Nghiên cứu xác định các hidrocacbon thơm nhóm btex bằng phương pháp phân tích động lực học kết hợp với vi chiết pha rắn màng kim rỗng và sắc kí khí


ng
lc hc kt hp vi vi chit pha r
r




i hc Khoa hc T 
c
Lu: 60 44 27
ng dn: GS. TSKH. Nguyc Hu
o v: 2011


Abstract. Tng quan v t h
chip chng lc hnh
p chng vi chit pha r
c nghim: ch to
thit b vi ching ph trong; kh  dng c
dp chu v thit b chi
kim rng ph trong; s  dng trong thit b vi ching; kim
vi chii ht khp
cht Btex trong m th
thut cg s 
trong mc.

Keywords. ; c; ; ; ng
lc hc; Chit pha rn

Content

M U
 ng tri khoa ht nhm ci tm
ngu tc nhiu sn phm phc v i sng
ci nhu to lc trong sn xui s
ng ti sy, vi
ra nhng bi o v ng s i vi
 gii.
c bic th
thi c sn xut, dch v t ti cht
c ngc mn ch yu
ca ngun thp cht h b p cht hn v
cht rn, kim loi n v
Thc tr x ng cc ta hit nhiu v bt
c 
to ra trong nhi my ng ln
i vi h c khi.
 nh
t th
m phc v cho  o v ng. Mt trong nhp cht
 ng hp chc s
dng trong rt nhin xuy da, dt vi, thuc
bo v thc v t cc
ng ti sc khi, ng t
ng thc thit lp mp ch
Bp vi nhu kim hi
 t sc cn thit.
Xu nhu trong thc t
ng png lc hc kt hp
vi vi chit pha ri m

-               nh
c.
-   i ph  h kh thi, d         
 d
-        u trong vi     
c thi ti mt s  i.

NG QUAN
1.1. GII THIT H
1.1.1 Cu tt cp ch

Bt s t c

STT

Benzen
Toluen
Etylbenzen
m-Xilen
1
  
t
C
6
H
6
C
6
H
5

CH
3
C
6
H
5
C
2
H
5

m-CH
3
C
6
H
4
CH
3
3
Kh
t (gam/mol)
87,12
92,15
106,17
106,17
4
  
0
C) 

760mmHg
80,1
110,6
136,2
139,1
5
y
(
0
C)
5,5
-95
-95
-47,9
6
T trng (g/cm
3
)
0,8765
20/4
0,8669
20/4
0,8670
20/4
0,8642
20/4
7
 n cc
3,0
2,3

-
2,4
8
n ln vi
c


-

9
H s 
H
0,225 (25
0
C)
0,224 (25
0
C)
-
0,232-0,248 (25
0
C)
10
Mt s t
chung c 
ch 
BTEX
 p ch  u,  u ki  ng tn ti dng th
lng, d          


Ghi chú: “-”: không có số liệu
* Ứng dụng và nguồn phát thải các hợp chất hiđrocacbon thơm nhóm BTEX
c s dng
trong rt nhin xuy da, dt vi, thuc bo v
thc vt lo ng
c
ng rt ln xu dn ph
d ng s 
khi ng vp th 
 bng nhing, qua da trong thc
hoc cc b.
i s n mnh m ca khoa ht trong s d
lii mnh m 
ng s phn x 
thi ra hou qun ca m
ln chuy
dng, m  
cht rt d 
1.1.2 Gii hp chc
Bng 1.2: Quy chun Vit Nam v ch    ng v    
(QCVN 01-2009/BYT)
Cht
Benzen
Toluen
Etylbenzen
Xilen
N  t    
-
6


10
700
300
500
M 
B
C
C
C

A- Xét nghiệm ít nhất 01 lần/01 tuần do cơ sở cấp nước thực hiện
B- Xét nghiệm ít nhất 01 lần/06 tháng do cơ sở cấp nước thực hiện
C- Xét nghiệm ít nhất 01 lần/02 năm do cơ sở cung cấp nước thực hiện
Bng 1.3: Quy chun Vit Nam v  i c      
2009/BTNMT)
Cht
Benzen
Toluen
Etylbenzen
Xilen
ng tuy, H (ppm)
10
20.000
8.000
20.000
N t, C
tc
(mg/l)
0,5
1.000

