hoàn thiện quy trình sản xuất và sử dụng vắc xin nhũ dầu tụ huyết trùng trâu bò p52 phòng bệnh tụ huyết trùng cho đàn trâu bò nuôi ở việt nam

8
^
/r^
r^
A«i^^Vtfsajfr*M*»flivWS#^
(V-«eH?##.tii»V¥^Nifii^<V*N*yii^^
»-^

G6NG
KGHg B() NdNG
NGHISP*
PIMfl
£HGN
TR.ONO
BifeM
cAP
NHA
Ntrd^C
KCO4/06-W
I
Bi0
eAo
f
fee
10P
^^^^^^i^^^^B^^^^^
JO
KHOA
HOC VA
CONG
NGHE

BO NONG NGHIEP
&
PINT
CHirONG
TRINH
KHCN TRQNG
DIEM CAP NBA
Nir6'C
KC
04/06-10
Dir
AN
SAN
XUAT
THU'
NGHIEM
BAO CAO
TONG
HOP
KET QUA
KHOA HQC CONG
NGHE
DlT
AN
"HOAN THIEN
QUI TRINH SAN
XUAT
VA
SU*
DUNG VAC

XIN
NHU
DAU
TU
HUYET TRUNG TRAU
BO CHUNG P52
PHONG
BENH
TU HUYET TRUNG CHO
DAN
TRAU
BO
NUOI
6
VIET NAM"
Ma so: KC.04 DA 07/06-10
Chu
nhiem
da an
(kitten)
chu
tri
du*
an
^fcy
ten)
6NGGIAMD6C
TRAN
XUAN
H^NH

Ban chu
nUem
chircmg
trinh
(k^
tin)
^HAMQUANGTHAI
Bo Khoa hoc va C6ng nghe
^y
ten)
'W^
(JgriSCKltaii PvyCJtwf
TP. Ho
Chi
Minh, 2010
S
I/O
(
2M0
CONG TY TNHH
MOT
THANH CONG HOA XA HOI CHU
NGHIA
VIET NAM
VIEN
THUOC THU Y
TW
Doc lap -
Ty
do -

Hanh
phuc'
S6:JJ.S./DN-CTTY
TP.
HCM,
ngay
i^'thang
^Tnam
2010.
V/v:
De
nghi
ddnh gia
kit qua
de tai/d\e
an a cap nha
mc&c
Kinh
giri: - Ban chu
nhi^m Chu-ffng
trinh KC 04/06-10
- Van
phong
cac
ChiroTng
trinh KHCN
trgng diln c3p
Nha
nu-d-c
can cir

vao Thong
tu
s6:12/2009/TT-BKHCN ngay 08/5 /2009 cua Bp
trucmg
Bo
Khoa hoc va Cong nghe
huang
dan ve
viec
danh gia nghiem thu de tai khoa hoc cong
nghe va du an san xuat thuc nghiem cap nha
nuac,
Cong ty TNHH
mgl
thanh vien
thuoc
thu y TW de nghi Ban
chii
nhiem Chuong trinh KC 04/06-10 va Van phong cac
Chucrng
trinh KHCN trong dien cap Nha nuac xem xet va to
chuc
danh gia cap nha
nuac
Icet
qua thuc hien doi
vai
dy an sau day:
Ten du an:
Hoan

thien quy
trlah
san
xu^t vk
su"
dung \ic xin
nhu
dan tu huyet
r^'^ng
trau b6
chdng
P52 ph6ng
b^nh
tu huyet trung cho dan
trSu bd
nu6i d Viet Nam.
Ma
s6
du an: KC 04 DA 07/06-10
Thuoc: - Chuong trinh KHCN trong
diim cdp
Nha
nu&c "Nghien
ciJu,
phat
trien va rfng dung c6ng
ngfad
sinh hoc",
Ma
s6:

KC 04/06-10
Hop
d6ng
KHCN
s6:
07/2008/HD
- DACT-KC 04 DA
07/06-10
Thai gian thuc hien theo hop dong: tu thang 3 nam 2008
d^n
thang 2 nam
2010.
Thai gian
dugc
dieu chinh, gia han (neu c6) den: Khong
Chu nhiem
dir
an: TS. Tran Xuan Hanh
Du an tren da
dugc
hoi dong danh gia ca so hop ngay 13 thang 4 nam 2010,
xep
loai
"Dat".
Kem theo cong van nay
la
ho so danh gia cap nha nuac, gom:
1.
Bao cao tong hop ket qua, bao cao torn tat va san pham KHCN cua de tai, du
an vcri so

luong
va yeu cau theo
hop
dong;
2.
Bao cao nhan xet ve to
chiic
thuc hien cua ca
quan
chu tri
d§
tai, du an;
3.
Hop
d6ng
va thuyet minh de tai, du an kem theo;
4.
Thong tu ban hanh danh muc vac xin,
ch6 phim
sinh hoc, vi sinh vat. hoa
chit dung trong
thti
y dugc phep
luu
hanh tai Viet Nam do Bo NN&PTNT ban hanh
nam 2009;
giky chung
nhan dang ky san
xuit
thuoc

thii
y do
Cue
thu y cip nam
2G10;
dSc
tai
lifu
ve ket qua kiem nghiem vac xin tu huyet trung trau bo nhu
dSu
chung P52, la cac 16 san pham dugc san
xudt
trong du an; cac bao cao ve ket qua su
dung vac xin
nhia d4u
tu
huySt
trung trau bo
6k
tiem phong tai cac dia phuang;
5.
Cac Bien ban kiem tra dinh ky
ciia
Ban chu nhiem chuong trinh, ca quan chu
quan,
Bg
KH&CN;
6. Bao cao
dk nghj quy^t
toan tai chinh cua

dk
tai,
dir
an;
7.
So nhat ky
dir
an;
8. Quyet dinh va bien ban danh gia cua Hoi dong danh gia cap ca so;
9. Van ban xac nhan ve su thoa thuan cua cac
t^c
gia ve
vice
sap xep thu tu ten
trong danh sach tac gia thuc hien
d6
tai, du ^n;
11.
Cac tai lieu khac
(n6u
c6).
So
lugng
ho so gom:
- 05
bg
(ban sao)
diy
du tai lieu ke tren;
- 08 bg (ban sao) cac tai lieu tren

trir
tai lieu so 7 (tai lieu thiet ke, so lieu ).
De nghi Ban chu nhiem Chuong trinh KC 04/06-10 va Van phong cac Chuong trinh
KHCN trong dien cap Nha nuac xem xet va to chuc danh gia nghiem thu cap nha
nuac ket qua
d^
tai/du
an./i^^:=i-
THUTRU'OfNG
TO
CHlTC
CHU TRI
DlT AN
'^S^^
^AZn niAM
B6C
IT
THANH
|»
I
THUO'f
PHAM
OUANG
THAI
CONG TY THUOC THU
Y
TW
CONG
HOA XA HOI CHU NGHIA VIET NAM
fioc lap - Ty do - Hanh phuc

