Báo cáo "Nghiên cứu quy trình tổng hợp Howiiol A " doc

4. J. S. Brimacombe and L.C. N. Tuker - Reaction
of
D-glycero-D-glulo-heptono-y-Iactone
with acetone, Carbohydrate Research 2 (1966) 341-348.
5. Tonny
K. M. Shing, Hon-chung Tsui, Zhao-hui Zhou
~nd
Thomas
C.
W.
Mak -
Stereose1ective -syntheses od 2,4:5,6-Di-O-isopropylidene-I-C-phenyl-D-glycero-D-ido-
hexitol and 2,4:5,6-Di-O-isopropylidene-I-C-phenyl-D-glycero-D-gulo-hexitol from
D-
glycero-D-gulo-heptono-y-Iactone. X-ray Structure
of
I-O-Acetyl-2,4: 5,6-Di-O-
isopropylidene-I-C-phenyl-D-glycero-D-ido-hexitol, J. Chern. Soc. Perkin Trans 1 (1992)
887-893.
6. Masayoshi Tsubuki, Kazuo Kanai, Hiromasa Nagase, and Toshio Honda -
Stereocontrolled Syntheses
of
Novel Styryl Lactones, (+)-Goniodiol, (+)-Goniotriol, (+)-
8-Acetylgoniotriol, (+ )-Goniofufurone, (+ )-9-Deoxygoniopypyrone, (+ )-Gonipypyrone,
and (+ )-Altholactone from Common Intermediates and Cytotoxicity

of
Their congeners,
Tetrahedron
55 (1999) 2493-2514.
7. Tonny K. M. Shing and Vicint W-F. Tai - Facile and Enantiospecific Syntheses
of
Goniotriol Analogues,
J.
Org. Chern 64 (1999) 2140-2144.
SUMMARY
STUDY
ON
THE SYNTHESIS OF HOWIINOL A
The antitumor compound howiinol A has been isolated and characterized for the first time
from the root and stem bark
of
Goniothalamus howii Merr. (Annonaceae). This compound
blocked the cell cycle transition from G 1 phase to S phase and inhibited the activity
of
topoisomerase II both inside and out side the cells. The methode
of
howiinol synthesis has been
studied by the scientists
of
lnstitute
of
Materia Medica Beijiing in 1998. Herein, we describe
another methode for the synthesis
of
howiinol A. The structure

of
howiinol and intermediate
products were estabilished by MS and
NMR
spectroscopies.
Dia
chi:
Nh(in hili
ngay
15 tJuing 2 niim
2008
Vi~n
H6a
hQc,
Vi~n
KH&CNVN.
89