400
1.000

ng tuyng phc phn triu (ppm), ca m
phn nguy hi trong cht thng tuyi (H
tc
ng cht thi nguy
hng tuyi
+ N  (mg/l) ca mn nguy hi trong dung dch sau
 cht thi khi tinh chun b mu b
ching n t (C
tc
ng cht thi nguy hng
t [7, 8].
i, s m cp ch
n th nhi n
ng sng ca nhiy, cng bi
hu hi hn ch s t cng.
P CHT

Vip cht hu
sinh hc li v
- p ch 
- N p chng ng nhn
- n mng phc tp
Hin nay, ch  hp th hng ngoi ( UV- c s d
p chn chun b m  
hp vi mt s hp cht nht nh, kh ng vi nhin ch. Vic
c, tp trung m tiy mu thc t hoc tm


c la chn,
s dt chun b mt trong nhc tinh
ng trc tin kt qu t chun b mn
u t n, gim thi gian chun b mu, hn ch s dng ln
c hi, tit kic vng mu c
n ph 
lp li tt, kh n lt hp v   
c gii hn, ch ng hp
c th. Vic chun b mt b 
 i hn th
35, 46, 52, 53].
Ngay t t chun b mu
ng dt ly mu trc ti
git pha lng, chit pha r u thp k a th k t
vi chii nhi
 gii [4, 18, 37, 43]. Tu c thc hin chin cht
ct pha rt pha lng. Nh 
trit vi chit vi ching (Hollow Needle
Film Microextraction: HNF-ng dt b sc
t s p cht h
1.2.1. Mt s k 

n b m




* Kĩ thuật không gian hơi trực tiếp
t k thut chun b mt
u quc c  

cht cu m u. Hiu qu cng
vic gia nhii pH cho mu hoc gin KGH mu.
* Kĩ thuật vi chiê
́
t pha rắn ma
̀
ng kim rỗng phu
̉
trong (HNF-ME)
c ct vi ching ph  ci tin ct
vi chit pha rng (s dng sc kim loi ph pha 
chit d cu t cht t ng cha ch
mc ph a mng hp kim
 (c 0,2-p ch t
c bin nhit HNF-ME, vic la ch 
 c t ng yu t  mang li hiu qu
t. So vt vi chit pha rng, s ci
tim khc phc mt s  i nh i
hn, gc tip vi m bn ca thit b i nh
d g d b hng [3, 14, 26, 36, 38].
c ph a mng vi m 
nhng cha m ng hoc KGH mu
lng, KGH mu rn Thc hi cho mt phng mc
tii my, nh ng thp ph
p th (gp thu) ct tr
bng h ng cht vi ching
 c gii hp bi
nhit khi c
mh  dng [24, 34, 48].
Kt hp vt pha rn s dng si ching lc

hng dc chuyn khi gi
 p cht BTEX.
1.3 NG LC HP CHT BAY
NG VI CHIT PHA R
ng lc hp trung
 chuyn khi gia hai pha, pha l. T s- c
quynh c  pha l
c khu b mp trong c
chuyn khn ra r hc cho th 
quan ging ch u trong pha lng. Mt mi quan
h tuyn ti git c i quan h 
cho th t ti ng vu kii gian
ly mi. D liu thi gian chit thc t p vi d 
th biu din quan h ging chi ng thng vi thi
gian ly mu ngi gian cn thit tng.
Ba pha tn t             
t v ng lc hu b
cng sn khi ca mt ch pha la
 bi mt.
 ng lc h  c s d 
t pha rn trong mt h thng hai pha (nn mme SPME). S chuyn khi
 mc s dng vi gi nh hc vc hai.
 c nghi
t pha rn trong dung di vi vi chit pha r
ph thuc c  mt thay th cho mt. Tr 
chuyn kh m mnh lu s khu
c s d    s chuyn khi th  nh lut Fick th hai. Ti b mt pha
l  pha l ch n
a ch ti trng. S chuyn khi ti hai
b mo quy tc chuyn khi nh.

Mn thay th cho mn b
  ng lc hc ca vi chit pha rt
uy quan h ging cht chi u ca
ch c s d d c nghim
tu kin chi
ng lc hc ca vi chit pha r
t pha r thuc: pha l
  mt, b mt l mi b mt
   chuyn kh   khu          
c biu th bnh lut Fick th nht ca s khu
 ng chuyn kh
(1.3.1)
  l i, bng t l  
i vi s chuyn khng. D
1
 
2
 s khua ch

g
 ch
f

 chng chc
b  l chit SPME s i t l 
kh
(1.3.2)
  mt c
S khua ch
1

ng
l
2
10
4
-10
5
ln. T y rng gradient n 
 so vt h


(1.3.3)