TP.
HCM, ngay
^ thang .^"
nam 2010
BAO CAO VE VIEC HOAN THIEN
HO
SO
DANH GIA CAP CO
SO
I.
Nh&ng
thong tin chung
1.
Ten du an: Hoan
thi$n
quy trinh
sdn
xuat va
siJ
dung
vdc
xin nhu dau tu
huyet trung
trSu
b6
chiing
P52 ph6ng benh tu huyet
triing
cho dan
trSu

bo
nuoi d Viet Nam.
Ma
s6 dir
an: KC 04 DA 07/06-10
Thuoc:
- Chuong trinh KHCN trong
dilm
cip Nha
nuoc "NgMen
cilu,
phat trien
va
ling
dung c6ng nghe sinh hoc",
Ma s6: KC 04/06-10
2.
Chu nhiem du an: TS. Tran Xuan Hanh
3.
Co quan chu tri du an: Cong ty
thu6c thii
y TW - NAVETCO
4.
Chii
tich hoi
d6ng
danh gia: PCS. TS.
TrSn
Dinh
TCr.

Hoi thu y Viet Nam.
5.
Thoi
gian danh gia: Bat dau:
09gia.
ngay
13/4/2010
Ka
thuc: 11 gia, ngay
13 M
/2010
II.
Noi dung da thuc hien theo ket
luan
cua hoi
d6ng
cip ca so:
1.
NhiJng
noi dung da bo sung hoan thien:
Du an da chinh
sila cAc iSi
in an, chinh ta, sap xep trat
tit
cac noi dung
trong bao cao hoan chinh theo gop y cua Hoi dong.
2.
NhQng van de bo sung moi:
- Bo sung nhOng hinh anh va giai thuong du an tham gia hoi chg
Techmart Viet Nam Asean + 3 vao thang 9/2009.

- Giai thuong TOP TEN NGANH
HANG
san phSm thuong hieu Viet hoi
nhap WTO cho vac xin tu huyet trung trau bo nhu dau chung P52.
3.
Nhung vSn de chua hoan thien duac (neu ro ly do):
- IChong
III.
KiSn nghj ciia chii nhiem de
tii/du'
an:
Du an da hoan thanh diy dii cac noi dung va vugt dang l<y ve so lugng
san phim vac xin nhu d4u tu huyet triing trau bo chung P52.
San pham vac xin da dugc sii dung tiem phong de phong benh tu huyet
triing cho dan trau bo rat hieu qua tai hau het cac tinh trong nuoc dac
biet cac tinh Tay Nguyen va da xuat khau.
Be nghi Hoi dong nghiem thu cap nha nuoc cong nhan ket qua du an.
CHU NHIEM BE TAX, DU AN
(Ho, ten va
chii
ky)
TRAN
XUAN
HANH
XAC
NHAN CUA
CHU
TICH
HOl
D6NG

(HQ,
ten va chit ky}
XAC NHAN CUA
T6
cHtrc CHU
TRI
DE
TAI,
Dir
AN
,
chit
ky va dong
ddu)
'^SooioSr
PGS,TS.gi^J)^^
PHAM
QUANG
THAI
BAO CAO GIAI TRINH
MOT SO
VAN
DE
TAI
HQI
NGHI NGHIEM THU
CAP
CO
Sd
Du-

an: HOAN THIEN QUI TRINH SAN XUAT VA
SU'
DUNG VAC XIN NHU DAU
TU HUYET TRUNG TRAU
B6
CHUNG P52 PHONG BENH
TV
HUYET TRUNG
CHO DAN TRAU BO 6 VIET NAM
1.
Noi ro
hem
ve cai tien moi
truong
nuoi cay
Cai tien moi
trydng
nuoi cay de san xuat vac xin nhu dau la van de
then chot quyet dinh den thanh cong
ciia dir
an. Qua trinh cai tien dugc
thuc hien bang
each
bo xung mot so cac yeu to dinh
duong
can thiet nham
nang cao
sir
phat trien
ciia

vi khuan P.multocida trong dieu kien nuoi cay
trong Fermenter
voi
cac thong so ve pH,
toe
do khuay dao, do thong
Idii
(do hoa tan oxy) da dugc chuan hoa.
Viec cai tien moi truong thuc hien trong du an nay da dam bao dugc
3 van de:
Tang hieu qua nuoi cay ciia vi khuan P.multocida,
chiing
P52
Moi
trirong
de che tao va de kiem soat ve mat chat lugng
Khong
CO sir
bien dong ve gia thanh san xuat moi tnrong
Thirc
te cho thay nong do vi khuan thu hoach dugc tang
len
khi nuoi
cay trong moi truong cai tien khong
nhitng
dam bao du tieu chuan de san
xuat vac xin nhu dau, ma con mang y
nghia
kinh te rat
Ion.

Vi day la mot du an san xuat thu nghiem, san pham la vac xin doi
hoi ky thuat cao va dieu kien nghiem ngat khi san xuat, hon
nira
trong dieu
kien kinh te thi truong,
sir
canh tranh giiia cac nha san xuat rat khac nghiet,
do vay viec
giii
bi mat cong
thiic,
cac bi quyet la van de can
dirge
ton
trong, vi vay chiing toi xin phep khong neu chi tiet cong thirc, thanh phan
moi trucmg cung nhu cong
thitc
phoi hgp lam nhii dau. Tuy nhien chiing toi
khang
djnh
rang chat lugng vac xin san xuat tir moi truong cai tien dat chit
lugng tot va dieu nay da dugc chiing minh qua
16 16
vac xin voi hon 7 trieu
lieu
vac xin da san xuat deu dat tieu chuan chat lugng va khi sir dung trong
thuc te cho
kit
qua an toan va hieu qua bao ho cao.
2.

