Tải bản đầy đủ (.ppt) (49 trang)

Nhiễm độc đioxin và các hợp chất có độc giống đioxin do ô nhiễm môi trường pdf

Bạn đang xem bản rút gọn của tài liệu. Xem và tải ngay bản đầy đủ của tài liệu tại đây (1.13 MB, 49 trang )










PGS.TS.DƯƠNG THANH LIÊM
PGS.TS.DƯƠNG THANH LIÊM
Bộ môn Dinh dưỡng
Bộ môn Dinh dưỡng
Khoa Chăn nuôi Thú Y
Khoa Chăn nuôi Thú Y
Trường Đại học Nông Lâm
Trường Đại học Nông Lâm

 !
"
#
 !
"
#




$
$
$


$
2,3,7,8-Tetrachlorodibenzo-p-dioxin
%&'()*&+,$+ &/012&3)*245-67'6&

8239:23)*/6;&/-67'6&
8239:23)*/6;&/-67'6&
67'6&<$6=>7?:7(&-@AB@C
67'6&<$6=>7?:7(&-@AB@C












 !"#$%&$
'(')*+,



D
E
F
G
H

I
J
K


D
E
F
G
H
I
K
J
L
)(*MN2=3(&/3O53P2245
)(*MN2=3(&/3O53P2245
Q+L
Q+L
82QR*MS08&3@;$+QR*MS?+
82QR*MS08&3@;$+QR*MS?+
23$7M
23$7M
2O*3T/U&$V&W
2O*3T/U&$V&W
2+&//U&&36X(*3Y39:23)*2+&/012Q+2+&/ZX&Q[&/
2+&//U&&36X(*3Y39:23)*2+&/012Q+2+&/ZX&Q[&/

\7@8&3?]201/^,012A012$_2C245
\7@8&3?]201/^,012A012$_2C245
282-%&'()*245-67'6&

282-%&'()*245-67'6&
A/(`&\WHDDFCa
A/(`&\WHDDFCa
-.../..0.12$+#"13
.....01$2+#"#1
.....0.12+#"#1
....012"+#"#1
.../..01$2+#"#1

...1"4#"#1
.0../..01$2+#"#1
..../.5..012$+#"#1
.....0.12+#"#1
.....01$2+#"#1
...012"+#"#1

67'8
93:;34<
=4>?@AB.
=

C$;4#4<
①. DD = dibenzo-p-dioxin
②. DF = dibenzofuran
ATSDR (Agency for Toxic Substances and Disease Registry)

bc,39:23)*3O53P20123.6
bc,39:23)*3O53P20123.6
/^,23d*&/ef6Zg2&3)*
/^,23d*&/ef6Zg2&3)*

4 x 10
-1
Sarin *
4 x 10
-1
Bufotoxin
2 x 10
-1
Muscarine
3 x 10
-2
Dioxin *
3 x 10
-4
Diphtheria toxin
5 x 10
-6
Tetanus toxin A
3 x 10
-8
Botulinum toxin A
LD
50
mg/kg
/>
h@;0ei&/$e9&/012$_2AjL6C
h@;0ei&/$e9&/012$_2AjL6C
24528239:23)*/6;&/-67'6&b
24528239:23)*/6;&/-67'6&b
11.D.././D./12

..D.././D..D1C$..D././D.12
..D..D././D.1C$..././D.12
...D././D..D1C$...D././D12
..D././D..D1C..D././D..D1C
...D././D.D1C..D././D.12
...D././D.1C..D././D1
67
'8934#
ECF'>G

H+
67
'8934#
ECF'>G

H+

S&3*k&/0ei&/$e9&/012$_2245
S&3*k&/0ei&/$e9&/012$_2245
-67'6&Q+28239:23)*/6;&/-67'6&
-67'6&Q+28239:23)*/6;&/-67'6&
M7&/0Ol
jm$+0ei&/$e9&/012$_2A7'626*,>n(6Q5$>&*C
$+&`&/01245?1*0i&23)**M7&/3o&39:28223)*/6;&/-67'6&a
jL6$+3h@;&3^&0ei&/$e9&/012$_2245?o639:23)*/6;&/-67'6&a
7*5$jm@p\(?A'jL6C
&
6pH

/(`&/;2Q+@_3Y&3*3+&3-67'6&

/(`&/;2Q+@_3Y&3*3+&3-67'6&
67'6&$+@c&:3q?:3r=3s&/?7&/?(;&245282&/+&3
2s&/&/36V
"
:$6V&n(5&0d&$7&3e2s&/&/36V
"
:@c&'()*
&3_5t*3(;2*Mu@^(W0;*23)**3c60`&3_5W2s&/
&/36V
"
:@c&'()*0`&3_5Q+*q,*MU&//6),v
.&/0s
"
2&3)*245-67'6&$+JWKWFWG<*>*M523$7M7-6Z>&w7<:<
-67'6&ACa3^
"
:&6V&Ix<yxl3(;2-6V
"
*2zJWIWy<
*M623$7M7:3>&7',52>*62526-AJWIWy<C0e92@{-r&/&3e
$+23)*$+?Mr&/$8?+(-525?*M7&/236d&*M5&36V
"
*
5?a
67'6&0e923Y&3*3+&3=36&3[&/39:23)*2O23]52$7ZR
*820s
"
&/Z|6&36V
"
*0s