Trong pha polime, s khua ch tronu kin tr
kho  vi
(1.3.4)
   
f
 ch b
m
f
 ti b mt trong c
2
 s chuyn khi
ca chng D
2
/ i vi khuch
nh.
Trong suy m
c chiu ca cha pha l

t SPME b . N ch
cn kit do s hp th SPME, chng s  
Ti b mt lng lc ca s bc t pha l 
lch n  ng. Gi C
0
g
 
ca chng. Lng lc ca s ch
g
0
 C
g
. T l
c gi  thun vi C
g
0
C
g
t trn
nh, t l i  b mt l b m, t l 
s bng t l 
(1.3.5)
 ng s t l  thuu yu t, din
 mu kin khuy ca pha lng. Gi C
s
 ca ch
l
1
ng s ng phn ca chia pha la


(1.3.6)

 vit l
(1.3.7)
t hp v vit l
(1.3.8)
Gi K
2
ng s ng tng phn ca ch

(1.3.9)
 gi nh rng ch tuy n 
Gi ng trong s x n khc ki
ta chp x (C
f
+ C

)/2. Gi V
f
 a
ng chic n 
(1.3.10)
Gi C
0
 u ca chng. Ch
 u bu t pha lng. N ca chi trong
pha l
(1.3.11)
  u th pha l
S d- biu th K, C

s
C
g
 hng C
0

kt qu 
(1.3.12)
 ng vi 2 bi   
c gii vu kiu sau: khi t = 0, n = 0.
(1.3.13)
Pi vng lc hc c
 hin mc tip ging chi
u C
0
 t mi quan h t l thun tuyi thi gian ly
mu t k t  
(1.3.14)
 hing tng phn. Gi
(1.3.15)
 
(1.3.16)
Mp s c s d 
s hp th c mt rc suy ra t 
ng lc hc ca s chuyn khi  hai b mt c  
m    thu s chuyn
khi, hng s t l ng s  c va h th
 t t. Mi quan h t l thun
trc tip gi
0

 cho vic
t tng.

1.4.1. Gii thiu chung v 








H thng chung ca mt thit b s ph
ng), c
c hoc cc t b phn c
mu, ti dng lng ho nhi u
 mu hoc mt phi c
nh lt (vi ct mao qut
i ct nht ra khi ci nhng khong th
nhau. Ti chc nhn bit bng vii th n hoc
nhit so vt. Mi s c chuyn
n, khuy  x  lii dng
s [4, 11].

n la
  n lt trong nhng
 nhng nhc
cn l t tan trong ngn l-t
 trong mng (300-400V) to bn cng mun cc
n cng n t  v u ng mung 0,5-1,0cm).

Th  thn tr gin c
-12
 
t hin t  c sinh ra trong ngn l-
khit. Khi ch a ra t cn la nh nhit
  b gy mch, b  oxi c  
ng h
C
6
H
6

6CH + O
2

+
+ 6e
-

1.5.1.Gii hn
Gii h thp nht (x
L
) ca ch
h th
L
u ca mu trng
n nn [22].
Hình 1.3: Sơ đồ khối thiết bị sắc kí khí
T
.

L B B
y y k S
(1.5.1)
Vi
B
y
a mu trng sau n
b
m lp l-10
m). S
b
 lch chuu ca mu trng s hc chn theo
 tin cy mong mun.

1
1
b
n
B bj
j
b
yy
n



(1.5.2)

22
1

1
()
1
b
n
b bi b
i
b
S x x
n




(1.5.3)
y
.
B
B
L
kS
xx
b

(1.5.4)
Mu trc chun b vi n ch
B
i h
hi

.
B
B
k S y
LOD
b


(1.5.5)
ng hu tr  lch chun mu trng S
B

ng sai s c
B
=S
y

vi mu nn y
B
c ng vi n n Y
LOD
=a+3.S
y

nh  c sau:

3.
y
Sa
LOD

b


(1.5.6)
1.5.2. Gii hng
Gii hc xem  thp nht (x
Q
) ca ch
c v
Q
ng v
hiu ca mu trng nn [22, 33].

.
QB
B
y y K S
(1.5.7)
i h

10.
B
Sa
LOQ
b


(1.5.8)

2: 





T B
t
+ Cht chu-xilen (PA. tinh khit cho s
g Merck- c).
          -
c).
2.1.2. Thit b
+ H thng s-2010, Shimadzu.
n t (SEM): JEOL- 15kV)
y t gia nhi 
i
2.2. CH TO THIT B VI CHING PH TRONG [12]
2.2.1. 












 nh. 













