Marrone 2007 fungicide

Milsana® Fungicide
Nick Macris
Director, Business Development

(727) 742-2571 (mobile)
(530) 750-2800 (office)
www.marroneorganics.com


Milsana® Fungicide Overview


Source: Extract from giant knotweed Reynoutria
sachalinensis (REYSA).



Target pathogens: Milsana® effectively controls powdery
mildew, gray mold, rust, and bacterial blight on ornamental
plants and edible crops.



Mode of Action: Induction of plant defense responses.
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–
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

Reactive oxygen species
Enzymes of the phenolic pathway
Lignification of cell walls
Papilla formation
Phytoalexins

Has EPA crop and non crop registrations as biochemical
biopesticide. California - non crop label only.


Milsana® Label Recommendations


Apply at the rate of 0.5-1.0% in 50 to 100 gallons of
water per acre.



Add 0.02% wetting agent such as Nu-Film P.



Use the spray mixture preventatively at the 4-6 leaf
plant stage and repeat spraying every 7-14 days
depending on disease pressure.


Milsana® on Ornamentals
 Begonias

 Freesias

 Lisianthus

 Poinsettias

 Salvias

 Zinnias

 Crape

 Gerbera

myrtle
 Petunias
 Snapdragons

 Roses
Diseases

Powdery Mildew (Oidium
spp)
Gray Mold (Botrytis cinerea)
Rust (Puccinia antirrhini)


Milsana® on Food Crops
 Cucumbers

 Strawberries

 Melons

 Lettuce

 Squash

 Pumpkins

 Grapes

 Tomatoes

 Peppers

*
Diseases

Powdery Mildew (Sphaerotheca spp, Erysiphe cichoracearum )
Gray Mold (Botrytis cinerea)
Bacterial blight (Xanthomonas campestris)*


Summary of Milsana® Activity
Summary of REYSA Extract Activity on Various Edible Crops and Diseases, 1994-2001
Crop / Plant
Cucumbers

Diseases
Sphaerotheca fuliginea

Induction Activity
+++

Squash

S. fuliginea

+++

Melons

S. fuliginea

+++

Grapes

Uncinula necator

+++

Peppers

Xanthomonas spp.

++

Pumpkin

S. fuliginea

++

Lettuce

Erysiphe cichoriasearum

++

Strawberries

S. macularis

++

Wheat

Erysiphe graminis

++

Beans

Botrytis cinerea
Sclerotinia

+

(-)


Field Data
Grape powdery mildew trial,
(W.D. Gubler, Univ. of California, Davis, July 2000)

Trt#

Product, sequence

(among 24 combinations tested)

Severity %

Incidence
%

1

Untreated

62.0 a

100 a

2

Serenade® WP + Rally® WP, 7x

4.0 b

40.0 b

3

Milsana®, 7x

2.2 b

28.8 b

4

Mankocide® + Microthiol® 80 DF, 5x 2.0 b
and Sulfur 80 DF, 7x

32.5 b

5

Sulfur 80 DF 1x followed by
Procure® 50 WS + Sulfur 80
DF,7x

1.3 b

21.3 b

6

Serenade® WP, (low) 13x

1.2 b

33.1 b

7

Abound® 2.08 SC, 7x

0.5 b

13.8 b


Field Data
Botrytis disease ratings and yield of “Trust”
Tomatoes
(Central Mississippi Research Center, 2003)

Treatment

Disease
Marketable yield
rating
per plant (lb)
(0-100%)

Untreated Control

53.3 a
9.6 a
Milsana®
26.7 b
11.4 b
Elevate® 50WG 16.7 b
11.2 b
Switch® 62.5 WG
26.7 b
11.4 b
Serenade®
20.0 b
10.7 a
Scala®
53.3 a
10.7 a


Regulatory/Toxicology


Current EPA registration for crop and non crop
(ornamentals) uses.



CA non crop label only (MOI will submit crop label
by the end of 2007).



More targets will be added (e.g. tomato, turf).



All other crops and diseases are opportunities for
IR-4 priorities.
MOI is working on an organic formulation.




Potential IR-4 Projects


Test Milsana® as part of IPM programs in
ornamentals, vegetables, fruit, vines (Botrytis,
mildews, bacterial diseases. Other diseases ?



Test Milsana® on turf diseases.



Test efficacy against other pathogens, such as
oomycetes (Phytophthora spp. and downy
mildew).