Đánh giá tác dụng cầm máu của Terlipressin trong điều trị xuất huyết tiêu hóa do vỡ giãn tĩnh mạch thực quản



QRRRSTUVVRWXYZ[ZY\\
Z]Q^Z_`abcX
S]defgVhij

qrQl
xrwmnypQz{Xps|
VklSmnop
psst
smuvpw
2
M

9*)$8'
*)9:#$,"'}9*)$8'*)3$")$5$A)}3EO~)?

:'$#67A5€'
5?$'()#6.NOP#D$‚#$'*)DE()17*)$)$ƒ)8„?'…)D†)$C:#$D$‚#‡.=)H3ˆ‰?")8A3Š$3"445
#6.
7*)$8'*)9:#$C"'D‹ŒL2
L2)$CNŽ)$?'ŽDŽ#H)?#CCŽ.#‘"3FE&'5EFGG')J4Ž#7*)$
)$ƒ)G".Š$'#$’)N3Ž)&A8„?'…)D†)$C:#$D$‚#‡.=)8Aˆ“&”#C CŽ.‡.")€'G3'NOP##$'"&AC 2
)$>C+)$>C  N'•. DE!D$O~)? ‡.'#> H–)? D$(C DFE&'5EFGG')})$>C 2 N'•. DE!D$O~)?‡.'Š$0)? H–)?
DFE&'5EFGG')J—3GŽ)$2)$>C D$4/DFE&'5EFGG')#>Š$=)˜)?Š'™C G3ŽD#$=/CŽ.
5š1Œ
1ˆ.$O›)?#='
D$'*)Dœ&*D“83)?
5š1Œ
1?'=CG@N)8!C.5$='DE./)1$0)?#>G$#7'*D8D&*#$=/C.D'
5$D#)?)$OD$~'?'"))C 8'*)J )$?'D#H)?#C C.#"DFE&'5EFGG')#$3D$4/#>D$GH)?

D$.@##$3)$)?7*)$)$).4D$./DD'(.$>"H38?')D)$C:#$D$#.=)1N#7'*DĂ)$)?DEO~)?
$P5#$O"D$D')$A)$)'G3'#")D$'*5#CC.J
ÂÊsÔkƠƯĐwlăp{âpsêzôs{sơôưmđpr{llprÊlêàả{ôsđnêảmr{ãá{ạƯàpw

QằdaQ^

ẳẵắẵẵặầẩẫấậèẻẽẻéẹề
ểềễẵếẻ ệì éỉẻ ềẻè ẻẻè ềĩầ ỉ
ềẻèíẻèịòệểềẽẻéẹềềầấìềặỏệõ
ấẫẻè ềầẫóọịềẻèẻ ềẵ ồẻ èổ
ềỗẻèẻốộờõởầéỡớẵềẫắỏệõõẻ
ẻợẻùẵắẵẵặầẩẫấậèẻẽẻ
éẹềểềễẵếẻấìẻèẵềủấẫẻèũầẵéú
ệụẻềếéịẵỡớẵíẻèẩụẻừẫửèầẻữứựó
ờỳấỷỹấõềỡớẵồùấìẩểòýẻèềếéịẵị
òịẩẫ ấậ èẻ ẽẻ éẹề ểề ễẵếẻ ềụẻ
ỡốỵềệốẵợéóểềỹấõềỡớẵồùềếéịẵ
ẩẫấậèẻẽẻéẹềểềễẵếẻỡỡốỵềề0
123ỏẳ4ẳóồẫẻèềịềõẻòịòỡớẵồù
ỳềịềẵ5ềềẫéẹềỡầẻèỡốỵềẩ6ẻèò7
ẻấìỡềẻèéẻỡốỵềõẵễẵếềụé
éịẵ ồẫẻè ềếéịẵ ềắò ềẵó89ẻ ỳẻ ệì

ấầũẫòồừũũẻỹỡốỵềỡẻệìẵ5ềềẫéẹề
ẻầẻỹõẵễẵếềụé éịẵềầẫẻốẻèệẹềặ
ẻớẵ ẻốỵề ỡ9éó8
ẻè ỡẻè ềĩầ ấầũẫ

