Báo cáo " Nghiên cứu thành phần hóa học cây xích thược (Paeonia veitchii Lynch. var beresowskii " pptx

Tap chi lloa hoc, T. 46 (3), T, 292 - 297, 2008
NGHIEN cuu THANH PHAN
HOA.
HQC
CAY
XfCH THlJQC
(PAEONIA VEITCHII LYNCH. VAR BERESOWSKII
Dell
I'da
soan
28-3-20IJ7
PHAM
HAl
YEN',
PHAN
VAN
KIEM',
L12
NGOC
THANH'
.
NGUYEN
XUAN
NHIEM',
CH,\U
VAN
MINH'
l\/i¢n
Hod
hoc
cdc

H(Jp
cluit
Thien
nhien,
\/i¢n
Khoa
hoc
vel
Cong
ngh¢ Vi¢t Nam
"Truong
Dai
hoc Bach Khoa Hd
N(ii
SUMMARY
From the methanolic extract
of
the roots of Paeonia veitchii Lynch. val' bcresowskii Shiff
pacon
if/orin (1), benzoylpaconifiorin (2). gallic
acid
(3),
gallic
acid
methyl
ester
(4), salicinol (5),
isosalicin (6),
benzoic
acid

(7),
tianshic
acid
(8)
were
isolated
by various chromatography
methods. Their
chemical
structures
were
identified by
NMR
spectroscopic
data. This is the firs!
report
of
5,6
and 8 from family Ranunculaceae,
Key words: Paeonia veitchii, salicinol, isosalicin, Paeoniaceae.
1-
MO DAU
Cay xich thiroc c6 ten khoa hoc la
Paeonia
veitchii
Lynch. var
beresowskii
Shiff
(Paeoniaceae) c6 nguon goc
iJvung

Dong
a
gam
Trung Quoc, Nhat Ban, Trieu Tien, Nhirng narn
1970,
cay duoc di thuc trong it Sa Pa. Nhirng
nghien ciru
v6 thanh phan hoa h9C cho thay re
cay
chua
chi! yeu la paeoniflorin voi
ham
luang
khoang 2% re kho, ngoai ra
con
co paeonal va
mot
manateepen
glycasid thu duoc bang
each
xii Iy
paeaniflarin
voi kali
cacbanat
trang
metana!'
Theo
D6
Huy
Bich va es [1]

paeoniflarin co tac
dung
ire
che
than kinh,
chong co that va chong viem rna it doc,
Paeaniflorin co tac
dung
chong viern r6 ret tren
mo
hinh
gay phu ban chan
chuot
cong trang.
Trang
y h9C co truyen, xich thuoc duoc dung M
tri cac benh dau nrc nguc, chay mau duoi da,
viem
tac
dong
mach,
viern rnang phoi do lao,
xa
gan, viern nha chu,
mun
nhot
v.v
Trang
y h9C
co truyen

Trung
Quoc,
xich thuoc
con
duoc
dung
lam thuoc giam dau,
cam mau
va khang
292
khuan,
va la
mot
thanh phan
trang
che
pham
thuoc Trung
Quoc
dieu tri benh ung
thu
va tim
mach
[11. Bai
baa
nay thong
baa
kct qua nghien
ctru thanh phan hoc, hoc cua cay thuoc
qui

nay.
Bang cac phuong phap sac ky, 8 hop chat da
dtroc phan lap til dich chiet metanal cua re cay
la
paeoniflorin
(1),
benzoyl paeoniflorin
(2),
axit
galic
(3), metyI gaIat (4), salicinol (5),
isosalicinol (6), axit benzoic (7) va axit tianshic
(8). Can true cua cluing diroc xac dinh bang cac
phuong phappho.
II -
THl/C
NGHII;;M VA
PHUONG
PHAP
NGHIENCDtJ
L
Phuong
phap
chnng
a) Phuong pluip
phanlap
cdc hop chat
SAc
ky 16p mong (TLC):
SAc

ky
lop
m6ng
dieu
che
duoc thuc hien tren
ban
rnong trang
siln DC-Alufolien 60
F",
(Merck
1,05715),
RP"
F'>4' (Merck).
Phat
hien
chat
bang den
til"
ngoai
6 hai buoc song
254
nm va 368 nm hoac
dung