Cach che khang nguyen
diing
trong ky thuat
ELISA
phat hien
Ichang
the
THT trau bo? Tac gia c6 the dong y chuyen giao
ley
thuat ELISA?
Ky thuat ELISA
dliu
tien dugc chung toi phat trien de sir dung phat
hien khang the tu huyet triing heo (Septicaemic Pasteurellosis) vgi khang
nguyen
diing
chua vi khuan
Pasteurella
multocida serotype B:2. Ky thuat
nay dugc thirc hien tai khoa thu y (Vet School) truong dai hgc Queensland,
Australia
duoi
su huang dan cua giao su Alan Frost. Tir ket qua nay, chung
toi da chuan hoa de dung kiem tra
Idiang
the benh tu huyet triing trau bo
(Haemorrhagic septicaemia). Khang nguyen diing trong ky thuat nay la
khang nguyen chiu nhiet, diing chung VP 816 (hoac) HPKT99. Day la
chung dugc phan lap tir mot
6 djch

tu huyet triing trau bo va heo tai tinh
Kontum vao nam 1999 va bang cac phuong phap khac nhau (huyet thanh
hoc,
PCR) da xac dinh la vi khuan P. multocida serotype B:2 (phuong phap
che tao khang nguyen tham khao trong luan an tien
sT ciia
Tran Xuan Hanh,
2002).
Ve mat chuyen giao ky thuat: Day la mot phuang phap danh gia
mien dich trong benh tu huyet trung rat chinh xac va hieu qua ve mat kinh
te,
do vay chung toi san sang chuyen giao ky thuat neu dugc yeu cau.
3.
Loi chinh ta va
each
trinh bay trong bao cao.
Chiing toi da kiem tra
lai
mot
each
can than, sira loi chinh ta, cac loi
in an va trinh bay lai mot so bang
bieu
cho de theo doi
hem
theo nhu gop y
ciia
hoi dong.
Chu nhiem du an
TS.

Tran Xuan Hanh
CONG TY TNHH
MOT
THANH
VIEN THUOC THU Y
TW
CONG HOA XA HOI CHU NGHIA VIE
I
NAM
Doc
lap - Ty do -
Hanh
phiic
TP.
HCM,
ngay
Jc
thang
,-?
nam 2010
DANH SACH TAC
GIA
THVC
HIEN
DE
TAI
KHCN/Dir
AN SXTN
CAP
NHA NlTdC

(Danh sach
nhitng
ca
nhan
da
dong
gop
sang
tao
chii
yeu cho de
tai,
du an
ditac
sap xep
theo
thit
tu do
thoa thuan)
1.
Ten
dir
an:
Hoan thien
quy
tiinh sJn xuS't v4 sil
dung
vdc
xin nhu dau tu
huyg't

triing
trau
bo
chiing
P52
ph6ng
bfinh
tu
huyet triing
cho dan
ttau
bo
nuoi
S Vi$t
Nam.
Ma
s6
du
an:
KC 04 DA
07/06-10
Thuoc:
Chuong
trinh KHCN trong diem
cdp Nha
nuoc "Nghien
clJu,
ph£t tri^n
v4 iJng
dung cong

ngh^
sinh
hoc".
Ma s6:
KC
04/06-10
2.
Thai gian thirc hien:
tir
thang
3
nam 2008
dSn
thang
2
nam 2010
3.
T6
chirc
chii
tri: Cong
ty
TNHH mot thanh vien
thudc thii
y
TW-NAVETCO.
4.
Co quan chu quan:
Bo
Nong nghiep

va
PTNT.
5.
Tac gia thuc hien
de
tai/dir
an tren gom
nhimg nguoi
c6 ten
trong danh sach sau
So
TT
1
2
3
4
5
6
7
8
9
Ch^c
danh khoa hoc, hoc vi,
ho va
ten
TS.
Tran Xuan Hanh
TS.
Nguyen Thien Thu
TS.

Pham Quang Thai
BS.
To Thi
Phan
BS.
VoCongMmh
ThS.
D6 Vanfiiang
BS.
Pham Hao Quang
ThS.
Nguyen Van Dung
KS.
Nguyen Tang Kien
To
chirc
cong tac
Cong ty thuoc thu y TW
Cong ty thuoc
thii
y TW
C6ng ty thuoc thu y TW -
Cong ty thuoc
thii
y.TW
Cong ty thuoc
thii
y TW
Cong ty thuoc
thii

y TW
•
Cong ty thuoc
thii
y TW
Cong ty thuoc
thii
y TW
Cong ty thuoc thu y TW
ChCtky
1.)^''^-
'Wfz^^^'
/^t^£
-^
^y^-
•f'tfii-
V>
Chu
nhifm
de
tai/dy
an
(Ho,
ten
vd chu ky)
Thu
truong
to
chiic
chu tri

de
tai/du*
an
', chir ky vd dong ddu)
^•si^rrS^^ynMO GIAM
DOC
PHAM
QUANG
THAJ
CONG TY TNHH MOT
THANH
VIEN CONG HOA
XA
HOI CHU NGHIA VIET NAM
THUOC
THi) Y
TW Doc lap -
Tir
do - Hanh
phiic
TP.
HCM. ngay 9
llidng
4 nam 2010
NHAN XET VE TO
CHlTC THtfC
HIEN
DE TAI
KHCN/Dir AN
SXTN CAP NHA

NlTOfC
1.
Thong tin chung:
1 Ten
dir
an:
Ho&n
thien quy trinh san
xurft
va
si
dung vac xin nhu
diu
tu
huy^t
triing
trSu
b6 chiing P52 ph6ng
bfinh
tu
huy^t triing
cho
dJn
trau bo
nuoi d
Vi6t
Nam
Ma
s8 dif
an: KC 04 DA 07/06-10

Thuoc: Chuong trinh KHCN trong diim cap nha nuoc
"Nghi8n
ci?u,
ph^t
trien va
itng
dung cong nghe sinh hoc",
Ma
s6:
KC 04/06-10
2.
Ten chu nhiem: TS. Tran Xuan Hanh
3.
Ten to chirc chii tri: Cong ty TNHH mot thanh vien thuoc thu y TW-
NAVETCO
4.
Tong kinh phi thuc hien: 6.695,876 trieu
d6ng
- Trong do, Kinh phi tir ngan sach SNKH: 2.000 tr.d
- Ty
le
va kinh phi thu
h6i (ddi v&i Die
an SXTN): 60%
bSng
1.200
Tr. d.
5.
Thoi gian thirc hien: 24 thang
- Bat dau (theo hgp dong): thang 3 nam 2008

-
KSt
thuc (theo hgp
d6ng):
thang 2 nam
2010
-
Dirge
dieu chinh, gia han
(niu
c6) den: Khong
6. Tai lieu kem theo (neu c6): (van ban gia han, ket luan cua thanh tra, kiem
tra )
Dir
an khong phai gia han
II.
Nhan xet
vl t6
chirc thirc hien:
1.
Nhan xet
vk Ti6n
do thirc hien:
Thuc hien dung han:
Dir
an trien khai thuc hien dung han.
BChSng
thuc hien diing han (neu ro ly do
):
Khong.