"
25735,0e92'N2*82Z|628223)*
Qs2ia36V
"
*0s
"
*;6*3S23$+*uKxx7237:3c&]&/*.7
*3+&3-67'6&A}5@(35M5WHDGGt(5&/WHDDyCa

67'6&2O|0^(~
67'6&2O|0^(~
67'6&2O*3T*Y?*3),=3U:&i6*MV&*3d/6•6l*M7&/
&e•2W=3s&/=3SA&`&/0s
"
*3):CW0)*08A&`&/0s
"
257Ca
67'6&0e92*3c6M5?s6*Mef&/*u=3S*3c6WM82*3c6*u
282&3+?8,2s&/&/36V
"
:W*u&3[&/ &/Q^
"
*23)*2O
23]5$7W0`&3_5ZR238,a
/7+6M5W-67'6&2€&2O&/(`&/;2*u282n(8*MY&3*_
&36V&l37.*0s
"
&/&N6${5W238,Mu&/v
67'6&*u=3s&/=3S=3(*MNQ+70)*W06282$7.6*3_2Q^
"

*
Q+&e•2a+@5(0O23N&/06Q+723(o6*3]2•&Q+
06T?0S23$+'^?&3^
"
:Q+72i*3T&/ef6a
/(,36T?&3)*$+-67'6&0e92*Y?*3),*M7&/*3_2
:3q?W0•
"
2Z6V
"
*$+@c&:3q?*u@[5W*3R*W282O23]5
23)*Z‚7aaa
;6Q•6*3R*W@[5W28W3ƒ(3d*282$7.6-67'6&*Y?*3),
*M7&/?s?„a

/(`&:38*@6&3-67'6&*u@c&'()*2s&/&/36h:
/(`&:38*@6&3-67'6&*u@c&'()*2s&/&/36h:
3**:l……$&†>ZHGa†7M$-Z5&=a7M/…j\\…>&Q>'*a&@‡…yxb,725?>…ˆ35*M>@\7(M2>@7‡@3>M?5$M72>@@>@
3**:l……$&†>ZHGa†7M$-Z5&=a7M/…j\\…>&Q>'*a&@‡…yxb,725?>…ˆ35*M>@\7(M2>@7‡@3>M?5$M72>@@>@
 !"#$%&'"()*+#(,
'-'*./0$&
/1#(2&34&/5
 &6&
6
789:/;</"4+#=
/">?@"A1.2,
/"4?1/AB5CD
&-#&#
EFA1"4@G#H/
6&6&


789:/&-I&
A,
!",J(<";
10K.L-
 &6
M1,49N49@&,*#5
:>"5*#5'
<O
EF'-'*#52
;A+"4@P&$#&
J&*Q#&A>/&#/O
 EF;"<4R"SA>/
 -4&"TKEF"4@*#(UPO
;/N4$+#
;/N4$+#
-V0W@AB
-V0W@AB
(&9
(&9
MSA+#$//@
MSA+#$//@
3,R",J'-'
3,R",J'-'
,R",J'-'
,R",J'-'
(<";$//@
(<";$//@

/(`&:38*@6&3-67'6&*u0;*23)**3c6

/(`&:38*@6&3-67'6&*u0;*23)**3c6
 6
;9Q2*#5/
&&6#& OO
M1;9Q&("&9N4A@
 &6XY$//@&*&KZ%L&,4K&O=/
 &6[H/&9(J&\]<AB/^A1/
6N"&A,M1A,

'"/-_*+#(,*]<O
M1-'/(0K*]-/(

'"/-_*+#(,*]<O
K%,0KF?",O
 '"/-_*+#(,*]<OM1,;<-@0@O
 '/'-_1/$+#M1;<$//@
 '"*+#$+#*]<OM1,<A$_&%,/
?@I4JKL>
MN44O'8;FP<.
H+4#4
6Q'4JKIOH+R
" ST%4
R" AL4A
I4O$M!PSU
P%$VKI4O$

67'6&*M7&/*3_2:3q?|‰
67'6&*M7&/*3_2:3q?|‰
Nguồn: FISIS (Food Safety and Inspection Service) 2005
Nguồn: FISIS (Food Safety and Inspection Service) 2005