òồừũũẻệìừồệòồừũũẻ3
ềòềỡốỵềẻẻè

ẻốỵềỡ9é ềĩầ ấầũẫòồừũũẻ ẻốềẫ éẹề
éẹẻỹ3ẫẩìấìịềẩẻèòủẻữ
ựóẵẻẻỹềịềẻèẻềẵấớừồệòồừũũẻộ
ờõởầé ềýẻẵóọẻấỳấỷỹề0ẻè
ẻ ìẻẻèẻềẵ ỡớìẻìẻé éề
ẵ ỡịẻ èị ịề ẩẻè ềụé éịẵ ềĩầ
ừồệòồừũũẻồẫẻèỡớẵồùẵắẵẵặầ
ồẻẩẫèẻấậẽẻéẹềểềễẵếẻộõẻ
ấõẻẹềầó

Qd R

qQ!l{u"pw
ắềếẻẻèõẻẻợẻùẵắẵẵ
ặầồẻẩẫấậèẻẽẻéẹềểềễẵếẻộ
õẻẻợẻủèầẻấìẫềắòềẵấìỡớẵồùẹ
!"#$%&'()$*+,"'-./30)12$3"445#6.17*)$8'*) õẻ ấõẻ ẹề ầ2 ịẻè #$ứ$ ỡẻ
9:#$,"'1;8<'='5$>)?1 @)? "17A50'
ịẻèứ$#$ứ$ó
BC"'&+D3)EFG'HF)DI?C"'&J#3C
&'()*+,*-.+,/.01.,.,2.3õẻẻợẻ
5?A/)$K)+2L2L2M
5?A/NOP##$45D$.K)+29L8L2
ồẫẻèỡỉẵ72ứ4
5$ìèþÒÒÁ6ÎìÉÞÎðÞÒ
12

34546789

2

!"#%&'(#&)*((+,&#-./0123+4"(5"#678#
(#98:&;"(<,""=+>0+?8-#=+8#@"3>&)(*
AB03."1B#=+8#@"3(C"3DEF98(5"#678#
8G.H
JKLMNOPNQRSTULVWXY
Z[-8#\"38#] !"#1^+(_Z[-%&'(#&)*((+,&#-./0F0`(/7/B)a
(D(Z[-E#b&(#&c(FB63+;6DEF98(5"#678#
8G.(
3efgheijklhehemhn[D8Ao"#"#p" q
(+,&8#&r" ds88#r" 0D"%D8 !"#1B8t6
6D&:&."=+>0+u8-vwAo"#"#p"x8#+.(#B"#
y"#-61B(#_0/z+(<0"3{"3B)H
|4eij n ds8 +}& (8#&r"#+o" ."3DE/"3(7+Ao"#1+o"78#
.+1B8-/"3(#,6(_|4eij
ds8 +}& (8#&r"#+o" ."3DE/"3(7+Ao"#1+o"78#
.+H

KPLVY3#+,"8@&8."(#+oE(+*"8@&?
8->0>D"##"3"3b&"#+,"8-"#-68#@"3H

ắ


PRPY'(8;8D8Ao"#"#p" q
(+,&8#&r""3#+,"8@&1B01+o"> ds8#D6
1B%`("3#+o6 8'E8@& D"#3+D6@8 =
6'(6D&?6@8 =%3."HH.& -8D8Ao"#
"#p" }& ds8"=+>0+ 8#r" 0D"%D8 !"#
1B +}&((|#-6 ds8 /"3 "3.) (_uF)E<_>>+"xF+}&#Ă+ t&y63?>.& -/&)(<Â
63Êv#(+,6(5"#678#(<0"3ÔƠ#H
|#-6 y+*E(8 +}&(8#&r"H
ƯĐăâêôăơưđ
\F+o& ds8(#&(#cE(#_06b&Ao"#D"
(#\"3"#'(1B%GF(#_0E#d"3E#DE(#\"3
,)#8?E#t"6}6HwH
àảãáơạáãđ
o"#"#p" ds83+;+(#8#1}68 8#1B
E#d"3E#DE"3#+,"8@&1BAo"#"#p" ~"3
(9"3&)o"(#.6 3+."3#+,"8@&Ho"#"#p"
8-:&)}"(ằAẳ#"3(#.6 3+."3#+,"8@&
(+*E(<0"3A'(Â(#ẵ+ +6"B0H