2.
Nhan xet
v6
tinh hinh
sil
dung va huy dong nguon kinh phi thuc hien.
Du an su dung kinh phi diing muc
dich,
tiet kiem va diing nguyen tac tai
chinh.
Nhan xet ve tinh hinh huy dong kinh phi theo cam ket.
Co quan chu tri da cap
dii
von tu c6 de trien khai du an nhu da cam ket.
3.
Nhan xet, ket luan chung:
- Du an dugc
t6
chuc thuc hien dat yeu cau ve so lugng, chat lugng cac
san pham da dang
Ic^
d
dang ket qua I, II, III, IV.
- Ve tien do thai gian: Dat yeu cau.
ThO tru'ong
to chirc chu tri
, chu
Icy
va dong
ddu)

C6NG
TY THUOC
THfl Y
TW CONG HOA
XA Hpl
CHU NGHIA VIET NAM
D9C
lap - Ty do - Hanh phuc
TP.
Ho
Chi
minh,
ngay
17
thang 03 nam 2010
BAO CAO THONG KE
KET QUA
THlTC
HIEN DE
TAI/DU
AN SXTN
I. THONG
TIN
CHUNG
1.
Ten de tai/du an: Hoan thien qui trinh san xua't va su' dung vac xin nhu
diu
tu
huye't
triing

trSu
bo chiing P52 phong benh tu huyet triing cho dan
trSu
bo
cl
Viet Nam
Ma s6: KC
04
DA 07/06-10
Thuoc:
- Chuong trinh KH&CN trong
diim c§p
nha nuoc "Nghien
ciiu,
phat trien va img dung cong nghe sinh hgc"
- Ma s6:KC
04/06-10
2.
Chii nhiem de
tai/dir
an:
Ho va ten: Tran Xuan Hanh
Ngay, thang, nam sinh:
1957
Nam/NO:
Nam
Hoc ham, hgc vi: Tien
si
Chiic
danh khoa hgc:

Chiic
vu: Pho
tflng
giam d6c
Dienthoai:
T6
chvrc: 8 38225955 Nha rieng: Mobile: 0908356656
Fax: 08 38225060 E-mail:
Ten to chirc dang cong tac: Cong ty TNHH mot thanh vien
thu6c
thu y
TW -NAVETCO
Dia chi
t6
chirc: 29
Nguyin
Dinh Chiiu,
Ql,
TP.
H6
Chi Minh
Dia chi nha rieng: 29
Nguyin
Dinh
ChiSu,
Ql. TP.
H6
Chi Minh
3.
To chirc chii tri de tai/dir an:

Ten to chiic chu tri
Ah
tai: Cong ty TNHH mot thanh vien thu6c thu y
TW-NAVETCO
Dien thoai: 8 38225955 Fax: 08 38225060
E-mail:
1
Website: www.navetco.com.vn
Dia chi: 29
Ngiiyin
Dinh
Chiiu,
Ql, TP.
H6
Chi Minh
Hg va ten
thii
truong
tfl
chiic: PHAM QUANG THAI
S6 tai khoan: 931.90.01.00030
Kho bac nha nuoc quan
1
- TP. Ho Chi Minh
Ten
CO
quan chu quan
6h
tai: Bp Nong nghiep va PTNT
n.

TiNH
HINH THl/C
HIEN
1.
Thdi
gian thirc hien de tai/dy ^n:
- Theo Hgp
dSng
da ky
kSt:
tir
thang 3
nam
2008
dSn
thang 2 nam 2010
- Thirc te thirc hien; tir thang 3/nam 2008 den thang 2 nam
2010
- Dugc gia han (neu c6): khong
2.
Kinh phi va sir dung
Itinh
phi:
a)
T6ng s6
kinh phi thuc hien: 6.695,876 tr.d, trong do:
+ Kinh phi he ttg tir SNKH: 2000 tr.d.
+ Kinh phi tir cac
nguSn
khac: 4.695,876 tr.d.

+ Ty le va kinh phi thu
h6i
d6i
vdi dir
an
(nSu
c6): 60%. Thu hoi
1.200
tr.d
b) Tinh hinh
c4p
va sit dung kinh phi tit nguon SNKH:
s6
TT
1
2
3
Theo
kS
hoach
Thoi gian
(Thang, nam)
12/2008
2009
2010
Tong
Kinh phi
(Tr.d)
1.200
647

153
2.000
Thuc ti
a
Thoi gian
(Thang, nam)
9/2008
12/2008
3/2009
2010
at
tuac
Kinh phi
(Tr.d)
Cap 840
Cap 360
Cap 453
Cap 347
2.000
Ghi chu
(So de nghi
quyet toan)
502,440 tr.d
1.449,2
tr.d
48,36 tr.d
c) Ket qua sir dung kinh phi theo cac khoan chi:
Bdi
v&i du
an:

Ban vi tinh: Trieu dong
S6
TT
1
2
3
4
5
6
7
Npi
dang
cac khoan chi
Thiet bi, may moc
mua moi
Nha
xirong
xay
dung moi,
c^i
tao
Kinh phi ho trg
cong nghe
Chi phi
lao dgng
Nguy6n vat
li?u,
nang luiprng
Thue thiet bi, nha
xuong

BChac
Tong cong *
Theo ke hoach
Tong
1.700
0
700
561,6
1.919,026
1.210
605,25
6.695,876
SN
KH
200
0
700
200
700
0
200
2.000
Nguon
khac
1.500
0
0
361,6
1.219,026
1.210

405,25
4.695,876
Thifc
te dat
dirffc
Tong
1.709,763
0
700
561,6
1.909,263
1.210
605,25
6.695,876
SNKH
200
0
700
200
700
0
200
2.000
Nguon
khac
1.509,763
0
0
361,6
1.209,263