.
.
&&`_/KN4
&&a_/T#
&a&_-F^&-?
&&b_/8K/
c,_d!"/
-J
e
c,_d!
"/-J
aaGaa
,5(f(<

]2-67'6&*M7&/282$7.6*3_2:3q?2O&/(`&/;2
23•&&(s6|282&e•2bU2‰
(www.ejnet.org/dioxin,2002)

+?$e9&/67'6&*M7&/
+?$e9&/67'6&*M7&/
*3_2:3q?|‰AHDDyCl
*3_2:3q?|‰AHDDyCl
/>B6&=

\_3):*3(-67'6&Q+28239:23)*
\_3):*3(-67'6&Q+28239:23)*
/6;&/-67'6&ABCQ+72i*3T
/6;&/-67'6&ABCQ+72i*3T
..58
../.5.W(9$VKX

/.05..0Y+
5..M!P%$VKZ
..G."&M!P%$VKH+*
/./.5.5[+M!P%$VKZP[+







 
! "#$%
7&0ef&/23S&30T-67'6&'^?&3^
"
:Q+72i*3T27&&/ef6$+27&
0ef&/*3_2:3q?A0•
"
2Z6V
"
*$+&3[&/*3]2•&2O&/(`&/;2*u
0s
"
&/Q^
"
*C<:3i6&36Š?*3]2):am(527&0ef&/•&(;&/&3[&/
*3_2:3q?&36T?-67'6&W2i*3T*S23$‹,?s
"
*$e9&/$•&-67'6&a\c&
:3q?*3_2:3q?2O&/(`&/;201&/Qg**S23$‹,-67'6&&36X(3i&


\_:3^&Z;Q+*S23*r-67'6&*M7&/2i*3T
\_:3^&Z;Q+*S23*r-67'6&*M7&/2i*3T
M7&/2i*3TW=37c&/HxŒ-67'6&0e92*Y?*3),*M7&//5&Q+HŒ
*M7&/?8(a
67'6&*^
"
:*M(&/234,d(|?s?„Q+/5&W0^,23S&3$+&3[&/&i6
&3.,2c?&3)**S23*r-67'6&*M7&/2i*3T&/ef6a
67'6&AJWKWFWGC*g:*M(&/*M7&/?s?„245&/ef6=37c&/
y<Hy::Za67'6&0e92$7.6*Mu=3z62i*3TM)*23^
"
?W?)*
=37c&/F&•?0T$7.6*Mu0e92=3z5&/•ZŽ&/2823Z8&:3^&
3(•W*3s&/*3ef&/:3c6?)**uE<Hx&•?W*•,*3(s
"
2Q+7$7.6
?s*S23*r-67'6&a
M7&/n(8=3]W$e9&/-67'6&*S23*r2573i&@7Q•6$e9&/-67'6&
0e92$7.6Zza67'6&*M7&/2i*3T*•&/*•$V
"
Q•6*(k6*3P245
27&&/ef6l*u=37c&/‘Hx&/…=/23)*Z‚

7$N2?•6@6&30d&
=37c&/Fx&/…=/23)*Z‚7|Fx*(k6a
(,&36V&2•&/Q•6@_/6c?$e9&/-67'6&*M7&/?s6*Mef&/W
$e9&/-67'6&*S23$‹,*M7&/2i*3T2‹&//6c?-ƒ&aS-rW|
]2W&`&/0s
"

jm*M7&/@[5&/ef6/6c?*u/68*MR*M(&/ZY&3
Kx<Ky&/…=/|&3[&/&•?/6[5*3^
"
:&6V&Gx'(;&/2€&=37c&/
Jx&/…=/Q+7&3[&/&•?0ƒ(*3^
"
:&6V&Dxa

Be9&/-67'6&*M7&/@[5?“*3;&/=V
Be9&/-67'6&*M7&/@[5?“*3;&/=V
|282&e•2=382&35(A&/…=/Z‚7C
|282&e•2=382&35(A&/…=/Z‚7C

+K$4+

4=+
/
\4OW+K1C!W84
W+
5
\4OW+K1$-C(]^4
50
^_
500
+++
/6&

W`
/50
\4OW+K16!Wa

&'&
()*
(theo Schecter, 1994b )
PCDD: polychlorinated
dibenzodioxin
PCDF: polychlorinated
dibenzofuran
n
Total TEQs = Sum (CI x TEFi)
i=1
Toxicity equivalent (TEQ)