áảơặầáđáẩẫẫơấầậưèơạáãđ
áảơặầ
ấầẻẽéẹ ấầẻẽéẹ

&ề+(<&"3AÂ"#u"C6x
Ô?wểễ?{ế

Ôv?ễể?Ô
ìFo".6Ê"ỉux
yƠÊếwuễế?ếếx
ếwÊếwuwwx
[-(+}">Gux
yếÊếwuv?x
yÔÊếwuƠwx
3&),""#p"%3."
ĩíds&ux
yÔÊếwuƠwx
ễÊếwuvế?ếx
Eệw?w{
ĩị+<&>ux
ếÊếwuwx
{Êếwuv?x
+6[#+F/ĩ&3#ux
Ơ?wểy?w{
Ơ?vểy?ễ
'(6D&"ò"3ux
ÔuÔv?x
ÔuÔv?x
ỏ626nõóọồeóổỗồồfốóeigộ2ờnồởóhỡkớheợ
234356789







!"$%&'()$)$*)+,)-./0102&34)/56&"70&3")/'8)$&9:;<=>25?&9)/'@A"B&$"C%&&0D"
$E-F4GH/0?)&I)$.JK$&$LKM"N)2)/"CD))$*)AO/-)+,F43PQ"250R. S$0+FTU"/$&3")/
'8)$G,.VK56.B&.W")X)/ +,)$P)$-"YZ$[)/KE\L]$WK'0(&G^5XK50R.K$")//0_-$-0
)$E.'()$)$*)2`ab>2>;cY
efghijklmnopqrstsuvwxvvyz
q{v|}g~€
q{vi}g~€
‚
g
ƒ
g
ƒ
„…+(K!..W"`†c
‡ˆ
ˆ=2‰
‡Š
‰=2‰
a‹>2>;
„$Œ050R.K!..W"
b>2>;
Š>2>
ˆ
Š
:Š2Š
‹‡/0Œ
‹>2>;
=2‰
;
>

ŠŠ2Š
‡ <‡:/0Œ
b>2>;
‡Š2Š
‰
Š2:
‡:T:Ž/0Œ
:
b>2>;
=2‰
‡
=2‰
b:Ž/0Œ
‡
„…+(K!. .W")$E. `ˆ=2‰†cK-4$O))$E. ‡`‰=2‰†cYL]$WK'0(&),CKE‘)/$I&$’)/]D2`a‹>2>;cY
efghjklmwqf“vyzpys‚qyp
klm
„…+(K$NC.W"&W0a$W&`†c
„$Œ050R.`/0Œc

q{v|}g~€
>`>c
>

q{vi}g~€
`Š2Šc
b:Ž

Z$[)/KE'()$)$*)'@K$NC.W"&W0a$W&)$E.2)$E.‡KE'()$)$*)`Š2Š†cG,&$Œ0
/0-)K$NC.W"&W0a$W&'()$)$*)),C+,G,4)/,C&$VŠY

efgh”jklmp•n–gh—–wqf“vyz
klm
q{v|}g~€
q{vi}g~€
‚
„…+(&˜G4)/`†c
`Š2Šc
‰`‡Š2Šc
‹>2>;
„…+(&˜G4)/)$E.`Š2Š†c&$Ba$O))$E.‡`‡Š2Š†c2\L]$WK'0(&),CKE‘)/$I-&$’)/
]D2`a‹>2>;cY
efgh™jqrshsšgg›vnsmgnoœlžŸghvyz‚qfsp z“¡g
q¢ghœ
q{v|}g~€ q{vi}g~€
‚
„$Œ0/0-))£.G0()`)/,Cc
=2=;¤‡2ˆ
=2‰;¤‡2:ˆ
b>2>;
¥O)G@.W"a$N0&3"C^)`5¦Gc
‡2:¤2ˆ‡
:2>Š¤‡2Žˆ
‹>2>
12

34546789
2
2


!#$%&'()*+,-./0*12%3%,4(567859:58;7#$%&'</,=+,$%3%,4(7698>?:78@;#$%
&'<(A/B)B,B4C%D,EF&G.+H>8>5IJ*1%,.K%8/,L.D.F%%M( &.N%/0*%DOP%,BQF,F.%,4( RS.
T,U%D/,VBWVB4WVT,)BO.N/I

XYZ[\]

