cập nhật các hướng dẫn kiểm soát acid uric và bệnh gout từ các khuyến cáo quốc tế

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Prevalence generally ranges from < 1% to 4%

Gout is the most common form of inflammatory arthritis in adults and the second most common form of arthritis (a,c)

US (2011): 8.3 million (gout), 43 million (hyperuricemia)

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Cácviêm

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hóa purin và H/C hóa

<small>RLCH Purin gianhanh trong 2 niên</small>

<small>Theo AHA (American Heart Association): </small>

<small>(HK 28,8 % ~ )</small>

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<i><small>Frances Rees, Michelle Hui & Michael Doherty. Optimizing current treatment of gout. Nature Reviews Rheumatology 10, 271 283 (2014) Published online 11 March 2014 </small></i>

- ACID URIC

Gout

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<small>(80%-90% of all gout patients)(5%-10% of all gout patients)</small>

Acid Uric

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Gout: An old disease in new perspective - A review.

<i><small>Gaafar Ragab, MohsenElshahaly, ThomasBardin. Journal of Advanced Research. Volume 8, Issue 5. September 2017, Pages 495-511</small></i>

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kháng viêm khơng có Steroid (NSAID), Colchine

Allopurinol: 200 800 mg/ngày (TB 300 mg/ngày) Febuxostat: 40 120 mg/ngày (TB 80 mg/ngày)

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American College of Rheumatology Guidelines for Management of Gout (ACR 2012/2015)

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máu (HD) = 0.6mg x 2 /1 (not dialyzable)

acid uric tay là nhómmen XO (Xanthine Oxidase Inhibitor- XOI).

tiêu acid uric <6 mg/L là, <5 .

phòng trong 3 tháng (khơng tophi) 6 tháng (có tophi) sau khitiêu acid uric.

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ACR 2012/2015:- ULT

<small>Khanna D, et al. Arthritis Care Res (Hoboken). 2012 Oct;64(10):1447-61</small>

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uric ngay

(> 480 mmol/L)

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EULAR recommendation for Treating to Target 2017

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2016 EULAR Recommendations for the Management of Gout

<i><small>Richette P et al. Ann Rheum Dis 2017;76:29-42</small></i>

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2016 EULAR Recommendations for the Management of Gout

<i><small>Richette P et al. Ann Rheum Dis 2017;76:29-42</small></i>

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The British Society for Rheumatology Guideline for the Management of Gout (BSR 2017)

<i><small>Michelle Hui et al., Rheumatology 2017;56:e1-e20</small></i>

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<i><small>Schumacher HR Jr, et al. BMJ. 2002;324(7352):1488 1492; Rubin BR, et al. Arthritis Rheum. 2004;50(2):598 606Zhang S & Zhang Y & Liu P. Clin Rheumatol (2016) 35:151 158.</small></i>

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<i><small>Michelle Hui et al., Rheumatology 2017;56:e1-e20</small></i>

BSR 2017

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- ACID URIC

<i><small>Improving cardiovascular and renal outcomes in gout: what should we target ? The Lancet Journals. Published Online: 21 April 2016 </small></i>

<small>< 5 mg/dl (< 300 mmol/l)</small>

<small>Gout (Tophi), CKD, CV disease Gout (Ko có tophi, khác) </small>

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How Gout can Kill You

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Improving adherence to gout therapy: an expert review

<i><small>Fernando Perez-Ruiz, Giovambattista Desideri. Dove Press Ltd. May 2018 Volume 2018:14 Pages 793802 </small></i>

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<small>Gout 20 </small>

<small>-Improving adherence to gout therapy: an expert review</small>

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<small>URAT1Uric acid transporter</small>

<small>MCP-1monocyte chemotactic protein -1NONitric oxidevasodilatation factor</small>

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sinhnhân Gout

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1. RLCH Purin và acid uric máu ngày càng gia và liên quan

urate

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Acid Uric

soát acid uric máu soát acid uric máu

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