1.210
405,25
4.695,876
(*)
Chua tinh
kinh
phi
tic
von tu co de
SXso hegng
vac xin
vuat
du loan 4 trieu lieu.
- Ly do thay doi (neu c6):
3.
Cac van ban hanh chinh trong qua
trinh thurc
hien
de
tai/dy an:
(Liet ke cac quyet
dinh,
van ban cua ca
quan
quan ly
tir
cong
dogn
xac dinh
nhiem

vu,
xet
chon,
phi duyet
kinh
phi, hop
dong,
dieu chinh
(thai
gian,
noi dung
kinh
phi thuc
hien
neu
c6);
van
ban cm to chuc chi tri
de
tai,
du an
(dan,
kien
nghi
dieu
chinh
neu co)
So
TT
1

2
3
4
So,
th&i
gian ban
hanh van ban
28/8/2007
27/8/2008
So
1691/QD-
BKHCN,
ngay 16/8/2007
S6
2060/QD-
BKHCN,
Ngay 24/9/2007
Ten van ban
Tom tat hoat dong KHCN
ciia
to chirc dang
ky
chii
tri DA
Don dang ky chu tri thirc hien
dir
an cap nha
nuoc
Quy6t
dinh phe duyet Danh muc

dir
an
SXTN
thuoc
cac chuong trinh
BCH&CN
trong diem cap Nha nuac giai doan 2006-
2010 de xet chon giao
trirc
tiep thirc hien
trong
kS
hoach 2008
Quyet dinh thanh lap Hoi dong khoa hoc va
cong nghe cap Nha
nu6c
tu van xet chon to
chijc
ca nhan chu tri thuc hien
dir
an SXTN
dl
thirc hien trong ke hoach nam 20O8 thuoc
Chuong trinh "Nghien
ciiu,
phat trien
va
ling dung cong
nghS
sinh hpc".

MasdKC
04/06-10
Ghi chu
Bo
KHCN
ban
hanh
Bo KHCN
ban
hanh
5
6
7
8
9
10
S6 2337/QD-
BKHCN
Ngay 18/10/2007
S6
137/QD-
BKHCN
Ngay 23/1/2008
So 293/QD-
BKHCN
Ngay 29/02/2008
S6
07/2008/HB-
DACT-KC04
DA 07/06-10

Ngay 4/6/2008
Ngay 13/6/2008
S6
82a/2010/QD-
CTTY, ngay
15/3/2010
Quyet djnh phe duyet cac to
chive
ca nhan
triing
tuyen
chu tri thirc hien cac de tai, du
an SXTN nam 2008 (dot I) thuoc Chuong
trinh "Nghien
ciru,
phat trien va img dung
cong nghe sinh hoc" ma so KC
04/06-10
Quyet dinh
thanll lap
to tham dinh de tai
KH&CN,
dir
an SXTN cap Nha nuoc nam
2008
thuQc
Chuong trinh "Nghien
ciru,
phat
triln va

img dung cong nghe sinh hoc". Ma
S6KC
04/06-10
Quy^t
djnh phe duyet kinh phi 07 de tai, 02
dir
an SXTN bit
dlu
thirc hien nam 2008
thuoc Chuong trinh KH&CN trong diem
cap
Nha nuoc giai doan
2006-2010
"Nghien
cim, phat trien
va
img dung cong nghe sinh
hoc".
Ma so KC
04/06-10
Hgp dong nghien cim khoa hoc
va
phat trien
cong nghe
Ban qui che chi tieu kinh phi Du an SXTN
"Hoan thien qui trinh san xuat va
sii:
dung
vac xin nhu dau tu huyet triing trau bo
chUng

P52 phong benh tu huyet trung cho
dan trau bo
ct
Viet Nam"
Ma
s6:
KC
04 DA 07/06-10
Quyet dinh thanh
lip
Hoi dong nghiem thu
cap ca so du an SXTN thuoc Chuong trinh
trong diem cap Nha
nude
Bo KHCN
ban hanh
Bg KHCN
ban hanh
Bg KHCN
ban
haiili
Van phong
cac
chircmg trinh,
Chuong trinh
KC04/06-10-BP
KHCN
Co quan chu tri
Dir
an SXTN

ban hanh
(NAVETCO)
Co quan chii tri
diran
(NAVETCO)
4.
To
chu-c
phoi hop thuc hien di tai,
du-
an: Khong
S8
TT
1
Ten to chirc
dang ky theo
Thuyit minh
Ten to chirc da
tham gia thirc
hien
Ndi dung
tham
gia
chuyiu
Sim phSm
cha
yeu
dat duac
Ghi
chii*

- Ly do thay doi (neu c6):
5. Ca nhan tham
s6
TT
1
2
3
4
5
6
Tin
cd nhUn
diing ky theo
Thuyit minh
Tran Xuan
Hanh
Pham Quang
Thai
To Thi Phan
Nguyin
Thien Thu
D6
Van
Dung
Vo Cong
Minh
;ia thyc
hien
Ten cd nhSn
d5

tham gia
thivc
hiin
Tran Xuan
Hanh
Pham Quang
Thai
To Thi Phan
Nguyen
Thien Thu
D6
Van
Dung
Vo Cong
Minh
}e
tai,
duan:
Npi
dung tham gia
chinh
Chu
nhiSm:
To
chu'c,
quan iy,
thyc
hi6n triin
khai
dU

^n
theo tie'n dp
vd
qui
trinh
cong nghe
Phu trdchphat
trien mang
ludi
ph3n pho'i
va tieu
thu san pham.
Phu trach ky thuat
duan,
hodn
thien
cac qui trinh san
xua't qui mo cong
nghiep.
Thi/ky
dUan.
Phu
trach chuan hoa
qui trinh bao quan,
van chuyen vacxin;
So sanh vacxm nhu
dau
vdi
cac vacxin
truyen thong khac.

