭѫQJSKiSSHDN
±]HUR ]QWӹOӋYӟLQӗQJÿӝ
........13

+uQK  ĈҥR KjP EұF  FӫD ODPLYXGLQ

ÿѭӡQJQpWOLӅQ
Yj]LGRYXG
LQ 

—JPO 
—J

ÿӭW
WURQJPHWKDQRO0NJLWrQFKӍEѭӟFV
..........................................16

+uQK D
 3KәWӹ VӕSKәFӫDDFHWDP

—JPO F
—JPO G
—

PHSKHQR[DORQ
Oj—JPOWURQJPHW

SKә  EұF  FӫD DFHWDPLQRSKHQ WҥL FiF Q

—JPO
G
—JPO H
—JPONKL

Oj—JPOWURQJPHWKDQRO ǻȜ
...............................................................18 QP

+uQK3KәKҩSWKөFӫDGXQJGӏFK$0
AMO 100 mg/L + CLO 100 mg/L ............................................................................26


+uQK3Ĉ+EұFQKҩWFӫDGXQJGӏFK$0
±140 mg/L) .................28
+uQK3Ĉ+EұFFӫDGXQJGӏFK
&/2QӗQJÿӝ 
±140 mg/L) .....................29

+uQK  3Ĉ+7Ĉ  FӫD GXQJ
±140 mg/L)
GӏFK
YӟL$02
Vӕ FK
Q
CLO 60 mg/L ............................................................................................................30

vi





×