thực tập hóa dược

–
.
.
.

:
.

4

3

.
-

1


4

2

2-


-










su

3


trong HPLC)

II. K
NaCl

Pt.l.: 58,44

Khi
NaCl

Na

+ Cl

A. P



dung d

Na+ + Mg[(UO2)3(CH3COO-)8] + CH3COO- + 9H2O = NaMg[(UO2)3(CH3COO-)9.9H2O

B. P




4


-

Bromid

590 nm k

Iodid

Sulfat

Bari

d sulfuric 1M

Arsen

C - 105
:
NaCl + AgNO3 = AgCl + NaNO3

5


A. H

B. H
dextrin (1/50) v

-

C. C

khô

6


1. T
2. T
hydroclorid.
3. T

procain

1. K
Công

H2N

COOCH2

CH2

N

C2H5
C2H5

.HCl

Ptl: 272,8
-N,N-Diethylaminethyl p-aminobenzoat hydroclorid

C14H20N2O2

trong ethanol 96
A. P
aceton, thêm 1
B. T
0,1%
C. P



-

ArNH2 + NaNO2 + 2 HCl

+

[Ar-N N]Cl- + NaCl + 2H2O
7


N=N-Ar
NaO

NaO
-

[Ar-N N]Cl +

– naphtol
Ar =

COOCH2CH2N(C2H5)2

D. P

pH
-

-20C.

+

KBr [Ar-N N]Cl- + NaCl + 2H O
ArNH2 + NaNO2 + 2 HCl
2
10 -150C

Ar =

COOCH2CH2N(C2H5)2

8


2

2
13H20N2O2

2

CH3
NH CO CH2

N

C2 H 5
C2 H 5

.HCl.H2O

CH3

Ptl: 288,82
-(N.N-diethylamino)-N-(2,6-dimethylphenyl)acetamid hydroclorid,

C14H22N2O.HCl.H2O

monohydrate
trong
ethanol 96

o

o

-79 C.

2

a trong 1ml ethanol 96

o

2
o

C.

9


COOH
OCOCH3

Ptl: 180,2

C9H8O4



ch H2SO4

10


COONa

COOH

ONa

OCOCH3
3NaOH

CH3COONa

2H2O

COOH
OH

H+

CH3COOH



3


CaCO3

3
3COO)3.




3


3

0,5%
; 0,1ml acid acetic bang

trong ethanol 96

g

11


COONa

COOH

OCOCH3

OCOCH3

H2O + CH3COONa

NaOH

phenolphthalein)
-10
9H8O4

99,5-101,0% C9H8O4

COONa

COOH

OH

OCOCH3
2NaOH

CH3COOH

H 2O



45,04mg C9H8O4.
-

Acid (1) + base (2) = base (1) + acid (2)


2,

12

NH3, SO3…




…




COOH
OH

Ptl: 138,1

C7H6O3

-Hydroxybenzoic acid

o

m

3

2

4

.

13


COOH

COOH

COOH
OH

OH

O

HNO2
HO

O=N

O

O

O

C
O

CuSO4
HO

Cu

N

O

O

N

N OH
2SO4

H2SO4
COOH

COOCH3

OH
CH3OH

OH

H+
(-H 2O)

COONa
OH

Ptl: 160,1

C7H5NaO3

ether.

3

14


-161C.

15


M PARACETAMOL

diclofenac natri

paracetamol.
aracetamol
NH CO CH3
HO

C8H9NO2

Ptl: 151,2

-hydroxyacetanilid ( p-acetamidophenol)
B
phenolat).
A
3

B

16


HO

NHCOCH3

HO
O

H+

HO

o

t

NH2

K2Cr2O7

NH2

NH2

NH

O

N
HO

C.
NaNO2
-napthol

HO

NHCOCH3

H+

HO

to

NH2

NaNO2/H+

NaO
+

HO

NaO

N N Cl

N N
NaO

D.

– 980.
E. P

2SO4

17

riêng.

0ml. thêm 10ml NaOH
0,4%

A = lg = lg
0

A=ε
ε
mol/l

A (1%, 1cm) =

–

18


Cl

CH2

COONa

N
Cl

C14H10Cl2NNaO2

Ptl: 318, 1

: Mononatri-2-(2,6-dicloroanilino)phenyl acetat

96
A. thêm 1ml HNO3
nâu.
B.
C.
[
3

K3[Fe(CN)6] + HCl diclofenac H4[Fe(CN)6] + HCl

19

FeCl3

Fe4[Fe(CN)6]3 + HCl


barbital, diazepam

phenobarbital, diazepam.

-

O
HN

C2H5

O

C2H5

HN
O

C8H12N2O3

Ptl: 184,19

cid 5,5-diethyl barbituric

3

3

20


O
HN

O
N

C2 H 5

O

NaOH

C2H 5

HN

C2H5

NaO

O

Ag

O

N

C 2H5

N

C2H 5

AgO

Ag+

C2 H5

HN

O

+

O



2



-




254

– ethanol 96- clo




.


h (2).
*P
P


21




ƒ

a dung môi.
R ƒ=

Rƒ
ƒ

r

Rr =

Rr




22

NaOH 0,1M.
-

O
HN

O
N

C2H5

O

C2H5

HN

C2H5

NaO

NaOH

C2H5

HN

O

O







cân). B
8H12N2O3

– 101,0%
2
O
HN

C 2H5

O

C 6H 5

HN
O

C12H22N2O3

Ptl: 232,2
23

H2O


5-ethyl-5-phenylbarbituric

A
B
-

thêm 5mg NaNO2

24


CH3
N

O

N

Cl

C16H13ClN2O

Ptl: 248,7

-cloro-2,3-dihydro-1-methyl-5-phenyl-1,4-benzodiazepin-2-on.



.

A
–
B
-330

– 155.
C

2CO3

3

A

B. L

25