Post doc labex michem IPCM

Recruitment of a postdoctoral research fellow (12 months)
Employer:
Sorbonne
University
(LabEx MiChem)
Location:
Paris, France

Design of thermoresponsive hybrid nanoparticles
for biomedical applications
Background
Amphiphilic block copolymer assemblies have been widely investigated as
drug delivery vehicles for biomedical applications. In the past decade, the
development of controlled radical polymerization techniques and the
polymerization induced self-assembly (PISA) process have provided
straightforward synthetic tools to access a variety of self-assembled stimuliresponsive nanoparticles (NPs).

Gross salary:
33-36 k€/year upon
experience
In the framework of the LabEx MiChem, a collaborative project has been
proposed between the Institut Parisien de Chimie Moléculaire (IPCM) and the
Discipline:
laboratory of PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX
Polymer Chemistry (PHENIX), two complementary partners in the Labex MiChem. The polymer
Macromolecular
chemistry team of IPCM at Sorbonne University (SU), one of the pioneering
engineering
team in the development of the PISA technique, has been developing new
Hybrid synthesis
strategies to synthesize worm-like NPs directly in water using PISA1–4 while the

inorganic colloids team of PHENIX (SU) possesses solid expertise in the field
Organization type: of magnetic nanoparticles (MNPs) synthesis and characterization, recently
Academia
applied in the biomedical field.5–7
Job type: Postdoc
Duration:
12 months, starting
before December
2019

The current project targets the design of novel thermosensitive magnetic
filomicelles by PISA and their application to drug delivery. Indeed, it was
evidenced in the literature that such anisotropic NPs presented enhanced
drug-delivery along with an increased blood circulation time. Furthermore,
the presence of such MNPs within thermosensitive NPs can provide targeting
and remote drug delivery properties to the designed drug delivery system
(DDS).

Required qualifications:
 A PhD in Polymer Chemistry or any related field with experience in macromolecular
engineering using controlled radical polymerization (CRP) will be preferred. Alternatively, a
strong background in the synthesis and characterization of thermosensitive polymers or
hybrids would be a major asset for the success of the project.
 The applicant should be open to work at the interface of polymer chemistry, inorganic
chemistry and biochemistry.
 A strong command of written and spoken English is recommended.
 Good communication, laboratory and organizational skills.
Application:
Curriculum Vitae // List of publications // References from two people
All documents must be sent by e-mail to both contacts below

Franỗois Stoffelbach () (IPCM)
and Christine Ménager () (PHENIX)
Sorbonne University / Campus Pierre & Marie Curie, 4 place Jussieu, 75005 PARIS – FRANCE
REFERENCES: (1) Rieger, J. Macromol. Rapid Commun., 2015, 36, 1458. (2) Mellot, G. et al. Macromolecules, 2018,
51, 10214. (3) Mellot, G. et al. Angew. Chemie - Int. Ed., 2019, 58, 3173. (4) Biais, P. et al. Polym. Chem., 2018, 9,
4483. (5) Cazares-Cortes, E. et al. Nanomaterials, 2018, 8, 850. (6) Cazares-Cortes, E. et al. ACS Appl. Mater.
Interfaces, 2017, 9, 25775. (7) Griffete, N. et al. Nanoscale, 2015, 7, 18891.