67'6&2On(5@[5?“0e92=3s&/~
67'6&2On(5@[5?“0e92=3s&/~
67'6&23(,X&n(5@[5?“M)*&36X(”
67'6&23(,X&n(5@[5?“M)*&36X(”
67'6&*S23*r*M7&/@[5?“Z|6QY-67'6&3€5*5&*;**M7&/@[52O
3+?$e9&/Z‚7257a
M7&/*3f6=•23727&ZNW-67'6&*u?“@–*M(,X&@5&/27&M)*
&36X(a
]5Z‚2O*3T3):*3rDyŒ$e9&/-67'6&*M7&/@[5?“Q+*S23*_
*M7&/?sZ+72O&36X(23)*Z‚72450]5*M—a
36X(&/36V&2](237*3),-67'6&36V
"
&-6V
"
&*M7&/@[5?“Q•63+?
$e9&/*uJx0d&Kx&/…=/jm|282&e•22s&/&/36V
"
:Q+*uK

0d&HK&/…=/jm|282&e•22O&X&2s&/&/36V
"
::38**M6T&
=‚?a
3>7Z87287245k23]2}*d*3d/6•6AˆC*3Y3+?$e9&/
*M(&/ZY&3$+Jx&/…=/jmA*M7&/23)*Z‚7CWQ•6/68*MR*35,0k6
*u*3):KaH&/…=/jmA*M7&/23)*Z‚7C0d&257HHx&/…=/jm
A*M7&/23)*Z‚7CAWHDDFCa

]223):&3g&-67'6&*M7&/2i*3T
]223):&3g&-67'6&*M7&/2i*3T






1/15"L ;4#4b<
11"L ;4#4<
101/ECF;4>$`10<
..cY;4>"H4"#$10<
..
U%#MOKI4"d^_13c;4>"H4"#1/<
C!K
;$<e!@
;d4
X<
C!K
;$<eXJ
",e!@

7R+M!&'>G

Loài động vật
Loài động vật
LD
LD
50
50


(
(
µ
µ
g/kg)
g/kg)
Chuột lang 2
Chuột bạch 40
Khỉ 50
Người
Người
?
?
Chuột 130
Thỏ 200
Chuột đồng 4000
B6X(/^,&/1012245
B6X(/^,&/1012245
67'6&AC
67'6&AC


3)*012-525?-67'6&?+
3)*012-525?-67'6&?+
n(^&016‰0˜M˜6'(;&/Q6h*&5?
n(^&016‰0˜M˜6'(;&/Q6h*&5?
uHDEJ0d&HDFHWn(^&0s
"
6‰0˜M˜6=37c&/FEWD*M6V
"
($S**3(;2-6V
"
*
2z$V&=37c&/3i&HWy*M6V
"
(3>2*5A=37c&/HxŒ-6V
"
&*S23?6X&5?
6V
"
*5?CW*M7&/@;&+,2OEIŒ$+23)*0s
"
2?+(525?WJFŒ$+
23)*0s
"
2*MU&/WGWFŒ23)*?+('5&3WQ+xWEŒ$+23)*?+(*S?aO
/ƒ&y*M6V
"
(&/ef66V
"
*5?*M7&/=37c&/JyayGy*3s&):ZRc&3

3e|&/245-67'6&a
O0d&GEŒ$e9&/-67'6&0e92:3(&*u*MV&=3s&/W-67'6&2€&0e92
:3(&ZŽ&/'>*c6W*+(vM7&/0OW2O=37c&/H…K-6V
"
&*S23ZR:3(&
&36X($ƒ&AyJaxxx3>2*5ZR:3(&3i&I$ƒ&C0˜:3834,HIŒMu&/
245?6X&5?*M7&/0O?s
"
*&{5$+Mu&/0e•2:3€&/3s
"
a

o&39:*3(;2$+?Mr&/$82^,/`?JWI<Q+JWIWy<Q+-67'6&0e92
@6&3M5*M7&/n(8*MY&3*k&/39:JWIWy<W/^,M5ZV
"
&3(&/*3eQ+
/^,M5&3[&/Q)&0XQX@]2=3z>W2‹&/&3e=3c&•&/@6&3@c&
24527&&/ef6a
6V
"
&6V
"
*5?2O=37c&/Fxaxxx&/ef6/•
"
:&36X(Q)&0XQX@]2=3z>
Q+*M7&/@6&337.*ZY&3*3ef&/-73PZRc&33e|&/-67'6&*M_2
*6d:37•
"
2/68&*6d:*uZ;?“a


8,Z5,n(^&016‰M˜623)*012-525?
8,Z5,n(^&016‰M˜623)*012-525?
'(;&/$+&/?.2W&s&/*3s&?6X&5?
'(;&/$+&/?.2W&s&/*3s&?6X&5?

™3723]523)*012-525?
™3723]523)*012-525?

82QR*MS23R(c&33e|&/-67'6&
82QR*MS23R(c&33e|&/-67'6&
|?6X&5?6h*&5?
|?6X&5?6h*&5?
Vị trí sơn màu sẫm
chịu ảnh hưởng
của chất độc dioxin
Nhiều trẻ em VN bị
Khuyết tật do cha
mẹ bi nhiểm chất độc
màu vàng da cam.

×