HoEln
thien qui
ttinh ki^m nghi§m
cac chi tieu vacxin
bang
phUPng
phap
thay
thS'
va trong
tai.
Phu trach
tri^n
khai
san
xu3't
vac xin qui
m6 cong nghiep
San pham
chuyiu
dat dugc
To chuc thuc hien
day du cac noi
dung cua du an,
dung tien dp.
Hoan tat bao cao
To chuc phat trien
mang
luoi
va Tieu

thu hon 6 trieu
lieu vac xin nhu
dau
- Phu trach ky
thuat du an
- Hoan thien cac
qui trinh cong doan
SX cong nghiep
vac xin nhu dau
Chuan hoa qui
trinh bao quan.
van
chuyen,
sir
dung vac xin
nhil.
Danh gia so sanh
VX nhii v6i cac
loai vac xin keo
phen khac
Xay dung qui
trinh kiem nghiem
vac xin.
Xac dinh do dai
mien dich cua vac
xin
San xuat duac
hon 7 trieu lieu
vac xin nhu dau
Gin

chu*
7
8
9
Pham
Hao
Quang
Pham Hao
Quang
Nguyen van
Dung
Nguyen
Tang Kien
Xay
dtfng phUdng
phap kiem tra
mien djch bao ho
dan gia
sue dUdc
tiem vacxin bang
ky thuat ELISA,
Thu nghiem thuc
dia danh gia an
toan va hieu
luc
vac xin
Phu trach thiet bi
Thiet lap qui trinh
ky thuat ELISA
dung phat

hien
khang the P.
multocida.
Ung
dung xac dinh
khang the bao ho
tren dan trau bo
duoc
tiem vac xin
a
thuc dia
Khang dinh vac
xin an toan va
hieu
lu'c
tren thuc
te san xuat
Huong dan su
dung thiet bi va
dam bao boat
dong
ciia
thiet bi
trong san xuat
- Ly do thay doi ( neu co):
6, Tinh hinh hop tac quoc te: Khong
- Ly do thay doi (neu co):
7.
Tinh hinh to chuc hoi thao, hoi nghi:
sS

TT
1
2
3
4
5
6
7
Theo ke hoach
(Noi dung,
thai
gian,
kinh
phi,
dia
diem)
Viing
Tay Nguyen
Viing
mien Trung
Viing Tay Nam bp
Viing
Dong Nam bp
Phia
Bac
Hoi nghi khoa hoc co so
nghiem thu tien dp
H3i d6ng
KHCN danh gia
nghiem thu cap co so

Thuc te dat
dieac
(Noi dung, thai gian,
kinh
phi, dia diem)
Vac xin va van de phan
ling sau khi tiem vac xin
va bien phap phong tri
-
To chuc tai Da Lat, thang
8/2009
Hue-3/2010
Dong Thap
BaRia
Ha
Noi
Danh gia ket qua tien dp
cua DA, thang 6/2009, tai
Congty
Danh gia nghiem thu co
so ket qua du an - ngay
13/4/2010, tai
Congty
Ghi
chii*
- Ly do thay doi (neu co):
8. Tom tat cac noi dung, cong viec chu yeu:
(Neu tai muc
15
cua thuyet minh, khong bao gom

•
Hoi (hao khoa hoc.
dien
tra khao
adi
trong
nu&c
vd nuac
ngoai)
Sd
TT
1
2
3
4
5
6
7
Cac noi dung, cong viec
chuyiu
(Cac mSc danh gia chit yeu)
Hoan thien qui trinh cong nghe
san xuat vac xin THT trau bo
nhu dau chiing P52
6
qui mo
cong nghiep.
Hoan thien qui trinh
ki^m
nghiem vac xin THT trau bo

nhu
dSu chimg
P52.
Xay dung phuong phap danh
gia mien dich va bao
h6 ciia
vac
xin trong
di^u ki6n
thuc
te'
bang
ky thuat ELISA.
Xay
dirng
qui trinh bio quan,
van chuyen va
sir
dung vac xin.
Danh gia so sanh hieu qua
phong benh
ciia
vac xin nhu
P52 vol cac vac xin truyen
thong khac
San xuat 3 trieu lieu vac xin
THT trau bo nhu dau
Dao tao khoa hpc (NCS thac sT,
sinh vien TNDH)
Dao tao lam

chii
qui trinh san
xuat, su dung thanh thao thiet bi
san xuat
Thiyi
gian
(Bat
ddu,
ket thiic
-
thang
nam)
Theo ke
hoach
4-12/2008
6-12/2008
-12/2009
6-12/2008
6/2008
-
12/2009
6/2008
-
12/2009
12/2009
12/2008
Thuc te
dat duac
12/2008
12/2008

12/2009
12/2008
6/2009
3/2010
da
SX 7 trieu
liSu
VX
1 thac
sT.
1 BS
da t6t
nghiep
l^gircti,
ca quan
thuc hien
BS.
To Thi
Phan
ThS.
Do Van
Dung
BS.
Pham
Hao Quang
TS,
l^guyen
Thien Thu
TS.
Nguyen

Thien Thu
BS.
Vo Cong
Minh
TS.Tran
Xuan Hanh.
BS.
To Thi
Phin.
KS.
Nguyen
Tang Kien
- Ly do thay
d6i
(neu co):
III.
SAN PHAM KH&CN CUA DE TAI,
Dl/
AN
1.
San
phSm
KH&CN da tao ra:
a)
San
phim Dang I:
Sd
TT
1
Ten san pham vd

chi tieu
ch&t
luang chii yiu
Vac xin nhii dau
THT trau bo chung
P52 dat chat
luong
xuat xuong ve vat
ly, vo trung, an toan
va hieu luc
Ban
vi do
Lieu
S6
lufitg
3 trieu
Theo ke
hoach
3 trieu
77iHC
ti
dat duac
Hon 7 trieu
b) San pham Dang II:
SS
TT
1
2
3
Ten san pham

Hoan thien qui trinh
cong nghe san xuat
vac xin THT trau bo
nhu dau chung P52
6
qui mo cong
nghiep.
Hoan
thiSn
qui trinh
kiem nghiem vac
xin THT
trau
bo nhil
d^u
chung P52.
Xay dung phuang
phap danh gia mien
dich va bao
h6 ciaa
vac xin trong dieu
kien thuc
te'
bang ky
thuat ELISA.
Yeu
can
khoa
hpc
chn dat

Theo ke hoach
On dinh moi truong
nuoi cay; hieu chinh
cac thong
s6
ky thuat
nuoi cay; hoan thien he
thong tao nhu, ra chai
tren day
chuyen
tu
d6ng
va ban tu dong
khep kin, v6 triing
6
qui mo cong nghiep
- Danh gia tinh on dinh
ve vat ly, vo trung, an
toan va mien dich cua
vac
xin
- Danh gia dp dai mien
dich cua vac xin
- Danh gia tinh nhay
cam va dac hieu cua ky
thuat ELISA khi dung
kiem tra mien dich
THT tren trau bo
- Lien he so sanh
giua

phuong phap ELISA va
phuang phap bao ho
thu dong tren chupt khi
ti6n
hanh kiem tra mien
Thuc te
dat duac
Qui trinh san xuat
vac xin vo boat tu
huyet trung trau
bo
nhQ
dau chung
P52 (qui mo cong
nghiep)
Qui trinh kiem
nghiem vac xin vo
hoat tu huyet
trung trau bo nhu
dau chung P52
Qui trinh ky thuat
ELISA dung phat
hien khang the
Pasteurella
multocida
serotype
B:2
Ghi chu
Dat theo
dang ky