 ,  : 30,8mm; 





 : 0,52





 :
t s ch 
 m ta ra x            
diclometan, n-hexan. Sau khi ra sch b chun b tm kim.
2.2.2. 















:
- Polimet

(CH
3
)
3
Si O Si O
CH
3
H
Si(CH
3
)
3
n







 

 ng
  

  c nghi
i kt qu quan t 
2.2.3.  


 (



 ) 



 ch c
 c pha s   i mt n    
polihidromech pha
n m

 

 y thm lau sch lp
   nhi 
khong 1 gi, 

 





 () cho
, ng 200
0




. Kt qu
 c ph ng. 























 , ti












 .
 
 c nghim (3.1). T 
kt qu 
tr n ct qu kh 
ng n t n 0,3g/ml c

ca chn n   
EX. Tin t SEM (loi
-u kin thc hin  i th 15kV). Kt qu
c nghin t c cho
 bng 3.1 v
2.3 KH  DNG CA KIM
2.3.1 Khi gian gii hp
Thi gian gii h ng th      
injector c i gian gii hng cht chit
c gii hi nhi tu injector c
khi gian gii hng th
20s. Tit vi t y pittong 30 lrong th
khu   nhi  t vi chic gii hp bi nhit t u
-FID,  200
0
C, (s ph thuc ca s m dii
gian gii hc ch ra  b.5).

Bng 2.1: Khi gian gii hp khi vi chiu
c
Thi gian gii
hp (s)
S m dit
Benzen
Toluen
Etylbenzen
m-Xilen
3
8283
8676

6594
7296
5
13421
13844
10940
12743
7
20635
20221
16943
19426
10
25213
24090
19368
21252
13
29268
27338
21409
24294
15
29942
28039
21740
24835
20
29938
28025

21745
24901

2.3.2 Kh  dng ca kim
Kh ng c l s d vi chit ca 1 kim
sau khi             
diclometan. Tich benzen, toluen, etylbenzen, m-xilen
c vi th u 7ml trong l i Na
2
SO
4
, khuu vi t
100 vn b  
t vi t y pittong 30 li gian 5
i hu injector cc s m di
n mp li nhiu l
gii hp vu ki m di cn gii hp. Nu
s m din gii hp, chng t 
s dng tc kt qu kh b
Bng 2.2: Kh l dng ca thit b
S ln gii hp
S m dit
Benzen
Toluen
Etylbenzen
m-Xilen
1
30122
27102
21856

24820
2
29564
28213
21776
23719
3
29785
28024
21788
23976
4
29985
29034
21261
24965
5
30346
28209
21822
25813
6
30435
29278
22710
25898
7
29887
28217
21125

24723
8
29324
27953
21910
24791
9
29539
28275
21034
24904
10
29209
28249
21956
24975
11
30482
28237
21622
24861
12
30785
27294
21732
23719
13
30134
28973
21634

24725
14
30231
27836
21813
24036
15
30875
28095
21887
23902

 HP CH
MC
u ki
a) Điều kiện phân tích sắc kí khí của các chất nhóm BTEX
    200
0
C; t        
 
 t mao qun: Ct SPB-50: 30m x 0,25mm x 0,25   
a ct dn c c ca
 : nhi u 60
0
C, gi 15

0
C vi t 20
0
  

Nhi 
0

2
i split
 hn hu ki GC-
c ch 

 hn h
T c th
b) Xây dựng đường chuẩn dùng bơm tiêm Hamilton với các chất nhóm BTEX
ng chun s d   ton (gi t  ng chu  
ng thng tuyu th s ph thuc ca s m di
ng vi mng chn. Tip dng chun
t BTEu kin sng v
FID. Kt qu biu din s ph thuc ca s m ding chc
 ng 2.4.
Bng 2.4: Kt qu ng chu

ng cht
(x10
-10
g)
S m dit
Benzen
Toluen
Etylbenzen
m-Xilen
0,05
188

158
392
147
0,1
359
268
656
313
0,3
1248
741
2164
947
0,5
1989
1293
3870
1733
1
4194
2573
7504
3563
3
12320
8075
22659
11053
5
20401

13071
37476
17529

0 1 2 3 4 5
0
5000
10000
15000
20000
Duong chuan halmiton cua benzen
Y = A + B * X
Parameter Value Error
A 2.07495 32.39692
B 4088.89199 14.41593