^_/`*-%D,.K%Ba*B,b/,=18RaF/*c.O'
d*=/,*1_//.K*,4Feb&fD.g%/E%,(SB,/,VB
`*-%/,hL%DDi+Rj/k9lmn>/*c.8,o*,_/Rj
ON%,%,p%%F(8%D*1K%%,p%B,Q1_*Dp1d$
DF% Rj eb 0hq*8#F W! ON%, %,p% &jb &.N%
#.2* /0'#2* d$ DF% 3 (aB #A %i%D 6#.r(
s,.Remt*D,/0*%DOP%,BFb<&j(aB#A(=/
()*%i%DIuDv* %,.K%(jWV+,p% O!B)B
ON%,%,p%&jb%D,.K%Ba*3,F.%,4(B4#iB
#.r(B,*%DRj%,h%,F*8,F1%4.B)B,T,)BRj
WV T,)BO.N/D.wF ,F.%,4( Rj T,U%D B4 C
%D,EF/,!%DTKI
J0b%D%D,.K%Ba*BQFB,x%D/U.8/yRNBo(
()*3%,4( 56;n8z{%,4( 76zn8z{<8WVT,)BO.N/%j1B4C%D,EF
/,!%DTK&G.+H>8>lIJyRN%j1D.!%D%,h
%D,.K%Ba*BQFB)B/)BD.-T,)B/0K%/,_D.G.
%,h}FRT~0l€8 be~0R*%e9€I^_/`*-%D,.K%
Ba*B,b/,=18/yRNBo( ()*D.wF,F.%,4(
6%,4( 5 ??8?{‚%,4( 7 5n8z{T,b-%D/,L.D.F%/k57m79D.LRjT,)BO.N/
/,VBWVB4C%D,EF/,!%DTKIJyRNB,-1()*
/).+,)//0b%D%D,.K%Ba*%j1D.wF,F.%,4(

RjT,U%DB4WVT,)BO.N/&G.+ƒ>8>l6%,4(5
>{‚%,4( 7?8?{%D,.K%Ba*BQF}FRT~0?‚l€I
…bF%%b*&jBA%DWV#g/c%DT_/z%D,.K%
Ba*%Dv*%,.K%8(„#U./0K%99?ON%,%,p%
B,b /,=1 /y RN /† &b%D 3 %,4( e„%D
/~0R.+0~WW.%Wb&G.D.-ehqBRj/,=+,$%B4C
%D,EF /,!%D TK &G.%D*1 B$ `*1 /,*AB Rj
‡‡ ˆ >8nn6;l{s‰<7€IJyRN/†&b%D/0b%D
%D,.K% Ba* BQF B,x%D /U.3%,4( 5 6e„%D
/~0R.+0~WW.%234356789




/~0R.+0~WW.%%D,EF /,!%D TK &G.+ H >8>lIŠ.2* %j1B,b
/,=1e„3%,w%D/0*%D/p( 1/_RG%B4T,%‹%D%A.Wb.Bo( ()*%,F%,B,4%D&jWŒ%
Wj%D79D.L/,P&.NBW†e%D/~0R.+0~WW.%/,K(
&jbBŽ%D&v%#~( RS.Rq.B,Rj( D.-( /yRN
/†&b%DI
!Rhq%D()*+,-./0*12%3%,4(567859:
58;7#$%&'</,VBWV/,=+,$%%,4(7698>?:
78@;#$%&'D.F%%M(&.N%/0*%DOP%,D.wF,F.%,4(T,U%D
B4WVT,)BO.N//,VBWVI

XY‘\]

’*F%D,.K%Ba*n>ON%,%,p%d*=/,*1_/
/.K* ,4F eb &f D.g% /E%, (SB, /,VB `*-%8
B,x%D/U.0x/0F(A/W!T_/R*“%WF*
mJ~0R.+0~WW.%B4T,-%‹%DT.r( Wb)/B,-1
()*BFb6/”RNT.r( Wb)/B,-1()*3%,4(
/~0R.+0~WW.% ;n8z{8%,4( T,U%D e„%D /~0m
R.+0~WW.%Rjzn8z{&G.+H>8>lmJ~0R.+0~WW.%B4d*,hG%DRj( D.-( /yRN
/†&b%D6%,4(e„%D/~0R.+0~WW.%/”RN/†&b%DRj
?8?{8%,4( B,a%D 7?8?{ 6+ H >8>l<8BŽ%D
%,h Rj( D.-( W! Rhq%D ()* +,-./0*12%
6%,4( /~0R.+0~WW.%7859:58;7#$%&'‚%,4(
B,a%D98>?:78@;#$%&'86+H>8>5
\•–—˜™š›

uD,.K%Ba*#hqB,bj%/,j%,%,LWV,q+
/)BBQFON%,%,p%#g#œ%DC/,F(D.F%D,.K%
Ba*8#œ%D/,L.B4WV#4%DD4+BQF/“+/,r
O)BW81/)T,bFs=+Ba*&jT,bFs,ž%#b)%
,P%,-%,ŸN%,&.N%ŸSB, F.I





