-72
-72
i
i
ii
t
-
iii
............................................................................................................ ii
................................................................................................................. iii
..........................................................................................v
......................................................................................... vi
...................................................................... vii
.....................................................................................................................1
..........................................................................................1
.................................................................................................2
.....................................................................................................2
.....................................................................................................2
c ti n c
cc
................................................................2
.................................................................................2
..................................................................................2
................................................................................................................3
...........................................................................................3
....................................................................................3
......................................................................3
. 10
.13
14
1.1.5
.
.............................................25
..................................................................25
....................................................................29
..............................................................................................................31
.................................................31
.........................................................................................31
iv
............................................................................................31
.......................................................................................31
.....................................................................................31
............................................31
....................................................................................32
........................................................................32
..............................................34
..................................................................................37
..............................................................................................................38
........................................................38
3.1.
.........................................................................................38
....................................................................38
.............................................................................................................40
................................................................................................41
.................................................................................43
..................................................................................................45
3.2
len
.............................................................................46
n
.............................................51
3.4. Ng
...............................................55
.......................................................................................57
.................................................................................................................57
..................................................................................................................58
.........................................................................................59
........................................................................................59
......................................................................61
v
38-72
........................................................................................................... 34
... 38
........................................................ 40
..................................................................................... 42
.................................. 44
5
.... 45
H
.................................................................. 47
............................................................... 47
................................................................ 47
.............................................................. 47
................................... 52
....................... 55
vi
1:
.................................................................................... 49
2:
............................................................................................... 47
3:
............................................................................................... 50
4:
............................................................................................... 50
:
................................... 53
:
Zn trong gan................................................ 54
................................. 54
vii
Ca
: Canxi
Cs
:
Cu
:
Fe
:
Kg
: Kilogam
ng
Zn
KL
:
KP
:
LV
:
ME
:
P
:
Se
: Selen
:
TB
:
TCVN
:
TL
:
Tr
:
:
Zn
SLT
NST
VSV
:
viii
......................66
-
.........................................................................................................................67
1
,
,
.
sung cho kh u ph
h
av
d ng d
u su t s d ng
th
ng.
ng v t,
ng y u t c
thi
u
iv im
ph n c a nhi u lo
a nh ng
s
ch t trong h u
h
h
n, bi
o, sinh t ng h p
n ng mi n d
n ng
thi u h t m t s
u ph n
u qu
m hi u qu s d ng th c
p
ng, kh
th
nh t t,
ac
ng.
S
xu
(
n m nh m c
c nh
t o
u ki n thu n l
ph m b sung cho th
ch t
t li u kim lo
pc ns n
2
kh
c ch ph m ph c kim lo i t
n thi t ph i th nghi
so v
th
u
tri
ng, k m, selen n kh
n 38-72 tu n tu
ng v t
m,
ng c a ch ph m ph c kim lo i s t,
n xu t c
ng sinh s n giai
2.
.
2.2.1.
n kh
n xu t c
ng sinh s n.
2.2.2. X
nh li
ng b
sinh s n
n 38-72 tu n tu i.
2.2.3.
ng, s t n
ph c kim lo
gia c m.
c ti n c
c
cc
-
ng
.
Ngh
p cho
ng
i c a ch ph m
3
1
1.1.
1.1.1.
.
S li u t m
n s n xu t premix cho gia c m c a Trung Qu c
(Nanning Zeweier Feed Co. Ltd., (2011)) [87] cho bi
t o ra 1 kg premix
n ch
ph i s d
i v i 1 kg
t ch a 6.
ph i s d
y kh
cs d
tl
t o ph
ng
vi
kh c ph tr ng i v hi u qu kinh t
i
Kaluga (
[88]
. ., . . .,
o ra ch ph m ph
.