R SD N P
0.99997 66.39045 7 <0.0001

dien tich pic
luong chat (.10
-10
g/lit)

ng chun halmiton ca benzen
0 1 2 3 4 5
0
2000
4000
6000

8000
10000
12000
14000
Duong chuan halmiton cua toluen
Y = A + B * X
Parameter Value Error
A -2.82274 47.32021
B 2633.04112 21.05647

R SD N P
0.99984 96.97252 7 <0.0001

dien tich pic
luong chat (.10
-10
g/lit)

ng chu c
ng chu  
mc kt hp vi st qu u kin tc kho
c v n b u
kiTh ch m 
mui Na
2
SO
4
, gi  nhi 
0
C, khuu vi t t

trong thng vi m n p li 3 l ng
cht vi chic gii hp t-FID, 
200
0
C. Kt qu ng chu biu din s ph thuc ca s m di
 u ca tng chc ch  bng
2.5
Bng 2.5: Kt qu ng chu khi vi chi
KGH mc
N  ban
u
S m dit
Benzen
Toluen
Etylbenzen
m-Xilen
(x10
-6

0,05
506
327
236
271
0,10
784
635
466
524
0,50

3016
3099
2240
2487
1,00
5804
5930
4663
5093
2,00
11608
11727
8730
9623
5,00
29020
27831
22384
23502
10,00
58040
56067
42954
45439

p cht s mc tht
c ly t nguc thi cng sn xu
dt bao gm: BTEX-1: M c thi t    ng h     
khong 20m); BTEX-2: Mc t cc cc-Vic
p Vit Nam; BTEX-3: Mc thi t ng dt-t 8-ng

dt khong 15m); BTEX-4: Mc t cng thi ci-Cu giy- T
- i. BTEX-5: Mc thi t p B- i, BTEX-
6: Mc t c thi cp Quang Minh- i.
c l o qun  nhi 5-15
0
C. Ti
 thng st chun b mu HNF-
ng.T s m ding chu 
ng  cc, kt qu 
BTEX trong mc thc ch  bng 3.3

3: 










3.1. THIT B VI CHING PH TRONG
t chun b mu hii hin nac s d
t vi chit: vi chit pha rt pha lm chung
ct b n, d s d n
li. S a vic s dt chun b m
 thuc nhic ti 
thit b vi chi git b ct vi
chic ng dng rt r t ng gn ki h thng s

t pha rc s dng nhng thit b i chi
t lt thit bp phi nhng hn ch chung ct vi
chit pha r ch to thit b vi chit pha rng
ph trong mt loi kim y t ng bng hp kim
ng 
bi   ph lp
 chc chn. Na vic s dng s
trong c thy rng: st si nh 
 d n, d ki ti
n v mt kinh t u qu s dng. M ma kim ln
 hp ph cc chc nhi c
i vi nhng mu vi n thc ph l
tr m c tip vng mu. My, vi
chit pha rng ph trong (HNF-ME) l tin
t pha rng, bng ving nhiu l
ng nhiu lng cha mc tivi
 tc thi ca ch
c thit lp, nh v n tht tng ca
c n thi gian chun b m 
 ng mu c 
 sau:





 



-ME
 
          
      -   
          
         

     -    

          

 DNG TRONG THIT B VI CHING PH
TRONG
3.2.1. Ngc la ch ng





 





 vt liu
 dng trong ct sn). 











 , 





t t ch t
t b vi chit
 rng ph trong




Các phân tử chất phân
tích khuếch tán và hấp
phụ lên màng pha tĩnh ở
thành trong của kim
rỗng
Quá trình kéo đẩy pittong giúp
phân tử các chất phân tích tiếp
xúc với màng pha tĩnh
Mẫu phân
tích
R
r

h
y rolime s dt
vi ching ph trong phi tho t s t sau:
 n nhit
 
 i hi nhit

+  n li vi mi cht hoc mt ct
nh.
 n li v thuu t 
c c ng v c ng c 
cc chnh nhi 
n yu, lc Van der Wals.
            25
0
C
bng 1 g/cm
3
 c y p ch c
yu hoc. Qua kh ng cn hiu qu vi
chii hiu qu vi chit tt.
  
