Bài giảng rối loạn chuyển hóa lipid

Rối loạn chuyển hóa Lipid
PGS.TS Đỗ Hòa Bình
Môc tiªu
         

      ! " #$ %
&
' (  )      %
*+*&
,-.+!"#$/-
01&2
1. §¹i c¬ng.
3-456&'7&
)8
- Triglycerid 9&:);
- Phospholipid
- Cholesteron.

1.1. Tiªu ho¸, hÊp thu
1.2. Sö dông, vËn chuyÓn
trong m¸u
VËn chuyÓn phospholipid vµ cholesterol:
díi d¹ng lipo-protein (LP)

   3* 7 < % " 
+=*+*>?
&@4A2B.* 
C3(D*7B

E?F -+G1 23(G
&*BE
1.3. C¸c typ lipo-protein (LP).
1.3.1. Sù t¹o thµnh LP
HI &+1  . 3(*B
E!7)+8
=Chylomicron.
=LP tû träng rÊt thÊp9J3H38J*K*+3(;
=
LP tû träng thÊp93H383K*+3(;
-LP tû träng trung gian9LH38L*&***+
3(;
=LP tû träng cao9MH38M*+=*;
VLDL LDL HDL
Tỷ trọng
0,95 - 1,006 1,006 - 1,063 1,063 - 1,21
Dichuyển điện di
Tiền-
lipoprotein
-lipo-protein -lipo-protein
Tỷ lệ % protein
10 25 50
Tỷ lệ % lipid
90
75 50
Lipid chủ yếu
Triglycerid Cholesterol Phospholipid
Tóm tắt một số thành phần và tính chất của các LP
1.4. Sù ®iÒu hoµ cña néi tiÕt ®èi víi
chuyÓn ho¸ lipid.

1.4.1. Hormon lµm t¨ng tho¸i ho¸ lipid
=
N*! * 9O 4 P 
$&! " -;8 Q R    +*
&@&:→SSN7%PT=UV
=
W+*++X7Q4-R
=
Y*++&%NWM
→2*Z&+*→$7SSNO[
&@&:
=
\M X    1   # +R %
  G &E   -  1  1
SSNG&<
1.4.2. Hormon kÝch thÝch tæng hîp
triglycerid
= L+81] &2   *+*  P
^NH(M

 & %  &] *=WN! 
.)tæng hîp acid bÐo
= (+ _8 % ` A !  4
+4-a
2. Rèi lo¹n chuyÓn ho¸ lipid.
2.1. T¨ng lipid m¸u.
•
b45!V&`

1cO$dee=Uee&D!5
+R f0P9P!`
A;Q
- Ph©n lo¹i vµ c¬ chÕ:
g\h+0%!*%+?&P!+
17+!*+*HVR"&%
&4X$&!&:1"
4A23&%+O%45G2
2[&4-1Q!1745P&/i
.&`+4%
g%184%!!
4A"
gH$&+CQ8j&"!
14A!&!$&+$/PP"
&:9*;
=HËu qu¶:
 %&&5j
O@ "#$1O!4
%Oik1&+"#$8
i ! + $& < % & + -
#9;!%*+*!/-01
&2
l
2.2. Rèi lo¹n lipoprotein.
45h%*!$&3()h45
]&+
- T¨ng lipoprotein.
g M¾c ph¶i8 %  3(!   *Z& =*
+*945!-1c/-0!145;
g%m&+V3(8%β=3(On&*

%*+*
    % β= 3(  a β= 3( 7 On& % * 
*+*
    % aβ= 3( On& % 4: P! *!
*+*
+ Di truyÒn8T
=
Gi¶m LP:
go@ 7 β=! & h!  . 
a!)*G!!&
P
g\$&α=8X7)1!$&α=
! %J3H3  &   )
*+*G&@
l
2.3. Rèi lo¹n chuyÓn ho¸
cholesterol
T¨ng cholesterol m¸u

+ Nguyªn nh©n:
*H%a<%*+*8
1[<!&:1"!!p
qHOi&1$!<2-8j
&"
q%18%I?&814
5Q!<"4
qH"&8%!)
1E*
+ HËu qu¶:
W*+* &% Oi  +r

/ & "     &  2
< "      - #8 
hP/-01&2
F4A3H3MH371
4A14A.
Gi¶m cholesterol-m¸u
•
H%1$!
•
\$&P8&
•
\$& *+* ]& +!  * h
 
•
M"#$.+$/P&
+&&&"