, 2009)
ng - h
d
i
tradispersive particles) v
0,15
th
rong bi n, c th
.
ov b
ch tt
t polysaccarit t
ng h
b n
t quan tr
nc
ch
peroxidaza (GSH-
o qu
Cu, Fe,
n ph m t v t
t trong
n c a glutathione
y
4
nt c
kh
ng
ch t ch
u qu
o qu n th t
ng l
i cho s c kh
id
y b i ph n
c t do
i ph n
ch
-
p
h
ng ch
iv
i. Nhi u k t qu th c nghi m ch ra
r ng s thi u h t ho
am ts
as
n
gia c
ki
cb
u ph n
Ngu n cung c
ng cho v
y
t kh u ph
c
c b sung h n h p kh
ng bao g
ng, s t, k m, selen, coban, i
i d ng mu i
c oxit) b i
thi u h t ho c m
ng (do nhi u y u t
u ki n
t
cv
thu h ach, b o qu
ng,
bi n v.v...).
ng mu
ng pH th p
ng b
n
ch
sinh h
h p thu c
(Aoyagi, S and Baker, 1995) [24], (Underwood, EJ and Suttle, 1999) [79].
Hi
x y ra gi
(Moldal, M and Bairagi, 2007)[55].
d ng c
t v i nhau
ng cao c
m
c l i (Lesson, S and Summers, 2008) [44],
[63], (Zhao, J, Shirley, 2008) [86]
5
t
t
tan d
n c n tr
c ch t v
s
n v ng, k
h p thu (Lesson, S and Summers, 2008) [45],
(Oberleas,D, Muhrer and B.L, 1966) [64], nh
i s hi n di n c a Ca -
cb
i cao
trong kh u ph n.
M
mu
n ph m cu
i
th p (Mohana, C, and Nys, 1998) [54], (Van der Klis, J.D, 2002) [82]
tc
so v
c
th
[45], (Nollet, L, Van der Klis, J
and P, 2007)[59].
Nhi u k t qu
(Ammerman, CB and Miller,
1972)[23], (Aoyagi, S and Baker, 1995)[24], (Biell, R.R, Emmert and Baker,
1997)[25] cho th
id
t
ng b h
u khi t i 80%, ch y
av
i
p sinh h c th p c a
ng
ng.
polysaccarit
q
cho
6
- -D-
hydrat.
,
cho
Nh m
sinh h c t
d ng ch
ng
h p th
av
s d
i ch t [Ammerman, (1995)] [21]
u ph n
ph
id
c ch t h
c protein ho
ch
i d ng ph c
ng
u tr
gelatin, keo tinh b t,
t
ng [(Dziechciarek, 1998)[30]; (Hussain, 2001)[41]; (Miles,
2002) [53]; (Taylor, 2005) [78].
c
h p ph
ng
th
h
a gia
b
7
ph n ng v
v y,
gi m thi u s m
ki n t
u
h p thu
ru t non (Leeson, 2001)[45]. Nh
d
cs
i d ng h
sinh h c c
u ph n
(Cao, 2002)[27]; (Fly, A.D , 1989)[32];
(Halford, 2006) [37]; (Lim, H, 2006) [46]; (Nollet, 2005) [58]; (Van der Klis,
2002) [82]; (Zhao, J, 2008) [86].
*
ng s
ng v t t n t
i d ng ph c v i
c t
ph
i d ng h p ch t
c d tr trong gan, t y, th
t
S
t trong
pt
thu s t c
ti p
ph thu
ph c ch t c a s
tc
ng
ng c
c kh v
i Fe(II) s
c h p th
t, ch y u t i khu v
thu
p th
t c
c ru
Theo Biell, Emmert, Baker (1995) [25
ng h tr
th s t trong h
t s axit h
o k t t
k
c n tr
c
i Fe
p th s
v
b
tc av t
ng thi u s t h
ng s
th
p
id
y ra
ti p thu sinh h c
8
thi u s t, ch
c
m xu
m theo hi
n ng mi n d ch
n ch m tr , r i lo n h th
ng thi
,b
.
ng (Cu)
Theo Waldroup, P.W (2001) [74
v
ng c ch
m vi sinh
ng ru
n
n
n lacto.
