Bài soạn Chapter 14 Chemical Equilibrium

Chapter 14
Chemical
Equilibrium
2011, NKMB Co., Ltd.
Chemistry, Julia Burdge, 2
st
Ed.
McGraw Hill.
Mr. Truong Minh Chien ;
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2
Hemoglobin
•
protein (Hb) found in red blood
cells that reacts with O
2


enhances the amount of O
2
that can
be carried through the blood stream
Hb + O
2
⇔ HbO
2

the Hb represents the entire protein
– it is not a chemical formula

the ⇔ represents that the reaction is

in dynamic equilibrium
Chemistry, Julia Burdge, 2
nd
e., McGraw Hill.
3
Hemoglobin Equilibrium System
Hb + O
2
⇔ HbO
2
•
the concentrations of Hb, O
2
, and HbO
2
are all
interdependent
•
the relative amounts of Hb, O
2
, and HbO
2
at equilibrium
are related to a constant called the equilibrium
constant, K

the larger the value of K, the more product is found at
equilibrium
•
changing the concentration of any one of these

necessitates changing the other concentrations to
reestablish equilibrium
Chemistry, Julia Burdge, 2
nd
e., McGraw Hill.
4
O
2
Transport
Hb
+
O
2
⇔
in the lungs, with high
concentration of O
2
, the
equilibrium shifts to
combine the Hb and O
2

together to make more
HbO
2
in the cells, with low
concentration of O
2
, the
equilibrium shifts to

break down the HbO
2

and increase the amount
of free O
2
HbO
2
O
2

in
lungs
Hb
HbO
2
O
2

in
cells
Chemistry, Julia Burdge, 2
nd
e., McGraw Hill.
5
HbF
Hb
Fetal Hemoglobin, HbF
HbF + O
2

⇔ HbFO
2
•
fetal hemoglobin’s
equilibrium constant is
larger than adult
hemoglobin
•
because fetal hemoglobin
is more efficient at
binding O
2
, O
2
is
transferred to the fetal
hemoglobin from the
mother’s hemoglobin in
the placenta
Hb
+
O
2
⇔
HbO
2
O
2
HbO
2

O
2
Hb
+
O
2
⇔
HbFO
2
HbFO
2
O
2
Chemistry, Julia Burdge, 2
nd
e., McGraw Hill.