NGHIÊN cứu BIẾN THIÊN NHỊP TIM BỆNH NHÂN TĂNG HUYẾT áp NGUYÊN PHÁT TRÊN 40 TUỔI

480
NGHIÊN CU BIN THIÊN NHP TIM
BT ÁP NGUYÊN PHÁT TRÊN 40 TUI

Trn Minh Trí
1
, Hu
2

1

2



:  

:  

m-


gian (ms): SDNN, ASDNN, SDANN, RMSSD.

2


                 




g bình là 48.91 ± 1.45.


 



ính.
: 


SUMMARY
Objectives: Heart rate variability (HRV) is a useful noninvasive tool to assess cardiac
autonomic function. The purpose of this study was to (1) compare measures of time and
frequency domain analysis of HRV between hypertensive and normotensive subjects and (2)
their correlations in gender. The HRV was determined from 24-hour Holter records, using 4 time
domain measures (SDNN, ASDNN, SDANN, RMSSD), 5 frequency domain measures (HF, LF,
ULF, VLF, TF)
Results: There were 45 hypertensive subjects with a mean age (+/-SD) of 49.82 ± 0.97
years and 31 normotensive subjects with a mean age of 48.91 ± 1.45 years. The HRV of all
measures show significant difference between the hypertensive patients and control group
(p<0.01) and there were no significant difference between male and female in hypertensive
group (p>0.05).
Conclusion: Our results suggest that HRV is reduced in men and women with systemic
hypertension over 40 years old.



3


       
481





 



- 
- 

Window XP.

- 
vi
  -    

-  

- 

- 
-       

[1]
SDNN (ms)






h


[1]
HF, ms
2

-thn kinh phó giao cm
LF, ms
2
-
thn kinh giao cmthn kinh phó giao cm


VLF, ms
2
-
thn kinh giao cmphó giao cm
angiotensi
ULF, ms
2
--

thn kinh giao cm

TF, ms

2
 0.4Hz.
S 17.0

482






p
Nam, n(%)

Nam, n(%)



24 (53.3)
21(46.7)
18 (58.1)
13(41.9)
>0.05

49.82 ± 0.97
48.91 ± 1.45
>0.05





p
ASDNN (ms)
48.65 ± 3.07
37.38 ± 2.10
<0.01
SDANN (ms)
100.72 ± 5.79
84.86 ± 4.14
<0.01
SDNN (ms)
113.84 ± 5.81
95.17 ± 4.45
<0.01
RMSSD (ms)
33.10 ±5.01
24.62 ± 2.06
<0.01
LnULF (ms
2
)
2.38 ± 0.14
2.04 ± 0.09
<0.01
LnVLF (ms
2
)
4.37 ± 0.21
3.63 ± 0.12

<0.01
LnLF (ms
2
)
4.27 ± 0.23
3.34 ± 0.12
<0.01
LnHF (ms
2
)
4.59 ± 0.21
3.61 ± 0.13
<0.01
LnTF (ms
2
)
7.04 ±0.20
6.22 ± 0.10
<0.01
LF/HF
0.93 ± 0.02
0.93 ± 0.02
>0.05

- 
-


Nam





THA (1)
(n=24)
HABT (2)
(n=18)
p (1) và (2)
THA (3)
(n=21)
HABT (4)
(n=13)
p (3) và (4)
p(1)và (3)
ASDNN
40.12
47.53
0.03
34.26
50.21
0.001
>0.05
SDANN
91.91
104.11
0.06
76.80
96.03
0.001

>0.05
SDNN
102.66
116.32
0.04
86.61
110.39
0.001
>0.05
RMSSD
24.71
28.39
0.20
24.50
39.62
0.001
>0.05
LnULF
2.11
2.39
0.04
1.95
2.37
0.01
>0.05
LnVLF
3.77
4.48
0.001
3.48

4.21
0.001
>0.05
LnLF
3.12
4.25
0.001
3.58
4.29
0.001
>0.05
LnHF
3.34
4.47
0.001
3.91
4.74
0.001
<0.05
LnTF
6.13
7.03
0.001
6.33
7.04
0.001
>0.05







-resampling).




45] v




483


1],Jagmeet P. Singh [5], Knut Sevre [6].

7]
8]

meet P. Singh [5], Knut
Sevre [6].







1. nh (2009). Bin thiên nhp tim và giá tr d báo ca các
ch s bin thiên nhi vt hin ri lon nhp tht nng  bnh nhân
t áp nguyên phát. Tp chí ni khoa 1/2009; trang 258-262.
2. Hu 24 gi trong bnh lý tim mch. Nhà xut
bi hc Hu.
3. Julius S (1991). Autonomic nervous system dysregulation in human hypertension. Am J
Cardiol; 67: 3B-7B.
4. James V. Freeman et al (2006). Autonomic Nervous System InteractionWith the
Cardiovascular System During Exercise. Progress in Cardiovascular Diseases, Vol. 48, No.
5 (March/April): pp 342-362.
5. Jagmeet P. Singh, Martin G et al (1998). Reduced Heart Rate Variability and New-Onset
Hypertension: Insights Into Pathogenesis of Hypertension: The Framingham Heart Study.
Hypertension; 32;293-297.
6. Knut Sevre, Johan D et al (2001). Autonomic Function in Hypertensive and
Normotensive Subjects: The Importance of Gender. Hypertension;37;1351-1356.
7. Malliani A, Pagani M, Furlan R et al (1997). Individual recognition by heart rate
variability of two different autonomic profiles related to posture. Circulation; 96:4143
4145.
8. Tsuji H, Venditti FJ Jr et al (1996). Determinants of heart rate variability. J Am Coll
Cardiol; 28:15391546.