Dat theo
dangky
Dat theo
dangky
4
5
6
Xay dung qui trinh
bao quan vac xin.
Xay dung qui trinh
van chuyen vac xin
Xay dung qui
trinh
sii
dung vac xin
dich a dan trau bo duac
tiem vac xin nhu dau
chiing P52.
- Moi lien he giua
phuong phap ELISA va
cong cuang doc
Xdc
dinh duoc thai
gian va dieu kien bao
quan vac xin nhu dau
- Qui
each
dong goi,
sap xep thich hop tirng
loai bao bi trong, bao bi

ngoai theo yeu cau van
chuyen.
- Danh gia theo doi
nhiSt d6
vh.
dilu ki6n
van
chuyen.
- Xac dinh doi
tuong
tiem phong vac xin
- Qui dinh lieu tiem
duong tiem vac xin
- Bao quan vac xin
trong qua trinh tiem
- Bao
bi,
nhan mac, han
diJng,
each
tidm,
dudng
tiSm,
lilu
tifem.
Qui trinh bao
quan vac xin vo
hoat tu huyet
triing trau bo nhu
dau chung P52

Qui trinh van
chuyen vac xin vo
hoat tu huyet
trung trau bo
nhQ
dau chung P52
Qui trinh su dung
vac xin vo hoat tu
huyet trung trau
bo
nhij
dau chung
P52
Dat theo
dang ky
Dat theo
dang ky
Dat theo
dang ky
- Ly do thay doi (neu co):
c) San pham Dang IV:
SS
TT
1
2
Ten san pham
Kiem tra dap
ling
mien
dich

6
trau bo sau khi
tiem vac xin tu huyet
triing trau bo bang
phuong phap ELISA
Bao cao
tdng kSt
du an
Yeu cau khoa
hpc
can dat
Theo
kl hoach
1
1
Thuc te
dat duoc
1
1
SS luang,
noicdng
bo
(Tap
chi,
nha
xuat ban)
Khoa
hgc
ky
thuat

thii
y
Tap
XVI.
S6 5-2009
1
d) Ket qua dao
tao:
Sd
TT
1
2
CSp ddo
tao, Chuyen
nganh
diio tcio
Thac sy
Tien sy
SS luang
Theo ke
hoach
0
0
Thirc te dat
dugc
02
0
Ghi
chii
(Thai gian liet

thiic)
01 da
tot
nghiep 2009
•
Ly do thay doi (neu
c6):
e)
Th6ng
ke danh muc san pham KHCN da dugc ung dung
S6
TT
1
2
3
4
5
6
Ten
kit qua
da
dirofc
ung dung
Qui trinh san xuat vac
xin vo hoat tu huyet
trung trau bo nhu dau
chiing P52 (qui mo cong
nghiep)
Qui trinh kiem nghiem
vac xin vo boat tu huyet

trimg trau bo nhu dau
chiing P52
Qui trinh ky thuat
ELISA dung phat hien
khang the
Pasteurella
multocida serotype B:2
Qui trinh bao quan vac
xin vo hoat tu huyet
trung trau bo nhu dau
chiing P52
Qui trinh van chuyen
vac xin vo hoat tu huyet
trung trau bo nhu dau
chiing P52
Qui trinh
sOr
dung
vac xin vo hoat tu huyet
Tlt&i
gian
12/2008
12/2008
3/2009
12/2008
12/2008
12/2008
Dia diem
(Ghi
ro

ten.
dia
chi nai ung dung)
Cong ty TNHH
mot thanh vien
thuoc thu y TW
Cong ty TNHH
mot thanh vien
thuoc thu y TW
Cong ty TNHH
mot thanh vien
thuoc
thii
y TW
Cong ty TNHH
mot thanh vien
thuoc
thii
y TW
Cong ty TNHH
mot thanh vien
thuoc thu y TW.
Cac chi
cue thii
y
Cong ty TNHH
mot thanh vien
vao thuc te
Kit qua
so'bo

Ap dung san xuat 7
trieu lieu vac xin
THT trau bo nhu
dau chiing P52 cung
cap cho thi truong
trong nuac va xuat
khau
Ap dung de kiem
nghiem vac xin
THT trau bo nhu
dau chiing P52
i
truac khi xuat
xuong
Duac ap dung de
danh gia mien dich
ciia
trau bo duac
tiem vac xin THT
trau bo
Ap dung tai kho vac
xin
ciia
Cong ty va
tai cac chi
cue thii
y
Ap dung tai Cong ty
i
Ichi

van chuyen vac
xin tai
cac chi cue
thii
y va
tii
cac chi
cue
toi dia diem
tiem phong
Cac chi
ciic thii
y va
nguoi
sii
dung vac
niing
trSu
bo nhu dau
chung P52
thuoc thu y TW.
Cac chi
cue thii
y
xin de tiem phong
2.
f)anh
gia ve hieu qua do de tai,
du'
an mang lai:

a) Hieu qua ve khoa hoc va cong nghe:
- Hoan thien qui trinh cong nghe san xua't vac xin THT trau bo nhu dau
chiing P52 o qui mo cong nghiep va on dinh qui trinh la tien de cho viec dap
ung san pham theo nhu cau thj truong trong nuoc va xuat
l<liau
cung nhu ap
dung de san xuat cac loai vac xin dang
nhO
dau khac.
- Sir dung cong nghe len men vi sinh hien dai khep kin,
ciing
voi cong thiic
nhu, thiet bi tao nhu cong suat
Ion
lam cho san pham vac xin tao ra co chat
lugng
dong deu va
6n
dinh
vl
chat
lugng.
Vac xin co tinh an toan va hieu
lire
cao,
miln
dich keo dai it nhat 1 nam. San pham mang tinh canh tranh cao va
phuc vu tot cong tac phong benh THT trau bo ca nuoc mot
each
hieu qua.