 !"#$%&'

()%*+ ,-.,/01,-.234567899:;)=>?
@ABCDEFGHAIJKA?JAL?CMFFHA?NOJPQFJ

FRSTFJUGVWA?XYZ[IJ\O]FJB^P_A?_VIJ_?
Z`ab?NOJPQFJ?J[F@ABO?X`O] ?cO]_Id[F
?NOJ PQFJ FRSefgh igh jklmnjopjhq jri
mnjlsmituvlmjwxmyjtzy{|}mn~ljri5
64klzQIFJ]`QVJ`S8e
8)..3 03604 
7899;) XdVIXVO `X SFA? `IJS]Sd
aSXVFSdJP`XXJS]e3hij{qm qyqqv h
vyqylilvz(03



Ă)ÂÊÔÔ #.ƠÔÔ78999;)ƯAd?VFO?X
XSOZ`PVĐZF`O?X`ddZ?XVSd`?XdVIXVOaXT
A FdX`?JXSI^ VO ?XS?PO? ` SFA?
aSXVFSdCdZVO]ăJ???AZ^e6âqyhwhn
Ă87Ă;0êôơTêôưe
đ)ÊÔ3.))0$Ơ.3.)0Ê.Ơ.
)!3.ÔÔ!7(9;)XdVIXVOF`O?X`d`
SFA?CdZVO]``IJS]SdaSXVFeiqm
qvy{hmy{hw8:ưààTưe
:)ảÔÊ*ƠãÊ*7(áạ;)XdVIXVOVO
CdZVO]`IJS]SdaSXVFăSIdSFC`F`OT
?X`ddZZ`ACdCdVOZ?AZ^e6âqyhwhnạ7(;
ơơàTơơằe

3++Ê4
Â,#!#''ẳ#Â$'#Âẳẳ#'ẳÂ!Â
Â#ÂÂ#'Â#!ẵ!ÂÂ7
ẵ!ÂÂ;Â'Â'ẳÂ'#ÂÂ#!,#Â

ưIS?VO?ắV?JAIIX]S?X`VO??VOSdCdZVO]CdZVO]ZA?`XAI?AX``IJS]Sd
aSXVFS?PX]OF^ISX?PO?TặSFJPSVJ`IV?SdX`P ằầàơ?`ơầàơắSaSdAS?Z`X
?JVFSF^`?XdVIXVO?XS?PO?eẩ?XCVO]ZVS]O`ZắV?JXAI?AX``IJS]SdaSXVF
SOZ OZ`F`IVFJP`?SV?XS?PO?IS?VO?ắX ZVaVZZ VO?` à ]X`AIăX`AI ơ X`A?VO
?XS?PO?ắV?J?XdVIXVOSOZ]X`AIàX`A?VO?XS?PO?ắV?J`A??XdVIXVOeXdVIXVOV
FSISCd`F`O?X`ddVO]CdZVO]IẫeằSOZI`VCd^XZAFVO]?JP`X?SdV?^XS?V`Iẫeằ
ZFXSVO]?Ja`dAP`Cd``Z?XSOAV`OắV?J`A?ZVXOF`O?JXS?`XFAXXO?CdZVO]
SOZ?JZAXS?V`O`J`IV?Sd?S^C?ắO?ắ`]X`AIeJaSdAS?V`O`JSP`?S?VFấFSF^`
?XdVIXVOA]]?Z?JS??XdVIXVOFSOCAZ`X?XS?PO?`CdZVO]ZA?`?J
XAI?AX ``IJS]SdaSXVFIFVSdd^ VO FS `O`?`C?SVOVO] OZ`F`IVF JP`?SV
?XS?PO?e
%4ậÊèÊ363ÊãẻƠÔẽÊ*06ÊÔ*Ê**.0.6ÊÔÔ*.ƠéÔ*.Ơ0+Ê6Ô*64

11

234356789