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Therapeutic strategies for
Hypertrophic Cardiomyopathy patient with
Syncope.
Nguyen Thi Mai Ngoc MD, PhD
Viet Nam National Heart Institute
Bach Mai General Hospital


Definition of syncope and sudden death

Syncope was defined as a sudden and
brief loss of consciousness associated with a
loss of postural tone and a spontaneous
recovery.






Prognosis profiles for HCM and targets for therapy


Clinical pathways in HCM


Indication for ICDs in HCM


Definition of syncope and sudden death

Family screening for HCM patients and family
members



Genetic testing.



Interpretation.



Genetic Counseling.


Characteristic & prognosis implication of myosin missense
mutation in HCM:


High risk of sudden death:

Mutation Arg403Gln
Arg719Trp
Arg453Cys.


Intermediate risk of premature sudden death:
Arg249Gln

Glu930Lys



Carrier of other MYH7 mutations would normal risk of premature sudden
death: Gly256Glu, Val606Meth, Leu908Val


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