-
VS
cong nghe: Vac xin dugc san xuat dat cong nghe tien tien dugc ap dung
o
nhieu nuoc tren
thi
gioi.
b) Hieu qua ve kinh te xa hoi:
Do
nhijng iru
viet
ciia
vac xin nhQ dau tu huyet tning trau bo chiing P52 da
dugc nghien
cuu
trong du an, loi ich
ciia
vac xin the hien
cii
the
nhir
sau:
+ Giam so
Ian
tiem phong tit
1
nam 2
Ian
xuong
1

nam
1 Ian
(hoac
1,5
lin).
+ Giam chi phi to chirc tiem phong cho cac
dja
phuong.
+ Tiet kiem thgi gian va nhan
lire.
+ Tang ty le tiem phong va ty le bao ho cho dan trau bo.
+ Nang cao hieu qua kinh te cho nguoi chan nuoi.
Chi phi
t6
chirc tiem phong cho
1
dau trau
bo/l
nam
dugc
so sanh:
Chi so
Vac xin
GiaVX
(d6ng)
Lan
tiem/nam
Chi phi
tiem
phong/lan

(d6ng)
Chi
phi/con/
nam
(d6ng)
Ghi
chii
keo phen
Vac xin
nhu dau
1.300
1.424
2
1
1,5
2.000
2,000
2.000
6.600
3.424
5.136
Viing
it
de doa
Viing CO
nguy
eg
cao
So lugng trau bo ca nuoc hien co khoang 8 trieu con, nhu vay neu ty le tiem
phong

uoc
tinh dat khoang 50% (4 trieu con) chi phi cho viec tiem phong vac
xin cho moi loai vac xin trong
1
nam se la:
-I-
Vac xin keo phen: 4 (trieu con) x 6.600 (dong) = 26,4 ty
d6ng
/nam
-I-
Vac xin nhii dau (tiem
1
Ian):
4 trieu x 3424 (d) = 13,7 ty
dong/nam
-I-
Vac xin nhii dau (tiem 1,5 lin): 4 trieu x
5136
(d) = 20,5 ty
d6ng/nam
3.
Tinh hinh thirc hien che do bao cao,
kilm
tra cua de tai, da an:
SS
TT
I
NSidung
Bao cao dinh ky
LJn

1
Lin
2
Lan 3
Th&i
gian
thuc hien
11/11/2008
29/5/2009
11/12/2009
Ghi chii
(Tom tat ket
qua.
lie!
luan chinh,
ngicai
chii tri )
DlT an dugc to chirc trien khai
nghiem tiic, khoa hgc cac noi dung
de ra. Da hoan thanh 3 noi dung:
Hoan thien qui trinh cong nghe san
xuat vac xin nhii dau qui mo cong
ngiep;
SX dugc 927.125
liSu
VX;
Dao tao can bg, cong nhan lam chii
qui tring va van hanh thiet bi.
Hoan thanh cac noi dung nhu dang
ky dung tien do va chat lugng. Da

san xuat
dii
3 trieu lieu vac xin nhQ
dau THT trau bo dat tieu
chuin
xuat xuong.
Hoan thanh toan bg cac noi dung
cua du an dung
tiSn
do va
chit
II
m
Kiem tra dinh ky
LSn 1
Lan 2
Lan 3
Nghiem thu co so
01/12/2008
18/7/2009
03/02/2010
13/4/2010
lugng bao gom cac san pham dang
1,11,
IV nhu da dang ky.
Hoan thanh mot so noi dung nhu
da dang
l^y
nam 2008.
Da hoan thanh tot cac noi dung

da^
dang ky. Thuc hien vugt tien do ve
so lugng san pham.
- De nghi du an tham gia Techmart
Viet Nam ASEAN + 3 (9/2009).
- Du an hoan thanh day du cac noi
dung theo dung tien do va co chat
lugng.
- Hoan tilt hho so, to chirc nghiem
thu cap
CO
so va chuan bi cho
nghiem thu cap Nha nuoc.
Du dieu kien danh gia ket qua du-
an o
c8p
Nha
nude.
Chu nhiem de tai
(Ho
ten,
chu ky)
Thu truong to chu'c chu tri
'n,
chu:
ky va dong ddu)
TONG GIAM DOC
TOIVI
TAT KET QUA
Nham han che nhugc diem cua vac xin THT trau bo keo phen, vac xin

hien nay dang dugc sir dung phong benh THT trau bo
a
nuac ta, trong
chuong trinh cai tien nang cao chat lugng cua vac xin THT, Trung tam
nghien cim
thii
y thuoc Cong ty thuoc
thii
y TW-NAVETCO, da nghien
ciiu
cai tien chat bo
trg
mien dich
ciia
vac xin THT trau bo keo phen chimg P52
thanh vac xin THT trau bo nhii dau (vac xin THT trau bo keo phen chiing
P52 da dugc hoi dong khoa hgc Bg Nong Nghiep & PTNT thong qua va cho
phep sir dung). Vac xin THT trau bo nhii dau chung P52, sau khi nghien ciru
thanh cong trong phong thi nghiem da dugc kiem nghiem tai Trung tam kiem
nghiem thuoc
thii
y TW
1
va ket qua dat cac chi tieu ve vo triing, an toan va
hieu
lire.
Tir nhimg ket qua thu dugc trong phong thi nghiem va ngoai thuc te
san xuat, nham hoan thien mot so van de trong san xuat vac xin nhii dau, de
CO
the san xuat theo qui mo cong nghiep, chiing toi de xuat thuc hien du an

san xuat thir nghiem nay.
Du an thuc hien va hoan thanh 6 noi dung, bao gom: i/ Hoan thien qui
trinh cong nghe san xuat vac xin THT trau bo nhii dau chimg
P52
qui mo
cong nghiep; ii/ Hoan thien qui trinh kiem nghiem vac xin THT nhii dau; iii/
Hoan thien qui trinh bao quan, sir dung, van chuyen vac xin THT trau bo
nliQ
dau; iv/ So sanh hieu qua ciia vac xin THT trau bo nhii dau chiing P52 voi
cac vac xin THT khac; v/
Xay
dung phuong phap kiem tra mien djch de danh
gia miln dich ciia dan gia
site
dugc tiem phong vac xin THT; vi/ Thu nghiem
tiem phong vac xin trong san xuat.
Kit
qua cua du an chi ra rang vac xin THT trau bo nhu dau chiing
P52
da
dugc san xuit thanh cong tai Cong ty thuoc thu y TW - NAVETCO, cong