ng h tr tu
ho
n d ch,
ng c a h th
ch, h tr
ng t i
o hemoglobin, t o
tr
chuy n s
i hocmon, protein,
hydrocacbon, c n thi t cho vi
ng s
ng c
ng th
ng gi
n m t s enzym.
ng trong vi c c ng c l
collagen nh
t ngang c a
(Y.Pekel and M.Alp, 2011)
[85]
ng h p thi
hi
n
ng thi
v
ng: R i lo n ch
n, xu t hi n
i c a h ng c u b thu ng
ng b
c ch , h th ng th n kinh b
ng r i lo n,
b
k m (Zn)
K
i ph bi n nh t trong h th ng enzym t
gia c
k tv
m tham
i di n cho t t c
c axit amin ch
n
(Underwood, E.J, and Falchuk, 1999) [79], (Valee, B.L, and Suttle) [80].
tk
t trong protein c
ng v t (Fraker, P.J, King and Vollmer, 2000) [33]. K
trong m t lo
ng bao g m: S
ty u
9
ng mi n d ch, sinh s
ng l
(Hussain, N, Jaitley and Florence, 2001) [41], (Shankar,
A.H and Prasad, 1998) [69], ( Song, Y, S, W and E.Ho, (2009) [72].
K m h tr
sinh d
iv
tr ph c h
t
ng.
K
t trong hoocmon insulin, c i
thi
p ch
ch
d ng vitamin c
n
c
c
c th
K
t s c quan tr
b
iv
ng h p collagen
t trong nh ng protein t o l
v
ng h
am gia
a
n, ch
o
( Novus, 2009) [61].
ng h p thi u k m: Gi m kh
b
nt
yd
m c mi
n hi
c ch
t hi n hi n
ng xu t huy
ng l
n ng
c s d ng r
gia th
selen (Se)
iv
tri
ng c
kh
c bi
iv
ng. Selen
ng c
(Schwarz, K and Foltz, 1957) [68]
a b nh suy t ng
ra r ng selen
nh ho i t gan
th
m.
t trong b n y u t
10
n nh t c a h th ng ch
t x t
enzym (Taylor. T.M, and Weiss, 2005) [78].
u bi t r
kh e m
cm
th ng ch
o. H th
t ch
enzym ch
ng ct
-
(Mohana, C and Nys, 1998)
[54], (Surai, P, (2002) [74].
n c a enzym glutathion peroxidase GSH-Px
(Wang, Z, Pan and Zhou, 2012) [84]. Ho
khi
t
u hi n thi u selen. Selen trong
u ch
v
gi m thi
m, s n xu t hoocmon tuy
ng h
ng hi u qu th tinh.
th
i d ng selenit (Na2
SeO3), selenat (Na2 SeO4) ho c selenua (Na2 Se), trong khi trong th
t
c
ho
t v
1.1.2 Nhu c u Fe, Cu, Zn
gia c
i lo
ng
gia c m
khi thi
[62]
[45]
(Leeson
11
,
[45].
NRC (1994) [62]
(Leeson
[45].
. NRC (1994) [62]
12
-
[45].
(NRC, 1994) [62].
Theo NRC (1994) [62]
[45]
Ross: 0,15;
2001) [45]
(Mahan et al., 2005) [50].
13
[63]
kho
tan
[52].
t
gievskii, 1982) [35].
(Suttle, NF and Peter, DW, 1985) [77]
[63]. (Mason, J, Lamand, CA and Kelleher, CA., 1980; Loneragan et al.,
1998) [51]
14
con.
[63].
[64]
(Sebastian et al, 1996) [70].
Selen
-
methionine (Suttle, 2010)
[76]
[39].
1.1.4
d
(NRC, 1994) [62].
ng gia c m
15
thu (Suttle, 2010) [76].
kh c ph c nh
c
mu
[88]
ph
mong
o ra ch ph m
ng -
ph
h
o v
b
t polysaccarit t
rong bi n
(arabinogalactan).
1.1.5
*
K
[2]
nh