p ch
  trong trong kim vi chit
Vit mt s c
rt quan tr  u t quynh
n hiu qu ct la ch i gian vi chit, gii hn ca
c kha ch  tht
cn thi chung cho vic la chng
s  (K) cu t cng s ng
  c nhiu, t trng
[4, 36, 38, 47].
V m  ng cht chic nhi
i hn c i vu
thc t c chp. M
dng mu cc hi i
n gii h mang li mc tin to l

s n ct chun b m.
   t trng
 ca ch
a, ti hp vu t c
mt loi chng th  rng
 
 ph n t 
t vi ching ph trong d
b cu t  ng
m       c ph 
a mng hp kim 
   (c 0,2      
hp ch c
bi   bn nhi  l    
ng rt ln th
b, gii hu qu vi chit
cu t  
ph c nghi
hin t  kim tra.
 = R  r = R  R(1-C/D)
1/2
(3.1)
Hình 3.3: Sơ đồ
mặt cắt ngang kim
vi chiết
 tr ng ca kim
 a kim sau khi ph  khi
 ch.
T y  ph thung rng cm R, nng
 dung dch ph C (bic khi pha dung d ph trng D ci

t loi loc ph t kim rng nh 
 thu dung dng pha  
trong ca kim rng.

I HT KH
c ci hp bi nhit   i
cc li ct
h d to thit b vi chi
rng ph   nh a kim nh, d n
 a kim b hn ch nhiu. Th 
(khong mu ti
khi vi ching m ti i gian
 i n 8cm, khi gii hp nhit ti
c 
u, dn vic gii hp ct kh
gii hp b y ra sai s.
 ch to trong vi chi 
 li hp nhi 
i hp di
 a kim ng gia nhi i hp c
chc di

P CHC
c
T kt qu khu t t vi chit trong KGH mu lng kt hp
v- 
c ch 


p chc

V c, kt
qu dng chu c ch  bng 2.5. T  liu biu din s ph
thuc ca di ca chu lng chun
  s hi quy ca tng chn mm Origin
6.0 n

Thiết bị vi chiết pha rắn màng
kim rỗng phủ trong với:
- pha tĩnh
polimetylhydrosiloxan

- độ dày màng pha tĩnh phủ là
22μm

Lấy 7ml mẫu lỏng vào lọ
14ml có nút kín, thêm 4g
Na
2
SO
4
, khuấy 100
vòng/phút ở nhiệt độ phòng,
pH=7


Vi chiết trên KGH mẫu nước trong 5 phút, tốc độ kéo
đẩy pittông 30 lần/phút

Các chất phân tích được giải
hấp tại đầu injectơ của máy sắc
kí khí (GC/FID), 200
0
C trong 15
giây



0 2 4 6 8 10
0
10000
20000

30000
40000
50000
60000
Duong chuan phan bo cua benzen
Y = A + B * X
Parameter Value Error

A 120.27698 42.07255
B 5787.45636 9.753

R SD N P

0.99999 87.54562 7 <0.0001

dien tich pic
nong do ban dau (.10
-6
g/lit)

ng chu ca benzen trong mc

0 2 4 6 8 10
0
10000
20000
30000
40000
50000
60000

Duong chuan phan bo cua toluen
Y = A + B * X
Parameter Value Error
A 226.35741 113.86557
B 5578.0964 26.39561

R SD N P
0.99994 236.93436 7 <0.0001

dien tich pic
nong do ban dau (.10
-6
g/lit)

        TH     
THUT C 
 CHC
 ng s 
t hp vi st h
BTEX trong mng ln mu lng (10-c
c tit ng hp ph (cha cht hp ph chun Chromosorb P NAW) gn ngay
ti ct qu cho thy, gii hn LOD
cng 0,6 (vi benz
-1
(vi
hng LOQ trong khong 2,0-
-1
.
ng s  dt HF-LPME kt hp vi
s i hn

LOD cm trong khong 0,005-
-1
, h s bing RSD trong
khong 2,02-4,61%.
ng s 
bt HF-t hp vi s
Kt qu cho thy, gii h  n LOD c      ng 0,06-

-1
, h s u trong khong 112- s bing 6,5-11,4% (n=5)







Nu thc hin trong luc tin nh
pht chun b mu mi s d
 nhng kt qu  t s kt lun sau:
1.  ch tc dng c vi chit pha rng n, hiu qu i vi
vip cht h
2. p cht h
ng lc hc di quan h tuya n u ca ch
ng cht chit c.
3.  
c thi thc t ca mt s 
i.
Qua tht qu n thy SP
ri hn thp (c 10

-7
n,
d thc hi i vi nhing
m tip t ph
ng dng ri v
mu thc phm.

References




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preparation for gas chromatographic determination of halogenated volatile organic
     , J. Chromatogr A, 1216,
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26.         -Phase
Microexatraction Method for the Study of the Volatility of Selected Flavor
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